ES2176841T3 - Metodo para la preparacion de derivados de alfa-bromolactama. - Google Patents

Metodo para la preparacion de derivados de alfa-bromolactama.

Info

Publication number
ES2176841T3
ES2176841T3 ES98103570T ES98103570T ES2176841T3 ES 2176841 T3 ES2176841 T3 ES 2176841T3 ES 98103570 T ES98103570 T ES 98103570T ES 98103570 T ES98103570 T ES 98103570T ES 2176841 T3 ES2176841 T3 ES 2176841T3
Authority
ES
Spain
Prior art keywords
short chain
rent
arilo
preparation
heterocicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98103570T
Other languages
English (en)
Inventor
Stefan Abrecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Basilea Pharmaceutica AG
Original Assignee
Basilea Pharmaceutica AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica AG filed Critical Basilea Pharmaceutica AG
Application granted granted Critical
Publication of ES2176841T3 publication Critical patent/ES2176841T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA PREPARACION 1. METODO PARA LA FABRICACION DE COMPUESTOS DE FORMULA DONDE R ES HIDROGENO, ALQUILO DE CADENA CORTA, ALCOXI DE CADENA CORTA, CICLOALQUILO, CICLOALQUENILO, CICLOALQUILO - ALQUILO DE CADENA CORTA, ALQUENILO DE CADENA CORTA, ALQUINILO DE CADENA CORTA, ARILO, ARILO - ALQUILO DE CADENA CORTA, HETEROCICLO O HETEROCICLO - ALQUILO DE CADENA CORTA; LAS FRACCIONES ALQUILO DE CADENA CORTA, CICLOALQUILO, ALQUENILO DE CADENA CORTA, CICLOALQUENILO, ALQUINILO DE CADENA CORTA, ARILO - ALQUILO DE CADENA CORTA, ARILO Y HETEROCICLO PUEDEN NO ESTAR SUSTITUIDAS O ESTAR SUSTITUIDAS CON AL MENOS UN GRUPO SELECCIONADO DE ENTRE CARBOXI, AMINO, CARBAMOILO, NITRO, CIANO, ALQUILO DE CADENA CORTA, ALCOXI DE CADENA CORTA, HIDROXI, HALOGENO, Y SE REFIERE ADEMAS AL USO DE COMPUESTOS PREPARADOS SEGUN EL PROCESO MENCIONADO PARA LA PREPARACION DE DERIVADOS CEFEMAS, ISOCEFEMAS Y CARBACEFEMAS.
ES98103570T 1997-03-10 1998-03-02 Metodo para la preparacion de derivados de alfa-bromolactama. Expired - Lifetime ES2176841T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97103964 1997-03-10

Publications (1)

Publication Number Publication Date
ES2176841T3 true ES2176841T3 (es) 2002-12-01

Family

ID=8226572

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98103570T Expired - Lifetime ES2176841T3 (es) 1997-03-10 1998-03-02 Metodo para la preparacion de derivados de alfa-bromolactama.

Country Status (16)

Country Link
US (1) US6114541A (es)
EP (1) EP0864564B1 (es)
JP (1) JP2938427B2 (es)
KR (1) KR100280561B1 (es)
CN (1) CN1193014A (es)
AR (1) AR015571A1 (es)
AT (1) ATE219056T1 (es)
AU (1) AU728147B2 (es)
BR (1) BR9800844A (es)
CA (1) CA2231631A1 (es)
CY (1) CY2392B1 (es)
DE (1) DE69805887T2 (es)
DK (1) DK0864564T3 (es)
ES (1) ES2176841T3 (es)
TR (1) TR199800403A2 (es)
ZA (1) ZA981885B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9901712D0 (sv) * 1999-05-11 1999-05-11 Astra Ab New process
US7741327B2 (en) 2008-04-16 2010-06-22 Hoffmann-La Roche Inc. Pyrrolidinone glucokinase activators
TWI685497B (zh) 2014-06-02 2020-02-21 西班牙商伊史帝夫製藥公司 具有多重模式抗疼痛活性的１-氧雜-４,９-二氮雜螺十一烷化合物之烷基衍生物
TW201615643A (zh) 2014-06-02 2016-05-01 伊史帝夫博士實驗室股份有限公司 具有多重模式抗疼痛活性之１－氧雜－４，９－二氮雜螺十一烷化合物之烷基與芳基衍生物
US10689398B2 (en) 2015-10-23 2020-06-23 Esteve Pharmaceuticals, S.A. OXA-Diazaspiro compounds having activity against pain
CA2999940A1 (en) 2015-10-23 2017-04-27 Laboratorios Del Dr. Esteve, S.A. Substituted morpholine derivatives having activity against pain
JP6891386B2 (ja) 2015-10-23 2021-06-18 エステベ ファーマシューティカルズ, ソシエダッド アノニマEsteve Pharmaceuticals, S.A. 疼痛に対して活性を有するオキサ−アザスピロ化合物
TN2018000122A1 (en) 2015-11-16 2019-10-04 Esteve Labor Dr Oxadiazaspiro compounds for the treatment of drug abuse and addiction
CN107129454A (zh) * 2017-05-04 2017-09-05 唐山威格化学工业有限公司 N‑辛基吡咯烷酮的合成方法
IL273751B2 (en) 2017-10-17 2024-02-01 Esteve Pharmaceuticals Sa Salts of (R)-9-(5,2-difluorophenethyl)-4-ethyl-2-methyl-1-oxa-9,4-diazaspiro[5.5]undecan-3-one

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT620225E (pt) * 1993-04-16 2003-03-31 Basilea Pharmaceutica Ag Derivados de cefalosporina
US5523400A (en) * 1993-04-16 1996-06-04 Hoffmann-La Roche Inc. Cephalosporin antibiotics
US5811419A (en) * 1996-01-16 1998-09-22 Hoffmann-La Roche Inc. Isooxacephem-derivatives

Also Published As

Publication number Publication date
CY2392B1 (en) 2004-09-10
CN1193014A (zh) 1998-09-16
TR199800403A3 (tr) 1998-09-21
DK0864564T3 (da) 2002-09-23
ZA981885B (en) 1998-09-10
JP2938427B2 (ja) 1999-08-23
TR199800403A2 (xx) 1998-09-21
KR19980080035A (ko) 1998-11-25
DE69805887T2 (de) 2003-02-20
US6114541A (en) 2000-09-05
ATE219056T1 (de) 2002-06-15
BR9800844A (pt) 2000-05-02
AR015571A1 (es) 2001-05-16
JPH10273481A (ja) 1998-10-13
KR100280561B1 (ko) 2001-02-01
EP0864564B1 (en) 2002-06-12
AU728147B2 (en) 2001-01-04
CA2231631A1 (en) 1998-09-10
EP0864564A1 (en) 1998-09-16
DE69805887D1 (de) 2002-07-18
AU5737498A (en) 1998-09-10

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