ES2181608T1 - Procedimiento para la produccion de derivaods de acido hialuronico reticulados de forma multiple. - Google Patents
Procedimiento para la produccion de derivaods de acido hialuronico reticulados de forma multiple.Info
- Publication number
- ES2181608T1 ES2181608T1 ES00901776T ES00901776T ES2181608T1 ES 2181608 T1 ES2181608 T1 ES 2181608T1 ES 00901776 T ES00901776 T ES 00901776T ES 00901776 T ES00901776 T ES 00901776T ES 2181608 T1 ES2181608 T1 ES 2181608T1
- Authority
- ES
- Spain
- Prior art keywords
- production
- derivaods
- procedure
- multiple shaped
- hialuronic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 4
- 239000002537 cosmetic Substances 0.000 abstract 1
- 229920002674 hyaluronan Polymers 0.000 abstract 1
- 229960003160 hyaluronic acid Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Rheumatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Surgery (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la producción de derivados de ácido hialurónico reticulados de forma múltiple, cuyo procedimiento comprende reticular covalentemente HA por vía de dos o más grupos funcionales diferentes, en donde dicha reticulación se efectúa poniendo en contacto HA con uno o más agentes reticulantes químicos con el fin de formar dos o más reticulaciones químicamente distintas entre dichas moléculas de HA.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9902412 | 1999-02-03 | ||
| GBGB9902412.7A GB9902412D0 (en) | 1999-02-03 | 1999-02-03 | Process |
| PCT/GB2000/000321 WO2000046253A1 (en) | 1999-02-03 | 2000-02-03 | Process for the production of multiple cross-linked hyaluronic acid derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| ES2181608T1 true ES2181608T1 (es) | 2003-03-01 |
| ES2181608T3 ES2181608T3 (es) | 2006-06-16 |
| ES2181608T5 ES2181608T5 (es) | 2016-07-22 |
| ES2181608T9 ES2181608T9 (es) | 2017-02-09 |
Family
ID=10847046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00901776.5T Expired - Lifetime ES2181608T5 (es) | 1999-02-03 | 2000-02-03 | Procedimiento para la producción de derivados de ácido hialurónico reticulados de forma múltiple |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7385052B2 (es) |
| EP (1) | EP1149116B9 (es) |
| JP (1) | JP2002536466A (es) |
| CN (1) | CN1200951C (es) |
| AT (1) | ATE315050T2 (es) |
| AU (1) | AU773518B2 (es) |
| BR (1) | BR0007980A (es) |
| CA (1) | CA2361981C (es) |
| DE (2) | DE60025328T3 (es) |
| DK (1) | DK1149116T5 (es) |
| ES (1) | ES2181608T5 (es) |
| GB (1) | GB9902412D0 (es) |
| MX (1) | MXPA01007876A (es) |
| NZ (1) | NZ512993A (es) |
| WO (1) | WO2000046253A1 (es) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9902652D0 (en) * | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
| US6288043B1 (en) * | 1999-06-18 | 2001-09-11 | Orquest, Inc. | Injectable hyaluronate-sulfated polysaccharide conjugates |
| AU2002214443B2 (en) | 2000-11-03 | 2005-12-15 | Vitrolife Ab | Evaluation and preservation solution |
| US7816316B2 (en) | 2002-11-21 | 2010-10-19 | Chugai Seiyaku Kabushiki Kaisha | Sustained release drug carrier |
| TWI251596B (en) * | 2002-12-31 | 2006-03-21 | Ind Tech Res Inst | Method for producing a double-crosslinked hyaluronate material |
| AU2003901834A0 (en) * | 2003-04-17 | 2003-05-01 | Clearcoll Pty Ltd | Cross-linked polysaccharide compositions |
| WO2005054302A1 (ja) * | 2003-12-05 | 2005-06-16 | Chugai Seiyaku Kabushiki Kaisha | 薬物担体及びその製造方法 |
| GB0329907D0 (en) * | 2003-12-23 | 2004-01-28 | Innomed Ltd | Compositions |
| US8524213B2 (en) * | 2003-12-30 | 2013-09-03 | Genzyme Corporation | Polymeric materials, their preparation and use |
| EP1750769B1 (en) * | 2004-05-20 | 2013-01-23 | Mentor Worldwide LLC | Methods for making injectable polymer hydrogels |
| WO2005113608A1 (en) * | 2004-05-20 | 2005-12-01 | Mentor Corporation | Method of covalently linking hyaluronan and chitosan |
| US7993678B2 (en) * | 2005-09-26 | 2011-08-09 | Novozymes Biopolymer A/S | Hyaluronic acid derivatives |
| DE102006013594A1 (de) * | 2006-03-22 | 2007-09-27 | Biopolymer Gmbh & Co. Kg | Quervernetzte Gele von Hyaluronsäure und deren Verwendung |
| CN101153061A (zh) * | 2006-09-29 | 2008-04-02 | 北京普麦迪克生物技术研究所 | 一种透明质酸及其二次交联形成凝胶的方法 |
| FR2918377B1 (fr) | 2007-07-05 | 2010-10-08 | Estelle Piron | Gel co-reticule de polysaccharides |
| US8318695B2 (en) * | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
| ATE544786T1 (de) * | 2007-09-28 | 2012-02-15 | Shiseido Co Ltd | Quellbares vernetztes hyaluronsäurepulver und herstellungsverfahren dafür |
| FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
| ITMC20080129A1 (it) * | 2008-07-08 | 2008-10-07 | Phitogen Holding S P A | Sintesi di acido ialuronico reticolato con inibitore della ialuronidasi microincapsulato. |
| US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
| US9371402B2 (en) | 2009-04-09 | 2016-06-21 | Scivision Biotech Inc. | Method for producing cross-linked hyaluronic acid |
| US20110081398A1 (en) * | 2009-10-01 | 2011-04-07 | Tyco Healthcare Group Lp | Multi-mechanism surgical compositions |
| US8968785B2 (en) * | 2009-10-02 | 2015-03-03 | Covidien Lp | Surgical compositions |
| KR101122163B1 (ko) * | 2009-12-01 | 2012-03-16 | (주)셀인바이오 | 아토피 피부염에 효과적인 히알루론산 유도체 및 그 제조방법 |
| EP3078388B1 (en) | 2010-03-22 | 2019-02-20 | Allergan, Inc. | Cross-linked hydrogels for soft tissue augmentation |
| IT1399508B1 (it) * | 2010-04-22 | 2013-04-19 | Nobil Bio Ricerche Srl | Dispositivo per impianto con proprieta' antibatteriche e superficie multifunzionale |
| ITAN20110138A1 (it) | 2011-10-12 | 2012-01-11 | Regenyal Lab S R L | Sintesi di un gel iniettabile multifasico a base di acido ialuronico monofasico libero e reticolato e di acido ialuronico bifasico associato con idrossiapatite con inibitore della ialuronidasi microincapsulato. |
| KR20140059238A (ko) * | 2011-11-11 | 2014-05-15 | 미바 메디컬 아이엔시. | 주사 시술용 보형물 |
| CN103181902B (zh) * | 2011-12-30 | 2016-06-08 | 张文芳 | 一种凝胶微球及其质控方法 |
| FR2991876B1 (fr) | 2012-06-13 | 2014-11-21 | Vivacy Lab | Composition, en milieu aqueux, comprenant au moins un acide hyaluronique et au moins un sel hydrosoluble de sucrose octasulfate |
| FR2994846B1 (fr) | 2012-08-29 | 2014-12-26 | Vivacy Lab | Composition, sterilisee, comprenant au moins un acide hyaluronique et de l'ascorbyl phosphate de magnesium |
| CN102863631B (zh) * | 2012-09-29 | 2013-11-13 | 杭州嘉伟生物制品有限公司 | 外科整形用组织填充剂交联透明质酸钠凝胶及其制备方法 |
| CN103055353B (zh) * | 2013-01-21 | 2014-12-24 | 华熙福瑞达生物医药有限公司 | 一种手术用防粘连膜的制备方法 |
| EP3617236B1 (en) * | 2013-06-28 | 2024-07-31 | Galderma S.A. | Shaped cross-linked hyaluronic acid product |
| HK1224315A1 (zh) * | 2013-06-28 | 2017-08-18 | Galderma S.A. | 用於制备交联的透明质酸产物的方法 |
| WO2015005345A1 (ja) * | 2013-07-08 | 2015-01-15 | 電気化学工業株式会社 | コアシェル型架橋ヒアルロン酸ゲル粒子、その製造方法及び医用材料 |
| US9572832B2 (en) * | 2013-08-29 | 2017-02-21 | Holy Stone Healthcare Co., Ltd. | Compound of glycosaminoglycan and its fabrication method as well as application |
| US9155757B2 (en) | 2013-10-07 | 2015-10-13 | Laboratoires Vivacy | Methods and kits for treating vaginal and vulvar vestibule mucosa disorders |
| FR3015290B1 (fr) | 2013-12-23 | 2017-01-13 | Lab Vivacy | Compositions d'acide hyaluronique compreant de la mepivacaine |
| CN103920182B (zh) * | 2014-04-16 | 2015-10-21 | 华熙福瑞达生物医药有限公司 | 一种生物可吸收止血膜 |
| EP3204017A4 (en) * | 2014-10-08 | 2018-06-27 | Andreas Voigt | Micronized hydrophilic cross-linked biopolymer systems and method of making same |
| US10004824B2 (en) | 2015-05-11 | 2018-06-26 | Laboratoires Vivacy | Compositions comprising at least one polyol and at least one anesthetic |
| FR3036035B1 (fr) | 2015-05-11 | 2018-10-05 | Laboratoires Vivacy | Compositions comprenant au moins un polyol et au moins un anesthesique |
| US10130578B2 (en) | 2015-07-23 | 2018-11-20 | Johnson & Johnson Consumer Inc. | Topical delivery of skin compositions having low pH |
| WO2017102001A1 (fr) | 2015-12-16 | 2017-06-22 | Vplus International Sa | Composition d'acide hyaluronique pour injections peniennes |
| US11254792B2 (en) | 2015-12-29 | 2022-02-22 | Galderma Holding SA | Method for deacetylation of biopolymers |
| PT3623390T (pt) | 2016-05-31 | 2023-10-27 | Galderma Sa | Reticulador de hidrato de carbono |
| CN106279729A (zh) * | 2016-08-26 | 2017-01-04 | 北京大清生物技术有限公司 | 一种透明质酸交联凝胶及其制备方法与应用 |
| KR20180027126A (ko) | 2016-09-06 | 2018-03-14 | (주)한국비엠아이 | 가교화 히알루론산 유도체 매트릭스가 포함된 지혈 조성물 |
| FR3058064B1 (fr) | 2016-10-28 | 2020-08-07 | Lab Vivacy | Composition a base d'acide hyaluronique comprenant de la mepivacaine |
| CZ2016826A3 (cs) | 2016-12-22 | 2018-07-04 | Contipro A.S. | Léčivý prostředek s nosičem na bázi hyaluronanu a/nebo jeho derivátů, způsob výroby a použití |
| EP3675822A1 (en) * | 2017-10-12 | 2020-07-08 | Solyplus Berlin GmbH | Mechanical processing of biopolymers |
| KR102336680B1 (ko) * | 2017-11-29 | 2021-12-08 | 주식회사 파마리서치 | 자극의 강도에 따라 변화하는 물성을 가지는 코어-쉘 구조의 히알루론산 겔 및 이의 제조방법 |
| EP3787702B1 (en) | 2018-05-03 | 2024-08-07 | CollPlant Ltd. | Dermal fillers and applications thereof |
| IT201800006127A1 (it) * | 2018-06-07 | 2018-09-07 | Sintesi di un gel iniettabile (filler) ad alta biocompatibilità a base di Ialuronato di sodio monofasico reticolato e Ialuronato di sodio lineare multifrazionato intercalato. | |
| CN112807479B (zh) * | 2018-08-20 | 2022-08-05 | 稳得希林(杭州)生物科技有限公司 | 多糖基组织粘合医用胶及其应用 |
| CN110229357B (zh) * | 2019-06-28 | 2022-03-11 | 浙江科技学院 | 一种交联透明质酸凝胶的制备方法 |
| AU2020395955A1 (en) | 2019-12-02 | 2022-07-14 | Galderma Holding SA | High molecular weight esthetic compositions |
| CN111000796A (zh) * | 2019-12-31 | 2020-04-14 | 瑞希(重庆)生物科技有限公司 | 一种透明质酸钠凝胶及其制备方法和应用 |
| FR3111903B1 (fr) | 2020-06-24 | 2022-12-02 | Lab Vivacy | Procede d’incorporation de composes organiques en solution au sein d’un hydrogel |
| FR3113522B1 (fr) | 2020-08-20 | 2025-04-18 | Lab Vivacy | procédé d’évaluation des caractéristiques rhéologiques d’un gel |
| CN112030566B (zh) * | 2020-09-30 | 2022-10-21 | 山东华熙海御生物医药有限公司 | 一种依克多因缓释微囊及其制备方法和应用 |
| KR20230153377A (ko) * | 2021-03-02 | 2023-11-06 | 시매테스 | 중합체를 기반으로 하는 이식가능한 또는 주입가능한 생성물 및 그의 제조 방법 |
| CN114478831B (zh) * | 2022-01-21 | 2023-06-27 | 湖南益安生物科技有限公司 | 一种高分子材料及其制备方法与应用 |
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| US4716224A (en) † | 1984-05-04 | 1987-12-29 | Seikagaku Kogyo Co. Ltd. | Crosslinked hyaluronic acid and its use |
| US4582865A (en) * | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| US4851521A (en) | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| SE452469B (sv) † | 1986-06-18 | 1987-11-30 | Pharmacia Ab | Material bestaende av en tverbunden karboxylgrupphaltig polysackarid och forfarande vid framstellning av detsamma |
| IT1198449B (it) * | 1986-10-13 | 1988-12-21 | F I D I Farmaceutici Italiani | Esteri di alcoli polivalenti di acido ialuronico |
| IT1219587B (it) * | 1988-05-13 | 1990-05-18 | Fidia Farmaceutici | Polisaccaridi carbossiilici autoreticolati |
| US5800541A (en) | 1988-11-21 | 1998-09-01 | Collagen Corporation | Collagen-synthetic polymer matrices prepared using a multiple step reaction |
| US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
| US5550187A (en) | 1988-11-21 | 1996-08-27 | Collagen Corporation | Method of preparing crosslinked biomaterial compositions for use in tissue augmentation |
| US5356883A (en) † | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
| GB9024223D0 (en) | 1990-11-07 | 1990-12-19 | Fermentech Ltd | Production of hyaluronic acid |
| IT1260154B (it) | 1992-07-03 | 1996-03-28 | Lanfranco Callegaro | Acido ialuronico e suoi derivati in polimeri interpenetranti (ipn) |
| US5578661A (en) | 1994-03-31 | 1996-11-26 | Nepera, Inc. | Gel forming system for use as wound dressings |
| JP3420851B2 (ja) † | 1994-12-06 | 2003-06-30 | 株式会社資生堂 | 癒着防止剤 |
| US5690961A (en) * | 1994-12-22 | 1997-11-25 | Hercules Incorporated | Acidic polysaccharides crosslinked with polycarboxylic acids and their uses |
| US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| US6060534A (en) * | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
| GB9902652D0 (en) * | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
| US6472379B1 (en) † | 1999-03-15 | 2002-10-29 | Trustees Of Boston University | Angiogenesis inhibition |
-
1999
- 1999-02-03 GB GBGB9902412.7A patent/GB9902412D0/en not_active Ceased
-
2000
- 2000-02-03 CN CNB008046425A patent/CN1200951C/zh not_active Expired - Fee Related
- 2000-02-03 DE DE60025328.7T patent/DE60025328T3/de not_active Expired - Lifetime
- 2000-02-03 WO PCT/GB2000/000321 patent/WO2000046253A1/en not_active Ceased
- 2000-02-03 AT AT00901776T patent/ATE315050T2/de active
- 2000-02-03 AU AU23075/00A patent/AU773518B2/en not_active Ceased
- 2000-02-03 DK DK00901776.5T patent/DK1149116T5/en active
- 2000-02-03 DE DE1149116T patent/DE1149116T1/de active Pending
- 2000-02-03 JP JP2000597323A patent/JP2002536466A/ja active Pending
- 2000-02-03 EP EP00901776.5A patent/EP1149116B9/en not_active Expired - Lifetime
- 2000-02-03 CA CA002361981A patent/CA2361981C/en not_active Expired - Fee Related
- 2000-02-03 ES ES00901776.5T patent/ES2181608T5/es not_active Expired - Lifetime
- 2000-02-03 NZ NZ512993A patent/NZ512993A/xx not_active IP Right Cessation
- 2000-02-03 MX MXPA01007876A patent/MXPA01007876A/es not_active IP Right Cessation
- 2000-02-03 BR BR0007980-4A patent/BR0007980A/pt not_active Application Discontinuation
-
2001
- 2001-08-02 US US09/920,286 patent/US7385052B2/en not_active Expired - Lifetime
-
2005
- 2005-07-19 US US11/185,575 patent/US7514541B2/en not_active Expired - Lifetime
-
2009
- 2009-03-23 US US12/409,361 patent/US8080641B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1200951C (zh) | 2005-05-11 |
| DK1149116T4 (en) | 2016-04-25 |
| MXPA01007876A (es) | 2003-06-04 |
| ATE315050T2 (de) | 2006-02-15 |
| GB9902412D0 (en) | 1999-03-24 |
| WO2000046253A1 (en) | 2000-08-10 |
| EP1149116B1 (en) | 2006-01-04 |
| US20090247741A1 (en) | 2009-10-01 |
| AU773518B2 (en) | 2004-05-27 |
| DE60025328T2 (de) | 2006-09-28 |
| CA2361981A1 (en) | 2000-08-10 |
| ES2181608T3 (es) | 2006-06-16 |
| AU2307500A (en) | 2000-08-25 |
| DK1149116T3 (da) | 2006-05-15 |
| ES2181608T5 (es) | 2016-07-22 |
| DE1149116T1 (de) | 2002-11-14 |
| ES2181608T9 (es) | 2017-02-09 |
| EP1149116B9 (en) | 2017-01-25 |
| DE60025328D1 (de) | 2006-03-30 |
| EP1149116A1 (en) | 2001-10-31 |
| DK1149116T5 (en) | 2017-02-13 |
| BR0007980A (pt) | 2001-10-30 |
| DE60025328T3 (de) | 2016-07-28 |
| EP1149116B2 (en) | 2016-03-30 |
| US8080641B2 (en) | 2011-12-20 |
| JP2002536466A (ja) | 2002-10-29 |
| US7385052B2 (en) | 2008-06-10 |
| US7514541B2 (en) | 2009-04-07 |
| CA2361981C (en) | 2008-06-10 |
| NZ512993A (en) | 2004-02-27 |
| US20050250939A1 (en) | 2005-11-10 |
| US20020091251A1 (en) | 2002-07-11 |
| CN1342171A (zh) | 2002-03-27 |
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