ES2195545T3 - Derivados de triazolopurina, composicion medicinal que contiene los derivados, agnete compatibilizante del receptor a3 de adenosina y remedio contra el asma. - Google Patents
Derivados de triazolopurina, composicion medicinal que contiene los derivados, agnete compatibilizante del receptor a3 de adenosina y remedio contra el asma.Info
- Publication number
- ES2195545T3 ES2195545T3 ES99909349T ES99909349T ES2195545T3 ES 2195545 T3 ES2195545 T3 ES 2195545T3 ES 99909349 T ES99909349 T ES 99909349T ES 99909349 T ES99909349 T ES 99909349T ES 2195545 T3 ES2195545 T3 ES 2195545T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- alkyl
- phenyl
- alkyl group
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un derivado de triazolopurina representado mediante la fórmula general (1): en la que R1 representa un grupo alquilo, o un grupo fenilo que está opcionalmente sustituido con un grupo alquilo de C1-6; R2 representa un grupo piridilo, un grupo furilo, un grupo tienilo, un grupo alquilo de C1-6, un grupo fenilo-alquilo de C1-6 que opcionalmente tiene de 1 a 3 grupos alcoxi de C1-6 como sustituyentes, un grupo estirilo que opcionalmente tiene de 1 a 3 grupos alcoxi de C1-6 como sustituyentes, un grupo naftilo que opcionalmente tiene un grupo hidroxi como sustituyente, o un grupo fenilo que opcionalmente tiene de 1 a 3 grupos seleccionados de un grupo alquilo de C1-6, un grupo alcoxi de C1-6, un grupo nitro, un grupo hidroxilo, un grupo amino, un grupo N-alquilo de C1-6-amino, un grupo N, N-dialquilo de C1-6-amino, un grupo N-fenilo-alquilo de C1-6-amino, un grupo N, N-bisfeniloalquilo de C1-6-amino, un grupo fenilo, un grupo fenoxi, un grupo fenilo-alcoxi de C1-6, un grupo alquilo de C1-6 sustituido con átomos de halógeno, un grupo alcoxi de C1-6 sustituido con átomos de halógeno, un grupo dialquilo de C1-6-fosforilmetilo, un grupo alquilo de C1-6-tio, un grupo alcoxi de C1-6-alquilo de C1-6, un grupo fenilo-alcoxi de C1-6-alquilo de C1-6y un átomo de halógeno como sustituyente; y A representa un grupo: **(Fórmula)** en los que R3 representa un grupo alquilo de C1_6o un grupo fenilo-alquilo de C1-6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9136798 | 1998-04-03 | ||
| JP28919498 | 1998-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2195545T3 true ES2195545T3 (es) | 2003-12-01 |
Family
ID=26432810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99909349T Expired - Lifetime ES2195545T3 (es) | 1998-04-03 | 1999-03-26 | Derivados de triazolopurina, composicion medicinal que contiene los derivados, agnete compatibilizante del receptor a3 de adenosina y remedio contra el asma. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6288070B1 (es) |
| EP (1) | EP1069126B1 (es) |
| JP (1) | JP4077155B2 (es) |
| KR (1) | KR100513062B1 (es) |
| CN (1) | CN1122033C (es) |
| AT (1) | ATE241629T1 (es) |
| AU (1) | AU760399B2 (es) |
| CA (1) | CA2326716C (es) |
| DE (1) | DE69908335T2 (es) |
| ES (1) | ES2195545T3 (es) |
| NO (1) | NO317709B1 (es) |
| TW (1) | TW553945B (es) |
| WO (1) | WO1999051606A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001023391A1 (en) | 1999-09-28 | 2001-04-05 | Otsuka Pharmaceutical Factory, Inc. | Triazolopurine derivatives, drug compositions containing the same and adenosine a3 receptor affinitive agents |
| KR20030076633A (ko) * | 2001-02-05 | 2003-09-26 | 가부시키 가이샤 오오쯔카 세이야쿠 고우죠우 | 트리아조로퀴나졸린 및 피라졸로 트리아조로피리미딘유도체, 의약조성물,아데노신 에이3 수용체 친화제,안압저하제, 녹내장의 예방 및 치료를 위한 제제 및안압저하 방법 |
| JP4545437B2 (ja) * | 2001-10-15 | 2010-09-15 | シェーリング コーポレイション | アデノシンａ２ａ受容体アンタゴニストとしてのイミダゾ（４，３−ｅ）−１，２，４−トリアゾロ（１，５−ｃ）ピリミジン |
| WO2011010306A1 (en) | 2009-07-21 | 2011-01-27 | Ramot At Tel-Aviv University Ltd. | A3 adenosine receptor ligands for modulation of pigmentation |
| CA3087655A1 (en) * | 2018-01-04 | 2019-07-11 | Impetis Biosciences Ltd. | Tricyclic compounds, compositions and medicinal applications thereof |
| US11718622B2 (en) | 2020-03-16 | 2023-08-08 | Exelixis Inc. | Heterocyclic adenosine receptor antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0217748B1 (en) * | 1985-09-30 | 1991-02-06 | Ciba-Geigy Ag | 2-Substituted-e-fused-[1,2,4,]triazolo-[1,5-c]pyrimidines pharmaceutical compositions and uses thereof |
| AU612331B2 (en) * | 1986-09-30 | 1991-07-11 | Ciba-Geigy Ag | 2-substituted-e-fused-(1,2,4)triazolo(1,5-c)pyrimidines pharmaceutical compositions |
| IT1277392B1 (it) * | 1995-07-28 | 1997-11-10 | Schering Plough S P A | Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina |
| AU4471297A (en) * | 1996-10-07 | 1998-05-05 | Kyowa Hakko Kogyo Co. Ltd. | Fused purine derivatives |
-
1999
- 1999-03-26 KR KR10-2000-7010769A patent/KR100513062B1/ko not_active Expired - Fee Related
- 1999-03-26 EP EP99909349A patent/EP1069126B1/en not_active Expired - Lifetime
- 1999-03-26 US US09/647,613 patent/US6288070B1/en not_active Expired - Lifetime
- 1999-03-26 DE DE69908335T patent/DE69908335T2/de not_active Expired - Lifetime
- 1999-03-26 JP JP2000542327A patent/JP4077155B2/ja not_active Expired - Fee Related
- 1999-03-26 AU AU28568/99A patent/AU760399B2/en not_active Ceased
- 1999-03-26 AT AT99909349T patent/ATE241629T1/de not_active IP Right Cessation
- 1999-03-26 ES ES99909349T patent/ES2195545T3/es not_active Expired - Lifetime
- 1999-03-26 CA CA002326716A patent/CA2326716C/en not_active Expired - Fee Related
- 1999-03-26 CN CN99806269A patent/CN1122033C/zh not_active Expired - Fee Related
- 1999-03-26 WO PCT/JP1999/001592 patent/WO1999051606A1/ja not_active Ceased
- 1999-03-31 TW TW088105086A patent/TW553945B/zh not_active IP Right Cessation
-
2000
- 2000-10-02 NO NO20004953A patent/NO317709B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999051606A1 (en) | 1999-10-14 |
| CN1301266A (zh) | 2001-06-27 |
| JP4077155B2 (ja) | 2008-04-16 |
| DE69908335D1 (de) | 2003-07-03 |
| CN1122033C (zh) | 2003-09-24 |
| NO317709B1 (no) | 2004-12-06 |
| NO20004953D0 (no) | 2000-10-02 |
| CA2326716A1 (en) | 1999-10-14 |
| TW553945B (en) | 2003-09-21 |
| EP1069126B1 (en) | 2003-05-28 |
| CA2326716C (en) | 2006-12-12 |
| ATE241629T1 (de) | 2003-06-15 |
| AU2856899A (en) | 1999-10-25 |
| DE69908335T2 (de) | 2004-04-29 |
| US6288070B1 (en) | 2001-09-11 |
| KR20010042240A (ko) | 2001-05-25 |
| EP1069126A1 (en) | 2001-01-17 |
| KR100513062B1 (ko) | 2005-09-05 |
| EP1069126A4 (en) | 2002-03-27 |
| NO20004953L (no) | 2000-11-28 |
| AU760399B2 (en) | 2003-05-15 |
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