ES2179238T3 - Procedimiento para la preparacion de derivados de acidos2- piperazuinocarboxilico opticamente activos. - Google Patents

Procedimiento para la preparacion de derivados de acidos2- piperazuinocarboxilico opticamente activos.

Info

Publication number
ES2179238T3
ES2179238T3 ES97106476T ES97106476T ES2179238T3 ES 2179238 T3 ES2179238 T3 ES 2179238T3 ES 97106476 T ES97106476 T ES 97106476T ES 97106476 T ES97106476 T ES 97106476T ES 2179238 T3 ES2179238 T3 ES 2179238T3
Authority
ES
Spain
Prior art keywords
optically active
preparation
piperazuinocarboxilico
procedure
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97106476T
Other languages
English (en)
Inventor
Rudolf Dr Fuchs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2179238T3 publication Critical patent/ES2179238T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

DERIVADOS OPTICAMENTE ACTIVOS DEL ACIDO 2-PIPERAZINCARBOXILICO DE FORMULA GENERAL DONDE X ES ALCOXI O UN GRUPO AMINO (SUSTITUIDO), PREPARADOS MEDIANTE HIDRATACION ASIMETRICA DE LOS CORRESPONDIENTES DERIVADOS DEL ACIDO PIRAZINCARBOXILICOS Y CATALISIS MEDIANTE COMPLEJOS DE RODIO OPTICAMENTE ACTIVOS. LOS COMPUESTOS DE FORMULA I SON PRODUCTOS INTERMEDIOS PARA LA FABRICACION DE PRINCIPIOS ACTIVOS FARMACEUTICOS, POR EJEMPLO INHIBIDORES DE LA PROTEASA DEL VIH.
ES97106476T 1996-04-23 1997-04-18 Procedimiento para la preparacion de derivados de acidos2- piperazuinocarboxilico opticamente activos. Expired - Lifetime ES2179238T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH102896 1996-04-23

Publications (1)

Publication Number Publication Date
ES2179238T3 true ES2179238T3 (es) 2003-01-16

Family

ID=4200769

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97106476T Expired - Lifetime ES2179238T3 (es) 1996-04-23 1997-04-18 Procedimiento para la preparacion de derivados de acidos2- piperazuinocarboxilico opticamente activos.

Country Status (9)

Country Link
US (1) US5945534A (es)
EP (1) EP0803502B1 (es)
JP (1) JP4138906B2 (es)
AT (1) ATE219769T1 (es)
CA (1) CA2201218C (es)
DE (1) DE59707584D1 (es)
DK (1) DK0803502T3 (es)
ES (1) ES2179238T3 (es)
PT (1) PT803502E (es)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5011995A (en) * 1987-07-28 1991-04-30 Ciba-Geigy Corporation Process for the preparation of optically active secondary amines
US4996361A (en) * 1987-07-30 1991-02-26 The University Of British Columbia Process for the preparation of optically active secondary arylamines
ATE163926T1 (de) * 1991-11-08 1998-03-15 Merck & Co Inc Hiv-protease-inhibitoren verwendbar in der aids- behandlung
EP0564406B1 (de) * 1992-04-02 1999-05-06 Novartis AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
US5353193A (en) * 1993-02-26 1994-10-04 Lsi Logic Corporation High power dissipating packages with matched heatspreader heatsink assemblies
EP0612758B1 (de) * 1993-02-26 2003-04-09 Syngenta Participations AG Ferrocenyldiphosphine als Liganden für homogene Katalysatoren
WO1995002584A2 (en) * 1993-07-16 1995-01-26 Merck & Co., Inc. Process for making hiv protease inhibitors
IL110255A (en) * 1993-07-16 1998-12-06 Merck & Co Inc Formation and resolution of 2-tert-butylcarboxamido-piperazine
CN1046272C (zh) * 1993-11-22 1999-11-10 广荣化学工业株式会社 N-叔丁基-2-吡嗪羧基酰胺类的制造方法
TW472047B (en) * 1994-02-04 2002-01-11 Merck & Co Inc Process for making HIV protease inhibitors
JPH07291943A (ja) * 1994-04-22 1995-11-07 Koei Chem Co Ltd 光学活性Ｎ−ｔｅｒｔ−ブチル−２−ピペラジンカルボキサミドを製造する方法
US5612484A (en) * 1995-05-18 1997-03-18 Merck & Co., Inc. Process for making HIV protease inhibitors
EP0744401B1 (de) * 1995-05-23 2001-11-21 Lonza Ag Verfahren zur Herstellung von optisch aktiven 2-Piperazincarbonsäurederivaten
US5723615A (en) * 1995-06-28 1998-03-03 Merck & Co., Inc. Process for preparing 4-tert-butyloxycarbonyl-(S)-piperazine-2-tert-butylcarboxamide
GB2302690A (en) * 1995-06-28 1997-01-29 Merck & Co Inc Process for preparing chiral 1,4-diacyl-(S)-piperazine-2-carboxamides using a diene/chiral bisphosphine/rhodium or iridium hydrogenation catalyst

Also Published As

Publication number Publication date
JP4138906B2 (ja) 2008-08-27
JPH1045726A (ja) 1998-02-17
PT803502E (pt) 2002-11-29
EP0803502A2 (de) 1997-10-29
CA2201218A1 (en) 1997-10-23
DK0803502T3 (da) 2002-09-23
ATE219769T1 (de) 2002-07-15
CA2201218C (en) 2004-09-28
DE59707584D1 (de) 2002-08-01
US5945534A (en) 1999-08-31
EP0803502B1 (de) 2002-06-26
EP0803502A3 (de) 1997-11-19

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