ES2196026T3 - Uso de ndv en la fabricacion de un medicamento para tratar el cancer. - Google Patents
Uso de ndv en la fabricacion de un medicamento para tratar el cancer.Info
- Publication number
- ES2196026T3 ES2196026T3 ES94916604T ES94916604T ES2196026T3 ES 2196026 T3 ES2196026 T3 ES 2196026T3 ES 94916604 T ES94916604 T ES 94916604T ES 94916604 T ES94916604 T ES 94916604T ES 2196026 T3 ES2196026 T3 ES 2196026T3
- Authority
- ES
- Spain
- Prior art keywords
- ndv
- manufacture
- treat cancer
- medicinal product
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 241000711404 Avian avulavirus 1 Species 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/17—Newcastle disease virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION PROPORCIONA UN METODO DE TRATAMIENTO DE CANCER EN UN MAMIFERO QUE COMPRENDE LA ADMINISTRACION AL MAMIFERO DE UNA CANTIDAD EFECTIVA DE VIRUS, PARTICULARMENTE VIRUS DE LA ENFERMEDAD DE NEWCASTLE O OTROS PARAMIXOVIRUS. LA INVENCION ADEMAS PROPORCIONA UN METODO DE TRATAMIENTO DE CANCER EN UN MAMIFERO QUE COMPRENDE LA ADMINISTRACION DE TALES VIRUS AL MAMIFERO EN COMBINACION CON OTRO AGENTE COMO UN COMPUESTO QUIMIOTERAPEUTICO, INMUNOADYUVANTE, CITOQUINA O AGENTE INMUNOSUPRESOR. LA INVENCION PROPORCIONA ADEMAS UN METODO DE DETECCION DE CELULAS CANCERIGENAS EN UN MAMIFERO UTILIZANDO PARAMIXOVIRUS COMO UN AGENTE DE PRESENTACION Y COMO UN INDICADOR DEL CRECIMIENTO DE CELULAS CANCERIGENAS EN EL MAMIFERO.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5551993A | 1993-04-30 | 1993-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196026T3 true ES2196026T3 (es) | 2003-12-16 |
Family
ID=21998395
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02026340T Expired - Lifetime ES2310580T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones purificadas del virus de la enfermedad de newcastle. |
| ES94916604T Expired - Lifetime ES2196026T3 (es) | 1993-04-30 | 1994-04-29 | Uso de ndv en la fabricacion de un medicamento para tratar el cancer. |
| ES04017349T Expired - Lifetime ES2315595T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones para tratar cancer con uso de virus. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02026340T Expired - Lifetime ES2310580T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones purificadas del virus de la enfermedad de newcastle. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04017349T Expired - Lifetime ES2315595T3 (es) | 1993-04-30 | 1994-04-29 | Composiciones para tratar cancer con uso de virus. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7056689B1 (es) |
| EP (4) | EP1486211B1 (es) |
| JP (3) | JP4338781B2 (es) |
| AT (3) | ATE411809T1 (es) |
| AU (1) | AU699487B2 (es) |
| CA (1) | CA2161671A1 (es) |
| DE (3) | DE69432409T2 (es) |
| DK (3) | DK1486211T3 (es) |
| ES (3) | ES2310580T3 (es) |
| HK (1) | HK1052871A1 (es) |
| PT (3) | PT696326E (es) |
| WO (1) | WO1994025627A1 (es) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2310580T3 (es) * | 1993-04-30 | 2009-01-16 | Wellstat Biologics Corporation | Composiciones purificadas del virus de la enfermedad de newcastle. |
| EP1905304A3 (en) * | 1997-10-09 | 2008-08-13 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US20030044384A1 (en) | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7470426B1 (en) | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| US7780962B2 (en) | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| FR2788099B1 (fr) | 1999-01-06 | 2001-02-09 | Vallourec Mannesmann Oil & Gas | Assemblage filete de deux tubes metalliques a couple eleve de vissage |
| AU2005201079C1 (en) * | 1999-04-15 | 2008-11-06 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| CN1477964A (zh) * | 1999-04-15 | 2004-02-25 | 应用病毒治疗肿瘤 | |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| AUPQ425699A0 (en) | 1999-11-25 | 1999-12-23 | University Of Newcastle Research Associates Limited, The | A method of treating a malignancy in a subject and a pharmaceutical composition for use in same |
| AR028039A1 (es) | 2000-05-03 | 2003-04-23 | Oncolytics Biotech Inc | Remocion de reovirus de celulas neoplasticas intermediadas por ras a partir de composiciones celulares mixtas |
| US7306902B2 (en) | 2002-06-28 | 2007-12-11 | Oncolyties Biotech Inc. | Oncolytic viruses as phenotyping agents for neoplasms |
| US8491884B2 (en) | 2000-05-03 | 2013-07-23 | Oncolytics Biotech Inc. | Virus clearance of neoplastic cells from mixed cellular compositions |
| WO2002000233A2 (en) | 2000-06-26 | 2002-01-03 | Wellstat Biologics Corporation | Purging of cells using viruses |
| AR035227A1 (es) | 2001-02-20 | 2004-05-05 | Oncolytics Biotech Inc | Uso de un agente quimioterapeutico para la manufactura de un medicamento para la sensibilizacion de celulas neoplasicas resistentes a agentes quimioterapeuticos con reovirus |
| NZ527687A (en) | 2001-05-11 | 2005-10-28 | Wellstat Biolog Corp Formerly | Preferential binding of an oncolytic virus such as Newcastle Disease Virus (NDV) to leukocytes compared with erythrocytes used as a therapy for cancer |
| US7615209B2 (en) * | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| US20040005546A1 (en) | 2002-02-28 | 2004-01-08 | Oncolytics Biotech Inc. | Use of ribozymes in the detection of adventitious agents |
| CA2374388C (en) | 2002-02-28 | 2005-07-12 | Matthew C. Coffey | The use of ribozymes in the detection of adventitious agents |
| US20050220818A1 (en) * | 2002-06-21 | 2005-10-06 | Wellstat Biologics Corporation | Administration of therapeutic viruses |
| AU2003287472A1 (en) * | 2002-11-05 | 2004-06-03 | Wellstat Biologics Corporation | Treating carcinoid neoplasms with therapeuthic viruses |
| AU2002953436A0 (en) | 2002-12-18 | 2003-01-09 | The University Of Newcastle Research Associates Limited | A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis |
| CA2519337A1 (en) * | 2003-03-24 | 2005-03-03 | Wellstat Biologics Corporation | Anti-cancer virus desensitization method |
| KR101279748B1 (ko) * | 2003-11-04 | 2013-07-04 | 가부시키가이샤 디나벡크 겐큐쇼 | 유전자 도입된 수상세포의 제조방법 |
| WO2005051433A1 (en) * | 2003-11-25 | 2005-06-09 | United Cancer Research Institute | Method for treating human tumor cells with a newcastle disease virus strain and a chemotherapeutic agent |
| US20070207149A1 (en) | 2004-04-27 | 2007-09-06 | Wellstat Biologics Corporation | Cancer treatment using viruses and camptothecins |
| EP1775343A4 (en) * | 2004-06-24 | 2007-11-14 | Dnavec Research Inc | ANTITUM-AGENT WITH DENDRITIC CELL WITH THE TRANSFECTED RNA VIRUS |
| CA2612949C (en) * | 2005-07-14 | 2015-04-28 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
| JP5603012B2 (ja) | 2005-12-02 | 2014-10-08 | トヘ モウント シナイ スクール オフ メディシネ オフ ニューヨーク ウニベルシトイ | 非天然表面タンパク質を提示するキメラウイルス及びその使用 |
| US20090175826A1 (en) | 2006-06-05 | 2009-07-09 | Elankumaran Subbiah | Genetically-engineered newcastle disease virus as an oncolytic agent, and methods of using same |
| US9241998B2 (en) * | 2007-05-21 | 2016-01-26 | Board Of Regents, The University Of Texas System | Methods and compositions for treatment of cancer using oncolytic RSV activity |
| EP2345415B1 (en) * | 2008-09-16 | 2015-01-21 | GenomIdea Inc. | Therapeutic/prophylactic agent for prostate cancer |
| EP2393921B1 (en) | 2009-02-05 | 2015-07-15 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
| EP2327764B1 (en) | 2009-11-30 | 2011-12-28 | United Cancer Research Institute | New clone of Newcastle disease virus, its manufacture and its application in the medical treatment of cancer |
| PE20151921A1 (es) | 2013-03-14 | 2015-12-26 | Icahn School Med Mount Sinai | Virus de la enfermedad de newcastle y usos de los mismos |
| AU2015222685A1 (en) | 2014-02-27 | 2016-09-08 | Viralytics Limited | Combination method for treatment of cancer |
| CN121343934A (zh) | 2017-05-10 | 2026-01-16 | 制药五有限责任公司 | 对补体灭活作用具有抗性的用于治疗癌症的包膜病毒 |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| EP3837277A4 (en) | 2018-08-17 | 2022-05-11 | Icahn School of Medicine at Mount Sinai | RECOMBINANT NEWCASTLE DISEASE VIRUSES AND THEIR USES IN THE PREVENTION OF RSV DISEASE OR HUMAN METAPNEUMOVIRUS INFECTION |
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| ES2188593T3 (es) | 1992-03-24 | 2003-07-01 | United Cancer Res Inst | Vacuna que contiene un virus vivo. |
| DK0689447T3 (da) | 1993-02-16 | 1999-10-18 | Onyx Pharma Inc | Cytopatiske vira til behandling af og profylakse for neoplasia |
| ATE208421T1 (de) | 1993-03-16 | 2001-11-15 | Hoegen Paul Von | Stimulierung der immunantwort durch virales protein |
| ES2310580T3 (es) * | 1993-04-30 | 2009-01-16 | Wellstat Biologics Corporation | Composiciones purificadas del virus de la enfermedad de newcastle. |
| US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| AU2003287472A1 (en) * | 2002-11-05 | 2004-06-03 | Wellstat Biologics Corporation | Treating carcinoid neoplasms with therapeuthic viruses |
-
1994
- 1994-04-29 ES ES02026340T patent/ES2310580T3/es not_active Expired - Lifetime
- 1994-04-29 DE DE69432409T patent/DE69432409T2/de not_active Expired - Lifetime
- 1994-04-29 EP EP04017349A patent/EP1486211B1/en not_active Expired - Lifetime
- 1994-04-29 WO PCT/US1994/004732 patent/WO1994025627A1/en not_active Ceased
- 1994-04-29 DE DE69435118T patent/DE69435118D1/de not_active Expired - Lifetime
- 1994-04-29 EP EP94916604A patent/EP0696326B1/en not_active Expired - Lifetime
- 1994-04-29 AT AT04017349T patent/ATE411809T1/de not_active IP Right Cessation
- 1994-04-29 CA CA002161671A patent/CA2161671A1/en not_active Abandoned
- 1994-04-29 DK DK04017349T patent/DK1486211T3/da active
- 1994-04-29 EP EP08166836A patent/EP2009119A1/en not_active Withdrawn
- 1994-04-29 EP EP02026340A patent/EP1314431B1/en not_active Expired - Lifetime
- 1994-04-29 AT AT02026340T patent/ATE401092T1/de not_active IP Right Cessation
- 1994-04-29 PT PT94916604T patent/PT696326E/pt unknown
- 1994-04-29 ES ES94916604T patent/ES2196026T3/es not_active Expired - Lifetime
- 1994-04-29 DK DK94916604T patent/DK0696326T5/da active
- 1994-04-29 AT AT94916604T patent/ATE236271T1/de not_active IP Right Cessation
- 1994-04-29 ES ES04017349T patent/ES2315595T3/es not_active Expired - Lifetime
- 1994-04-29 DK DK02026340T patent/DK1314431T3/da active
- 1994-04-29 PT PT02026340T patent/PT1314431E/pt unknown
- 1994-04-29 JP JP52456394A patent/JP4338781B2/ja not_active Expired - Fee Related
- 1994-04-29 AU AU68213/94A patent/AU699487B2/en not_active Ceased
- 1994-04-29 PT PT04017349T patent/PT1486211E/pt unknown
- 1994-04-29 DE DE69435155T patent/DE69435155D1/de not_active Expired - Lifetime
- 1994-06-16 US US08/260,536 patent/US7056689B1/en not_active Expired - Lifetime
-
2003
- 2003-07-12 HK HK03105047.9A patent/HK1052871A1/en unknown
-
2005
- 2005-03-24 JP JP2005087342A patent/JP2005187484A/ja not_active Withdrawn
-
2006
- 2006-05-26 US US11/441,201 patent/US7736640B2/en not_active Expired - Fee Related
-
2009
- 2009-03-26 JP JP2009077773A patent/JP2009149689A/ja not_active Withdrawn
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