ES2179871T3 - Composicion oftalmica que contiene un polimero hidrofilo sensible a los iones y una sal inorganica en una relacion que confiere baja viscosidad. - Google Patents

Composicion oftalmica que contiene un polimero hidrofilo sensible a los iones y una sal inorganica en una relacion que confiere baja viscosidad.

Info

Publication number
ES2179871T3
ES2179871T3 ES95914363T ES95914363T ES2179871T3 ES 2179871 T3 ES2179871 T3 ES 2179871T3 ES 95914363 T ES95914363 T ES 95914363T ES 95914363 T ES95914363 T ES 95914363T ES 2179871 T3 ES2179871 T3 ES 2179871T3
Authority
ES
Spain
Prior art keywords
hydrophyle
conferses
ions
relationship
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95914363T
Other languages
English (en)
Inventor
Kari Lehmussaari
Eija Vartiainen
Timo Reunamaki
Olli Oksala
Sakari Alaranta
Esko Pohjala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Santen Pharmaceutical Co Ltd
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2179871T3 publication Critical patent/ES2179871T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ESTA INVENCION SE REFIERE A UN COMPUESTO OFTAMICO EN FORMA DE SOLUCION ACUOSA TOPICA QUE CONSISTE ESENCIALMENTE EN: UN AGENTE ACTIVO OFTALMOLOGICAMENTE QUE CONTIENE GRUPOS BASICOS, UN ION SENSIBLE, UN POLIMERO HIDROFILICO QUE CONTIENE GRUPOS ACIDICOS EN UNA CANTIDAD DE 0.004 A 1.5%, AL MENOS UNA SAL SELECCIONADA A PARTIR DEL GRUPO DE SALES INORGANICAS Y AMORTIGUADORES EN UNA CANTIDAD TOTAL DE 0.01 AL 2.0 % EN PESO, Y OPCIONALMENTE UN AGENTE HUMECTANTE Y UN PRESERVANTE, SIENDO EL INDICE ENTRE LA SAL Y EL POLIMERO TAL QUE LA SOLUCION TENGA UNA VISCOSIDAD INFERIOR A 1000 MPAS, Y EL PH DE LA SOLUCION SE HALLE COMPRENDIDO ENTRE 4.0 Y 8.0. EL COMPUESTO CONTIENE UNA CANTIDAD SUFICIENTE DE POLIMEROS PARA PROPORCIONAR UNA ABSORCION CONTROLADA DEL MEDICAMENTO EN EL OJO, REDUCIENDOSE SU VISCOSIDAD PARA FACILITAR UN MEJOR MANEJO DEL MISMO.
ES95914363T 1994-03-31 1995-03-29 Composicion oftalmica que contiene un polimero hidrofilo sensible a los iones y una sal inorganica en una relacion que confiere baja viscosidad. Expired - Lifetime ES2179871T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9401109A SE9401109D0 (sv) 1994-03-31 1994-03-31 Opthalmic composition II

Publications (1)

Publication Number Publication Date
ES2179871T3 true ES2179871T3 (es) 2003-02-01

Family

ID=20393512

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95914363T Expired - Lifetime ES2179871T3 (es) 1994-03-31 1995-03-29 Composicion oftalmica que contiene un polimero hidrofilo sensible a los iones y una sal inorganica en una relacion que confiere baja viscosidad.

Country Status (25)

Country Link
US (1) US5795913A (es)
EP (1) EP0755246B1 (es)
JP (1) JPH10503471A (es)
KR (1) KR970702025A (es)
CN (1) CN1114399C (es)
AT (1) ATE220538T1 (es)
AU (1) AU694498B2 (es)
BG (1) BG63144B1 (es)
BR (1) BR9507439A (es)
CA (1) CA2186591A1 (es)
CZ (1) CZ286496A3 (es)
DE (2) DE69527422T2 (es)
DK (1) DK0755246T3 (es)
EE (1) EE03662B1 (es)
ES (1) ES2179871T3 (es)
HU (1) HU223070B1 (es)
MX (1) MX9603919A (es)
NO (1) NO314435B1 (es)
PL (1) PL316585A1 (es)
PT (1) PT755246E (es)
RO (1) RO115410B1 (es)
RU (1) RU2157194C2 (es)
SE (1) SE9401109D0 (es)
SK (1) SK281473B6 (es)
WO (1) WO1995026712A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY116782A (en) 1997-12-22 2004-03-31 Otsuka Pharma Co Ltd Water-soluble eye drop
AU4808000A (en) 1999-04-28 2000-11-10 Situs Corporation Drug delivery system
AT407482B (de) * 1999-05-10 2001-03-26 Armin Dr Ettl Kalziumantagonistische augentropfen zur prophylaktischen behandlung der cataract
US6218428B1 (en) 2000-04-28 2001-04-17 Emil Chynn Ophthalmic composition
MXPA04008171A (es) * 2002-02-22 2004-11-26 Pharmacia Corp Formulacion oftalmica con sistema de goma.
US7030149B2 (en) 2002-04-19 2006-04-18 Allergan, Inc. Combination of brimonidine timolol for topical ophthalmic use
AU2003252746A1 (en) 2002-07-31 2004-02-16 Senju Pharmaceutical Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
US8877168B1 (en) 2002-07-31 2014-11-04 Senju Pharmaceuticals Co., Ltd. Aqueous liquid preparations and light-stabilized aqueous liquid preparations
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
DE102005035986B4 (de) * 2005-07-28 2009-10-15 Bausch & Lomb Incorporated Steriles tropfbares mehrphasiges emulgatorfreies ophthalmisches Präparat
US20080057022A1 (en) * 2006-08-30 2008-03-06 Erning Xia Ophthalmic Pharmaceutical Compositions and Uses Thereof
US9522153B2 (en) 2009-12-22 2016-12-20 Allergan, Inc. Compositions and methods for lowering intraocular pressure
IL212725A (en) * 2011-05-05 2016-06-30 Resdevco Res And Dev Co Glycerol Preparation for Non-surgical Conjunctivochalysis
WO2017035408A1 (en) 2015-08-26 2017-03-02 Achillion Pharmaceuticals, Inc. Compounds for treatment of immune and inflammatory disorders
AR106018A1 (es) 2015-08-26 2017-12-06 Achillion Pharmaceuticals Inc Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
EP3463344A4 (en) * 2016-06-01 2020-02-12 Harold Richard Hellstrom TREATMENT OF DRY EYE WITH PARASYMPATHIC AND ANTISYMPATHIC AGENTS
SG11201811491YA (en) 2016-06-27 2019-01-30 Achillion Pharmaceuticals Inc Quinazoline and indole compounds to treat medical disorders
PT3500255T (pt) 2016-08-19 2023-01-10 Orasis Pharmaceuticals Ltd Composições farmacêuticas oftálmicas e utilizações relacionadas com estas
CN110603252A (zh) 2017-03-01 2019-12-20 艾其林医药公司 用于治疗医学障碍的芳基、杂芳基和杂环药物化合物
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
EP3773576A4 (en) 2018-03-26 2021-12-29 C4 Therapeutics, Inc. Cereblon binders for the degradation of ikaros
PL3681500T3 (pl) * 2018-04-24 2022-08-01 Allergan, Inc. Zastosowanie chlorowodorku pilokarpiny w leczeniu starczowzroczności
US20230022157A1 (en) 2018-08-20 2023-01-26 Achillion Pharmaceuticals, Inc. Pharmaceutical compounds for the treatment of complement factor d medical disorders
JP7443375B2 (ja) 2018-09-06 2024-03-05 アキリオン ファーマシューティカルズ， インコーポレーテッド 医学的障害の治療のための大環状化合物
EP3866773B1 (en) 2018-10-16 2024-08-28 Georgia State University Research Foundation, Inc. Carbon monoxide prodrugs for the treatment of medical disorders
WO2020210630A1 (en) 2019-04-12 2020-10-15 C4 Therapeutics, Inc. Tricyclic degraders of ikaros and aiolos
CN115362162A (zh) 2020-02-20 2022-11-18 艾其林医药公司 用于治疗补体因子d介导的障碍的杂芳基化合物
TW202146412A (zh) 2020-03-05 2021-12-16 美商Ｃ４醫藥公司 用於標靶降解brd9之化合物
CN116437913A (zh) 2020-09-23 2023-07-14 艾其林医药公司 用于治疗补体介导的病症的药物化合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6056684B2 (ja) * 1977-11-07 1985-12-11 東興薬品工業株式会社 点眼剤
GB2169508B (en) * 1985-01-11 1989-02-01 Smith & Nephew Ass Ophthalmic compositions and use
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
FR2678832B1 (fr) * 1991-07-10 1995-03-17 Europhta Sa Laboratoire Nouvelles compositions ophtalmiques a resorption amelioree et leurs procedes de preparation.
RU2007152C1 (ru) * 1992-10-01 1994-02-15 Курский Государственный Медицинский Институт Офтальмологическое средство и способ его получения

Also Published As

Publication number Publication date
SE9401109D0 (sv) 1994-03-31
EE9600157A (et) 1997-06-16
PL316585A1 (en) 1997-01-20
HU223070B1 (hu) 2004-03-01
BR9507439A (pt) 1997-09-16
PT755246E (pt) 2002-11-29
CZ286496A3 (en) 1997-03-12
RO115410B1 (ro) 2000-02-28
JPH10503471A (ja) 1998-03-31
BG63144B1 (bg) 2001-05-31
HU9602692D0 (en) 1996-11-28
SK281473B6 (sk) 2001-04-09
MX9603919A (es) 1997-04-30
US5795913A (en) 1998-08-18
CN1144476A (zh) 1997-03-05
EP0755246A1 (en) 1997-01-29
DE69527422D1 (de) 2002-08-22
AU694498B2 (en) 1998-07-23
BG100914A (en) 1997-07-31
NO314435B1 (no) 2003-03-24
SK123896A3 (en) 1997-06-04
NO964071L (no) 1996-11-22
DE755246T1 (de) 1997-09-04
DE69527422T2 (de) 2003-03-20
CN1114399C (zh) 2003-07-16
EP0755246B1 (en) 2002-07-17
CA2186591A1 (en) 1995-10-12
EE03662B1 (et) 2002-04-15
RU2157194C2 (ru) 2000-10-10
DK0755246T3 (da) 2002-11-04
WO1995026712A1 (en) 1995-10-12
KR970702025A (ko) 1997-05-13
AU2139095A (en) 1995-10-23
HUT75664A (en) 1997-05-28
ATE220538T1 (de) 2002-08-15
NO964071D0 (no) 1996-09-27

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