BRPI0415466A - método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos - Google Patents

método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos

Info

Publication number
BRPI0415466A
BRPI0415466A BRPI0415466-5A BRPI0415466A BRPI0415466A BR PI0415466 A BRPI0415466 A BR PI0415466A BR PI0415466 A BRPI0415466 A BR PI0415466A BR PI0415466 A BRPI0415466 A BR PI0415466A
Authority
BR
Brazil
Prior art keywords
skin
patch
patient
pretreatment
drug delivery
Prior art date
Application number
BRPI0415466-5A
Other languages
English (en)
Inventor
Michel J N Cormier
Weiqi Lin
Juanita Johnson
Kofi Nyam
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0415466A publication Critical patent/BRPI0415466A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

"MéTODO E SISTEMA DE PRé-TRATAMENTO PARA INTENSIFICAR A DISTRIBUIçãO TRANSDéRMICA DE FáRMACOS". A invenção refere-se a um sistema de distribuição de fármacos para distribuir um agente biologicamente ativo através da pele de um paciente, que compreende (i) um emplastro de pré-tratamento adaptado para ser colocado sobre a pele do paciente, sendo que o emplastro de pré-tratamento tem uma membrana de revestimento e um arranjo de microprojeções, o arranjo de microprojeções ficando aderido à membrana de revestimento, o arranjo de microprojeções incluindo uma pluralidade de microprojeções adaptadas para perfurar o estrato córneo do paciente, o emplastro de pré-tratamento incluindo um modelo de pele que permanece sobre a pele do paciente depois que o emplastro de pré-tratamento é aplicado sobre a pele e removido da pele do paciente, e (ii) um emplastro de gel que tem uma superfície do topo e uma superfície do fundo, o emplastro de gel incluindo um reservatório que contém uma formulação de hidrogel, e o emplastro de gel tendo uma área de contato com a pele na faixa entre aproximadamente 0,5 e 30 cm¬ 2¬.
BRPI0415466-5A 2003-10-24 2004-10-21 método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos BRPI0415466A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51438703P 2003-10-24 2003-10-24
PCT/US2004/035061 WO2005042054A2 (en) 2003-10-24 2004-10-21 Pretreatment method and system for enhancing transdermal drug delivery

Publications (1)

Publication Number Publication Date
BRPI0415466A true BRPI0415466A (pt) 2006-12-19

Family

ID=34549332

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0415466-5A BRPI0415466A (pt) 2003-10-24 2004-10-21 método e sistema de pré-tratamento para intensificar a distribuição transdérmica de fármacos

Country Status (11)

Country Link
US (1) US20050106226A1 (pt)
EP (1) EP1675539A4 (pt)
JP (1) JP2007510445A (pt)
KR (1) KR20060108682A (pt)
CN (1) CN1897898A (pt)
AR (1) AR046307A1 (pt)
AU (1) AU2004285484A1 (pt)
BR (1) BRPI0415466A (pt)
CA (1) CA2543086A1 (pt)
TW (1) TW200517156A (pt)
WO (1) WO2005042054A2 (pt)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP1523367A1 (en) 2002-07-19 2005-04-20 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
AU2004253571A1 (en) * 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
JP2007503268A (ja) * 2003-08-25 2007-02-22 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答修飾化合物の送達
JP2007516781A (ja) * 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー 医療用具および該医療用具を含むキット
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US20080039805A1 (en) * 2004-06-10 2008-02-14 Frederickson Franklyn L Patch Application Device and Kit
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
BRPI0517749A (pt) 2004-11-18 2008-10-21 3M Innovative Properties Co dispositivo de aplicação para aplicar um dispositivo de micro-agulha a uma superfìcie de pele, e, método para usar um dispositivo de aplicação
EP1827564B1 (en) * 2004-11-18 2015-07-29 3M Innovative Properties Company Masking method for coating a microneedle array
ATE504328T1 (de) 2004-11-18 2011-04-15 3M Innovative Properties Co Mikronadelanordungsapplikator und halter
JP5015787B2 (ja) 2004-11-18 2012-08-29 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイの接触コーティング法
JP2008522875A (ja) * 2004-12-07 2008-07-03 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルの成形方法
EP1871459B1 (en) 2005-04-07 2019-06-19 3M Innovative Properties Company System for tool feedback sensing
FR2887457B1 (fr) * 2005-06-23 2007-10-05 Fond Bettencourt Schueller Vaccination par ciblage transcutane
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application
WO2007002521A2 (en) * 2005-06-27 2007-01-04 3M Innovative Properties Company Microneedle array applicator device
CA2613114C (en) * 2005-06-27 2015-02-24 3M Innovative Properties Company Microneedle cartridge assembly and method of applying
DE602006020738D1 (de) 2005-08-01 2011-04-28 Hisamitsu Pharmaceutical Co Adjuvans oder pharmazeutische zubereitung zur transdermalen oder transmukosalen verabreichung
EP2258441A3 (en) * 2005-09-02 2011-09-21 Intercell USA, Inc. Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
AU2006291157A1 (en) * 2005-09-12 2007-03-22 Alza Corporation Coatable transdermal delivery microprojection assembly
WO2007061781A1 (en) * 2005-11-18 2007-05-31 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
WO2007124411A1 (en) * 2006-04-20 2007-11-01 3M Innovative Properties Company Device for applying a microneedle array
EP2123296B1 (en) * 2007-01-31 2019-05-22 Hisamitsu Pharmaceutical Co., Inc. Adjuvant for transdermal or transmucosal administration and pharmaceutical preparation containing the same
JP5089691B2 (ja) 2007-06-26 2012-12-05 リンテック株式会社 経皮吸収型貼付剤
KR20140143461A (ko) 2007-08-06 2014-12-16 알레간 인코포레이티드 데스모프레신 약물 전달을 위한 방법 및 장치
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
SI2712622T1 (sl) * 2008-05-21 2016-10-28 Ferring B.V. Orodisperzibilni dezmopresin za povečanje začetnega obdobja spanja nemotenega z nokturijo
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
US20100266671A1 (en) * 2009-04-15 2010-10-21 Tyco Healthcare Group Lp Device and Method for Treating Dermal Tissue
SG170622A1 (en) * 2009-10-09 2011-05-30 Nitto Denko Corp A passive drug delivery device and a method of drug delivery
DE102009056745A1 (de) 2009-12-04 2011-06-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System für die Verabreichung von Peptiden
DE102009056746A1 (de) * 2009-12-04 2011-06-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System für die Verabreichung von Peptiden
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
JP5767094B2 (ja) * 2011-11-30 2015-08-19 ニチバン株式会社 経皮的薬物投与デバイス
US20140105959A1 (en) * 2012-10-12 2014-04-17 Allergan, Inc. Method and device for reducing dermal filler adverse events
WO2015064710A1 (ja) 2013-10-31 2015-05-07 久光製薬株式会社 アジュバント組成物、これを含むアジュバント製剤、及びキット
GB201716391D0 (en) 2017-10-06 2017-11-22 Xobaderm Ltd Kit for delivery of an active compound into a biological barrier
WO2019190267A1 (ko) * 2018-03-30 2019-10-03 랩앤피플주식회사 멀티형 마이크로 니들
KR102291392B1 (ko) * 2018-03-30 2021-08-20 랩앤피플주식회사 멀티형 마이크로 니들
KR102186163B1 (ko) * 2018-10-08 2020-12-04 연세대학교 산학협력단 다기능 마이크로구조체 패치
GB2579575B (en) * 2018-12-03 2021-10-06 Dermal Diagnostics Ltd Skin preparation patches
KR20220054290A (ko) * 2019-06-28 2022-05-02 패스포트 테크놀로지스, 인크. 형성된 통로를 통한 영구적 전달 패치
WO2022214544A1 (en) * 2021-04-07 2022-10-13 Københavns Universitet Multilayered patch
USD999384S1 (en) 2021-10-18 2023-09-19 Dbv Technologies Patch assembly
USD999385S1 (en) 2021-10-18 2023-09-19 Dbv Technologies Patch assembly
EP4201383A1 (en) * 2021-12-21 2023-06-28 DBV Technologies Improved patches and methods for delivering an active substance to the skin using the same
CA3234808A1 (en) * 2021-10-18 2023-04-27 Jerome Villette Improved patches and methods for delivering an active substance to the skin using the same
CA3236242A1 (en) * 2021-12-13 2023-06-22 Stephen Welsh Adhesive bandage system for medication delivery and indication of procedure location

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE25637E (en) * 1964-09-08 Means for vaccinating
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) * 1972-02-14 1973-08-13 Ici Ltd Pansements
FR2232331B1 (pt) * 1973-06-06 1978-03-24 Guerin A Ets
US5080646A (en) * 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (en) * 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
AU3245393A (en) 1991-12-09 1993-07-19 Square One Medical Rotary lock for needle sheaths
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
US5611806A (en) * 1994-05-23 1997-03-18 Samsung Electro-Mechanics Co., Ltd. Skin perforating device for transdermal medication
EP0796128B1 (de) 1994-12-09 1999-03-10 Novartis AG Transdermales system
AU5869796A (en) 1995-05-22 1996-12-11 Ned A. Godshall Micromechanical patch for enhancing the delivery of compound s through the skin
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
AU707065B2 (en) * 1995-08-29 1999-07-01 Nitto Denko Corporation Microporation of human skin for drug delivery and monitoring applications
US7184826B2 (en) 1996-06-18 2007-02-27 Alza Corporation Device and method for enhancing transdermal flux of agents being delivered or sampled
ES2200187T3 (es) 1996-07-03 2004-03-01 Altea Therapeutics Corporation Microporacion mecanica multiple de la piel o de la mucosa.
CA2265906C (en) 1996-09-17 2003-11-11 Deka Products Limited Partnership System for delivery of drugs by transport
AU722574B2 (en) * 1996-12-20 2000-08-10 Alza Corporation Device and method for enhancing transdermal agent flux
DE19654391A1 (de) 1996-12-27 1998-07-02 Basf Ag Katalysator zur selektiven Herstellung von Propylen aus Propan
ID21673A (id) 1996-12-31 1999-07-08 Shell Internationale Res Maatc Anjungan tiang dengan alur vertikal
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
PT1037686E (pt) * 1997-12-11 2005-10-31 Alza Corp Aparelho para potenciar o fluxo de agente transdermico
WO1999029364A1 (en) * 1997-12-11 1999-06-17 Alza Corporation Device for enhancing transdermal agent flux
CN1206004C (zh) * 1997-12-11 2005-06-15 阿尔扎有限公司 增强透皮物剂流量的装置
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
JP4210782B2 (ja) * 1999-10-13 2009-01-21 アークレイ株式会社 採血位置表示具
AU782610B2 (en) * 1999-12-10 2005-08-11 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
EP1335711B1 (en) * 2000-09-08 2007-07-25 Alza Corporation Transdermal device
PT1341442E (pt) * 2000-10-13 2005-09-30 Alza Corp Aplicador de impacto com um conjunto de microlaminas
WO2002030300A2 (en) * 2000-10-13 2002-04-18 Alza Corporation Microprotrusion member retainer for impact applicator
NZ525294A (en) * 2000-10-13 2005-02-25 Alza Corp Apparatus and method for piercing skin with microprotrusions
EP1333880B1 (en) 2000-10-26 2009-04-15 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
WO2002074173A1 (en) * 2001-03-16 2002-09-26 Alza Corporation Method and apparatus for coating skin piercing microprojections
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
ES2333849T3 (es) * 2001-04-20 2010-03-02 Alza Corporation Disposicion de microsalientes que presenta un revestimiento que contiene un agente beneficioso.
WO2003048031A2 (en) * 2001-11-30 2003-06-12 Alza Corporation Methods and apparatuses for forming microprojection arrays
HUP0402605A2 (hu) * 2001-12-20 2005-06-28 Alza Corporation Eszköz mikroszkopikus bemetszések ejtésére állat bőrszövetén
CN100464800C (zh) * 2002-06-28 2009-03-04 阿尔扎公司 具有被涂覆的微突物的经皮药物传输装置
AR042815A1 (es) * 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
BRPI0412029A (pt) * 2003-06-30 2006-09-05 Alza Corp formulações para microprojeções revestidas contendo contra-ìons não-voláteis
AU2004285481A1 (en) * 2003-10-24 2005-05-12 Alza Corporation Apparatus and method for enhancing transdermal drug delivery
KR20070001886A (ko) * 2003-10-28 2007-01-04 알자 코포레이션 치료용 펩타이드 및 단백질의 폴리머 컨쥬게이트의 피복된미세돌출부를 통한 전달
US7097631B2 (en) * 2003-10-31 2006-08-29 Alza Corporation Self-actuating applicator for microprojection array
BRPI0416042A (pt) * 2003-11-13 2007-01-02 Alza Corp composição e aparelho para suprimento transdérmico

Also Published As

Publication number Publication date
WO2005042054A2 (en) 2005-05-12
WO2005042054A3 (en) 2005-09-15
AR046307A1 (es) 2005-11-30
KR20060108682A (ko) 2006-10-18
TW200517156A (en) 2005-06-01
EP1675539A2 (en) 2006-07-05
US20050106226A1 (en) 2005-05-19
EP1675539A4 (en) 2007-09-12
CN1897898A (zh) 2007-01-17
JP2007510445A (ja) 2007-04-26
CA2543086A1 (en) 2005-05-12
AU2004285484A1 (en) 2005-05-12

Similar Documents

Publication Publication Date Title
TW200517156A (en) Pretreatment method and system for enhancing transdermal drug delivery
BRPI0417757A (pt) método e sistema de liberação de agente transdérmico assistida por freqüência
ES2687258T3 (es) Procedimiento de fabricación de conjuntos de microagujas
BRPI0416822A (pt) método e sistema de liberação de vacina transdérmica com ultra-som
BRPI0416132A (pt) sistema e método para liberação de vacina transdérmica
ES2333849T3 (es) Disposicion de microsalientes que presenta un revestimiento que contiene un agente beneficioso.
US20060051404A1 (en) Microstructure roller system
TWI565491B (zh) With an array of micro-protrusions
US20040138610A1 (en) Active agent delivery device having composite members
BR0114909A (pt) Dispositivos de distribuição de drogas transdérmicas possuindo microprotuberâncias revestidas
BRPI0517501A (pt) dispositivo médico apropriado para uso na administração de um componente ativo na ou através da pele
BRPI0415761A (pt) aparelho e processo para reforçar a distribuição transdérmica de medicamento
BRPI0415986A (pt) método e aparelho para reduzir a incidência do uso de tabaco
AR048827A1 (es) Aparato y metodo para la administracion transdermica de agentes basados en fentanil
BRPI0509493A (pt) aparelho e método para a liberação transdérmica de vacina da influenza
BR0313474A (pt) dispositivo de distribuição transdérmica de vacina tendo microprotuberáncias revestidas
TW200618830A (en) Micorprojection apparatus and system with low infection potential
BR0312671A (pt) Dispositivo de microagulhas, método para utilizar um dispositivo de microagulhas, e, método para aplicar um dispositivo de microagulhas
BRPI0509788A (pt) aparato e método para liberação transdérmica de agentes de hormÈnio paratireóides
CN103079634A (zh) 可整合至施药器的内置式非语言指导设备
BRPI0411032A (pt) composição adesiva hidrófila, artigo médico, método para a fabricação da composição adesiva, e, dispositivo de administração transdérmica
JP2021500397A (ja) 片頭痛および群発頭痛の治療に適したゾルミトリプタン治療濃度を迅速に得る方法
AR054225A1 (es) Aparato y metodo para suministro transdermico de agentes basados en epoyetina
TW200621316A (en) Apparatus and method for transdermal delivery of vascular endothelial growth factors
BR102022006951A2 (pt) Sistema incorporado em rolo de microagulhamento

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.