ES2196548T3 - Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica. - Google Patents

Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica.

Info

Publication number
ES2196548T3
ES2196548T3 ES98907359T ES98907359T ES2196548T3 ES 2196548 T3 ES2196548 T3 ES 2196548T3 ES 98907359 T ES98907359 T ES 98907359T ES 98907359 T ES98907359 T ES 98907359T ES 2196548 T3 ES2196548 T3 ES 2196548T3
Authority
ES
Spain
Prior art keywords
pirrolizina
heterociclica
hexahidro
substitution
regulate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98907359T
Other languages
English (en)
Inventor
James T Wasicak
David S Garvey
Mark W Holladay
Nan-Horng Lin
Keith B Ryther
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2196548T3 publication Critical patent/ES2196548T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Compuestos de hexahidro-1H-pirrolizina sustituidos en 7a de fórmula (I) *fórmula*, en la que A es un resto heterocíclico definido, composiciones de estos compuestos y uso de los citados compuestos para controlar selectivamente la transmisión sináptica en mamíferos.
ES98907359T 1997-02-19 1998-02-05 Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica. Expired - Lifetime ES2196548T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/802,978 US5733912A (en) 1997-02-19 1997-02-19 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission

Publications (1)

Publication Number Publication Date
ES2196548T3 true ES2196548T3 (es) 2003-12-16

Family

ID=25185234

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98907359T Expired - Lifetime ES2196548T3 (es) 1997-02-19 1998-02-05 Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica.

Country Status (15)

Country Link
US (1) US5733912A (es)
EP (1) EP0970083B1 (es)
JP (1) JP2001512479A (es)
AR (1) AR011148A1 (es)
AT (1) ATE237618T1 (es)
AU (1) AU6318898A (es)
CA (1) CA2281800A1 (es)
CO (1) CO4920251A1 (es)
DE (1) DE69813536T2 (es)
DK (1) DK0970083T3 (es)
ES (1) ES2196548T3 (es)
PT (1) PT970083E (es)
TW (1) TW513425B (es)
WO (1) WO1998037082A1 (es)
ZA (1) ZA981301B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145722A (en) 2000-04-27 2012-03-30 Abbott Lab Diazabicyclic central nervous system active agents
US20030162770A1 (en) 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US7432009B2 (en) * 2002-04-03 2008-10-07 3M Innovative Properties Company Lamination apparatus and methods
DK1519939T5 (da) 2002-07-05 2011-01-24 Targacept Inc N-Aryl-diazaspirocykliske forbindelser og fremgangsmåder til fremstilling og anvendelse deraf
JP2008510711A (ja) * 2004-08-20 2008-04-10 ターガセプト，インコーポレイテッド 嗜癖治療におけるｎ−アリールジアザスピラ環状化合物の使用
CN101044134A (zh) * 2004-09-20 2007-09-26 塔加西普特公司 具有烟碱性胆碱能受体活性的氮杂螺烯和氮杂螺烷化合物
US8378109B2 (en) * 2004-12-07 2013-02-19 The Regents Of The University Of California Labeled ALPHA4BETA2 ligands and methods therefor
US9029557B2 (en) 2004-12-07 2015-05-12 The Regents Of The University Of California Labeled A4B2 ligands and methods therefor
DE102006050794A1 (de) * 2006-10-27 2008-04-30 Bayer Cropscience Ag Verwendung 7A-substituierter Hexahydro-1H-pyrrolizinverbindungen zur Bekämpfung tierischer Schädlinge
WO2014097150A1 (en) 2012-12-17 2014-06-26 Ranbaxy Laboratories Limited Process for the preparation of tofacitinib and intermediates thereof
JP6114841B2 (ja) 2013-02-28 2017-04-12 ダーミラ， インク．Ｄｅｒｍｉｒａ， Ｉｎｃ． グリコピロレート塩
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
JP7050165B2 (ja) 2018-02-26 2022-04-07 ギリアード サイエンシーズ， インコーポレイテッド Ｈｂｖ複製阻害剤としての置換ピロリジン化合物

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56156283A (en) * 1980-05-07 1981-12-02 Suntory Ltd 8-substituted pyrrolitidine and its quaternary ammonium salt
US4582836A (en) * 1985-01-09 1986-04-15 Mcneilab, Inc. Octahydroindolizine compounds useful as analgesics
US4689329A (en) * 1986-02-04 1987-08-25 Mcneilab, Inc. 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
ES2061502T3 (es) * 1986-06-27 1994-12-16 Beecham Group Plc Nuevos n-heterociclos biciclicos puenteados.
AU614513B2 (en) * 1987-04-15 1991-09-05 Beecham Group Plc 1-azabicyclic compounds
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
NZ226000A (en) * 1987-09-10 1991-06-25 Merck Sharp & Dohme Oxadiazolyl-azabicycloheptanes and pharmaceutical compositions
EP0307141B1 (en) * 1987-09-10 1993-01-13 MERCK SHARP & DOHME LTD. Oxazoles and thiazoles for the treatment of senile dementia
US4800207A (en) * 1987-11-02 1989-01-24 Mcneilab, Inc. Hexahydropyrrolizine compounds useful as analgesics
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
US5260293A (en) * 1988-01-30 1993-11-09 Merck Sharp & Dohme Limited Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
GB8808926D0 (en) * 1988-04-15 1988-05-18 Beecham Group Plc Novel compounds
EP0363085A3 (en) * 1988-10-03 1991-03-27 Beecham Group Plc Novel compounds
CA2000041A1 (en) * 1988-10-13 1990-04-13 Barry S. Orlek Compounds
EP0402056A3 (en) * 1989-06-06 1991-09-04 Beecham Group p.l.c. Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
US5177084A (en) * 1989-08-08 1993-01-05 Merck Sharp & Dohme Ltd. Therapeutic use of substituted benzenes, formulations thereof and novel substituted benzenes
EP0412798A3 (en) * 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
EP0413545B1 (en) * 1989-08-16 1997-05-14 Beecham Group Plc Azabicyclic compounds
DE69026197T2 (de) * 1989-10-07 1997-01-09 Beecham Group Plc Azabizyklische Verbindungen, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL97266A0 (en) * 1990-03-06 1992-05-25 Warner Lambert Co Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them
GB9005737D0 (en) * 1990-03-14 1990-05-09 Beecham Group Plc Novel compounds
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
EP0552213A1 (en) * 1990-10-12 1993-07-28 Beecham Group Plc 1,2,5,6-tetrahydropyridine oxime derivatives
IE922270A1 (en) * 1991-07-26 1993-01-27 Akzo Nv Pyrazole derivatives
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
SE9201478D0 (sv) * 1992-05-11 1992-05-11 Kabi Pharmacia Ab Heteroaromatic quinuclidinenes, their use and preparation
US5472958A (en) * 1994-08-29 1995-12-05 Abbott Laboratories 2-((nitro)phenoxymethyl) heterocyclic compounds that enhance cognitive function
US5567710A (en) * 1994-10-13 1996-10-22 Sibia Neurosciences, Inc. Polycyclic fused ring modulators of acetylcholine receptors
US5629325A (en) * 1996-06-06 1997-05-13 Abbott Laboratories 3-pyridyloxymethyl heterocyclic ether compounds useful in controlling chemical synaptic transmission

Also Published As

Publication number Publication date
WO1998037082A1 (en) 1998-08-27
CA2281800A1 (en) 1998-08-27
EP0970083A1 (en) 2000-01-12
TW513425B (en) 2002-12-11
AU6318898A (en) 1998-09-09
ATE237618T1 (de) 2003-05-15
AR011148A1 (es) 2000-08-02
HK1026416A1 (en) 2000-12-15
CO4920251A1 (es) 2000-05-29
PT970083E (pt) 2003-09-30
US5733912A (en) 1998-03-31
DE69813536T2 (de) 2004-02-19
DK0970083T3 (da) 2003-08-11
DE69813536D1 (de) 2003-05-22
EP0970083B1 (en) 2003-04-16
ZA981301B (en) 1998-08-28
JP2001512479A (ja) 2001-08-21

Similar Documents

Publication Publication Date Title
ES2196548T3 (es) Compuesto de hexahidro-1h-pirrolizina de sustitucion heterociclica en 7a utiles para regular la transmision sinaptica quimica.
ES2171222T3 (es) Compuestos de eter heterociclico de 3-piridiloxialquilo utiles para regular la transmision sinaptica quimica.
GT199900217A (es) Compuestos empleados en el tratamiento de padecimientos inflamatorios.
MX9705296A (es) Compuestos novedosos de imidazol 1,4,5-susbtituidos y el uso de los mismos para preparar composiciones para uso en terapia.
BR0116326A (pt) Compostos orgânicos
ES2134755T3 (es) Derivados de quinolina como antagonistas de leucotrieno d4, composiciones que contienen los mismos y procedimientos para su preparacion.
ES2135347B1 (es) Hidroxifeniltriazinas.
FI961506A0 (fi) Distamysiini A -analogit antituumorisina ja antiviraalisina aineina
ES2150607T3 (es) Silicato de sodio estratificado cristalino.
SE9702773D0 (sv) Novel compounds
ES2185660T3 (es) Nuevo uso de dexmedetomidina.
BR0114379A (pt) Derivados de c-ciclohexilmetilamina substituìdos
ATE198202T1 (de) Fibrinogen receptor antagonisten
MX9300412A (es) Derivados de 1h-bencimidazol sustituidos con pirroloimidazolilo e imadazopiridinilo
FI962481A0 (fi) 4-bentsoyyli-isokatsolit ja niiden käyttö herbisideinä
FR2443468A1 (fr) Pyrrolo ou pyrido-(2,1-c)-(1,4)-thiazines ou thiazepines a action antihypertensive
GT199900113A (es) Inhibidores de las fkbp.
ES2164151T3 (es) N-(indol-2-carbonil)glicinamidas sustituidas y derivados como inhibidores de la glucogeno fosforilasa.
AR004551A1 (es) Compuestos fungicidas (b)
NO931871L (no) Detergentblanding og anvendelse derav
AR006675A1 (es) 4-benzoilisotiazoles herbicidas, procedimiento para obtenerlas, las composiciones herbicidas que las contienen y el procedimiento de aplicacionde dichos compuestos.
FI851659L (fi) Jodiniumylfoereningar och foerfarande foer antimikrobiell anvaendning.
FI960588A0 (fi) Mikrobisideina käytettäviä tiokarbamoyyliyhdisteitä
SE8700566L (sv) Tetracykliska kinazolinoner
MX9203518A (es) 9-amino-2-fenilbiciclo [3.3.1] nonanos y 9-amino-2-fenilbiciclo [3.3.1] non-2-enos y drogas que los contienen.