ATE325110T1 - Sauerstoff enthaltende heterocyclische verbindungen - Google Patents
Sauerstoff enthaltende heterocyclische verbindungenInfo
- Publication number
- ATE325110T1 ATE325110T1 AT96915194T AT96915194T ATE325110T1 AT E325110 T1 ATE325110 T1 AT E325110T1 AT 96915194 T AT96915194 T AT 96915194T AT 96915194 T AT96915194 T AT 96915194T AT E325110 T1 ATE325110 T1 AT E325110T1
- Authority
- AT
- Austria
- Prior art keywords
- bond
- containing heterocyclic
- cyano
- combined
- heterocyclic compounds
- Prior art date
Links
- 229910052760 oxygen Inorganic materials 0.000 title abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title abstract 2
- 150000002391 heterocyclic compounds Chemical class 0.000 title abstract 2
- 239000001301 oxygen Substances 0.000 title abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- 125000006360 carbonyl amino methylene group Chemical group [H]N(C([*:1])=O)C([H])([H])[*:2] 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical compound [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12153795 | 1995-05-19 | ||
| JP25865195 | 1995-10-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE325110T1 true ATE325110T1 (de) | 2006-06-15 |
Family
ID=26458881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96915194T ATE325110T1 (de) | 1995-05-19 | 1996-05-20 | Sauerstoff enthaltende heterocyclische verbindungen |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0771794B1 (de) |
| JP (1) | JP4172817B2 (de) |
| KR (1) | KR100445356B1 (de) |
| CN (1) | CN1163493C (de) |
| AT (1) | ATE325110T1 (de) |
| AU (1) | AU705690B2 (de) |
| CA (1) | CA2195755A1 (de) |
| DE (1) | DE69636086T2 (de) |
| DK (1) | DK0771794T3 (de) |
| ES (1) | ES2258775T3 (de) |
| HK (1) | HK1000785A1 (de) |
| NO (1) | NO317631B1 (de) |
| PT (1) | PT771794E (de) |
| WO (1) | WO1996036624A1 (de) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT828728E (pt) * | 1995-05-18 | 2003-06-30 | Altana Pharma Ag | Di-hidrobenzofuranos de fenilo |
| ATE230404T1 (de) * | 1995-05-18 | 2003-01-15 | Altana Pharma Ag | Cyclohexyldihydrobenzofurane |
| JP2000501411A (ja) * | 1995-12-05 | 2000-02-08 | ダーウィン・ディスカバリー・リミテッド | ベンゾフランカルボキサミドおよびスルホンアミド |
| HUP0100042A3 (en) * | 1996-05-20 | 2003-01-28 | Darwin Discovery Ltd Cambridge | Benzofuran carboxamides medicaments containing the same and their therapeutic use |
| ES2188983T4 (es) * | 1996-08-19 | 2004-06-01 | Altana Pharma Ag | Nuevas benzofuran-4-carboxamidas. |
| AU4967697A (en) * | 1996-11-19 | 1998-06-10 | Kyowa Hakko Kogyo Co. Ltd. | Oxygenic heterocyclic compounds |
| EP1029860B1 (de) * | 1997-10-01 | 2003-04-16 | Kyowa Hakko Kogyo Co., Ltd. | Benzofuranderivate |
| JP2002502851A (ja) * | 1998-02-09 | 2002-01-29 | ダーウィン・ディスカバリー・リミテッド | ベンゾフラン−４−カルボキサミドとその治療的使用 |
| DE69916066T2 (de) * | 1998-07-06 | 2005-02-24 | Altana Pharma Ag | Neue benzoxazole mit pde-hemmender wirkung |
| BR9913405A (pt) | 1998-09-03 | 2001-10-02 | Kyowa Hakko Kogyo Kk | Composto heterocìclico que contenha oxigênio, e, inibidor de fosfodiesterase (pde) iv. |
| WO2000040714A2 (en) * | 1998-12-30 | 2000-07-13 | Oligos Etc. Inc. | Therapeutic phosphodiesterase inhibitors |
| WO2001007031A1 (en) * | 1999-07-26 | 2001-02-01 | Shionogi & Co., Ltd. | Benzene derivatives and immunopotentiating compositions or drug-sensitivity restoring agents containing the same |
| WO2003000697A1 (en) * | 2001-06-22 | 2003-01-03 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivative, process for producing the same, and use |
| DE10205274A1 (de) * | 2002-02-08 | 2003-08-21 | Boehringer Ingelheim Pharma | Neue Arzneimittelkompositionen enthaltend neben Anticholinergika heterocyclische Verbindungen |
| DE10216427A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittelkompositionen enthaltend heterocyclische Verbindungen und ein neues Anticholinergikum |
| AU2003252467A1 (en) * | 2002-07-03 | 2004-01-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for preparation of 1,3-benzodioxole-2-spiro- cycloalkane derivatives |
| EP1621196A4 (de) * | 2003-03-17 | 2007-03-21 | Kyowa Hakko Kogyo Kk | Therapeutisches und/oder präventives mittel für chronische hautkrankheiten |
| JPWO2004087146A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 微粒子混合物の製造方法 |
| WO2004087147A1 (ja) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co., Ltd. | 肺疾患の治療および／または予防剤 |
| EP1609471A1 (de) * | 2003-03-31 | 2005-12-28 | Kyowa Hakko Kogyo Co., Ltd. | Mittel zur behandlung und/oder prävention von lungenkrankheiten |
| JPWO2004087150A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 医薬組成物 |
| CA2520577A1 (en) * | 2003-03-31 | 2004-10-14 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical composition |
| WO2004096274A1 (ja) * | 2003-03-31 | 2004-11-11 | Kyowa Hakko Kogyo Co., Ltd. | 気道内投与剤 |
| JPWO2004087151A1 (ja) * | 2003-03-31 | 2006-06-29 | 協和醗酵工業株式会社 | 医薬組成物 |
| JPWO2004112791A1 (ja) * | 2003-06-23 | 2006-07-27 | 協和醗酵工業株式会社 | 肺疾患の治療および／または予防剤 |
| EP1504756A1 (de) * | 2003-08-06 | 2005-02-09 | Kyowa Hakko Kogyo Co., Ltd | Arzneimittelkompositionen enthaltend eine heterocyclischen Verbindung und ein Anticholinergikum |
| JPWO2006041121A1 (ja) * | 2004-10-13 | 2008-05-15 | 協和醗酵工業株式会社 | 慢性皮膚疾患の治療および／または予防剤 |
| US20080085858A1 (en) * | 2004-10-13 | 2008-04-10 | Kyowa Hakko Kogyo Co., Ltd. | Pharmaceutical Composition |
| WO2006123726A1 (ja) * | 2005-05-18 | 2006-11-23 | Kyowa Hakko Kogyo Co., Ltd. | 医薬組成物 |
| US20100056791A1 (en) * | 2006-09-01 | 2010-03-04 | Yasushi Kohno | Pyrazolopyridine carboxamide derivative and phosphodiesterase (pde) inhibitor containing the same |
| CA2661992A1 (en) * | 2006-09-06 | 2008-03-13 | Kyorin Pharmaceutical Co., Ltd. | Pyrazolopyridine derivative and phosphodiesterase (pde) inhibitor containing the same as active ingredient |
| US8148537B2 (en) * | 2006-12-22 | 2012-04-03 | Leo Pharma A/S | Substituted acetophenones useful as PDE4 inhibitors |
| PL2114951T3 (pl) | 2007-02-28 | 2014-10-31 | Leo Pharma As | Nowe inhibitory fosfodiesterazy |
| JP2010523725A (ja) | 2007-04-16 | 2010-07-15 | レオ ファーマ アクティーゼルスカブ | 皮膚疾患処置用ホスホジエステラーゼ阻害剤としてのトリアゾロピリジン |
| PL2379548T3 (pl) | 2008-12-19 | 2016-08-31 | Leo Pharma As | Triazolopirydyny jako inhibitory fosfodiesterazy do leczenia chorób skórnych |
| JP6174997B2 (ja) * | 2010-06-24 | 2017-08-02 | レオ ファーマ アクティーゼルスカブ | ホスホジエステラーゼ阻害剤としてのベンゾジオキソールまたはベンゾジオキセピンヘテロ環化合物 |
| MX2014006812A (es) | 2011-12-21 | 2014-10-13 | Leo Pharma As | [1,2,4] triazolopiridinas y su uso como inhibidores de fosfodiesterasa. |
| JP6785666B2 (ja) * | 2014-06-23 | 2020-11-18 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環化合物の調製方法 |
| CN106588841B (zh) * | 2015-10-19 | 2019-01-25 | 富乐马鸿凯（大连）医药有限公司 | 合成2,3-二氢-1-苯并呋喃-4-甲醛的方法 |
| CN106588900A (zh) * | 2015-10-20 | 2017-04-26 | 北京康辰医药科技有限公司 | 一种苯并双环化合物或其药学上可接受的盐、药物组合物及其应用 |
| CN106905336B (zh) * | 2017-01-22 | 2019-04-09 | 浙江工业大学 | 一种手性吡唑螺呋喃类化合物的不对称合成方法 |
| CN107325067B (zh) * | 2017-05-03 | 2020-05-12 | 广州中医药大学 | 磷酸二酯酶4抑制剂桑辛素m衍生物及其用途 |
| AU2018286964B2 (en) | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| CN109721579B (zh) * | 2017-10-27 | 2022-11-04 | 中国医学科学院药物研究所 | 7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 |
| CN109721580B (zh) * | 2017-10-27 | 2022-11-04 | 中国医学科学院药物研究所 | 3-苯基-7,8-脱氢葡萄藤戊素衍生物、其制法和药物组合物与用途 |
| CN114478413B (zh) * | 2022-01-14 | 2023-06-23 | 北京富盛嘉华医药科技有限公司 | 2-(2′-羟基-3′-甲代烯丙基-5′-甲基苯基)苯并三氮唑的制备方法及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2507604A2 (fr) * | 1977-04-19 | 1982-12-17 | Delalande Sa | Nouvelles trimethoxy-3,4,5 cinnamoyle piperazines, leur procede de preparation et leur application en therapeutique |
| CA1297877C (en) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides useful as antiemetic or antipsychotic agents |
| JPS62234083A (ja) * | 1986-02-28 | 1987-10-14 | アーバモント インク ディビーエイ アドリヤ ラボラトリーズ | 鎮吐薬または精神病治療薬として有用なカルボキサミド類 |
| JPH01207267A (ja) * | 1987-03-05 | 1989-08-21 | Yamanouchi Pharmaceut Co Ltd | ピリジン誘導体及び該化合物を含有する肝疾患治療剤 |
| ZA886585B (en) * | 1987-09-08 | 1990-05-30 | Lilly Co Eli | Specific 5-ht,antagonists |
| US5366986A (en) * | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
| CA2114114C (en) * | 1992-06-15 | 2005-05-03 | Nigel Robert Arnold Beeley | Trisubstituted phenyl derivatives as selective phosphodiesterase iv inhibitors |
| ES2152414T3 (es) * | 1994-07-22 | 2001-02-01 | Byk Gulden Lomberg Chem Fab | Dihidrobenzofuranos. |
| PT828728E (pt) * | 1995-05-18 | 2003-06-30 | Altana Pharma Ag | Di-hidrobenzofuranos de fenilo |
-
1996
- 1996-05-20 HK HK97102285A patent/HK1000785A1/en not_active IP Right Cessation
- 1996-05-20 JP JP53470896A patent/JP4172817B2/ja not_active Expired - Fee Related
- 1996-05-20 AT AT96915194T patent/ATE325110T1/de not_active IP Right Cessation
- 1996-05-20 DK DK96915194T patent/DK0771794T3/da active
- 1996-05-20 CA CA002195755A patent/CA2195755A1/en not_active Abandoned
- 1996-05-20 DE DE69636086T patent/DE69636086T2/de not_active Expired - Fee Related
- 1996-05-20 ES ES96915194T patent/ES2258775T3/es not_active Expired - Lifetime
- 1996-05-20 AU AU57029/96A patent/AU705690B2/en not_active Ceased
- 1996-05-20 PT PT96915194T patent/PT771794E/pt unknown
- 1996-05-20 EP EP96915194A patent/EP0771794B1/de not_active Expired - Lifetime
- 1996-05-20 KR KR1019970700326A patent/KR100445356B1/ko not_active Expired - Fee Related
- 1996-05-20 WO PCT/JP1996/001327 patent/WO1996036624A1/ja not_active Ceased
- 1996-05-20 CN CNB961905298A patent/CN1163493C/zh not_active Expired - Fee Related
-
1997
- 1997-01-14 NO NO19970151A patent/NO317631B1/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO970151D0 (no) | 1997-01-14 |
| ES2258775T3 (es) | 2006-09-01 |
| WO1996036624A1 (en) | 1996-11-21 |
| JP4172817B2 (ja) | 2008-10-29 |
| NO970151L (no) | 1997-03-06 |
| DE69636086T2 (de) | 2006-11-30 |
| KR100445356B1 (ko) | 2004-11-12 |
| CN1154697A (zh) | 1997-07-16 |
| AU705690B2 (en) | 1999-05-27 |
| EP0771794B1 (de) | 2006-05-03 |
| EP0771794A1 (de) | 1997-05-07 |
| DE69636086D1 (de) | 2006-06-08 |
| NO317631B1 (no) | 2004-11-29 |
| EP0771794A4 (de) | 1998-09-02 |
| AU5702996A (en) | 1996-11-29 |
| HK1000785A1 (en) | 2006-06-30 |
| KR970704724A (ko) | 1997-09-06 |
| CA2195755A1 (en) | 1996-11-21 |
| PT771794E (pt) | 2006-09-29 |
| CN1163493C (zh) | 2004-08-25 |
| DK0771794T3 (da) | 2006-09-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0771794 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |