ES2178153T3 - Una mezcla estsabilizada que comprende fibrinogeno. - Google Patents

Una mezcla estsabilizada que comprende fibrinogeno.

Info

Publication number
ES2178153T3
ES2178153T3 ES98904163T ES98904163T ES2178153T3 ES 2178153 T3 ES2178153 T3 ES 2178153T3 ES 98904163 T ES98904163 T ES 98904163T ES 98904163 T ES98904163 T ES 98904163T ES 2178153 T3 ES2178153 T3 ES 2178153T3
Authority
ES
Spain
Prior art keywords
solution
fibrinogen
stylized
mixture
lysine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98904163T
Other languages
English (en)
Inventor
Israel Nur
Lilliana Bar
Oded Lieberman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Omrix Biopharmaceuticals SA
Original Assignee
Omrix Biopharmaceuticals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP97101569A external-priority patent/EP0856317A1/en
Application filed by Omrix Biopharmaceuticals SA filed Critical Omrix Biopharmaceuticals SA
Application granted granted Critical
Publication of ES2178153T3 publication Critical patent/ES2178153T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Una disolución estabilizada de fibrinógeno contiene muestras, en particular una disolución estabilizada del componente biológico activo (BAC) que es una disolución de proteínas derivadas de plasma sanguíneo que comprende fibrinógeno, ácido tranexámico y argenina o lisina o mezclas de arginina o lisina, sus sales farmacéuticamente aceptables, así como, opcionalmente, sustancias que forman una disolución tamponada en un medio acuoso.
ES98904163T 1997-01-31 1998-01-30 Una mezcla estsabilizada que comprende fibrinogeno. Expired - Lifetime ES2178153T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97101569A EP0856317A1 (en) 1997-01-31 1997-01-31 A stabilized mixture comprising fibrinogen

Publications (1)

Publication Number Publication Date
ES2178153T3 true ES2178153T3 (es) 2002-12-16

Family

ID=8226433

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98904163T Expired - Lifetime ES2178153T3 (es) 1997-01-31 1998-01-30 Una mezcla estsabilizada que comprende fibrinogeno.

Country Status (13)

Country Link
US (1) US6121232A (es)
JP (1) JP3825055B2 (es)
KR (1) KR100345570B1 (es)
CN (1) CN1182879C (es)
AT (1) ATE218365T1 (es)
AU (1) AU724715B2 (es)
BR (1) BR9807043A (es)
CA (1) CA2279419A1 (es)
DE (1) DE69805772T2 (es)
ES (1) ES2178153T3 (es)
HU (1) HUP0000908A3 (es)
NO (1) NO993709L (es)
PL (1) PL194316B1 (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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US7276235B2 (en) * 1998-11-18 2007-10-02 Zlb Behring Gmbh Tissue glue with improved antiadhesive properties
DE10025001A1 (de) * 2000-05-22 2001-11-29 Aventis Behring Gmbh Gewebekleber mit verbesserten anti-adhäsiven Eigenschaften
CN100345591C (zh) * 2003-08-01 2007-10-31 上海新兴医药股份有限公司 耐干热处理的速溶冻干纤维蛋白原制剂
US7186684B2 (en) * 2003-08-07 2007-03-06 Ethicon, Inc. Hemostatic device containing a protein precipitate
US9358318B2 (en) * 2004-10-20 2016-06-07 Ethicon, Inc. Method of making a reinforced absorbable multilayered hemostatic wound dressing
CA2584698C (en) * 2004-10-20 2014-02-25 Ethicon, Inc. A reinforced absorbable multilayered hemostatic wound dressing and method of making
FR2887883B1 (fr) 2005-06-29 2007-08-31 Lab Francais Du Fractionnement Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
JP5393447B2 (ja) * 2007-03-22 2014-01-22 一般財団法人化学及血清療法研究所 固体状フィブリノゲン製剤
EP2011524A1 (en) 2007-07-02 2009-01-07 Omrix Biopharmaceuticals Ltd. Fibrin glue with a visualization agent
EP2034010A1 (en) 2007-08-30 2009-03-11 Omrix Biopharmaceuticals Ltd. Compositions suitable for repair and/or treatment of injured spinal tissue
WO2010032246A2 (en) * 2008-09-22 2010-03-25 Omrix Biopharmaceuticals Ltd. Implantable device comprising a substrate pre-coated with stabilized fibrin
JP5805542B2 (ja) * 2009-02-20 2015-11-04 オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ． 少なくとも２成分の薬物を投与する装置
WO2011092694A2 (en) 2010-01-28 2011-08-04 Omrix Biopharmaceuticals Ltd. Method for improved fibrin sealing
IL207586A0 (en) 2010-08-12 2010-12-30 Omrix Biopharmaceuticals Ltd A fibrin based therapeutic preparation and use thereof
DK3067431T3 (da) * 2010-09-15 2019-10-14 Debiopharm Int Sa Indretning omfattende blodkomponenter til at adskille målmolekyler eller partikler fra prøver
CA2812299C (en) 2010-09-23 2020-08-04 Inflammagen, Llc Administration of serine protease inhibitors to the stomach
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
IL213375A0 (en) 2011-06-05 2011-07-31 Omrix Biopharmaceuticals Device for spraying fluids in proximity to a surface
US20150064141A1 (en) 2012-04-05 2015-03-05 The Regents Of The University Of California Regenerative sera cells and mesenchymal stem cells
US10130346B2 (en) 2012-07-24 2018-11-20 Omrix Biopharmaceuticals Ltd. Device and method for the application of a curable fluid composition to a bodily organ
AU2013365623B2 (en) 2012-12-20 2017-08-24 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
BR112015015703A2 (pt) 2012-12-30 2020-02-04 Omrix Biopharmaceuticals Ltd dispositivo e método para a aplicação de uma composição fluida curável a uma porção de um órgão do corpo
USD754325S1 (en) 2013-06-06 2016-04-19 Omrix Biopharmaceuticals Ltd. Device of a curable fluid composition to a bodily organ
IL230151A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en) 2013-12-24 2014-09-30 Omrix Biopharmaceuticals Ltd One-component fibrin glue containing zymogens
US9314442B2 (en) 2014-03-25 2016-04-19 Leading BioSciences, Inc. Compositions for the treatment of autodigestion
IL231792A0 (en) 2014-03-27 2014-08-31 Omrix Biopharmaceuticals Ltd Device and method for the preparation and administration of one-component fibrin glue
IL234246A0 (en) 2014-08-21 2014-11-30 Omrix Biopharmaceuticals Ltd Stabilized thrombin
BR112017010250A2 (pt) 2014-11-18 2018-01-02 Omrix Biopharmaceuticals Ltd aparelho para secagem por aspersão e método de uso do mesmo
IL235751A0 (en) 2014-11-18 2015-02-26 Omrix Biopharmaceuticals Ltd An addition to the spray dryer
US10066224B2 (en) 2015-02-25 2018-09-04 Omrix Biopharmaceuticals Ltd. Method for purifying and quantifying thrombin and its degradation polypeptides
US10159720B2 (en) 2015-12-08 2018-12-25 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, preparation and uses thereof
IL242984A0 (en) 2015-12-08 2016-02-29 Omrix Biopharmaceuticals Ltd Thrombin microcapsules, their preparation and how to use them
IL242924A0 (en) 2015-12-03 2016-04-21 Omrix Biopharmaceuticals Ltd Syringe system for storing and mixing two ingredients
CN113908281B (zh) 2016-01-11 2023-09-15 恒翼生物医药(上海)股份有限公司 用于治疗和预防粘连及肠梗阻的组合物和方法
JP2017176713A (ja) * 2016-03-31 2017-10-05 テルモ株式会社 塗布具
IL247821A0 (en) 2016-09-14 2017-01-31 Omrix Biopharmaceuticals Ltd Adhesive preparations and their use
CN109081789B (zh) * 2017-06-13 2021-01-01 首都医科大学 氨基正己酰氨基甲环酰氨基正己酰脂肪氨基酸，其合成，活性和应用
IL261190A (en) 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
IL263679A (en) 2018-12-12 2019-03-31 Omrix Biopharmaceuticals Ltd Kits, methods, and compositions for preventing tissue adhesion
WO2020121289A1 (en) 2018-12-12 2020-06-18 Omrix Biopharmaceuticals Ltd. Low concentrated protein compositions for preventing tissue adhesion
EP4401801B1 (en) 2021-09-16 2026-02-18 Ethicon, Inc. Kit for composition for tissue tract sealing
US20250073313A1 (en) 2021-12-21 2025-03-06 Omrix Biopharmaceuticals Ltd. Highly soluble fibrinogen compositions
US20250108142A1 (en) 2023-09-28 2025-04-03 Ethicon, Inc. Methods for treating leakage from a gastrointestinal site

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT359653B (de) * 1979-02-15 1980-11-25 Immuno Ag Verfahren zur herstellung eines gewebekleb- stoffes
DK475386D0 (da) * 1986-10-03 1986-10-03 Weis Fogh Ulla Sivertsen Fremgangsmaade og apparat til fremstilling af biologiske stoffer
US5278189A (en) * 1990-06-04 1994-01-11 Rath Matthias W Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
US6019993A (en) * 1993-03-30 2000-02-01 Omrix Biopharmaceuticals S.A. Virus-inactivated 2-component fibrin glue

Also Published As

Publication number Publication date
BR9807043A (pt) 2000-03-28
CN1246069A (zh) 2000-03-01
NO993709L (no) 1999-09-28
HUP0000908A2 (hu) 2000-08-28
DE69805772D1 (de) 2002-07-11
CN1182879C (zh) 2005-01-05
JP3825055B2 (ja) 2006-09-20
NO993709D0 (no) 1999-07-30
AU6214598A (en) 1998-08-25
HUP0000908A3 (en) 2001-05-28
PL194316B1 (pl) 2007-05-31
AU724715B2 (en) 2000-09-28
KR100345570B1 (ko) 2002-07-26
PL334547A1 (en) 2000-03-13
US6121232A (en) 2000-09-19
KR20000070634A (ko) 2000-11-25
ATE218365T1 (de) 2002-06-15
DE69805772T2 (de) 2003-01-30
JP2000509630A (ja) 2000-08-02
CA2279419A1 (en) 1998-08-06

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