ATE247666T1 - Wasserlöslische prodrugs von 2,6- diisopropylphenol-analoga - Google Patents
Wasserlöslische prodrugs von 2,6- diisopropylphenol-analogaInfo
- Publication number
- ATE247666T1 ATE247666T1 AT99920385T AT99920385T ATE247666T1 AT E247666 T1 ATE247666 T1 AT E247666T1 AT 99920385 T AT99920385 T AT 99920385T AT 99920385 T AT99920385 T AT 99920385T AT E247666 T1 ATE247666 T1 AT E247666T1
- Authority
- AT
- Austria
- Prior art keywords
- propofol
- diisopropylphenol
- analogs
- water soluble
- soluble prodrugs
- Prior art date
Links
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical class CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 title abstract 7
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004134 propofol Drugs 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
- C07C39/26—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms
- C07C39/27—Halogenated derivatives monocyclic monohydroxylic containing halogen bound to ring carbon atoms all halogen atoms being bound to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/075,356 US6254853B1 (en) | 1998-05-08 | 1998-05-08 | Water soluble pro-drugs of propofol |
| PCT/US1999/010013 WO1999058555A2 (en) | 1998-05-08 | 1999-05-07 | Water-soluble pro-drugs of 2,6-diisopropylphenol analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE247666T1 true ATE247666T1 (de) | 2003-09-15 |
Family
ID=22125164
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99920385T ATE247666T1 (de) | 1998-05-08 | 1999-05-07 | Wasserlöslische prodrugs von 2,6- diisopropylphenol-analoga |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6254853B1 (de) |
| EP (1) | EP1075489B1 (de) |
| JP (1) | JP2002514656A (de) |
| AT (1) | ATE247666T1 (de) |
| AU (1) | AU765569B2 (de) |
| CA (1) | CA2331371A1 (de) |
| DE (1) | DE69910560T2 (de) |
| ES (1) | ES2204126T3 (de) |
| WO (1) | WO1999058555A2 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| CN1221249C (zh) | 1998-08-19 | 2005-10-05 | 斯凯伊药品加拿大公司 | 普鲁泊福的可注射水分散体 |
| US6150423A (en) * | 1998-10-15 | 2000-11-21 | Phoenix Scientific, Inc. | Propofol-based anesthetic and method of making same |
| US6362234B1 (en) * | 2000-08-15 | 2002-03-26 | Vyrex Corporation | Water-soluble prodrugs of propofol for treatment of migrane |
| WO2003026632A2 (en) | 2001-09-26 | 2003-04-03 | Theravance, Inc. | Substituted phenol compounds useful for anesthesia and sedation |
| GB0124071D0 (en) * | 2001-10-08 | 2001-11-28 | Kbig Ltd | Improvement in the administration of high boiling point aneasthetics |
| RU2316317C2 (ru) * | 2001-12-28 | 2008-02-10 | Эм-Джи-Ай Джи-Пи, Инк. | Составленные на основе воды фармацевтические композиции водорастворимых пролекарств пропофола |
| ITMI20020148A1 (it) * | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| US7312250B2 (en) | 2002-03-12 | 2007-12-25 | University Of Iowa Research Foundation | Fluorine-substituted alkyl phenol compounds and their uses |
| RU2297216C2 (ru) * | 2002-04-08 | 2007-04-20 | Эм-Джи-Ай Джи-Пи,Инк. | Фармацевтические композиции, содержащие растворимые в воде пролекарства пропофола, и способы их применения |
| AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
| DE20215415U1 (de) * | 2002-10-08 | 2004-02-26 | Biotechnologie Gesellschaft Mittelhessen Mbh | Wasserlösliche Medikamentenvorstufen von Propofol |
| ZA200504940B (en) * | 2003-01-28 | 2006-09-27 | Xenoport Inc | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| ES2581184T3 (es) * | 2003-01-31 | 2016-09-01 | Childrens Hospital Los Angeles | Composiciones orales de fenretinida que tienen mayor biodisponibilidad y métodos de uso de las mismas |
| US7468394B1 (en) * | 2003-03-11 | 2008-12-23 | Amphastar Pharmaceuticals, Inc. | Sterile pharmaceutical composition and process for a solution of propofol emulsion having microbial growth retardation |
| AU2003901815A0 (en) * | 2003-04-15 | 2003-05-01 | Vital Health Sciences Pty Ltd | Phosphate derivatives |
| US8546453B2 (en) * | 2003-08-14 | 2013-10-01 | Rensheng Zhang | Propofol compositions and methods for reducing pain associated with propofol injection |
| US7230003B2 (en) * | 2003-09-09 | 2007-06-12 | Xenoport, Inc. | Aromatic prodrugs of propofol, compositions and uses thereof |
| US20070043121A1 (en) * | 2003-09-29 | 2007-02-22 | Brown Milton L | Discovery of novel soluble crystalline anesthetics |
| WO2005044201A2 (en) * | 2003-10-24 | 2005-05-19 | Auspex Pharmaceuticals, Inc. | Ph sensitive prodrugs of 2,6-diisopropylphenol |
| US7241807B2 (en) * | 2004-07-12 | 2007-07-10 | Xenoport, Inc. | Prodrugs of propofol, compositions and uses thereof |
| CA2571407A1 (en) * | 2004-07-12 | 2006-02-16 | Xenoport, Inc. | Amino acid derived prodrugs of propofol, compositions and uses thereof |
| DE602005019210D1 (de) * | 2004-12-23 | 2010-03-18 | Xenoport Inc | Von serinaminosäure abgeleitete prodrugs von propofol, zusammensetzungen, anwendungen und kristalline formen davon |
| EP1853240A2 (de) * | 2005-02-18 | 2007-11-14 | Abraxis BioScience, Inc. | Zusammensetzungen, verwendungsverfahren und herstellung von 2,6-diisopropylphenol und analoga gegen ischämische schädigung |
| US9168216B2 (en) | 2005-06-17 | 2015-10-27 | Vital Health Sciences Pty. Ltd. | Carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof |
| US20080234229A1 (en) * | 2005-08-18 | 2008-09-25 | Auspex Pharmaceuticals, Inc. | Novel Therapeutic Agents for the Treatment of Cancer, Metabolic Diseases and Skin Disorders |
| US7589239B2 (en) * | 2005-09-02 | 2009-09-15 | Auspex Pharmaceuticals | Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders |
| WO2007128866A2 (en) * | 2006-05-09 | 2007-11-15 | Novobion Oy | Novel chemical compositions |
| US20100048732A1 (en) * | 2006-05-30 | 2010-02-25 | Emala Sr Charles W | Method of mediating Airway Smooth Muscle Construction Due to Airway Irritation |
| WO2008052044A2 (en) * | 2006-10-26 | 2008-05-02 | Xenoport, Inc. | Use of derivatives of propofol for treating diseases associated with oxidative stress |
| US20100069337A1 (en) * | 2006-10-31 | 2010-03-18 | Acey Roger A | Butyrylcholinesterase inhibitors |
| US9757399B2 (en) | 2006-10-31 | 2017-09-12 | Jal Therapeutics, Inc. | Butyrylcholinesterase inhibitors |
| RU2470907C2 (ru) | 2007-05-09 | 2012-12-27 | Сигничер Терапьютикс, Инк. | Терапевтические соединения |
| WO2008141097A2 (en) | 2007-05-09 | 2008-11-20 | Pharmacofore, Inc. | Stereoisomers propofol therapeutic compounds |
| US20090005444A1 (en) * | 2007-06-21 | 2009-01-01 | Xenoport, Inc. | Use of propofol prodrugs for treating alcohol withdrawal, central pain, anxiety or pruritus |
| WO2009036322A1 (en) * | 2007-09-14 | 2009-03-19 | Xenoport, Inc. | Use of propofol prodrugs for treating neuropathic pain |
| US20090098209A1 (en) * | 2007-10-15 | 2009-04-16 | University Of Kansas | Pharmaceutical compositions containing water-soluble derivatives of propofol and methods of administering same via pulmonary administration |
| GB0905834D0 (en) | 2009-04-03 | 2009-05-20 | Seps Pharma Nv | Phosphonyl-containing phenolic derivatives useful as medicaments |
| CN101575349B (zh) * | 2009-06-11 | 2011-07-20 | 中国科学院广州化学研究所 | 一种丙泊酚磷酸酯二钠盐的制备方法 |
| JP2011016777A (ja) * | 2009-07-10 | 2011-01-27 | Nipro Corp | 新規システイン誘導体 |
| WO2011094814A1 (en) | 2010-02-05 | 2011-08-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| CA2794734C (en) | 2010-03-30 | 2017-12-12 | Phosphagenics Limited | Transdermal delivery patch |
| WO2012122586A1 (en) | 2011-03-15 | 2012-09-20 | Phosphagenics Limited | New composition |
| US9023813B2 (en) * | 2011-04-13 | 2015-05-05 | NuTek Pharma Ltd. | Synthesis and use of glycoside derivatives of propofol |
| CN102382005B (zh) * | 2011-09-08 | 2015-01-21 | 四川大学 | 含氨基羧酸酰胺结构的丙泊酚酯类衍生物、制备方法及其用途 |
| GB201116271D0 (en) | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
| CN103880754A (zh) * | 2012-12-21 | 2014-06-25 | 西藏海思科药业集团股份有限公司 | 一种丙泊酚碱性氨基酸酯盐 |
| JP6254681B2 (ja) * | 2013-05-09 | 2017-12-27 | スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド | フェノール誘導体及びその製造方法及び医薬的な応用 |
| US9643917B2 (en) | 2014-02-17 | 2017-05-09 | Jiangsu Nhwaluokang Pharmceutical Research And Development Co., Ltd | Water-soluble propofol derivatives and uses thereof |
| KR102056649B1 (ko) * | 2014-09-04 | 2019-12-17 | 스촨 하이스코 파마수티컬 씨오., 엘티디 | 진정제 및 마취제의 제조에서의 ｇａｂａａ 수용체 강화제의 용도 |
| US10973761B2 (en) | 2015-12-09 | 2021-04-13 | Phosphagenics Limited | Pharmaceutical formulation |
| US11331271B2 (en) | 2016-05-27 | 2022-05-17 | The Johns Hopkins University | Buccal, sublingual and intranasal delivery of fospropofol |
| CN107556167A (zh) * | 2016-06-30 | 2018-01-09 | 陕西合成药业股份有限公司 | 一种麻醉类化合物及其制备方法和用途 |
| JP7198754B2 (ja) | 2016-12-21 | 2023-01-04 | アベーチョ バイオテクノロジー リミテッド | 方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4839464A (de) * | 1971-09-25 | 1973-06-09 | ||
| US4170614A (en) * | 1977-09-06 | 1979-10-09 | Ppg Industries, Inc. | Process for preparing halogenated diaryl hydrogen phosphates |
| DE3342109A1 (de) * | 1983-11-18 | 1985-05-30 | Toyo Jozo K.K., Tagata, Shizuoka | Enzymatische pruefmethode |
| US5262439A (en) * | 1992-04-30 | 1993-11-16 | The Regents Of The University Of California | Soluble analogs of probucol |
| US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
| US5308874A (en) | 1992-06-26 | 1994-05-03 | Vyrex Corporation | Airborne protectants against oxidative tissue damage |
| US5478857A (en) | 1993-12-23 | 1995-12-26 | Eli Lilly And Company | Use of PLA2 inhibitors as treatment for alzheimer's disease |
| GB9405593D0 (en) | 1994-03-22 | 1994-05-11 | Zeneca Ltd | Pharmaceutical compositions |
| US5561122A (en) * | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| US5529989A (en) * | 1995-01-09 | 1996-06-25 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Pancratistatin prodrug |
| US5496537A (en) * | 1995-03-23 | 1996-03-05 | Henry; Richard A. | Propofol hydrofluorocarbon propellant formulations |
| IT1281876B1 (it) * | 1995-05-10 | 1998-03-03 | Fidia Advanced Biopolymers Srl | Acido ialuronico e suoi derivati esterei per la preparazione di matrici per il rilascio controllato di farmaci. |
| US5637625A (en) * | 1996-03-19 | 1997-06-10 | Research Triangle Pharmaceuticals Ltd. | Propofol microdroplet formulations |
-
1998
- 1998-05-08 US US09/075,356 patent/US6254853B1/en not_active Expired - Lifetime
-
1999
- 1999-05-07 EP EP99920385A patent/EP1075489B1/de not_active Expired - Lifetime
- 1999-05-07 AU AU37894/99A patent/AU765569B2/en not_active Ceased
- 1999-05-07 CA CA002331371A patent/CA2331371A1/en not_active Abandoned
- 1999-05-07 JP JP2000548357A patent/JP2002514656A/ja active Pending
- 1999-05-07 WO PCT/US1999/010013 patent/WO1999058555A2/en not_active Ceased
- 1999-05-07 AT AT99920385T patent/ATE247666T1/de not_active IP Right Cessation
- 1999-05-07 DE DE69910560T patent/DE69910560T2/de not_active Expired - Lifetime
- 1999-05-07 ES ES99920385T patent/ES2204126T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1075489B1 (de) | 2003-08-20 |
| EP1075489A2 (de) | 2001-02-14 |
| WO1999058555A2 (en) | 1999-11-18 |
| US6254853B1 (en) | 2001-07-03 |
| AU3789499A (en) | 1999-11-29 |
| DE69910560T2 (de) | 2004-06-09 |
| DE69910560D1 (de) | 2003-09-25 |
| ES2204126T3 (es) | 2004-04-16 |
| CA2331371A1 (en) | 1999-11-18 |
| AU765569B2 (en) | 2003-09-25 |
| JP2002514656A (ja) | 2002-05-21 |
| WO1999058555A3 (en) | 2000-03-02 |
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