ES2176238T3 - Compuestos farmaceuticos que contienen paracetamol y l-cisteina o su precursor. - Google Patents

Compuestos farmaceuticos que contienen paracetamol y l-cisteina o su precursor.

Info

Publication number
ES2176238T3
ES2176238T3 ES94908449T ES94908449T ES2176238T3 ES 2176238 T3 ES2176238 T3 ES 2176238T3 ES 94908449 T ES94908449 T ES 94908449T ES 94908449 T ES94908449 T ES 94908449T ES 2176238 T3 ES2176238 T3 ES 2176238T3
Authority
ES
Spain
Prior art keywords
precursor
cisteine
compounds containing
pharmaceutical compounds
containing paracetamol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94908449T
Other languages
English (en)
Inventor
Roger Spencer Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Application granted granted Critical
Publication of ES2176238T3 publication Critical patent/ES2176238T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PRODUCCION DE UNA COMPOSICION FARMACEUTICA QUE COMPRENDE P-HIDROXIACETANILIDA Y L-CISTEINA O UN COMPUESTO QUE SE CONVIERTE EN LA MISMA IN VIVO, EL PROCESO COMPRENDE LA MEZCLA DE P-HIDROXIACETANILIDA Y L-CISTEINA O SU PRECURSO EN ESTADO SOLIDO Y ENTONCES SE DA FORMA A LA MEZCLA SOLIDA.
ES94908449T 1993-03-12 1994-03-08 Compuestos farmaceuticos que contienen paracetamol y l-cisteina o su precursor. Expired - Lifetime ES2176238T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939305058A GB9305058D0 (en) 1993-03-12 1993-03-12 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2176238T3 true ES2176238T3 (es) 2002-12-01

Family

ID=10731916

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02002974T Expired - Lifetime ES2254541T3 (es) 1993-03-12 1994-03-08 Composiciones farmaceuticas que contienen parracetamol y l-cisteina o un precursor de la misma.
ES94908449T Expired - Lifetime ES2176238T3 (es) 1993-03-12 1994-03-08 Compuestos farmaceuticos que contienen paracetamol y l-cisteina o su precursor.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES02002974T Expired - Lifetime ES2254541T3 (es) 1993-03-12 1994-03-08 Composiciones farmaceuticas que contienen parracetamol y l-cisteina o un precursor de la misma.

Country Status (20)

Country Link
US (2) US5716991A (es)
EP (2) EP1210939B1 (es)
JP (1) JPH08507305A (es)
KR (1) KR960700701A (es)
CN (1) CN1118989A (es)
AT (2) ATE314842T1 (es)
AU (1) AU674934B2 (es)
BR (1) BR9406227A (es)
CA (1) CA2157921C (es)
DE (2) DE69431151T2 (es)
DK (1) DK0689434T3 (es)
ES (2) ES2254541T3 (es)
GB (2) GB9305058D0 (es)
IL (1) IL108937A (es)
NO (1) NO318493B1 (es)
NZ (1) NZ262168A (es)
PT (1) PT689434E (es)
SG (1) SG48344A1 (es)
WO (1) WO1994020086A1 (es)
ZA (1) ZA941674B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032434A1 (en) * 1997-01-29 1998-07-30 Chong Kun Dang Corp. New analgesic composition
WO2001068069A2 (en) * 2000-03-15 2001-09-20 King's College London Pharmaceutical composition comprising paracetamol
KR100379155B1 (ko) * 2000-07-18 2003-04-08 삼진제약주식회사 새로운 진통제 조성물
US6623754B2 (en) 2001-05-21 2003-09-23 Noveon Ip Holdings Corp. Dosage form of N-acetyl cysteine
US20080188439A1 (en) * 2006-10-26 2008-08-07 Salhanick Steven D Directed metabolism of compounds by glucuronidation and sulfonation donors to decrease toxicity
ITMI20080187A1 (it) * 2008-02-07 2009-08-08 Velleja Res Srl Formulazioni di amminoacidi per la prevenzione del danno epatico da paracetamolo
US20110014285A1 (en) * 2009-07-15 2011-01-20 Herzenberg Leonore A N-acetyl cysteine compositions and methods to improve the therapeutic efficacy of acetaminophen
ITMI20130874A1 (it) * 2013-05-29 2014-11-30 Zambon Spa Compresse deglutibili di n-acetilcisteina

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3200039A (en) * 1962-05-28 1965-08-10 Pfizer & Co C Non-granulated tablets with 20% sorbitol in a particle size of from about 100mu to about 2000mu
GB1287431A (en) * 1969-04-16 1972-08-31 Aspro Nicholas Ltd Improvements in pharmaceutical formulations
GB1390032A (en) * 1971-08-27 1975-04-09 Sterling Winthrop Group Ltd Pharmaceutical compositions
GB1410909A (en) * 1971-10-26 1975-10-22 Sterling Winthrop Group Ltd Pharmaceutical compositions
GB1463505A (en) * 1973-11-21 1977-02-02 Nat Res Dev Pharmaceutical compositions
GB1583602A (en) * 1977-05-26 1981-01-28 Sterwin Ag N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives
EP0040472B1 (en) * 1980-05-20 1986-01-29 Mallinckrodt, Inc. (a Delaware corporation) Spray dried n-acetyl-p-aminophenol compositions and method for manufacture thereof
US4439453A (en) * 1980-12-22 1984-03-27 Monsanto Company Directly compressible acetaminophen granulation
IE55579B1 (en) * 1982-07-06 1990-11-07 Sterwin Ag Processes for preparing tablets by a modified'wet-granulation'technique
US4600579A (en) * 1983-06-07 1986-07-15 Mallinckrodt, Inc. N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same
US4760093A (en) * 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
US5037658A (en) * 1989-09-14 1991-08-06 Hoechst-Roussel Pharmaceuticals, Inc. Direct dry compressible acetaminophen composition
ATE125702T1 (de) * 1990-10-19 1995-08-15 Spirig Ag Feste, schnell-lösliche arzneimittelzubereitung enthaltend s-(carboxymethyl)-l-cystein und/oder n-acetylcystein.
US5474757A (en) * 1992-10-16 1995-12-12 Rutgers University Prevention of acetaminophen overdose toxicity with organosulfur compounds
FR2708602B1 (fr) * 1993-08-02 1995-10-06 Oreal Procédé d'extraction des composés malodorants présents dans une formulation contenant au moins un composé comportant un groupe thiol et compositions désodorisées ainsi obtenues.
US5370878A (en) * 1993-09-30 1994-12-06 Hallmark Pharmaceuticals, Inc. Method for preparing a direct compression granulated acetaminophen composition
JPH07130367A (ja) * 1993-10-29 1995-05-19 Sony Corp リチウム二次電池用正極活物質の製造方法

Also Published As

Publication number Publication date
DK0689434T3 (da) 2002-12-02
DE69434600D1 (de) 2006-03-30
NO953515L (no) 1995-09-07
ES2254541T3 (es) 2006-06-16
CN1118989A (zh) 1996-03-20
SG48344A1 (en) 1998-04-17
ATE221777T1 (de) 2002-08-15
EP0689434A1 (en) 1996-01-03
CA2157921C (en) 2006-07-11
WO1994020086A1 (en) 1994-09-15
IL108937A0 (en) 1994-06-24
GB2276319A (en) 1994-09-28
DE69431151D1 (de) 2002-09-12
GB9404427D0 (en) 1994-04-20
EP1210939A3 (en) 2002-08-07
DE69434600T2 (de) 2006-08-24
ZA941674B (en) 1995-09-11
PT689434E (pt) 2002-12-31
US5716991A (en) 1998-02-10
CA2157921A1 (en) 1994-09-15
IL108937A (en) 1999-10-28
NO318493B1 (no) 2005-03-29
EP1210939A2 (en) 2002-06-05
GB9305058D0 (en) 1993-04-28
DE69431151T2 (de) 2002-12-12
US5852055A (en) 1998-12-22
BR9406227A (pt) 1995-12-12
ATE314842T1 (de) 2006-02-15
EP1210939B1 (en) 2006-01-04
NZ262168A (en) 1997-05-26
AU6148794A (en) 1994-09-26
NO953515D0 (no) 1995-09-07
JPH08507305A (ja) 1996-08-06
GB2276319B (en) 1997-01-15
EP0689434B1 (en) 2002-08-07
AU674934B2 (en) 1997-01-16
KR960700701A (ko) 1996-02-24

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