ES2196252T3 - Dispositivo para la incorporacion y administracion de agentes biologicos activos. - Google Patents

Dispositivo para la incorporacion y administracion de agentes biologicos activos.

Info

Publication number
ES2196252T3
ES2196252T3 ES97201425T ES97201425T ES2196252T3 ES 2196252 T3 ES2196252 T3 ES 2196252T3 ES 97201425 T ES97201425 T ES 97201425T ES 97201425 T ES97201425 T ES 97201425T ES 2196252 T3 ES2196252 T3 ES 2196252T3
Authority
ES
Spain
Prior art keywords
incorporation
administration
biological agents
biologically active
active biological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97201425T
Other languages
English (en)
Inventor
Eugenia Ribeiro De Sous Leitao
Bruijn Joost Dick De
Hai-Bo Wen
Groot Klaas De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chienna BV
Original Assignee
Chienna BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chienna BV filed Critical Chienna BV
Application granted granted Critical
Publication of ES2196252T3 publication Critical patent/ES2196252T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30906—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth shot- sand- or grit-blasted
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00976—Coating or prosthesis-covering structure made of proteins or of polypeptides, e.g. of bone morphogenic proteins BMP or of transforming growth factors TGF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Cephalosporin Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION PROPORCIONA UN DISPOSITIVO IMPLANTABLE REVESTIDO CON UNA CAPA DE FOSFATO CALCICO Y OPCIONALMENTE UNA O MAS SUSTANCIAS BIOLOGICAMENTE ACTIVAS COMO FACTORES DE CRECIMIENTO, LIPIDOS, (LIPO)POLISACARIDOS, HORMONAS, PROTEINAS, ANTIBIOTICOS O CITOSTATICOS. EL DISPOSITIVO PUEDE OBTENERSE MEDIANTE UN PROCESO DE NANOTECNOLOGIUA QUE SUPONE SOMETER UN SUSTRATO A UN TRATAMIENTO DE SUPERFICIE HASTA OBTENER UNA RUGOSIDAD DE SUPERFICIE CON UNA DISTANCIA MAXIMA MEDIA (VALOR RA) ENTRE 10 Y 1.000 NM Y TRATANTO ESTA SUPERFICIE MEDIANTE PRECIPITACION DE FOSFATO CALCICO DE UNA SOLUCION QUE CONTENGA IONES DE FOSFATO Y DE CALCIO CON COPRECIPITACION OPCIONAL DE LA SUSTANCIA BIOLOGICAMENTE ACTIVA.
ES97201425T 1996-05-10 1997-05-12 Dispositivo para la incorporacion y administracion de agentes biologicos activos. Expired - Lifetime ES2196252T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201293 1996-05-10

Publications (1)

Publication Number Publication Date
ES2196252T3 true ES2196252T3 (es) 2003-12-16

Family

ID=8223977

Family Applications (2)

Application Number Title Priority Date Filing Date
ES97201425T Expired - Lifetime ES2196252T3 (es) 1996-05-10 1997-05-12 Dispositivo para la incorporacion y administracion de agentes biologicos activos.
ES97201424T Expired - Lifetime ES2185861T3 (es) 1996-05-10 1997-05-12 Material para implantes y procedimiento de fabricacion del mismo.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97201424T Expired - Lifetime ES2185861T3 (es) 1996-05-10 1997-05-12 Material para implantes y procedimiento de fabricacion del mismo.

Country Status (5)

Country Link
US (2) US6069295A (es)
AT (2) ATE235927T1 (es)
CA (2) CA2205104A1 (es)
DE (2) DE69716505T2 (es)
ES (2) ES2196252T3 (es)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6491723B1 (en) * 1996-02-27 2002-12-10 Implant Innovations, Inc. Implant surface preparation method
US5863201A (en) * 1994-11-30 1999-01-26 Implant Innovations, Inc. Infection-blocking dental implant
US6652765B1 (en) 1994-11-30 2003-11-25 Implant Innovations, Inc. Implant surface preparation
BR9509934A (pt) * 1994-11-30 1998-01-27 Implant Innovations Inc Preparação de superficie de implante
PT968011E (pt) * 1997-03-27 2004-12-31 Smith & Nephew Inc Processo de oxidacao em superficies de ligas de zirconio e produto resultante
SE9701647D0 (sv) * 1997-04-30 1997-04-30 Nobel Biocare Ab Calcium-phonsphate coated implant element
ATE235928T1 (de) 1998-09-15 2003-04-15 Isotis Nv Beschichtungsverfahren von medizinischen implantaten
JP3072373B1 (ja) * 1999-07-05 2000-07-31 工業技術院長 汚濁物質、雑菌付着抑制機能および耐酸性を有する人工歯根ならびに製造方法
US20060194008A1 (en) * 1999-09-22 2006-08-31 Princeton University Devices with multiple surface functionality
US8012590B2 (en) 2000-05-01 2011-09-06 The Regents Of The University Of California Glass/ceramic coatings for implants
US6610067B2 (en) 2000-05-01 2003-08-26 Arthrosurface, Incorporated System and method for joint resurface repair
EP2314257B9 (en) 2000-05-01 2013-02-27 ArthroSurface, Inc. System for joint resurface repair
US6805898B1 (en) * 2000-09-28 2004-10-19 Advanced Cardiovascular Systems, Inc. Surface features of an implantable medical device
US7083642B2 (en) * 2000-12-22 2006-08-01 Avantec Vascular Corporation Delivery of therapeutic capable agents
US7018418B2 (en) * 2001-01-25 2006-03-28 Tecomet, Inc. Textured surface having undercut micro recesses in a surface
US6620332B2 (en) * 2001-01-25 2003-09-16 Tecomet, Inc. Method for making a mesh-and-plate surgical implant
US6599322B1 (en) 2001-01-25 2003-07-29 Tecomet, Inc. Method for producing undercut micro recesses in a surface, a surgical implant made thereby, and method for fixing an implant to bone
JP2002322013A (ja) * 2001-04-25 2002-11-08 Univ Nagoya 活性物質の前駆体、該前駆体を用いた活性物質、及びその活性物質の製造方法
US7776085B2 (en) * 2001-05-01 2010-08-17 Amedica Corporation Knee prosthesis with ceramic tibial component
US20050177238A1 (en) * 2001-05-01 2005-08-11 Khandkar Ashok C. Radiolucent bone graft
US7695521B2 (en) 2001-05-01 2010-04-13 Amedica Corporation Hip prosthesis with monoblock ceramic acetabular cup
AU2002324443A1 (en) * 2001-06-14 2003-01-02 Amedica Corporation Metal-ceramic composite articulation
SE519531C2 (sv) * 2001-07-04 2003-03-11 Nobel Biocare Ab Implantat innefattande porarrangemang belagt med kalciumfosfat
JP4347044B2 (ja) * 2001-07-26 2009-10-21 アバンテク バスキュラー コーポレーション 可変放出プロフィールを有する治療用薬剤を送達するための装置
ES2247423T5 (es) 2001-11-19 2015-12-30 Scil Technology Gmbh Método de producción de un dispositivo recubierto homogéneamente que tiene propiedades osteoinductoras y osteoconductoras
JP4595081B2 (ja) * 2002-02-26 2010-12-08 オステム インプラント コ．リミテッド リン酸カルシウムコロイド、ドット、アイランド、薄膜または、グラニュール、およびその調製
EP1358859A1 (en) * 2002-04-29 2003-11-05 Politecnico Di Milano Bone prostheses having multilayer interface
GB0210786D0 (en) * 2002-05-10 2002-06-19 Plasma Coatings Ltd Orthopaedic and dental implants
US6794273B2 (en) * 2002-05-24 2004-09-21 Fujitsu Limited Semiconductor device and manufacturing method thereof
US20100185294A1 (en) * 2002-06-04 2010-07-22 Arthrosurface Incorporated Nanorough Alloy Substrate
SE523236C2 (sv) * 2002-07-19 2004-04-06 Astra Tech Ab Ett implantat och ett förfarande för behandling av en implantatyta
SE523288C2 (sv) * 2002-07-19 2004-04-06 Astra Tech Ab Ett implantat och ett förfarande för behandling av en implantatyta
ATE322916T1 (de) 2002-09-10 2006-04-15 Scil Technology Gmbh Unter verringerter sauerstoffkonzentration mit einem osteoinduktiven protein beschichtetes metallimplantat
AU2003297195A1 (en) * 2002-12-17 2004-07-22 Amedica Corporation Total disc implant
US8388624B2 (en) 2003-02-24 2013-03-05 Arthrosurface Incorporated Trochlear resurfacing system and method
GB0304168D0 (en) * 2003-02-24 2003-03-26 Benoist Girard Sas Surface treatment of metal
US20040167632A1 (en) * 2003-02-24 2004-08-26 Depuy Products, Inc. Metallic implants having roughened surfaces and methods for producing the same
US8251700B2 (en) * 2003-05-16 2012-08-28 Biomet 3I, Llc Surface treatment process for implants made of titanium alloy
US7067169B2 (en) 2003-06-04 2006-06-27 Chemat Technology Inc. Coated implants and methods of coating
US20040267376A1 (en) * 2003-06-25 2004-12-30 Kabushiki Kaisha Kobe Seiko Sho (Kobe Steel, Ltd) Ceramic member for medical implant and its production method
US7419680B2 (en) * 2003-10-01 2008-09-02 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
US9199005B2 (en) * 2003-10-01 2015-12-01 New York University Calcium phosphate-based materials containing zinc, magnesium, fluoride and carbonate
EP1529497B1 (en) * 2003-11-04 2009-10-28 Friadent GmbH Dental implant component
PT1529498E (pt) * 2003-11-05 2014-09-17 Dentsply Implants Mfg Gmbh Implante não metálico de várias peças
WO2005074530A2 (en) * 2004-01-30 2005-08-18 Georgette Frederick S Metallic bone implant having improved implantability and method of making the same
AU2005260590A1 (en) 2004-06-28 2006-01-12 Arthrosurface, Inc. System for articular surface replacement
SE530060C2 (sv) * 2004-09-01 2008-02-19 Nobel Biocare Ab Implantat för dental protetik och förfarande och system för framställning av implantatet
US7473278B2 (en) 2004-09-16 2009-01-06 Smith & Nephew, Inc. Method of surface oxidizing zirconium and zirconium alloys and resulting product
US8750983B2 (en) 2004-09-20 2014-06-10 P Tech, Llc Therapeutic system
US7785648B2 (en) * 2004-09-22 2010-08-31 New York University Adherent apatite coating on titanium substrate using chemical deposition
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
WO2006050365A2 (en) * 2004-10-28 2006-05-11 The Regents Of The University Of Michigan Methods for production of synthetic hydroxyapatite nanorods
CA2532388A1 (en) * 2005-01-07 2006-07-07 Inframat Corporation Coated medical devices and methods of making and using
US8017139B2 (en) 2005-02-23 2011-09-13 Zimmer Technology, Inc. Blend hydrogels and methods of making
WO2006091582A2 (en) * 2005-02-24 2006-08-31 Implant Innovations, Inc. Surface treatment methods for implants made of titanium or titanium alloy
TW200710093A (en) * 2005-04-22 2007-03-16 Hybrid Plastics Inc Biomimetic materials comprising polyhedral oligomeric silsesquioxanes
US7901462B2 (en) * 2005-06-23 2011-03-08 Depuy Products, Inc. Implants with textured surface and methods for producing the same
US7571295B2 (en) * 2005-08-04 2009-08-04 Intel Corporation Memory manager for heterogeneous memory control
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
CN101340935B (zh) * 2005-11-14 2013-05-08 拜奥美特3i有限责任公司 于植入物表面上淀积纳米粒子
US8262730B2 (en) * 2005-12-07 2012-09-11 Zimmer, Inc. Methods of bonding or modifying hydrogels using irradiation
CA2633096C (en) * 2005-12-15 2014-09-02 Smith & Nephew, Inc. Diffusion-hardened medical implant
US20070141108A1 (en) * 2005-12-20 2007-06-21 Zimmer, Inc. Fiber-reinforced water-swellable articles
US8017107B2 (en) * 2005-12-22 2011-09-13 Zimmer, Inc. Perfluorocyclobutane crosslinked hydrogels
US8252058B2 (en) * 2006-02-16 2012-08-28 Amedica Corporation Spinal implant with elliptical articulatory interface
US20070198093A1 (en) * 2006-02-17 2007-08-23 Amedica Corporation Spinal implant with offset keels
US8110242B2 (en) * 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
EP1847278A1 (de) * 2006-04-13 2007-10-24 Camlog Biotechnologies AG Bio-auflösende Salzbeschichtungen von Implantaten zum Schutz vor organischen Verunreinigungen
WO2008016712A2 (en) * 2006-08-02 2008-02-07 Inframat Corporation Medical devices and methods of making and using
CN101588826A (zh) * 2006-08-02 2009-11-25 英孚拉玛特公司 腔支撑装置及其制造及使用方法
NO20064595A (no) * 2006-10-10 2008-03-17 Roella Gunnar Titanimplantat og fremgangsmåte for fremstilling derav
US7972648B2 (en) * 2006-10-24 2011-07-05 Biomet 3I, Llc Deposition of discrete nanoparticles on a nanostructured surface of an implant
US9358029B2 (en) 2006-12-11 2016-06-07 Arthrosurface Incorporated Retrograde resection apparatus and method
KR100930279B1 (ko) * 2007-06-20 2009-12-09 재단법인서울대학교산학협력재단 인산칼슘 극초박막 및 그의 제조법
US20090008365A1 (en) * 2007-07-06 2009-01-08 Depuy Products, Inc. Microtextured Implants and Methods of Making Same
EP2022447A1 (en) 2007-07-09 2009-02-11 Astra Tech AB Nanosurface
KR100775537B1 (ko) * 2007-07-19 2007-11-28 (주)오스테오필 표면이 개질된 임플란트 제조 방법 및 그에 의해 제조된임플란트
US20090036996A1 (en) * 2007-08-03 2009-02-05 Roeber Peter J Knit PTFE Articles and Mesh
US20090187197A1 (en) * 2007-08-03 2009-07-23 Roeber Peter J Knit PTFE Articles and Mesh
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US20090043398A1 (en) * 2007-08-09 2009-02-12 Zimmer, Inc. Method of producing gradient articles by centrifugation molding or casting
US8062739B2 (en) * 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) * 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
EP2240116B1 (en) 2008-01-28 2015-07-01 Biomet 3I, LLC Implant surface with increased hydrophilicity
US8361381B2 (en) 2008-09-25 2013-01-29 Smith & Nephew, Inc. Medical implants having a porous coated surface
US9592043B2 (en) * 2009-03-31 2017-03-14 Covidien Lp Multizone implants
US20100268227A1 (en) 2009-04-15 2010-10-21 Depuy Products, Inc. Methods and Devices for Bone Attachment
US8696759B2 (en) 2009-04-15 2014-04-15 DePuy Synthes Products, LLC Methods and devices for implants with calcium phosphate
US9662126B2 (en) 2009-04-17 2017-05-30 Arthrosurface Incorporated Glenoid resurfacing system and method
US9283076B2 (en) 2009-04-17 2016-03-15 Arthrosurface Incorporated Glenoid resurfacing system and method
WO2016154393A1 (en) 2009-04-17 2016-09-29 Arthrosurface Incorporated Glenoid repair system and methods of use thereof
US8475536B2 (en) * 2010-01-29 2013-07-02 DePuy Synthes Products, LLC Methods and devices for implants with improved cement adhesion
CA2792048A1 (en) 2010-03-05 2011-09-09 Arthrosurface Incorporated Tibial resurfacing system and method
US8641418B2 (en) 2010-03-29 2014-02-04 Biomet 3I, Llc Titanium nano-scale etching on an implant surface
TWI543754B (zh) * 2010-06-24 2016-08-01 Univ Kaohsiung Medical Surface treatment of dental implants with tissue integration
DE102010025533B4 (de) 2010-06-29 2014-09-04 Heraeus Medical Gmbh Verfahren zur knochenwachstumsfördernden Beschichtung
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
EP2804565B1 (en) 2011-12-22 2018-03-07 Arthrosurface Incorporated System for bone fixation
ES2671740T3 (es) 2012-03-20 2018-06-08 Biomet 3I, Llc Superficie de tratamiento para una superficie de implante
DE112013003358T5 (de) 2012-07-03 2015-03-19 Arthrosurface, Inc. System und Verfahren für Gelenkoberflächenersatz und -reparatur
US9492200B2 (en) 2013-04-16 2016-11-15 Arthrosurface Incorporated Suture system and method
US20150250472A1 (en) 2014-03-07 2015-09-10 Arthrosurface Incorporated Delivery System for Articular Surface Implant
US10624748B2 (en) 2014-03-07 2020-04-21 Arthrosurface Incorporated System and method for repairing articular surfaces
US11607319B2 (en) 2014-03-07 2023-03-21 Arthrosurface Incorporated System and method for repairing articular surfaces
EP3137125B1 (en) * 2014-05-02 2020-03-04 The Royal Institution for the Advancement of Learning / McGill University Implant formed of structural porous biomaterial and method for manufacturing the same
US20150366668A1 (en) * 2014-06-23 2015-12-24 Community Blood Center Cellular-scale surface modification for increased osteogenic protein expression
CN108096640A (zh) * 2016-11-24 2018-06-01 重庆润泽医药有限公司 一种多孔材料
US10537661B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same
US10537658B2 (en) 2017-03-28 2020-01-21 DePuy Synthes Products, Inc. Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same
CA3108761A1 (en) 2017-08-04 2019-02-07 Arthrosurface Incorporated Multicomponent articular surface implant
GB2616360B (en) 2019-03-12 2023-11-29 Arthrosurface Inc Humeral and glenoid articular surface implant systems and methods

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3984914A (en) * 1974-07-24 1976-10-12 Robert Schwartz Oral implant
JPS5214095A (en) * 1975-07-23 1977-02-02 Sumitomo Chemical Co Implant in bone
US4687487A (en) * 1978-07-21 1987-08-18 Association Suisse Pour La Recherches Horlogere Joint implant
SE416175B (sv) * 1979-03-07 1980-12-08 Per Ingvar Branemark For implantering i kroppsvevnad serskilt benvevnad, avsett material
DE3223925C2 (de) * 1982-06-26 1986-07-31 Feldmühle AG, 4000 Düsseldorf Implantierbares Ellbogengelenk
GB8318483D0 (en) * 1983-07-08 1983-08-10 Zimmer Deloro Surgical Ltd Skeletal implants
US4636526A (en) * 1985-02-19 1987-01-13 The Dow Chemical Company Composites of unsintered calcium phosphates and synthetic biodegradable polymers useful as hard tissue prosthetics
FR2585576B1 (fr) * 1985-07-30 1992-01-03 Bioetica Sa Produit de remplacement de la matrice osseuse favorisant l'osteogenese
US4818559A (en) * 1985-08-08 1989-04-04 Sumitomo Chemical Company, Limited Method for producing endosseous implants
JPH0669482B2 (ja) * 1985-08-08 1994-09-07 住友化学工業株式会社 骨内インプラントの製造法
DD246028A1 (de) * 1986-02-12 1987-05-27 Karl Marx Stadt Tech Hochschul Keramisiertes metallimplantat
GB2189815B (en) * 1986-03-24 1990-10-10 Permelec Electrode Ltd Titanium composite materials coated with calcium phosphate compound and process for production thereof
US5344457A (en) * 1986-05-19 1994-09-06 The University Of Toronto Innovations Foundation Porous surfaced implant
JPS6399867A (ja) * 1986-10-17 1988-05-02 ペルメレツク電極株式会社 リン酸カルシウム化合物被覆複合材及びその製造方法
US4879136A (en) * 1987-02-24 1989-11-07 Dentsply G.M.B.H. Method of applying opaque dental ceramic material to a metal structure
JPS6486975A (en) * 1987-09-29 1989-03-31 Permelec Electrode Ltd Preparation of calcium phosphate compound coated composite material
EP0322250B1 (en) * 1987-12-23 1991-10-09 Sumitomo Chemical Company, Limited Coating liquor containing hydroxyapatite and method for forming hydroxyapatite coating film using the same
US5180426A (en) * 1987-12-28 1993-01-19 Asahi Kogaku Kogyo K.K. Composition for forming calcium phosphate type setting material and process for producing setting material
US4880610A (en) * 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
US5219361A (en) * 1988-09-16 1993-06-15 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
ES2044211T3 (es) * 1989-03-23 1994-01-01 Straumann Inst Ag Implante metalico.
JP2830262B2 (ja) * 1990-01-08 1998-12-02 住友化学工業株式会社 ハイドロキシアパタイト皮膜の形成方法
US5164187A (en) * 1990-04-05 1992-11-17 Norian Corporation Hydroxyapatite prosthesis coatings
JP2978203B2 (ja) * 1990-04-20 1999-11-15 日本特殊陶業株式会社 生体活性な表面層を有するセラミックス体の製造方法
SE468153B (sv) * 1990-10-08 1992-11-16 Astra Meditec Ab Saett foer ytbehandling av implantat av titan eller titanlegering
US5205921A (en) * 1991-02-04 1993-04-27 Queen's University At Kingston Method for depositing bioactive coatings on conductive substrates
US5478237A (en) * 1992-02-14 1995-12-26 Nikon Corporation Implant and method of making the same
US5358529A (en) * 1993-03-05 1994-10-25 Smith & Nephew Richards Inc. Plastic knee femoral implants
NL9301941A (nl) * 1993-11-09 1995-06-01 Klaas De Groot Werkwijze voor het aanbrengen van een bekleding van een bioactief materiaal op implantaten.
US5607480A (en) * 1993-11-10 1997-03-04 Implant Innovations, Inc. Surgically implantable prosthetic devices
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
BR9509934A (pt) * 1994-11-30 1998-01-27 Implant Innovations Inc Preparação de superficie de implante
AU723740B2 (en) * 1995-06-06 2000-09-07 Howmedica Inc. Biocompatible hydroxyapatite formulations and uses therefor
JPH0956805A (ja) * 1995-08-24 1997-03-04 Millennium Biologics Inc リン酸カルシウム材の薄膜製造のための改良焼結方法
US5730598A (en) * 1997-03-07 1998-03-24 Sulzer Calcitek Inc. Prosthetic implants coated with hydroxylapatite and process for treating prosthetic implants plasma-sprayed with hydroxylapatite

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US6069295A (en) 2000-05-30
ATE226453T1 (de) 2002-11-15
DE69720316D1 (de) 2003-05-08
DE69716505T2 (de) 2003-06-26
ATE235927T1 (de) 2003-04-15
DE69720316T2 (de) 2004-04-01
ES2185861T3 (es) 2003-05-01
CA2205107A1 (en) 1997-11-10
US6146686A (en) 2000-11-14
CA2205104A1 (en) 1997-11-10

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