ES2178764T3 - Acido nucleico complejado con polimero cationico, util para terapia genica. - Google Patents

Acido nucleico complejado con polimero cationico, util para terapia genica.

Info

Publication number
ES2178764T3
ES2178764T3 ES97911324T ES97911324T ES2178764T3 ES 2178764 T3 ES2178764 T3 ES 2178764T3 ES 97911324 T ES97911324 T ES 97911324T ES 97911324 T ES97911324 T ES 97911324T ES 2178764 T3 ES2178764 T3 ES 2178764T3
Authority
ES
Spain
Prior art keywords
nucleic acid
complex
useful
gene therapy
cationic polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97911324T
Other languages
English (en)
Inventor
Etienne Honore Schacht
Leonard Charles Willia Seymour
Karel Ulbrich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hybrid Biosystems Ltd
Original Assignee
Hybrid Systems Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybrid Systems Ltd filed Critical Hybrid Systems Ltd
Application granted granted Critical
Publication of ES2178764T3 publication Critical patent/ES2178764T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyamides (AREA)
  • External Artificial Organs (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

LA INVENCION SE REFIERE A VEHICULOS PORTADORES BASADOS EN POLIMEROS SINTETICOS UTILIZADOS PARA EL APORTE DE MATERIAL DE ACIDO NUCLEICO A CELULAS DE OBJETIVO EN SISTEMAS BIOLOGICOS QUE SE OBTIENEN MEDIANTE EL AUTOENSAMBLAJE DEL ACIDO NUCLEICO CON EL MATERIAL CATIONICO DEL POLIMERO DE MANERA QUE SE CONDENSE EL ACIDO NUCLEICO Y FORME UN COMPLEJO DE POLIELECTROLITO. ESTE COMPLEJO SE HACE REACCIONAR ENTONCES CON EL MATERIAL DEL POLIMERO HIDROFILICO REACTIVO QUE SE UNE AL COMPLEJO FORMANDO UN REVESTIMIENTO HIDROFILICO QUE ESTABILIZA EL COMPLEJO Y SUMINISTRA UNA CUBIERTA ESTERICA PROTECTORA EXTERNA. ESTOS VEHICULOS PORTADORES PUEDEN SER UTILES EN LA TERAPIA GENETICA.
ES97911324T 1996-11-06 1997-11-06 Acido nucleico complejado con polimero cationico, util para terapia genica. Expired - Lifetime ES2178764T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9623051.1A GB9623051D0 (en) 1996-11-06 1996-11-06 Delivery of DNA to target cells in biological systems

Publications (1)

Publication Number Publication Date
ES2178764T3 true ES2178764T3 (es) 2003-01-01

Family

ID=10802492

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97911324T Expired - Lifetime ES2178764T3 (es) 1996-11-06 1997-11-06 Acido nucleico complejado con polimero cationico, util para terapia genica.

Country Status (9)

Country Link
US (1) US6312727B1 (es)
EP (1) EP0941123B1 (es)
AT (1) ATE218891T1 (es)
AU (1) AU740747B2 (es)
CA (1) CA2271006A1 (es)
DE (1) DE69713381T2 (es)
ES (1) ES2178764T3 (es)
GB (1) GB9623051D0 (es)
WO (1) WO1998019710A2 (es)

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GB9623051D0 (en) 1997-01-08
EP0941123A2 (en) 1999-09-15
EP0941123B1 (en) 2002-06-12
US6312727B1 (en) 2001-11-06
AU4873997A (en) 1998-05-29
WO1998019710A2 (en) 1998-05-14
AU740747B2 (en) 2001-11-15
ATE218891T1 (de) 2002-06-15
WO1998019710A3 (en) 1998-09-17
DE69713381D1 (de) 2002-07-18
CA2271006A1 (en) 1998-05-14
DE69713381T2 (de) 2003-01-02

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