JP2009149689A - ウイルスに用いる癌の処置および検出方法 - Google Patents

ウイルスに用いる癌の処置および検出方法 Download PDF

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JP2009149689A
JP2009149689A JP2009077773A JP2009077773A JP2009149689A JP 2009149689 A JP2009149689 A JP 2009149689A JP 2009077773 A JP2009077773 A JP 2009077773A JP 2009077773 A JP2009077773 A JP 2009077773A JP 2009149689 A JP2009149689 A JP 2009149689A
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treatment
cancer
strain
ndv
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Robert M Lorence
エム． ローレンス ロバート
Kirk W Reichard
ダブリュ． レイチャード カーク
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Wellstat Biologics Corp
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Abstract

【課題】化学療法および放射線照射における最近の進歩に関わらず、癌が死因の上位に
位置する現在において、哺乳動物の癌を処置する方法において、医薬的に許容される担体
中でニューキャッスル病ウイルスの有効量を哺乳動物に投与することからなる方法を提供
すること。
【解決手段】哺乳動物の癌を処置する方法において、医薬的に許容される担体中でニュ
ーキャッスル病ウイルスの有効量を哺乳動物に投与することからなる方法および哺乳類動
物の癌を処置する方法において、ニューキャッスル病ウイルスを他の薬剤と併用し、その
両者をその併用が癌に対して有効である十分な量で哺乳類動物に投与することからなる方
法。
【選択図】なし

Description
図１は，無胸腺マウスにおけるＩＭＲ−３２ヒト神経芽腫異種移植片の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を例示する。 図２は無胸腺マウスにおけるＨＴ−１０８０線維肉腫異種移植片の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を示す。 図３は，無胸腺マウスにおけるＮＣｌ−Ｈ４６０ヒト大細胞肺癌異種移植片の生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を示す。 図４は，ＩＭＲ−３２ヒト神経芽腫異種移植片の，生存ＮＤＶ（７３−T株）全身性（腹腔内）注射後の退縮を示す。 図５は，比較的緩和なビレンスのＮＤＶ株（Ｍ，ＭａｓｓＭＫ１０７）の腫瘍退縮誘発における有効性を，比較的ビレンスの高いＮＤＶ株（７３−Ｔ）の場合とともに例示する。 図６は，無胸腺マウスにおけるＵ８７ＭＧヒトグリオブラストーマ異種移植片の生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を示す。 図７は無胸腺マウスにおけるＫＢ８−５−１１ヒト子宮頸部癌の生存ＮＤＶ（７３−T株）の腫瘍内注入後の増殖阻害を示す。 図８は，無胸腺マウスにおけるＰＣ−３ヒト前立腺癌の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を示す。 図９は無胸腺マウスにおけるＨＴ２９ヒト結腸癌の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の増殖阻害を示す。 図１０は無胸腺マウスにおけるＳＫ−ＢＲ−３ヒト乳癌の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の増殖阻害を示す。 図１１は，無胸腺マウスにおけるＳＷ６２０ヒト結腸癌の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の増殖阻害を示す。 図１２は，無胸腺マウスにおけるＮ四１７３８７ヒト結腸癌の，生存ＮＤＶ（７３−T株）の腫瘍内注入後の増殖阻害を示す。 図１３は，無胸腺マウスにおけるＴＨ１５１４５ヒト滑膜肉腫の生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を示す． 図１４は，無胸腺マウスにおけるＭＥＬ３３０ヒトメラノーマ異種移植片の生存ＮＤＶ（７３−T株）の腫瘍内注入後の退縮を示す。

Claims (1)

  1. 本明細書に記載の発明。
JP2009077773A 1993-04-30 2009-03-26 ウイルスに用いる癌の処置および検出方法 Withdrawn JP2009149689A (ja)

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JP52456394A Expired - Fee Related JP4338781B2 (ja) 1993-04-30 1994-04-29 ウイルスを用いる癌の処置および検出方法
JP2005087342A Withdrawn JP2005187484A (ja) 1993-04-30 2005-03-24 ウイルスに用いる癌の処置および検出方法
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