ES2179847T3 - Metodos biocataliticos para la sintesis e identificacion de compuestos biologicamente activos. - Google Patents

Metodos biocataliticos para la sintesis e identificacion de compuestos biologicamente activos.

Info

Publication number
ES2179847T3
ES2179847T3 ES94925870T ES94925870T ES2179847T3 ES 2179847 T3 ES2179847 T3 ES 2179847T3 ES 94925870 T ES94925870 T ES 94925870T ES 94925870 T ES94925870 T ES 94925870T ES 2179847 T3 ES2179847 T3 ES 2179847T3
Authority
ES
Spain
Prior art keywords
identification
methods
biocatalitical
synthesis
biologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94925870T
Other languages
English (en)
Inventor
J Wesley Fox
Jonathan S Dordick
Douglas S Clark
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curia Global Inc
Original Assignee
Albany Molecular Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Molecular Research Inc filed Critical Albany Molecular Research Inc
Application granted granted Critical
Publication of ES2179847T3 publication Critical patent/ES2179847T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Robotics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

ESTA INVENCION INCLUYE METODOS PARA LA PRODUCCION DE UNA LIBRERIA DE COMPUESTOS INICIALES MODIFICADOS MEDIANTE EL USO DE REACCIONES BIOCATALITICAS EN UN COMPUESTO INICIAL Y DE IDENTIFICACION DEL COMPUESTO INICIAL MODIFICADO CON LA ACTIVIDAD OPTIMA DESEADA. LA INVENCION INCLUYE COMPUESTOS INICIALES Y COMPUESTOS MODIFICADOS LIBRES EN SOLUCION. EL METODO ES UTIL EN LA PRODUCCION DE COMPUESTOS FARMACEUTICOS MODIFICADOS CON ACTIVIDAD ESPECIFICA DESEADA.
ES94925870T 1993-08-13 1994-08-12 Metodos biocataliticos para la sintesis e identificacion de compuestos biologicamente activos. Expired - Lifetime ES2179847T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10627993A 1993-08-13 1993-08-13

Publications (1)

Publication Number Publication Date
ES2179847T3 true ES2179847T3 (es) 2003-02-01

Family

ID=22310552

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94925870T Expired - Lifetime ES2179847T3 (es) 1993-08-13 1994-08-12 Metodos biocataliticos para la sintesis e identificacion de compuestos biologicamente activos.

Country Status (12)

Country Link
US (1) US20020039723A1 (es)
EP (1) EP0713533B1 (es)
JP (1) JPH09504424A (es)
KR (1) KR960704064A (es)
AT (1) ATE220420T1 (es)
AU (1) AU7564794A (es)
CA (1) CA2169456A1 (es)
DE (1) DE69430954T2 (es)
DK (1) DK0713533T3 (es)
ES (1) ES2179847T3 (es)
PT (1) PT713533E (es)
WO (1) WO1995005475A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295152A (en) * 1994-11-18 1996-05-22 Pfizer Ltd Preparation of a library of compounds by solid-phase synthesis
US6261813B1 (en) 1995-09-11 2001-07-17 Albany Molecular Research, Inc. Two step enzymatic acylation
BRPI0412279A (pt) 2003-07-02 2006-09-19 Diversa Corp glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos
US20080070291A1 (en) 2004-06-16 2008-03-20 David Lam Compositions and Methods for Enzymatic Decolorization of Chlorophyll
KR101381331B1 (ko) 2005-05-09 2014-04-04 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
DK2069389T3 (en) 2006-08-04 2015-01-12 Bp Corp North America Inc Glucanases, nucleic acids encoding them, and processes for their preparation and use
US8088593B2 (en) 2007-10-02 2012-01-03 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
UA111708C2 (uk) 2009-10-16 2016-06-10 Бандж Ойлз, Інк. Спосіб рафінування олії
US8754054B2 (en) 2010-07-09 2014-06-17 Albany Molecular Research, Inc. Antibacterial compounds, methods of making them, and uses thereof
CN106323875B (zh) 2011-01-21 2019-07-09 西拉诺斯知识产权有限责任公司 样品使用最大化的系统和方法
MX350504B (es) 2011-03-29 2017-09-07 Kellog Co Sistema de recuperación de calor.
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
CN104673850A (zh) * 2015-03-20 2015-06-03 北京农学院 异硫氰酸烯丙酯的固定化酶转化制备方法
CN112725174B (zh) * 2020-12-28 2022-09-06 黑龙江省农业科学院生物技术研究所 一种用于生物印迹酶的制备装置及方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof

Also Published As

Publication number Publication date
PT713533E (pt) 2002-11-29
EP0713533A1 (en) 1996-05-29
DE69430954D1 (de) 2002-08-14
ATE220420T1 (de) 2002-07-15
EP0713533B1 (en) 2002-07-10
KR960704064A (ko) 1996-08-31
DE69430954T2 (de) 2003-03-13
US20020039723A1 (en) 2002-04-04
AU7564794A (en) 1995-03-14
WO1995005475A1 (en) 1995-02-23
CA2169456A1 (en) 1995-02-23
DK0713533T3 (da) 2002-11-04
JPH09504424A (ja) 1997-05-06

Similar Documents

Publication Publication Date Title
PT713533E (pt) Processos biocataliticos de sintese e de identificacao de compostos biologicamente activos
ATE47711T1 (de) Biologisch aktive verbindung mit anti-prolyl endopeptidasewirkung.
BR9408051A (pt) Microcápsulas contendo composto sólido biologicamente ativo e processo para preparar microcapsulas contendo composto sólido biologicamente ativo
ES2188932T3 (es) Formulacion topica de vitamina d a base de liposomas.
ES2149170T3 (es) Inhibidores mejorados de trombina.
DE68913988D1 (de) Hydroxamsäure enthaltende collagenase-inhibitoren.
ES2162437T3 (es) Preparacion medicinal que contiene un gas noble lipofilo.
ES2052990T3 (es) Laca para uñas.
ES2062103T3 (es) Aglutinante para tejidos.
BR0107942A (pt) Polìmeros de proteìna de liberação lenta
MX9302618A (es) Antagonistas de endotelina de fenil sulfonamidas.
ATE203016T1 (de) Cryptophycine
ES2127212T3 (es) Estructura de soporte logico para sistemas conmutadores de telecomunicaciones.
ES2063173T3 (es) Empleo de polietileniminas alquiladas como medicamentos absorbedores de acido biliar, asi como preparados farmaceuticos.
BR9600992A (pt) Compostos piridonassulfonil uréia processo para sua produção e herbicidas contendo os mesmos
FI955720A0 (fi) Urokinaasireseptoriaktiivisuuden peptidi-inhibiittoreita
DE69801660D1 (de) Lokale behandlung von psoriasis unter verwendung neutralisierender antikörper gegen il-8
ES2071169T3 (es) 1-indolilalquil-4-(alcoxi-pirimidinil)piperazinas.
ES2029777T1 (es) Un metodo de preparacion de derivados de acido r-succinico.
ES2041378T3 (es) Procedimiento para la obtencion de catalizadores para la trimerizacion de isocianatos y su empleo.
NO973017D0 (no) Nye trienoiske retinoid forbindelser og fremgangsmåter
BR0011743A (pt) Método para modular a atividade de receptor de fxr
DE69317789D1 (de) Pflaster mit einem vorrat an medizinisch aktiver substanz
DK0734380T3 (da) 4-Benzoylisoxazoler samt deres anvendelse som herbicider
ES2080704A1 (es) Utilizacion de enzimas en la alimentacion de los animales para reducir los desechos nitrogenados.