ES2196548T3 - Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica. - Google Patents

Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica.

Info

Publication number
ES2196548T3
ES2196548T3 ES98907359T ES98907359T ES2196548T3 ES 2196548 T3 ES2196548 T3 ES 2196548T3 ES 98907359 T ES98907359 T ES 98907359T ES 98907359 T ES98907359 T ES 98907359T ES 2196548 T3 ES2196548 T3 ES 2196548T3
Authority
ES
Spain
Prior art keywords
pirrolizina
heterociclica
hexahidro
substitution
regulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98907359T
Other languages
English (en)
Inventor
James T Wasicak
David S Garvey
Mark W Holladay
Nan-Horng Lin
Keith B Ryther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2196548T3 publication Critical patent/ES2196548T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos de hexahidro-1H-pirrolizina sustituidos en 7a de fórmula (I) *fórmula*, en la que A es un resto heterocíclico definido, composiciones de estos compuestos y uso de los citados compuestos para controlar selectivamente la transmisión sináptica en mamíferos.
ES98907359T 1997-02-19 1998-02-05 Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica. Expired - Lifetime ES2196548T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/802,978 US5733912A (en) 1997-02-19 1997-02-19 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission

Publications (1)

Publication Number Publication Date
ES2196548T3 true ES2196548T3 (es) 2003-12-16

Family

ID=25185234

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98907359T Expired - Lifetime ES2196548T3 (es) 1997-02-19 1998-02-05 Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica.

Country Status (15)

Country Link
US (1) US5733912A (es)
EP (1) EP0970083B1 (es)
JP (1) JP2001512479A (es)
AR (1) AR011148A1 (es)
AT (1) ATE237618T1 (es)
AU (1) AU6318898A (es)
CA (1) CA2281800A1 (es)
CO (1) CO4920251A1 (es)
DE (1) DE69813536T2 (es)
DK (1) DK0970083T3 (es)
ES (1) ES2196548T3 (es)
PT (1) PT970083E (es)
TW (1) TW513425B (es)
WO (1) WO1998037082A1 (es)
ZA (1) ZA981301B (es)

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US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US7432009B2 (en) * 2002-04-03 2008-10-07 3M Innovative Properties Company Lamination apparatus and methods
PT1519939E (pt) 2002-07-05 2010-02-10 Targacept Inc Compostos n-arildiazaspirocíclicos e métodos para a sua preparação e utilização
JP2008510711A (ja) * 2004-08-20 2008-04-10 ターガセプト，インコーポレイテッド 嗜癖治療におけるｎ−アリールジアザスピラ環状化合物の使用
AU2005287037A1 (en) * 2004-09-20 2006-03-30 Targacept, Inc. Azaspiroalkene and azaspiroalkane compounds with nicotinic cholinergic receptor activity
US9029557B2 (en) 2004-12-07 2015-05-12 The Regents Of The University Of California Labeled A4B2 ligands and methods therefor
US8378109B2 (en) * 2004-12-07 2013-02-19 The Regents Of The University Of California Labeled ALPHA4BETA2 ligands and methods therefor
DE102006050794A1 (de) * 2006-10-27 2008-04-30 Bayer Cropscience Ag Verwendung 7A-substituierter Hexahydro-1H-pyrrolizinverbindungen zur Bekämpfung tierischer Schädlinge
EP2935216B1 (en) 2012-12-17 2018-06-27 Sun Pharmaceutical Industries Limited Process for the preparation of tofacitinib and intermediates thereof
NZ710740A (en) 2013-02-28 2020-06-26 Dermira Inc Glycopyrrolate salts
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
JP7050165B2 (ja) 2018-02-26 2022-04-07 ギリアード サイエンシーズ， インコーポレイテッド Ｈｂｖ複製阻害剤としての置換ピロリジン化合物

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US4582836A (en) * 1985-01-09 1986-04-15 Mcneilab, Inc. Octahydroindolizine compounds useful as analgesics
US4689329A (en) * 1986-02-04 1987-08-25 Mcneilab, Inc. 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
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EP0261763B1 (en) * 1986-06-27 1994-02-09 Beecham Group Plc Novel bridged bicyclic N-heterocycles
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
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GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
DE3877470T2 (de) * 1987-09-10 1993-06-24 Merck Sharp & Dohme Oxazole und thiazole zur behandlung seniler demenz.
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
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IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
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US5260293A (en) * 1988-01-30 1993-11-09 Merck Sharp & Dohme Limited Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia
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US5177084A (en) * 1989-08-08 1993-01-05 Merck Sharp & Dohme Ltd. Therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes
JPH03135978A (ja) * 1989-08-08 1991-06-10 Merck Sharp & Dohme Ltd 置換ピリジン、その製法、処方並びに痴呆症における使用法
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IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them
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US5472958A (en) * 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
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Also Published As

Publication number Publication date
AR011148A1 (es) 2000-08-02
PT970083E (pt) 2003-09-30
DK0970083T3 (da) 2003-08-11
JP2001512479A (ja) 2001-08-21
ZA981301B (en) 1998-08-28
EP0970083B1 (en) 2003-04-16
EP0970083A1 (en) 2000-01-12
DE69813536D1 (de) 2003-05-22
CA2281800A1 (en) 1998-08-27
WO1998037082A1 (en) 1998-08-27
DE69813536T2 (de) 2004-02-19
US5733912A (en) 1998-03-31
TW513425B (en) 2002-12-11
CO4920251A1 (es) 2000-05-29
ATE237618T1 (de) 2003-05-15
AU6318898A (en) 1998-09-09
HK1026416A1 (en) 2000-12-15

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