ATE218365T1 - Stabilisierte mischung auf fibrinogenbasis - Google Patents

Stabilisierte mischung auf fibrinogenbasis

Info

Publication number: ATE218365T1
Authority: AT; Austria
Prior art keywords: solution; fibrinogen; stabilized; based mixture; arginine
Prior art date: 1997-01-31

Application number

AT98904163T

Other languages

English (en)

Inventor

Israel Nur

Lilliana Bar

Oded Lieberman

Original Assignee

Omrix Biopharm Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-31

Filing date

1998-01-30

Publication date

2002-06-15

1997-01-31 Priority claimed from EP97101569A external-priority patent/EP0856317A1/de

1998-01-30 Application filed by Omrix Biopharm Sa filed Critical Omrix Biopharm Sa

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218365T1 publication Critical patent/ATE218365T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
239000000243 solution Substances 0.000 abstract 3
239000004475 Arginine Substances 0.000 abstract 2
102000008946 Fibrinogen Human genes 0.000 abstract 2
108010049003 Fibrinogen Proteins 0.000 abstract 2
239000004472 Lysine Substances 0.000 abstract 2
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
229940012952 fibrinogen Drugs 0.000 abstract 2
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
229960003121 arginine Drugs 0.000 abstract 1
239000008366 buffered solution Substances 0.000 abstract 1
229960003646 lysine Drugs 0.000 abstract 1
210000002381 plasma Anatomy 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 abstract 1
229960000401 tranexamic acid Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Surgery (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

AT98904163T 1997-01-31 1998-01-30 Stabilisierte mischung auf fibrinogenbasis ATE218365T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97101569A EP0856317A1 (de)	1997-01-31	1997-01-31	Fibrinogen enthaltende stabilisierte Mischung
PCT/EP1998/000502 WO1998033533A1 (en)	1997-01-31	1998-01-30	A stabilized mixture comprising fibrinogen

Publications (1)

Publication Number	Publication Date
ATE218365T1 true ATE218365T1 (de)	2002-06-15

Family

ID=8226433

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98904163T ATE218365T1 (de)	1997-01-31	1998-01-30	Stabilisierte mischung auf fibrinogenbasis

Country Status (13)

Country	Link
US (1)	US6121232A (de)
JP (1)	JP3825055B2 (de)
KR (1)	KR100345570B1 (de)
CN (1)	CN1182879C (de)
AT (1)	ATE218365T1 (de)
AU (1)	AU724715B2 (de)
BR (1)	BR9807043A (de)
CA (1)	CA2279419A1 (de)
DE (1)	DE69805772T2 (de)
ES (1)	ES2178153T3 (de)
HU (1)	HUP0000908A3 (de)
NO (1)	NO993709L (de)
PL (1)	PL194316B1 (de)

Families Citing this family (44)

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US7276235B2 (en) *	1998-11-18	2007-10-02	Zlb Behring Gmbh	Tissue glue with improved antiadhesive properties
DE10025001A1 (de) *	2000-05-22	2001-11-29	Aventis Behring Gmbh	Gewebekleber mit verbesserten anti-adhäsiven Eigenschaften
CN100345591C (zh) *	2003-08-01	2007-10-31	上海新兴医药股份有限公司	耐干热处理的速溶冻干纤维蛋白原制剂
US7186684B2 (en) *	2003-08-07	2007-03-06	Ethicon, Inc.	Hemostatic device containing a protein precipitate
US9358318B2 (en) *	2004-10-20	2016-06-07	Ethicon, Inc.	Method of making a reinforced absorbable multilayered hemostatic wound dressing
CA2584698C (en) *	2004-10-20	2014-02-25	Ethicon, Inc.	A reinforced absorbable multilayered hemostatic wound dressing and method of making
FR2887883B1 (fr)	2005-06-29	2007-08-31	Lab Francais Du Fractionnement	Procede de separation des proteines fibrinogene, facteur xiii et colle biologique d'une fraction plasmatique solubilisee et de preparation de concentres lyophilises desdites proteines
JP5393447B2 (ja) *	2007-03-22	2014-01-22	一般財団法人化学及血清療法研究所	固体状フィブリノゲン製剤
EP2011524A1 (de)	2007-07-02	2009-01-07	Omrix Biopharmaceuticals Ltd.	Fibrinleim mit Visualisierungsmittel
EP2034010A1 (de)	2007-08-30	2009-03-11	Omrix Biopharmaceuticals Ltd.	Zusammensetzungen zur Reparatur und/oder Behandlung von verletztem Rückenmarksgewebe
WO2010032246A2 (en) *	2008-09-22	2010-03-25	Omrix Biopharmaceuticals Ltd.	Implantable device comprising a substrate pre-coated with stabilized fibrin
JP5805542B2 (ja) *	2009-02-20	2015-11-04	オムリックス・バイオファーマシューティカルズ・リミテッドＯｍｒｉｘＢｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓＬｔｄ．	少なくとも２成分の薬物を投与する装置
WO2011092694A2 (en)	2010-01-28	2011-08-04	Omrix Biopharmaceuticals Ltd.	Method for improved fibrin sealing
IL207586A0 (en)	2010-08-12	2010-12-30	Omrix Biopharmaceuticals Ltd	A fibrin based therapeutic preparation and use thereof
DK3067431T3 (da) *	2010-09-15	2019-10-14	Debiopharm Int Sa	Indretning omfattende blodkomponenter til at adskille målmolekyler eller partikler fra prøver
CA2812299C (en)	2010-09-23	2020-08-04	Inflammagen, Llc	Administration of serine protease inhibitors to the stomach
IL210162A0 (en)	2010-12-21	2011-03-31	Omrix Biopharmaceuticals	Viral inactivated platelet extract, use and preparation thereof
IL213375A0 (en)	2011-06-05	2011-07-31	Omrix Biopharmaceuticals	Device for spraying fluids in proximity to a surface
US20150064141A1 (en)	2012-04-05	2015-03-05	The Regents Of The University Of California	Regenerative sera cells and mesenchymal stem cells
US10130346B2 (en)	2012-07-24	2018-11-20	Omrix Biopharmaceuticals Ltd.	Device and method for the application of a curable fluid composition to a bodily organ
AU2013365623B2 (en)	2012-12-20	2017-08-24	Omrix Biopharmaceuticals Ltd.	Viral inactivated biological mixture
BR112015015703A2 (pt)	2012-12-30	2020-02-04	Omrix Biopharmaceuticals Ltd	dispositivo e método para a aplicação de uma composição fluida curável a uma porção de um órgão do corpo
USD754325S1 (en)	2013-06-06	2016-04-19	Omrix Biopharmaceuticals Ltd.	Device of a curable fluid composition to a bodily organ
IL230151A0 (en)	2013-12-24	2014-09-30	Omrix Biopharmaceuticals Ltd	One-component fibrin glue containing a polymerization inhibitor
IL230150A0 (en)	2013-12-24	2014-09-30	Omrix Biopharmaceuticals Ltd	One-component fibrin glue containing zymogens
US9314442B2 (en)	2014-03-25	2016-04-19	Leading BioSciences, Inc.	Compositions for the treatment of autodigestion
IL231792A0 (en)	2014-03-27	2014-08-31	Omrix Biopharmaceuticals Ltd	Device and method for the preparation and administration of one-component fibrin glue
IL234246A0 (en)	2014-08-21	2014-11-30	Omrix Biopharmaceuticals Ltd	Stabilized thrombin
BR112017010250A2 (pt)	2014-11-18	2018-01-02	Omrix Biopharmaceuticals Ltd	aparelho para secagem por aspersão e método de uso do mesmo
IL235751A0 (en)	2014-11-18	2015-02-26	Omrix Biopharmaceuticals Ltd	An addition to the spray dryer
US10066224B2 (en)	2015-02-25	2018-09-04	Omrix Biopharmaceuticals Ltd.	Method for purifying and quantifying thrombin and its degradation polypeptides
US10159720B2 (en)	2015-12-08	2018-12-25	Omrix Biopharmaceuticals Ltd	Thrombin microcapsules, preparation and uses thereof
IL242984A0 (en)	2015-12-08	2016-02-29	Omrix Biopharmaceuticals Ltd	Thrombin microcapsules, their preparation and how to use them
IL242924A0 (en)	2015-12-03	2016-04-21	Omrix Biopharmaceuticals Ltd	Syringe system for storing and mixing two ingredients
CN113908281B (zh)	2016-01-11	2023-09-15	恒翼生物医药(上海)股份有限公司	用于治疗和预防粘连及肠梗阻的组合物和方法
JP2017176713A (ja) *	2016-03-31	2017-10-05	テルモ株式会社	塗布具
IL247821A0 (en)	2016-09-14	2017-01-31	Omrix Biopharmaceuticals Ltd	Adhesive preparations and their use
CN109081789B (zh) *	2017-06-13	2021-01-01	首都医科大学	氨基正己酰氨基甲环酰氨基正己酰脂肪氨基酸，其合成，活性和应用
IL261190A (en)	2018-08-16	2019-01-31	Omrix Biopharmaceuticals Ltd	Stable liquid preparations of thrombin
IL263679A (en)	2018-12-12	2019-03-31	Omrix Biopharmaceuticals Ltd	Kits, methods, and compositions for preventing tissue adhesion
WO2020121289A1 (en)	2018-12-12	2020-06-18	Omrix Biopharmaceuticals Ltd.	Low concentrated protein compositions for preventing tissue adhesion
EP4401801B1 (de)	2021-09-16	2026-02-18	Ethicon, Inc.	Kit für zusammensetzung zur gewebetraktabdichtung
US20250073313A1 (en)	2021-12-21	2025-03-06	Omrix Biopharmaceuticals Ltd.	Highly soluble fibrinogen compositions
US20250108142A1 (en)	2023-09-28	2025-04-03	Ethicon, Inc.	Methods for treating leakage from a gastrointestinal site

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT359653B (de) *	1979-02-15	1980-11-25	Immuno Ag	Verfahren zur herstellung eines gewebekleb- stoffes
DK475386D0 (da) *	1986-10-03	1986-10-03	Weis Fogh Ulla Sivertsen	Fremgangsmaade og apparat til fremstilling af biologiske stoffer
US5278189A (en) *	1990-06-04	1994-01-11	Rath Matthias W	Prevention and treatment of occlusive cardiovascular disease with ascorbate and substances that inhibit the binding of lipoprotein (A)
US6019993A (en) *	1993-03-30	2000-02-01	Omrix Biopharmaceuticals S.A.	Virus-inactivated 2-component fibrin glue

1997
- 1997-02-10 US US08/797,328 patent/US6121232A/en not_active Expired - Lifetime
1998
- 1998-01-30 JP JP53253698A patent/JP3825055B2/ja not_active Expired - Fee Related
- 1998-01-30 DE DE69805772T patent/DE69805772T2/de not_active Expired - Lifetime
- 1998-01-30 AU AU62145/98A patent/AU724715B2/en not_active Ceased
- 1998-01-30 AT AT98904163T patent/ATE218365T1/de active
- 1998-01-30 PL PL98334547A patent/PL194316B1/pl unknown
- 1998-01-30 ES ES98904163T patent/ES2178153T3/es not_active Expired - Lifetime
- 1998-01-30 KR KR1019997006883A patent/KR100345570B1/ko not_active Expired - Fee Related
- 1998-01-30 HU HU0000908A patent/HUP0000908A3/hu unknown
- 1998-01-30 CA CA002279419A patent/CA2279419A1/en not_active Abandoned
- 1998-01-30 CN CNB988021757A patent/CN1182879C/zh not_active Expired - Fee Related
- 1998-01-30 BR BR9807043-6A patent/BR9807043A/pt not_active IP Right Cessation
1999
- 1999-07-30 NO NO993709A patent/NO993709L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
BR9807043A (pt)	2000-03-28
ES2178153T3 (es)	2002-12-16
CN1246069A (zh)	2000-03-01
NO993709L (no)	1999-09-28
HUP0000908A2 (hu)	2000-08-28
DE69805772D1 (de)	2002-07-11
CN1182879C (zh)	2005-01-05
JP3825055B2 (ja)	2006-09-20
NO993709D0 (no)	1999-07-30
AU6214598A (en)	1998-08-25
HUP0000908A3 (en)	2001-05-28
PL194316B1 (pl)	2007-05-31
AU724715B2 (en)	2000-09-28
KR100345570B1 (ko)	2002-07-26
PL334547A1 (en)	2000-03-13
US6121232A (en)	2000-09-19
KR20000070634A (ko)	2000-11-25
DE69805772T2 (de)	2003-01-30
JP2000509630A (ja)	2000-08-02
CA2279419A1 (en)	1998-08-06

Legal Events

Date	Code	Title	Description
2002-12-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE218365T1 (de)	2002-06-15	Stabilisierte mischung auf fibrinogenbasis
ATE111360T1 (de)	1994-09-15	Chirurgisches klebstoffmaterial.
DE3751682D1 (de)	1996-03-07	Infektiöses System zur Arzneimittelabgabe
KR920019371A (ko)	1992-11-19	안정화된 인자 ⅷ 제제
NO20002357L (no)	2000-06-14	Fibrin-tetningsmidler eller -ad-hesiver inneholdende et hyaluronsyrederivat-materiale
DE69230670D1 (de)	2000-03-16	Zusammensetzungen, die eine blutgerinnselpolymermatrix zur verabreichung von osteogenen proteinen enthalten
ATE74519T1 (de)	1992-04-15	Waessrige loesung von fettloeslichen wirkstoffen.
FR2591485B1 (fr)	1989-07-28	Compositions stabilisees contenant l'activateur du plasminogene du tissu humain.
ATE248150T1 (de)	2003-09-15	Lactam-enthaltende hydroxamsäure-derivate, deren herstellung und deren verwendung als inhibitoren von matrix-metalloproteasen
FI964682A0 (fi)	1996-11-25	Glukagonia sisältävä farmaseuttinen valmiste
ES2179910T3 (es)	2003-02-01	Modificacion cristalina del cdch, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
ES2053676T3 (es)	1994-08-01	Formulacion de proteinas plasmaticas y recombinantes en medios de fuerza ionica elevada.
ES2139740T3 (es)	2000-02-16	Cola de fibrina de dos componentes.
JPS6485096A (en)	1989-03-30	Hybrid human protein c and biotechnological synthesis thereof
DK1124589T3 (da)	2003-05-05	Formulering af fibrin-vævsklæber og fremgangsmåde til fremstilling af denne
EP0233013A3 (de)	1987-10-14	Modifiziertes Enzym
ATE380202T1 (de)	2007-12-15	Interaktionssystem zur präsentation und entfernung von substanzen
TW337997B (en)	1998-08-11	Pharmaceutical preparation containing plasminogen activators
DE69528170D1 (de)	2002-10-17	Intrazelluläre verabreichung therapeutischer sustanzenmittels virosomen
AU569896B2 (en)	1988-02-25	Process for the dissolution of peptides and proteins
TR199900596T2 (xx)	1999-06-21	Otoim�n hastal�klara kar�� maddeler olarak proteinlerin kullan�m�.
ATE305612T1 (de)	2005-10-15	Reporterverbindungen und verfahren zur auffindung von hochspezifische proteaseaktivität
BR9811954A (pt)	2000-08-22	ácidos 3-aril-succinamido-hidroxâmicos, processos para sua produção e preparações farmacêuticas contendo estas substâncias
WO2003028654A3 (en)	2004-01-29	Storage-stable human fibrinogen solutions
CA2234204A1 (en)	1998-10-07	Novel antibody, renin-active substance containing the same and prorenin assay reagent using the same