ES2183338T3 - Epotilona modificada en la cadena lateral. - Google Patents

Epotilona modificada en la cadena lateral.

Info

Publication number
ES2183338T3
ES2183338T3 ES98912388T ES98912388T ES2183338T3 ES 2183338 T3 ES2183338 T3 ES 2183338T3 ES 98912388 T ES98912388 T ES 98912388T ES 98912388 T ES98912388 T ES 98912388T ES 2183338 T3 ES2183338 T3 ES 2183338T3
Authority
ES
Spain
Prior art keywords
side chain
modified
epotilone
epothilones
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98912388T
Other languages
English (en)
Inventor
Gerhard Hofle
Michael Sefkow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helmholtz Centre for Infection Research
Original Assignee
Helmholtz Centre for Infection Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helmholtz Centre for Infection Research filed Critical Helmholtz Centre for Infection Research
Application granted granted Critical
Publication of ES2183338T3 publication Critical patent/ES2183338T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Silicon Polymers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epoxy Compounds (AREA)

Abstract

La invención se refiere a epotilones con una cadena lateral modificada.
ES98912388T 1997-02-25 1998-02-25 Epotilona modificada en la cadena lateral. Expired - Lifetime ES2183338T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19707505 1997-02-25

Publications (1)

Publication Number Publication Date
ES2183338T3 true ES2183338T3 (es) 2003-03-16

Family

ID=7821415

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98912388T Expired - Lifetime ES2183338T3 (es) 1997-02-25 1998-02-25 Epotilona modificada en la cadena lateral.

Country Status (24)

Country Link
US (1) US6359140B1 (es)
EP (2) EP0975638B1 (es)
JP (1) JP2001513098A (es)
KR (1) KR100494179B1 (es)
CN (2) CN1544436A (es)
AR (1) AR011878A1 (es)
AT (1) ATE221888T1 (es)
AU (1) AU736062B2 (es)
BR (1) BR9807742B1 (es)
CA (1) CA2281105A1 (es)
CZ (1) CZ298027B6 (es)
DE (2) DE19880193D2 (es)
DK (1) DK0975638T3 (es)
ES (1) ES2183338T3 (es)
HU (1) HU228851B1 (es)
IL (1) IL131343A (es)
NO (1) NO327211B1 (es)
NZ (1) NZ337195A (es)
PL (1) PL190422B1 (es)
PT (1) PT975638E (es)
RU (1) RU2201932C2 (es)
TW (1) TW480263B (es)
WO (1) WO1998038192A1 (es)
ZA (1) ZA981575B (es)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
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US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
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US6320045B1 (en) 1997-12-04 2001-11-20 Bristol-Myers Squibb Company Process for the reduction of oxiranyl epothilones to olefinic epothilones
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
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EE04852B1 (et) 1999-02-22 2007-06-15 Gesellschaft Fuer Biotechnologische Forschung Mbh C-21 modifitseeritud epotioloonid, nende valmistamise meetod ning kasutamine ja ravimkoostise kasutamine vähkkasvajate või teiste proliferatiivsete haiguste ravimisel
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US6291684B1 (en) 1999-03-29 2001-09-18 Bristol-Myers Squibb Company Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
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US7125893B1 (en) * 1999-04-30 2006-10-24 Schering Ag 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
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Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
DE59609305D1 (de) * 1995-11-17 2002-07-11 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Herstellung
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
EP0975638B1 (de) * 1997-02-25 2002-08-07 Gesellschaft für biotechnologische Forschung mbH (GBF) Seitenkettenmodifizierte epothilone

Also Published As

Publication number Publication date
CN1128803C (zh) 2003-11-26
JP2001513098A (ja) 2001-08-28
DE19880193D2 (de) 2000-08-24
WO1998038192A1 (de) 1998-09-03
PL190422B1 (pl) 2005-12-30
NZ337195A (en) 2001-05-25
EP0975638B1 (de) 2002-08-07
ATE221888T1 (de) 2002-08-15
HU228851B1 (en) 2013-06-28
CZ298027B6 (cs) 2007-05-30
NO327211B1 (no) 2009-05-11
CN1248974A (zh) 2000-03-29
US6359140B1 (en) 2002-03-19
CZ286599A3 (cs) 2000-03-15
IL131343A (en) 2004-03-28
AU736062B2 (en) 2001-07-26
DE59805110D1 (de) 2002-09-12
EP0975638A1 (de) 2000-02-02
NO994071D0 (no) 1999-08-24
PL335329A1 (en) 2000-04-25
RU2201932C2 (ru) 2003-04-10
BR9807742B1 (pt) 2010-12-14
KR100494179B1 (ko) 2005-06-10
CN1544436A (zh) 2004-11-10
HUP0002189A2 (hu) 2001-10-28
BR9807742A (pt) 2000-02-22
HUP0002189A3 (en) 2001-12-28
AU6724998A (en) 1998-09-18
AR011878A1 (es) 2000-09-13
IL131343A0 (en) 2001-01-28
HK1023774A1 (en) 2000-09-22
KR20000075705A (ko) 2000-12-26
TW480263B (en) 2002-03-21
ZA981575B (en) 1998-09-08
EP1201666A2 (de) 2002-05-02
PT975638E (pt) 2002-12-31
CA2281105A1 (en) 1998-09-03
NO994071L (no) 1999-10-21
DK0975638T3 (da) 2002-11-18
EP1201666A3 (de) 2003-03-05

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