ES2184712T3 - Nuevos derivados de pirrolo-(3,4-b)quinoleina, su procedimiento de preparacion y su utilizacion a titulo de medicamento. - Google Patents
Nuevos derivados de pirrolo-(3,4-b)quinoleina, su procedimiento de preparacion y su utilizacion a titulo de medicamento.Info
- Publication number
- ES2184712T3 ES2184712T3 ES00922769T ES00922769T ES2184712T3 ES 2184712 T3 ES2184712 T3 ES 2184712T3 ES 00922769 T ES00922769 T ES 00922769T ES 00922769 T ES00922769 T ES 00922769T ES 2184712 T3 ES2184712 T3 ES 2184712T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- carbon atoms
- quinoleina
- pirrolo
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- XNMYNYSCEJBRPZ-UHFFFAOYSA-N 2-[(3-butyl-1-isoquinolinyl)oxy]-N,N-dimethylethanamine Chemical compound C1=CC=C2C(OCCN(C)C)=NC(CCCC)=CC2=C1 XNMYNYSCEJBRPZ-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de pirrolo[3, 4-b]quinoleína de forma general I **(Ver fórmula)** en la cual X representa un átomo de oxígeno o un átomo de azufre. **(Ver fórmula)** representa un radical divalente de fórmula **(Ver fórmula)** R1 representa un radical alquilo inferior que contiene de uno a tres átomos de carbono, un radical cicloalquilo inferior que contiene de tres a seis átomos de carbono, o R1 representa un radical alquilo inferior ligado a R4 para formar un ciclo con seis átomos que contienen 0, 1 ó 2 insaturaciones, R2, R3, R4 y R5 representan independientemente el uno del otro un átomo de hidrógeno, un grupo alquilo inferior que contiene de uno a tres átomos de carbono, un grupo cicloalquilo inferior que contiene de tres a seis átomos de carbono, o un grupo fenilo, los racémicos correspondientes, así como sus enantiómeros puros o sus mezclas en cualesquiera proporciones y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9905302A FR2792937B1 (fr) | 1999-04-27 | 1999-04-27 | NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2184712T3 true ES2184712T3 (es) | 2003-04-16 |
Family
ID=9544900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00922769T Expired - Lifetime ES2184712T3 (es) | 1999-04-27 | 2000-04-27 | Nuevos derivados de pirrolo-(3,4-b)quinoleina, su procedimiento de preparacion y su utilizacion a titulo de medicamento. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6335346B1 (es) |
| EP (1) | EP1091959B1 (es) |
| JP (1) | JP2002543078A (es) |
| CN (1) | CN1182136C (es) |
| AR (1) | AR035988A1 (es) |
| AT (1) | ATE226582T1 (es) |
| DE (1) | DE60000646T2 (es) |
| DK (1) | DK1091959T3 (es) |
| ES (1) | ES2184712T3 (es) |
| FR (1) | FR2792937B1 (es) |
| PT (1) | PT1091959E (es) |
| WO (1) | WO2000064897A1 (es) |
| ZA (1) | ZA200100165B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA72611C2 (uk) * | 2000-05-17 | 2005-03-15 | Орто-Макнейл Фармацевтикал, Інк. | Похідні заміщеного піролопіридинону, корисні як інгібітори фосфодіестерази |
| CA2490239C (en) | 2002-06-19 | 2011-05-24 | Janssen Pharmaceutica N.V. | Substituted 2,4-dihydro-pyrrolo (3, 4-b) -quinolin-9-one derivatives useful as phosphodiesterase inhibitors |
| FR2898358B1 (fr) * | 2006-03-08 | 2008-05-30 | Macef Sa | Association d'un antagoniste du recepteur 5ht2 et d'activateur du recepteur 5ht2 par modulation allosterique et leurs utilisations comme produits medicaux |
| FR2912747A1 (fr) * | 2007-02-19 | 2008-08-22 | Fourtillan Snc | Derives des 1-(1-hydoxy-3-oxo-propen-1-yl)-1,2,3,3a,8,8a-hexahydro- pyrrolo[2,3-b)indoles et leur utilisation en therapeutique |
| KR101646093B1 (ko) * | 2008-07-29 | 2016-08-05 | 아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이 | 세로토닌 활성을 가진 화합물, 이의 제조 방법 및 이를 포함하는 약학적 조성물 |
| CN104892605A (zh) * | 2015-07-06 | 2015-09-09 | 渤海大学 | 一种吡咯并[3,4-b]喹啉-1-酮衍生物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2023514A1 (de) * | 1970-05-14 | 1971-12-02 | Badische Anilin- & Soda-Fabrik Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 5,6-gamma-Pyridonderivaten |
| CA1332413C (en) | 1987-06-25 | 1994-10-11 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
| US4943579A (en) | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
| EP0556585A3 (en) | 1992-01-24 | 1993-09-01 | Takeda Chemical Industries, Ltd. | Condensed camptothecin derivatives their production and use as antitumor agents |
| IT1269862B (it) | 1994-05-30 | 1997-04-15 | Indena Spa | Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono |
| JPH0873461A (ja) | 1994-09-06 | 1996-03-19 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体、その製造法および抗腫瘍剤 |
| FR2724384B1 (fr) * | 1994-09-14 | 1999-04-16 | Cemaf | Nouveaux derives de la 3,4-dihydro beta-carboline agonistes de la melatonine, leur procede de preparation et leur utilisation a titre de medicament |
| FR2737725B1 (fr) * | 1995-08-08 | 1997-10-31 | Valentonine | Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament |
| IT1283635B1 (it) | 1996-05-10 | 1998-04-23 | Indena Spa | Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi |
-
1999
- 1999-04-27 FR FR9905302A patent/FR2792937B1/fr not_active Expired - Fee Related
-
2000
- 2000-04-27 DK DK00922769T patent/DK1091959T3/da active
- 2000-04-27 ES ES00922769T patent/ES2184712T3/es not_active Expired - Lifetime
- 2000-04-27 US US09/720,593 patent/US6335346B1/en not_active Expired - Fee Related
- 2000-04-27 WO PCT/FR2000/001123 patent/WO2000064897A1/fr not_active Ceased
- 2000-04-27 JP JP2000614249A patent/JP2002543078A/ja active Pending
- 2000-04-27 AT AT00922769T patent/ATE226582T1/de not_active IP Right Cessation
- 2000-04-27 PT PT00922769T patent/PT1091959E/pt unknown
- 2000-04-27 CN CNB008009201A patent/CN1182136C/zh not_active Expired - Fee Related
- 2000-04-27 DE DE60000646T patent/DE60000646T2/de not_active Expired - Lifetime
- 2000-04-27 EP EP00922769A patent/EP1091959B1/fr not_active Expired - Lifetime
- 2000-04-27 AR ARP000101995A patent/AR035988A1/es unknown
-
2001
- 2001-01-08 ZA ZA200100165A patent/ZA200100165B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1091959B1 (fr) | 2002-10-23 |
| FR2792937B1 (fr) | 2001-08-10 |
| DK1091959T3 (da) | 2003-02-24 |
| JP2002543078A (ja) | 2002-12-17 |
| ATE226582T1 (de) | 2002-11-15 |
| US6335346B1 (en) | 2002-01-01 |
| DE60000646D1 (de) | 2002-11-28 |
| PT1091959E (pt) | 2003-03-31 |
| WO2000064897A1 (fr) | 2000-11-02 |
| CN1306532A (zh) | 2001-08-01 |
| ZA200100165B (en) | 2001-08-03 |
| FR2792937A1 (fr) | 2000-11-03 |
| CN1182136C (zh) | 2004-12-29 |
| DE60000646T2 (de) | 2003-06-26 |
| AR035988A1 (es) | 2004-08-04 |
| EP1091959A1 (fr) | 2001-04-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW200833329A (en) | 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives, preparation thereof and therapeutic use thereof | |
| AR047823A1 (es) | Derivados de 1,2,3,4-tetrahidroisoquinolina sustituida | |
| CO6290657A2 (es) | Derivados polisustituidos de 2-aril-6-fenil-imidazo[1,2-alfa]piridinas su preparacion y su aplicacion en terapeutica | |
| CO5680403A2 (es) | Antagonistas de mchr1r | |
| CO5590895A2 (es) | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos | |
| ES2220529T3 (es) | Dibenzopiranos utiles como antagonistas del receptor de los glucocorticoides, en el tratamiento de la diabetes. | |
| AR058699A1 (es) | Derivados de sulfonamidoanilina como inhibidores de tirosina-quinasas jak-2 y jak-3 | |
| MX2009010024A (es) | Nuevo compuesto de adenina. | |
| AR087328A1 (es) | Derivados de imidazo[1,2-b]piridazina e imidazo[4,5-b]piridina como inhibidores de jak | |
| AR025386A1 (es) | Moduladores de los receptores activados del proliferador de peroxisomas | |
| CO6190523A2 (es) | Nuevos derivados de aminopirimidina como inhibidores de plk1 | |
| CO4950619A1 (es) | Derivados de acido arilsulfonil hidroxamico | |
| CO5031250A1 (es) | Compuesto farmaceutico | |
| AR041883A1 (es) | Compuestos de piridopirimidinona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen | |
| AR052903A1 (es) | Compuestos de bis arilo y heteroarilo sustituidos como antagonistas selectivos de 5ht2a, composiciones farmaceuticas que los contienen y su empleo en el tratamiento de trastornos del sueno. | |
| CO5680412A2 (es) | Agonistas del receptor adrenergico etilamino beta 2 sustituido con amino | |
| AR070801A1 (es) | Derivados pirimidin -piridina | |
| PA8776401A1 (es) | Nuevos compuestos hetericiclicos nitrogenados, su preparación y su utilización como medicamentos antibacterianos | |
| AR062499A1 (es) | Derivados de n-fenil pirazol y piridil pirazoles, composiciones farmaceuticas que los contienen y usos como agentes antiagregantes plaquetarios y antitromboticos. | |
| ECSP10010380A (es) | Nuevos derivados dihidroindolonas, su procedimiento de preparación y las composiciones farmacéuticas que los contienen | |
| NI200900147A (es) | Nuevos derivados tricíclicos su procedimiento de preparación y las composiciones farmacéuticas que los contienen. | |
| AR079077A1 (es) | Derivados de piridino-piridinonas, su preparacion y su aplicacion en terapeutica de enfermedades mediadas por la tirosina quinasa | |
| AR039988A1 (es) | Derivados de benzoxazina como moduladores de 5-ht6 y usos de los mismos | |
| GT200700084A (es) | Derivados de indanil-piperazinas, su procedimiento de preparación y las composiciones farmaceuticas que los contienen. | |
| AR053149A1 (es) | Uso de compuestos de diosmetina para la obtencion de composiciones farmaceuticas destinadas a la prevencion y/o tratamiento de patologias tromboticas y patologias que conlleven el riesgo de producir trombosis |