ES2173856T3 - Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas. - Google Patents

Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas.

Info

Publication number
ES2173856T3
ES2173856T3 ES90121961T ES90121961T ES2173856T3 ES 2173856 T3 ES2173856 T3 ES 2173856T3 ES 90121961 T ES90121961 T ES 90121961T ES 90121961 T ES90121961 T ES 90121961T ES 2173856 T3 ES2173856 T3 ES 2173856T3
Authority
ES
Spain
Prior art keywords
growth factor
cells
eucariot
expression
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90121961T
Other languages
English (en)
Inventor
Valle Francesco Della
Lanfranco Callegaro
Alessandro Negro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fidia SpA
Original Assignee
Fidia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia SpA filed Critical Fidia SpA
Application granted granted Critical
Publication of ES2173856T3 publication Critical patent/ES2173856T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN PROCESO PARA OBTENER, A PARTIR DE CELULAS TRANSFORMADAS, EL POLIPEPTIDO DENOMINADO FACTOR DE CRECIMIENTO DEL NERVIO ((BETA)-NGF), Y MAS ESPECIFICAMENTE, AL PROCESO PARA OBTENER, VOLVIENDO A COMBINAR TECNOLOGIA DE DNA USANDO CONSTRUCCIONES GENETICAS INSERTABLES EN LAS APROPIADAS LINEAS CELULARES EUCARIOTICAS, LA FORMA HUMANA MADURA BIOLOGICAMENTE ACTIVA ((BETA)-SUBUNIDAD).
ES90121961T 1989-11-16 1990-11-16 Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas. Expired - Lifetime ES2173856T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT04856489A IT1238348B (it) 1989-11-16 1989-11-16 Processo per la preparazione di costrutti genetici per l'espressione del fattore di crescita nervoso in cellule eucariote.

Publications (1)

Publication Number Publication Date
ES2173856T3 true ES2173856T3 (es) 2002-11-01

Family

ID=11267348

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90121961T Expired - Lifetime ES2173856T3 (es) 1989-11-16 1990-11-16 Proceso para la preparacion de vectores geneticos para la expresion del factor de crecimiento nervioso en celulas eucariotas.

Country Status (22)

Country Link
US (1) US5457034A (es)
EP (1) EP0432510B1 (es)
JP (2) JP3121611B2 (es)
KR (1) KR910009929A (es)
CN (1) CN1051934A (es)
AR (1) AR246983A1 (es)
AT (1) ATE214735T1 (es)
CA (1) CA2030108C (es)
DE (1) DE69033937T2 (es)
ES (1) ES2173856T3 (es)
FI (1) FI905691L (es)
HU (1) HUT61047A (es)
IE (1) IE904120A1 (es)
IL (1) IL96347A (es)
IT (1) IT1238348B (es)
NZ (1) NZ236058A (es)
PE (1) PE28191A1 (es)
PL (1) PL287811A1 (es)
PT (1) PT95911B (es)
TW (1) TW205069B (es)
YU (1) YU217890A (es)
ZA (1) ZA909122B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169762A (en) * 1983-03-03 1992-12-08 Genentech, Inc. Human nerve growth factor by recombinant technology
US6964947B1 (en) 1995-11-07 2005-11-15 Genentech, Inc. Stabilizing formulation for NGF
US6090781A (en) * 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
JP4486256B2 (ja) * 1998-10-22 2010-06-23 ザ・ジェネラル・ホスピタル・コーポレイション 副甲状腺ホルモン（ＰＴＨ）および副甲状腺ホルモン関連ペプチド（ＰＴＨｒＰ）の生物活性ペプチドおよびペプチド誘導体
AU7734800A (en) * 1999-09-29 2001-04-30 General Hospital Corporation, The Polypeptide derivatives of parathyroid hormone (pth)
ATE412670T1 (de) 1999-09-29 2008-11-15 Gen Hospital Corp Parathyroid hormon (pth) polypeptidderivate
WO2002009738A1 (en) 2000-07-28 2002-02-07 Murphy Christopher J Transplant media
US7572765B2 (en) * 2001-07-23 2009-08-11 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
AU2003220380A1 (en) 2003-03-19 2004-11-19 Bristol-Myers Squibb Company CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS
EP1653985A4 (en) 2003-07-17 2009-08-05 Gen Hospital Corp FORCED PARATHORMON (PTH) ANALOGUE
US20070207209A1 (en) * 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
WO2008019062A2 (en) * 2006-08-04 2008-02-14 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
CN101260398B (zh) * 2007-03-07 2013-06-05 舒泰神（北京）生物制药股份有限公司 神经生长因子基因定位改造动物及其制备方法和应用
BRPI0814962B8 (pt) * 2007-08-01 2021-05-25 Chugai Pharmaceutical Co Ltd métodos in vitro para determinar se um composto candidato é um agonista de longa duração ou de curta duração de um receptor acoplado à proteína g, polipeptídeo, seu uso e composição farmacêutica
CN101927012B (zh) * 2009-06-26 2013-08-14 丽珠医药集团股份有限公司 神经生长因子的病毒灭活方法
CN103002906B (zh) 2010-05-13 2017-12-29 总医院有限公司 甲状旁腺激素类似物及其应用
CN102816766A (zh) * 2012-05-04 2012-12-12 沈阳医学院 蛇毒神经生长因子活性多肽的筛选方法
JP2024527197A (ja) * 2021-07-30 2024-07-23 チェンドゥ ユノヴェル バイオファーマ カンパニー リミテッド． 組換えｃｈｏ細胞、その構築方法、並びにそれを用いた検出システム及び方法
CN115894705A (zh) * 2021-09-30 2023-04-04 三生国健药业（上海）股份有限公司 一种β-NGF融合蛋白、其制备方法及用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161152C (da) * 1983-03-03 1991-11-11 Genentech Inc Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
US4796580A (en) * 1987-09-11 1989-01-10 Allied-Signal Inc. Idle control valve for use with a throttle assembly of an internal combustion engine
JPH01211490A (ja) * 1988-02-19 1989-08-24 Tosoh Corp ヒト神経成長因子遺伝子セグメント
US5272063A (en) * 1988-11-22 1993-12-21 Syntex (U.S.A.) Inc. Process of making human nerve growth factor

Also Published As

Publication number Publication date
CA2030108C (en) 1998-04-28
FI905691A7 (fi) 1991-05-17
JP2001000194A (ja) 2001-01-09
IL96347A0 (en) 1991-08-16
ZA909122B (en) 1991-09-25
HU907174D0 (en) 1991-05-28
JP3121611B2 (ja) 2001-01-09
PT95911B (pt) 1998-01-30
ATE214735T1 (de) 2002-04-15
IT8948564A0 (it) 1989-11-16
PE28191A1 (es) 1991-10-28
NZ236058A (en) 1993-04-28
EP0432510A1 (en) 1991-06-19
JPH03224490A (ja) 1991-10-03
FI905691L (fi) 1991-05-17
FI905691A0 (fi) 1990-11-16
PL287811A1 (en) 1991-12-02
PT95911A (pt) 1991-09-13
CN1051934A (zh) 1991-06-05
AR246983A1 (es) 1994-10-31
DE69033937D1 (de) 2002-04-25
IT1238348B (it) 1993-07-13
KR910009929A (ko) 1991-06-28
DE69033937T2 (de) 2002-11-14
HUT61047A (en) 1992-11-30
CA2030108A1 (en) 1991-05-17
TW205069B (es) 1993-05-01
YU217890A (sh) 1993-05-28
US5457034A (en) 1995-10-10
AU645998B2 (en) 1994-02-03
AU6655890A (en) 1991-05-23
IL96347A (en) 1997-11-20
EP0432510B1 (en) 2002-03-20
IE904120A1 (en) 1991-05-22
IT8948564A1 (it) 1991-05-16

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