ES2170414T3 - Reduccion de efectos toxicos del carboplatino usando ditioeteres. - Google Patents
Reduccion de efectos toxicos del carboplatino usando ditioeteres.Info
- Publication number
- ES2170414T3 ES2170414T3 ES97941110T ES97941110T ES2170414T3 ES 2170414 T3 ES2170414 T3 ES 2170414T3 ES 97941110 T ES97941110 T ES 97941110T ES 97941110 T ES97941110 T ES 97941110T ES 2170414 T3 ES2170414 T3 ES 2170414T3
- Authority
- ES
- Spain
- Prior art keywords
- carboplatin
- dithioether
- ditioeters
- reduction
- toxic effects
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960004562 carboplatin Drugs 0.000 title abstract 5
- 231100000331 toxic Toxicity 0.000 title abstract 2
- 230000002588 toxic effect Effects 0.000 title abstract 2
- 190000008236 CARBOPLATIN Chemical compound 0.000 title 1
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 abstract 4
- KQYGMURBTJPBPQ-UHFFFAOYSA-L disodium;2-(2-sulfonatoethyldisulfanyl)ethanesulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)CCSSCCS([O-])(=O)=O KQYGMURBTJPBPQ-UHFFFAOYSA-L 0.000 abstract 2
- 206010065553 Bone marrow failure Diseases 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229950009278 dimesna Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
PARA REDUCIR EL EFECTO TOXICO DEL CARBOPLATINO, EN PARTICULAR LA APLASIA MEDULAR Y EL VOMITO, SE ADMINISTRA UN DITIOETER CUYA FORMULA (I) ES R 1 - (CH 2 ) N - S S - (CH 2 ) M - R 2 DONDE CADA UNO DE R S UB, 1 Y R 2 INDIVIDUALMENTE ES SO 3 H O PO 3 H 2 ; Y CADA UNO DE M Y N ES INDIVIDUALMENTE 1, 2, 3 O 4. SE ADMINISTRA AL PACIENTE UNA SAL FARMACEUTICAMENTE ACEPTABLE DEL MISMO, PREFERENTEMENTE DISODIO 2,2'' - DITIOBIS (ETANO SULFONATO) (DEMESNA), EN COMBINACION CON CARBOPLATINA, BASICAMENTE AL MISMO TIEMPO QUE SECUENCIALMENTE, LO QUE HACE QUE EL DITIOETER Y EL CARBOPLATINO SE VUELVAN COPRESENTES EN LA SANGRE DEL PACIENTE. ESTA INVENCION SE REFIERE TAMBIEN A UNAS COMPOSICIONES QUE COMPRENDEN CARBOPLATINO Y DITIOETER.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2643096P | 1996-09-23 | 1996-09-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2170414T3 true ES2170414T3 (es) | 2002-08-01 |
Family
ID=21831779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97941110T Expired - Lifetime ES2170414T3 (es) | 1996-09-23 | 1997-09-23 | Reduccion de efectos toxicos del carboplatino usando ditioeteres. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0957920B1 (es) |
| JP (3) | JP2001500872A (es) |
| CN (1) | CN1129432C (es) |
| AT (1) | ATE210987T1 (es) |
| AU (1) | AU712548B2 (es) |
| CA (1) | CA2263166C (es) |
| DE (1) | DE69709404T2 (es) |
| DK (1) | DK0957920T3 (es) |
| ES (1) | ES2170414T3 (es) |
| PT (1) | PT957920E (es) |
| WO (1) | WO1998011898A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6177411B1 (en) * | 1999-02-09 | 2001-01-23 | Bionumerik Pharmaceuticals, Inc. | Method for treating heavy metal poisoning |
| IL152433A0 (en) | 2000-04-26 | 2003-05-29 | Univ Oregon Health Sciences | Administration of a thiol-based chemoprotectant compound |
| AU2002251763B2 (en) * | 2001-01-19 | 2006-05-04 | Bionumerik Pharmaceuticals, Inc. | Method for treating cancer |
| US8710095B2 (en) | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
| US7282602B2 (en) * | 2004-09-21 | 2007-10-16 | Bionumerik Pharmaceuticals, Inc. | Medicinal disulfide salts |
| AU2008352597B2 (en) * | 2008-03-14 | 2012-03-08 | Bionumerik Pharmaceuticals, Inc. | Treatment methods and compositions for lung cancer, adenocarcinoma, and other medical conditions |
| CN111632146B (zh) * | 2020-05-29 | 2021-09-28 | 中山大学 | Oat抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789000A (en) * | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
-
1997
- 1997-09-23 ES ES97941110T patent/ES2170414T3/es not_active Expired - Lifetime
- 1997-09-23 WO PCT/GB1997/002582 patent/WO1998011898A1/en not_active Ceased
- 1997-09-23 DK DK97941110T patent/DK0957920T3/da active
- 1997-09-23 PT PT97941110T patent/PT957920E/pt unknown
- 1997-09-23 CA CA002263166A patent/CA2263166C/en not_active Expired - Fee Related
- 1997-09-23 AU AU43133/97A patent/AU712548B2/en not_active Ceased
- 1997-09-23 AT AT97941110T patent/ATE210987T1/de active
- 1997-09-23 EP EP97941110A patent/EP0957920B1/en not_active Expired - Lifetime
- 1997-09-23 DE DE69709404T patent/DE69709404T2/de not_active Expired - Lifetime
- 1997-09-23 JP JP10514414A patent/JP2001500872A/ja active Pending
- 1997-09-23 CN CN97198132A patent/CN1129432C/zh not_active Expired - Fee Related
-
2009
- 2009-02-12 JP JP2009030370A patent/JP2009143950A/ja active Pending
-
2013
- 2013-05-16 JP JP2013103975A patent/JP2013155200A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0957920B1 (en) | 2001-12-19 |
| EP0957920A1 (en) | 1999-11-24 |
| DE69709404D1 (de) | 2002-01-31 |
| WO1998011898A1 (en) | 1998-03-26 |
| DK0957920T3 (da) | 2002-04-02 |
| JP2009143950A (ja) | 2009-07-02 |
| CN1230887A (zh) | 1999-10-06 |
| PT957920E (pt) | 2002-06-28 |
| CA2263166A1 (en) | 1998-03-26 |
| JP2013155200A (ja) | 2013-08-15 |
| JP2001500872A (ja) | 2001-01-23 |
| DE69709404T2 (de) | 2002-05-29 |
| ATE210987T1 (de) | 2002-01-15 |
| CA2263166C (en) | 2006-12-12 |
| AU4313397A (en) | 1998-04-14 |
| AU712548B2 (en) | 1999-11-11 |
| CN1129432C (zh) | 2003-12-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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