ES2176429T3 - Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica. - Google Patents

Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica.

Info

Publication number: ES2176429T3
Authority: ES; Spain
Prior art keywords: heteroatom; substituted amine; primary; racements; hteroatoms
Prior art date: 1995-02-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES96900601T

Other languages

English (en)

Spanish (es)

Inventor

Friedhelm Balkenhohl

Klaus Ditrich

Christoph Nubling

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

BASF SE

Original Assignee

BASF SE

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-02-03

Filing date

1996-01-20

Publication date

2002-12-01

1995-06-29 Priority claimed from DE19523151A external-priority patent/DE19523151A1/de

1996-01-20 Application filed by BASF SE filed Critical BASF SE

2002-12-01 Application granted granted Critical

2002-12-01 Publication of ES2176429T3 publication Critical patent/ES2176429T3/es

2016-01-20 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000002255 enzymatic effect Effects 0.000 title 1
150000003141 primary amines Chemical group 0.000 title 1
150000003335 secondary amines Chemical group 0.000 title 1
150000001412 amines Chemical class 0.000 abstract 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
238000006470 amide elimination reaction Methods 0.000 abstract 1
VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical compound [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052731 fluorine Inorganic materials 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052698 phosphorus Inorganic materials 0.000 abstract 1
239000011574 phosphorus Substances 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Analytical Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES96900601T 1995-02-03 1996-01-20 Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica. Expired - Lifetime ES2176429T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19503605		1995-02-03
DE19523151A DE19523151A1 (de)	1995-02-03	1995-06-29	Racematspaltung primärer und sekundärer heteroatomsubstituierter Amine durch Enzym-katalysierte Acylierung

Publications (1)

Publication Number	Publication Date
ES2176429T3 true ES2176429T3 (es)	2002-12-01

Family

ID=26012141

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES96900601T Expired - Lifetime ES2176429T3 (es)	1995-02-03	1996-01-20	Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica.

Country Status (9)

Country	Link
US (1)	US6214608B1 (fr)
EP (1)	EP0801683B1 (fr)
JP (1)	JP3789938B2 (fr)
CN (1)	CN1087348C (fr)
AT (1)	ATE217024T1 (fr)
DK (1)	DK0801683T3 (fr)
ES (1)	ES2176429T3 (fr)
PT (1)	PT801683E (fr)
WO (1)	WO1996023894A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997020946A1 (fr) *	1995-12-06	1997-06-12	Bayer Aktiengesellschaft	Procede de production d'amines optiquement actives
DE19727517A1 (de) *	1997-06-30	1999-01-07	Basf Ag	Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung
DK1087934T3 (da)	1998-04-01	2004-06-28	Cardiome Pharma Corp	Aminocyclohexyletherforbindelser og anvendelser deraf
DE19837745A1 (de) *	1998-08-20	2000-02-24	Basf Ag	Enzymkatalysierte Racematspaltung von primären Aminen
WO2000047547A2 (fr) *	1999-02-12	2000-08-17	Nortran Pharmaceuticals Inc.	Composes d'amines cycloalkyles et utilisation de ceux-ci
US6979685B1 (en)	1999-02-12	2005-12-27	Cardiome Pharma Corp.	Cycloalkyl amine compounds and uses thereof
US7507545B2 (en)	1999-03-31	2009-03-24	Cardiome Pharma Corp.	Ion channel modulating activity method
DE19956786A1 (de)	1999-11-25	2001-05-31	Basf Ag	Verfahren zur Herstellung optisch aktiver Amine
US7524879B2 (en)	2000-10-06	2009-04-28	Cardiome Pharma Corp.	Ion channel modulating compounds and uses thereof
US7057053B2 (en)	2000-10-06	2006-06-06	Cardiome Pharma Corp.	Ion channel modulating compounds and uses thereof
US7067291B2 (en) *	2002-12-20	2006-06-27	Pfizer Inc.	Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
CA2524323C (fr)	2003-05-02	2012-05-15	Cardiome Pharma Corp.	Composes a base d'aminocyclohexyle-ether et leurs utilisations
US7345086B2 (en)	2003-05-02	2008-03-18	Cardiome Pharma Corp.	Uses of ion channel modulating compounds
WO2005018635A2 (fr)	2003-08-07	2005-03-03	Cardiome Pharma Corp.	Activite i modulant des canaux ioniques
US7345087B2 (en)	2003-10-31	2008-03-18	Cardiome Pharma Corp.	Aminocyclohexyl ether compounds and uses thereof
CA2561819A1 (fr)	2004-04-01	2005-12-01	Cardiome Pharma Corp.	Promedicaments de composes modulant les canaux ioniques et leurs utilisations
US7705036B2 (en)	2004-04-01	2010-04-27	Cardiome Pharma Corp.	Deuterated aminocyclohexyl ether compounds and processes for preparing same
WO2005097087A2 (fr)	2004-04-01	2005-10-20	Cardiome Pharma Corp.	Composes combines de modulation du canal ionique et utilisation desdits composes
US8263638B2 (en)	2004-11-08	2012-09-11	Cardiome Pharma Corp.	Dosing regimens for ion channel modulating compounds
US8692002B2 (en)	2004-11-18	2014-04-08	Cardiome Pharma Corp.	Synthetic process for aminocyclohexyl ether compounds
MX2007016248A (es)	2005-06-15	2008-03-07	Cardiome Pharma Corp	Procedimiento sintetico para la preparacion de compuestos de eter aminociclohexilico.
DE102005028492A1 (de) *	2005-06-20	2006-12-28	Basf Ag	Verfahren zur Herstellung von optisch aktiven Aminoalkylphenolen
ITMI20051943A1 (it) *	2005-10-14	2007-04-15	Procos Spa	Processo di risoluzione anantiomerica di 2-aminometil-pirrolidine 1-sostitute per ammidazione in presenza di lipasi
JP5039787B2 (ja) *	2006-09-13	2012-10-03	ビーエーエスエフソシエタス・ヨーロピア	光学活性な２−ベンジルオキシシクロヘキシルアミンの製造方法
ES2509220T3 (es) *	2009-01-16	2014-10-17	Basf Se	Separación de una mezcla de enantiómeros de (R)- y (S)-3-amino-1-butanol
US20130345475A1 (en)	2012-06-25	2013-12-26	Basf Se	Process for the racemization of optically active arylalkylamines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1191638B (it) *	1985-10-31	1988-03-23	Montedison Spa	Processo per la separazione enzimatica degli isomeri ottici del 2-amminobutanolo
US5057607A (en) *	1990-06-08	1991-10-15	Eli Lilly And Company	Enantiomerically selective biocatalyzed acylation
JP3409353B2 (ja) *	1992-04-30	2003-05-26	住友化学工業株式会社	アミド化合物の製造方法および使用される微生物
DE4332738A1 (de) *	1993-09-25	1995-03-30	Basf Ag	Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung
US5512454A (en) *	1994-02-03	1996-04-30	Bristol-Myers Squibb Company	Enzymatic acylation of 3-hydroxymethyl cephalosporins

1996
- 1996-01-20 CN CN96191757A patent/CN1087348C/zh not_active Expired - Lifetime
- 1996-01-20 EP EP96900601A patent/EP0801683B1/fr not_active Expired - Lifetime
- 1996-01-20 US US08/875,417 patent/US6214608B1/en not_active Expired - Lifetime
- 1996-01-20 JP JP52320596A patent/JP3789938B2/ja not_active Expired - Lifetime
- 1996-01-20 WO PCT/EP1996/000234 patent/WO1996023894A1/fr not_active Ceased
- 1996-01-20 ES ES96900601T patent/ES2176429T3/es not_active Expired - Lifetime
- 1996-01-20 PT PT96900601T patent/PT801683E/pt unknown
- 1996-01-20 DK DK96900601T patent/DK0801683T3/da active
- 1996-01-20 AT AT96900601T patent/ATE217024T1/de active

Also Published As

Publication number	Publication date
DK0801683T3 (da)	2002-06-17
ATE217024T1 (de)	2002-05-15
CN1172504A (zh)	1998-02-04
EP0801683B1 (fr)	2002-05-02
EP0801683A1 (fr)	1997-10-22
PT801683E (pt)	2002-09-30
CN1087348C (zh)	2002-07-10
US6214608B1 (en)	2001-04-10
WO1996023894A1 (fr)	1996-08-08
JP3789938B2 (ja)	2006-06-28
JPH10512759A (ja)	1998-12-08

Publication	Publication Date	Title
ES2176429T3 (es)	2002-12-01	Disociacion de racementos de aminas primarias y secundarias substituidas por hteroatomos mediante acilado catalizado por via enzimatica.
ES2141254T3 (es)	2000-03-16	Disociacion de racematos de aminas primarias y secundarias mediante acilacion catalizada por enzimas.
MX169933B (es)	1993-08-02	Procedimiento para la produccion biologica de amidas
ATE335511T1 (de)	2006-09-15	Ein verfahren zur inhibierung der komplementaktivierung über einen alternativen weg
DK1418170T3 (da)	2006-10-09	Fremgangsmåde til fremstilling af optisk aktive aminoalkohler ved racematspaltning
DE69425940D1 (de)	2000-10-26	Enzymatische synthese von ceramiden und hybrid-ceramiden
GB9726229D0 (en)	1998-02-11	Resolution of chiral amines
WO2004016625A3 (fr)	2005-05-06	Esters et amides organosilicies cataylses par des enzymes
PT904348E (pt)	2005-04-29	Processo para a producao de aminoalcoois e seus derivados
DE3875953D1 (de)	1992-12-17	Verfahren zur herstellung von organischen chemischen verbindungen.
DE50009670D1 (de)	2005-04-07	Verfahren zur herstellung optisch aktiver amine
DE50308966D1 (de)	2008-02-21	Vorrichtung zur erzeugung von hängenden tropfen und zugehöriges verfahren
ATE217025T1 (de)	2002-05-15	Verfahren zur herstellung von zwischenprodukten für synthese
CA2210519A1 (fr)	1996-08-08	Separation des racemates d'amines primaires et secondaires substittuees par des heteroatomes par acylation catalysee par des enzymes
ATE417919T1 (de)	2009-01-15	Mikrobiologisches verfahren zur herstellung von amiden
ATE267874T1 (de)	2004-06-15	Enzymkatalysierte racematspaltung von primären aminen
EA199901059A1 (ru)	2000-08-28	Способ получения энантиомерно обогащенных n-производных лактамов
DE50109809D1 (de)	2006-06-22	Verfahren zur Herstellung von D- oder L-Menthol
CA2256396A1 (fr)	1997-12-11	Procede de production d'amines optiquement actives
ATE304606T1 (de)	2005-09-15	Verfahren zur enzymatischen herstellung von enantiomerenreinen 1,3-dioxolan-4-on- und 1,3- oxathiolan-5-on-derivaten
YU16904A (sh)	2006-08-17	Enzimski postupak za razdvajanje enantiomera amino kiselina
SE8007282L (sv)	1981-04-18	Sett att framstella karbamylderivat av alfa-hydroxisyror och motsvarande hydroxisyror
ATE264918T1 (de)	2004-05-15	Verfahren zur herstellung von optisch aktivem 1,2,4-butantriol und optisch aktivem 3-hydroxy-gamma- butyrolacton mittels microorganismen
DE59208719D1 (de)	1997-08-28	Verfahren zur Herstellung von optisch aktivem Vinylglycin in freier oder geschützter Form über eine enzymatische, enantioselektive Hydrolyse
ATE109833T1 (de)	1994-08-15	Verfahren zur herstellung von l-tryptophan.