ES2176364T3 - Substancias fisiologicamente activas pf1092a, pf1092b y pf1092c procedimiento para su preparacion y composiciones contraceptivas y anticancerigena que las contienen como ingredientes activos. - Google Patents
Substancias fisiologicamente activas pf1092a, pf1092b y pf1092c procedimiento para su preparacion y composiciones contraceptivas y anticancerigena que las contienen como ingredientes activos.Info
- Publication number
- ES2176364T3 ES2176364T3 ES96100580T ES96100580T ES2176364T3 ES 2176364 T3 ES2176364 T3 ES 2176364T3 ES 96100580 T ES96100580 T ES 96100580T ES 96100580 T ES96100580 T ES 96100580T ES 2176364 T3 ES2176364 T3 ES 2176364T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- pf1092c
- pf1092b
- pf1092a
- active substances
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- AMAJXAHZCGMNST-JPRMETQZSA-N (4ar,5r,6r,7s)-6,7-dihydroxy-3,4a,5-trimethyl-4,5,6,7-tetrahydrobenzo[f][1]benzofuran-2-one Chemical compound C1=C2OC(=O)C(C)=C2C[C@]2(C)[C@@H](C)[C@@H](O)[C@@H](O)C=C21 AMAJXAHZCGMNST-JPRMETQZSA-N 0.000 title abstract 4
- 239000013543 active substance Substances 0.000 title abstract 4
- BVVRFLKHDORYLD-SSLUWCKPSA-N [(4ar,5r,6r,7s)-7-hydroxy-3,4a,5-trimethyl-2-oxo-4,5,6,7-tetrahydrobenzo[f][1]benzofuran-6-yl] acetate Chemical compound C1=C2OC(=O)C(C)=C2C[C@]2(C)[C@@H](C)[C@@H](OC(C)=O)[C@@H](O)C=C21 BVVRFLKHDORYLD-SSLUWCKPSA-N 0.000 title abstract 3
- 239000004480 active ingredient Substances 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 title 1
- 239000003433 contraceptive agent Substances 0.000 title 1
- 230000002254 contraceptive effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- -1 PF1092B Chemical compound 0.000 abstract 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 241000228143 Penicillium Species 0.000 abstract 1
- 238000004440 column chromatography Methods 0.000 abstract 1
- 230000002538 fungal effect Effects 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 229920001296 polysiloxane Polymers 0.000 abstract 1
- 229960003387 progesterone Drugs 0.000 abstract 1
- 239000000186 progesterone Substances 0.000 abstract 1
- 102000003998 progesterone receptors Human genes 0.000 abstract 1
- 108090000468 progesterone receptors Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SUMINISTRA NUEVAS SUBSTANCIAS FISIOLOGICAMENTE ACTIVAS PF1092A, PF1092B, PF1092C, QUE PUEDEN INHIBIR LA UNION DE LA PROGESTERONA AL RECEPTOR DE LA PROGESTERONA. ESTAS SUBSTANCIAS SE OBTUVIERON CULTIVANDO UN MICROORGANISMO FUNGAL QUE PERTENECE AL GENERO "PENICILLIUM" USANDO UN MEDIO QUE CONTENIA NUTRIENTES ORDINARIOS PARA MICROORGANISMOS Y AISLANDO LAS SUBSTANCIAS FISIOLOGICAMENTE ACTIVAS PF1092A, PF1092B, PF1092C A PARTIR DE LA MEZCLA DE CULTIVO RESULTANTE POR MEDIO DE UNA EXTRACCION DE SOLVENTES, CROMATOGRAFIA DE COLUMNA DE GEL DE SILICE, Y SIMILARES. LAS FORMULAS MOLECULARES DE LAS NUEVAS SUBSTANCIAS FISIOLOGICAMENTE ACTIVAS PF1092A, PF1092B, PF1092C SON C{SUB,17}H{SUB,20}O{SUB,5}, C{SUB,17}H{SUB,20}O{SUB,5} Y C{SUB,15}H{SUB,18}O{SUB,4} RESPECTIVAMENTE.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2086095 | 1995-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2176364T3 true ES2176364T3 (es) | 2002-12-01 |
Family
ID=12038888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96100580T Expired - Lifetime ES2176364T3 (es) | 1995-01-17 | 1996-01-16 | Substancias fisiologicamente activas pf1092a, pf1092b y pf1092c procedimiento para su preparacion y composiciones contraceptivas y anticancerigena que las contienen como ingredientes activos. |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US5712306A (es) |
| EP (1) | EP0722940B1 (es) |
| DE (1) | DE69620928T2 (es) |
| ES (1) | ES2176364T3 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1211977A (zh) * | 1996-02-19 | 1999-03-24 | 明治制果株式会社 | 新的四氢萘并呋喃酮衍生物及其制备方法 |
| US5817816A (en) * | 1996-06-20 | 1998-10-06 | Meiji Seika Kaisha, Ltd. | Sesquiterpene derivatives having progesterone receptor binding inhibitory activity |
| JP4201840B2 (ja) * | 1996-12-18 | 2008-12-24 | 明治製菓株式会社 | 新規テトラヒドロベンズインドロン誘導体 |
| CZ289242B6 (cs) * | 2000-08-10 | 2001-12-12 | Eduard Dr. Sardaryan | Prostředek s profylaktickým protinádorovým účinkem |
| WO2007000978A1 (ja) | 2005-06-27 | 2007-01-04 | Nippon Kayaku Kabushiki Kaisha | 生理活性物質ｎｋ１３６５０ｐ３、その製造法及び用途 |
| CN101959848B (zh) * | 2008-03-10 | 2016-03-09 | 亨斯迈石油化学有限责任公司 | 通过环己烷二甲醇的直接胺化生产环己烷二甲胺 |
-
1996
- 1996-01-11 US US08/585,411 patent/US5712306A/en not_active Expired - Lifetime
- 1996-01-16 DE DE69620928T patent/DE69620928T2/de not_active Expired - Fee Related
- 1996-01-16 ES ES96100580T patent/ES2176364T3/es not_active Expired - Lifetime
- 1996-01-16 EP EP96100580A patent/EP0722940B1/en not_active Expired - Lifetime
-
1997
- 1997-09-09 US US08/925,709 patent/US5789602A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69620928T2 (de) | 2002-12-12 |
| US5789602A (en) | 1998-08-04 |
| DE69620928D1 (de) | 2002-06-06 |
| EP0722940B1 (en) | 2002-05-02 |
| EP0722940A1 (en) | 1996-07-24 |
| US5712306A (en) | 1998-01-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA43332C2 (uk) | Сполука, що є похідним 2-амінобіцикло[3.1.0]гексан-2,6-дикарбонової кислоти, спосіб одержання цієї сполуки, фармацевтична композиція, що містить цю сполуку, проміжна сполука | |
| CA2174033A1 (fr) | Nouveaux composes pyridiniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent | |
| EE03253B1 (et) | (R)-5-karbamoüül-8-fluoro-3-N,N-diasendatud-amino-3,4-dihüdro-2H-1-bensopüraani d, nende valmistamise protsess ja neid sisaldavad ravimkoostised | |
| ES2120274T3 (es) | Utilizacion de un extracto de una bacteria filamentosa no fotosintetica y composicion. | |
| BR9905977A (pt) | Moduladores de ccr5 | |
| AU7576896A (en) | Lipopolyamines as transfection agents and their pharmaceutical applications | |
| DE69620877D1 (de) | Arzneimittelformulierungen für il-12 | |
| BRPI9917007B8 (pt) | azabicicloalcanos como moduladores de ccr5, composição farmacêutica contendo os mesmos, bem como seu uso | |
| EP0863755A4 (en) | ANTITHROMBOTIC DIAMINES | |
| EA200602191A1 (ru) | 5,5-дизамещённые-2-амино-4-тиазолидиноны и способ их получения, фармацевтическая композиция и способ лечения | |
| NO943038D0 (no) | Fremgangsmåte til fremstilling av virusresistente planter via innföring av utranslaterbar plussense RNA | |
| ATE224705T1 (de) | Zusammensetzungen mit kationischen amphiphilen und colipiden zur intrazellulären verabreichung therapeutischer moleküle | |
| ES2098140T3 (es) | Liosferas que contienen gonadotropina. | |
| TR200302320T4 (tr) | Benzazol türevleri ve bunların jnk modülatörleri olarak kullanımları | |
| DE69620727D1 (de) | Paclitaxel Prodrogen, Verfahren zur Herstellung und ihre Verwendung zur selektiven Chemotherapie | |
| DE60227068D1 (de) | Therapeutische verfahren unter verwendung von pflanzlichen zusammensetzungen | |
| ES2173887T3 (es) | Nuevos usos farmaceuticos de las enzimas de krill. | |
| BR0211559A (pt) | Compostos, composições de ligantes tetracìclicos terapeuticamente úteis e seus usos | |
| SE9704693D0 (sv) | Method of the prophylactic treatment of mastitis | |
| WO1997005899A3 (en) | Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same | |
| ES2057106T3 (es) | Compuestos tensioactivos y un procedimiento para su preparacion. | |
| AU6122994A (en) | Hiv protease inhibitors and their preparation | |
| ATE203665T1 (de) | Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung | |
| ATE234331T1 (de) | Lösemittelfreies verfahren zur herstellung von terpolymeren von maleinsäureanhydrid, c1-c4-alkyl vinylether und isobutylen mit hohem molekulargewicht und zahnprothesehaftmittel und zahnpasten die diese terpolymere enthalten | |
| FR2428049A1 (fr) | Nouveaux antibiotiques obtenus notamment a partir d'une souche de micromonosporaceae, leur preparation et leur application en therapeutique |