ES2191356T3 - Compuestos heterociclicos para la inhibicion de la secrecion de acidos gastricos, procedimientos para su preparacion y composiciones farmaceuticas de ellos. - Google Patents
Compuestos heterociclicos para la inhibicion de la secrecion de acidos gastricos, procedimientos para su preparacion y composiciones farmaceuticas de ellos.Info
- Publication number
- ES2191356T3 ES2191356T3 ES98957270T ES98957270T ES2191356T3 ES 2191356 T3 ES2191356 T3 ES 2191356T3 ES 98957270 T ES98957270 T ES 98957270T ES 98957270 T ES98957270 T ES 98957270T ES 2191356 T3 ES2191356 T3 ES 2191356T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- secretion
- inhibition
- procedures
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 210000004211 gastric acid Anatomy 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000028327 secretion Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- RLDQYSHDFVSAPL-UHFFFAOYSA-L calcium;dithiocyanate Chemical compound [Ca+2].[S-]C#N.[S-]C#N RLDQYSHDFVSAPL-UHFFFAOYSA-L 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Un compuesto de la Fórmula I **(Fórmula)** o una de sus sales farmacéuticamente aceptables, en que R1 es alquilo C1-C6; R2 es alquilo C1-C6; R3 es H o halógeno; y **(Fórmula)** es un heterociclo sustituido seleccionado entre **(Fórmula)** en que R4 es H, CH3, CH2OH o CH2CN; R5 es H o alquilo C1-C6; R6 es H, alquilo C1-C6, arilo, arilalquilo que contiene 1-2 átomos de carbono en la parte de alquilo, alquenilo C2-C6, halo(alquenilo C2-C6), alquinilo C2-C6, cicloalquilo C3-C7 o halo(alquilo C1-C6); R7 es H, halógeno, alquilo C1-C6, alquiltio C1-C6 o tiociano; n es 0 ó 1; y X es NH o O.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704404A SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | New compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2191356T3 true ES2191356T3 (es) | 2003-09-01 |
Family
ID=20409181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98957270T Expired - Lifetime ES2191356T3 (es) | 1997-11-28 | 1998-11-18 | Compuestos heterociclicos para la inhibicion de la secrecion de acidos gastricos, procedimientos para su preparacion y composiciones farmaceuticas de ellos. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6518270B1 (es) |
| EP (1) | EP1042324B1 (es) |
| JP (1) | JP2001525322A (es) |
| KR (1) | KR20010032559A (es) |
| CN (1) | CN1142933C (es) |
| AR (1) | AR016972A1 (es) |
| AT (1) | ATE233263T1 (es) |
| AU (1) | AU752187C (es) |
| BR (1) | BR9814755A (es) |
| CA (1) | CA2311798A1 (es) |
| CZ (1) | CZ292349B6 (es) |
| DE (1) | DE69811735T2 (es) |
| DK (1) | DK1042324T3 (es) |
| EE (1) | EE04060B1 (es) |
| ES (1) | ES2191356T3 (es) |
| HU (1) | HUP0100601A3 (es) |
| ID (1) | ID24730A (es) |
| IL (1) | IL136145A0 (es) |
| IS (1) | IS5486A (es) |
| MY (1) | MY121032A (es) |
| NO (1) | NO315704B1 (es) |
| NZ (1) | NZ504355A (es) |
| PL (1) | PL340920A1 (es) |
| PT (1) | PT1042324E (es) |
| RU (1) | RU2241000C2 (es) |
| SE (1) | SE9704404D0 (es) |
| SK (1) | SK283904B6 (es) |
| TR (1) | TR200001530T2 (es) |
| TW (1) | TW515798B (es) |
| UA (1) | UA70932C2 (es) |
| WO (1) | WO1999028322A1 (es) |
| ZA (1) | ZA9810468B (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2324093A (en) | 1996-01-04 | 1998-10-14 | Rican Limited | Helicobacter pylori bacterioferritin |
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
| AR025976A1 (es) | 1999-10-08 | 2002-12-26 | Affinium Pharm Inc | Inhibidores de fab i. |
| CA2444597A1 (en) * | 2001-04-06 | 2002-10-06 | Affinium Pharmaceuticals, Inc. | Fab i inhibitors |
| JP2003119140A (ja) * | 2001-08-08 | 2003-04-23 | Sankyo Co Ltd | ピロロピリダジン化合物を含有する医薬 |
| CA2482991A1 (en) * | 2002-04-19 | 2003-10-30 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof |
| WO2004022562A1 (en) | 2002-09-09 | 2004-03-18 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| AU2003266622A1 (en) * | 2002-09-25 | 2004-04-19 | Sankyo Company, Limited | Medicinal composition for inhibiting increase in blood gastrin concentration |
| AU2003266621A1 (en) * | 2002-09-25 | 2004-04-19 | Sankyo Company, Limited | Medicinal composition for treatment for or prevention of visceral pain |
| CA2508792C (en) | 2002-12-06 | 2013-02-05 | Affinium Pharmaceuticals, Inc. | Heterocyclic compounds, methods of making them and their use in therapy |
| US7160885B2 (en) | 2003-02-10 | 2007-01-09 | Cgi Pharmaceuticals, Inc. | Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity |
| AR043002A1 (es) * | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
| WO2004082586A2 (en) * | 2003-03-17 | 2004-09-30 | Affinium Pharmaceuticals, Inc. | Phamaceutical compositions comprising inhibitors of fab i and further antibiotics |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| WO2005005429A1 (en) | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
| US7259164B2 (en) | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
| WO2005041961A1 (en) | 2003-11-03 | 2005-05-12 | Astrazeneca Ab | Imidazo [1,2-a] pyridine derivatives for the treatment of silent gastro-esophageal reflux |
| CA2568914C (en) * | 2004-06-04 | 2013-09-24 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
| EP1787991B2 (en) * | 2004-07-28 | 2020-06-24 | Takeda Pharmaceutical Company Limited | PYRROLO[2,3-c]PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE |
| JP2008508347A (ja) * | 2004-08-02 | 2008-03-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ５置換された１Ｈ−ピロロ［３，２−ｂ］ピリジン |
| KR100946220B1 (ko) * | 2004-09-03 | 2010-03-08 | 주식회사유한양행 | 피롤로[3,2-ｃ]피리딘 유도체 및 그의 제조방법 |
| PL1784402T3 (pl) | 2004-09-03 | 2011-12-30 | Yuhan Corp | Pochodne pirolo[3,2-c]pirydyny oraz sposoby ich wytwarzania |
| US7642269B2 (en) | 2004-09-03 | 2010-01-05 | Yuhan Corporation | Pyrrolo[3,2-B]pyridine derivatives and processes for the preparation thereof |
| DK1784404T3 (da) | 2004-09-03 | 2012-02-13 | Yuhan Corp | Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
| WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| WO2007028051A2 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| EP1973902A2 (en) * | 2005-12-05 | 2008-10-01 | Affinium Pharmaceuticals, Inc. | 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents |
| CA2654202A1 (en) * | 2006-06-06 | 2007-12-21 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
| EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
| US8263613B2 (en) * | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
| NZ587039A (en) | 2008-02-13 | 2013-01-25 | Gilead Connecticut Inc | 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| KR101745732B1 (ko) | 2008-12-08 | 2017-06-12 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 ｓｙｋ 억제제 |
| KR101743784B1 (ko) | 2008-12-08 | 2017-06-05 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 ｓｙｋ 억제제 |
| ES2530449T3 (es) | 2010-03-11 | 2015-03-02 | Gilead Connecticut Inc | Inhibidores de Syk de imidazopiridinas |
| SMT201900411T1 (it) | 2012-06-19 | 2019-09-09 | Debiopharm Int Sa | Derivati di profaramci di (e)-n-metil-n-((3-metilbenzofuran-2-il)metil -3-(7-osso-5,6,7,8-tetraidro-1,8-naftiridin-3-il)acrilammide |
| SG11201600378SA (en) | 2013-07-30 | 2016-02-26 | Gilead Connecticut Inc | Formulation of syk inhibitors |
| EA029281B1 (ru) | 2013-07-30 | 2018-03-30 | Джилид Коннектикут, Инк. | Полиморф ингибиторов syk |
| US9687492B2 (en) | 2013-12-04 | 2017-06-27 | Gilead Sciences, Inc. | Methods for treating cancers |
| GB201321738D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| CA2955180A1 (en) | 2014-07-14 | 2016-01-21 | Gilead Sciences, Inc. | Combinations comprising entospletinib and a vinca-alkaloid for treating cancers |
| BR122023021456A2 (pt) | 2016-02-26 | 2024-02-20 | Debiopharm International S.A. | Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica |
| CN115028640A (zh) | 2017-08-25 | 2022-09-09 | 吉利德科学公司 | Syk抑制剂的多晶型物 |
| FI3923914T3 (fi) | 2019-02-14 | 2023-04-27 | Debiopharm Int Sa | Afabisiiniformulaatio, menetelmä sen valmistamiseksi |
| WO2020172431A1 (en) | 2019-02-22 | 2020-08-27 | Gilead Sciences, Inc. | Solid forms of condensed pyrazines as syk inhibitors |
| MA56184A (fr) | 2019-06-14 | 2022-04-20 | Debiopharm Int Sa | Afabicine pour utilisation dans le traitement d'infections bactériennes impliquant un biofilm |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507294A (en) * | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
| EP0068378B1 (en) * | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
| US4725601A (en) | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| AU7754691A (en) * | 1990-04-27 | 1991-11-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyridazines |
| US5041442A (en) | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
| WO1992006979A1 (de) * | 1990-10-15 | 1992-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue diazine |
| WO1993008190A1 (de) * | 1991-10-25 | 1993-04-29 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrrolo-pyridazine mit magen- und darmschutzwirkungen |
| DE69529056T2 (de) * | 1994-01-19 | 2003-11-13 | Sankyo Co., Ltd. | Pyrrolopyridazin-derivate |
| SE9602286D0 (sv) | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
-
1997
- 1997-11-28 SE SE9704404A patent/SE9704404D0/xx unknown
-
1998
- 1998-11-16 AR ARP980105799A patent/AR016972A1/es unknown
- 1998-11-16 TW TW087118942A patent/TW515798B/zh active
- 1998-11-16 ZA ZA9810468A patent/ZA9810468B/xx unknown
- 1998-11-17 MY MYPI98005216A patent/MY121032A/en unknown
- 1998-11-18 DK DK98957270T patent/DK1042324T3/da active
- 1998-11-18 IL IL13614598A patent/IL136145A0/xx unknown
- 1998-11-18 NZ NZ504355A patent/NZ504355A/en unknown
- 1998-11-18 SK SK674-2000A patent/SK283904B6/sk unknown
- 1998-11-18 CA CA002311798A patent/CA2311798A1/en not_active Abandoned
- 1998-11-18 WO PCT/SE1998/002091 patent/WO1999028322A1/en not_active Ceased
- 1998-11-18 EP EP98957270A patent/EP1042324B1/en not_active Expired - Lifetime
- 1998-11-18 CN CNB98813344XA patent/CN1142933C/zh not_active Expired - Fee Related
- 1998-11-18 ES ES98957270T patent/ES2191356T3/es not_active Expired - Lifetime
- 1998-11-18 DE DE69811735T patent/DE69811735T2/de not_active Expired - Fee Related
- 1998-11-18 US US09/194,823 patent/US6518270B1/en not_active Expired - Lifetime
- 1998-11-18 BR BR9814755-2A patent/BR9814755A/pt not_active Application Discontinuation
- 1998-11-18 CZ CZ20001947A patent/CZ292349B6/cs not_active IP Right Cessation
- 1998-11-18 JP JP2000523214A patent/JP2001525322A/ja active Pending
- 1998-11-18 EE EEP200000315A patent/EE04060B1/xx not_active IP Right Cessation
- 1998-11-18 KR KR1020007005804A patent/KR20010032559A/ko not_active Ceased
- 1998-11-18 TR TR2000/01530T patent/TR200001530T2/xx unknown
- 1998-11-18 ID IDW20000987A patent/ID24730A/id unknown
- 1998-11-18 HU HU0100601A patent/HUP0100601A3/hu unknown
- 1998-11-18 PT PT98957270T patent/PT1042324E/pt unknown
- 1998-11-18 PL PL98340920A patent/PL340920A1/xx not_active Application Discontinuation
- 1998-11-18 UA UA2000052801A patent/UA70932C2/uk unknown
- 1998-11-18 AT AT98957270T patent/ATE233263T1/de not_active IP Right Cessation
- 1998-11-18 RU RU2000113729/04A patent/RU2241000C2/ru not_active IP Right Cessation
- 1998-11-18 AU AU13565/99A patent/AU752187C/en not_active Ceased
-
2000
- 2000-05-10 IS IS5486A patent/IS5486A/is unknown
- 2000-05-26 NO NO20002721A patent/NO315704B1/no unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2088589C1 (en) | Derivatives of 17 beta-substituted-4-aza-5-5 alpha-androstane-3-ones, methods of synthesis of compounds, pharmaceutical composition, compound 4 | |
| DK0590919T3 (da) | Terapeutiske midler mod Parkinsons sygdom | |
| AU7517400A (en) | N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent | |
| AU7503087A (en) | Amide derivatives | |
| PL350775A1 (en) | Pharmaceutical compounds | |
| NZ334954A (en) | Substituted heterocycles as anti-tumor agents | |
| AU2492500A (en) | Aspartic protease inhibitors, compositions, and associated therapeutic methods | |
| HUP0102099A2 (hu) | Szubsztituált 2-oxo-alkánsav-[2-(indol-3-il)-etil]-amid-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerkészítmények | |
| IL134894A (en) | 2-substituted-1,3,4,5-tetrahydro-2h-gamma-carbolines, their preparation and pharmaceutical compositions containing them | |
| MY125562A (en) | Hexahydro-pyrido (4,3-b) indole derivatives as antipsychotic drugs | |
| EP1034783A4 (en) | AMIDE DERIVATIVES | |
| YU73202A (sh) | Novi proces za sintezu n-/(s)-1-karboksibutil/-(s)- alaninskog estra i primena u sintezi perindoprila | |
| PL335012A1 (en) | Novel derivatives of indan-1-ole, method of obtaining and composition containing them | |
| DK0775113T3 (da) | N-substituerede azabicycloheptan-derivater som neuroleptika osv. | |
| NO964216D0 (no) | Ester- og karbamatderivater av azoloner som er kraftige midler mot Helicobacter | |
| EP0812835A4 (en) | OPTICALLY ACTIVE THIAZOLIDINONE DERIVATIVES | |
| DK0412015T3 (da) | Hidtil ukendte N-(23-vincristinoyl)- og N-(5-noranhydro-23-vinblastinoyl)-1-aminomethylphosphon- syrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem | |
| ATE266648T1 (de) | Heterocyclische anthracyclinonderivate | |
| AR004401A1 (es) | Derivados de la tirosina, procedimiento para prepararlos y preparaciones farmaceuticas que los contienen. | |
| AP2002002707A0 (en) | 4, 5-Dihydro-Thiazo-2-Ylamine Derivatives and their Use as NO-Synthase Inhibitors. |