ES2196820T3 - Derivados de pirido(2,3-b)indolizina y aza-analogos de la misma; ligandos especificos de crf 1. - Google Patents
Derivados de pirido(2,3-b)indolizina y aza-analogos de la misma; ligandos especificos de crf 1.Info
- Publication number
- ES2196820T3 ES2196820T3 ES99928519T ES99928519T ES2196820T3 ES 2196820 T3 ES2196820 T3 ES 2196820T3 ES 99928519 T ES99928519 T ES 99928519T ES 99928519 T ES99928519 T ES 99928519T ES 2196820 T3 ES2196820 T3 ES 2196820T3
- Authority
- ES
- Spain
- Prior art keywords
- pirido
- indolizine
- aza
- analogs
- links
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- HOBCFUWDNJPFHB-UHFFFAOYSA-N indolizine Chemical compound C1=CC=CN2C=CC=C21 HOBCFUWDNJPFHB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 108091005471 CRHR1 Proteins 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/57—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Compuesto de fórmula: **(Fórmula)** o las sales farmacéuticamente aceptables del mismo, en el que: Ar es fenil, 1- ó 2-naftil, 2-, 3- ó 4-piridil, 2- ó 3-tienil, 4- ó 5-pirimidil, cada uno de los cuales está opcionalmente mono, di o trisustituido con halógeno, trifluorometil, hidroxi, amino, carboxamido, alquil C1-C6, cicloalquil C3-C7, ó alcoxi C1-C6, con la condición de que por lo menos una de las posiciones orto o para respecto al punto de unión de Ar en el sistema de anillo tricíclico esté sustituida; R1 y R2 representan independientemente alquil C1-C6; cicloalquil C3-C7; cicloalquil C3-C7 alquil (C1-C6); alcoxi C1-C6 alquil (C1-C6); o aril alquil (C1-C6) en el que aril es fenil, 1- ó 2-naftil, 2-, 3- ó 4-piridil, 2- ó 3-tienil, ó 2- 4- ó 5 pirimidil, cada uno de los cuales está opcionalmente mono o disustituido con halógeno, hidroxi, alquil C1-C6, cicloalquil C3-C7, alcoxi C1-C6 ó (alquileno C1-C6)-A-R4, en el que A es O, S, NH ó N (alquil C1-C6) y R4 es hidrógeno, cicloalquil C3-C7 óalquil C1-C6; ó R1 y R2 considerados conjuntamente representan -(CH2)n-A-(CH2)m-, en el que n es 2, 3 ó 4, A es metileno, oxígeno, azufre ó NR5, en el que R5 es hidrógeno, cicloalquil de C3-C7 ó alquil C1-C6 y m es 0, 1 ó 2; R3 es alquil C1-C6 ó (alquileno C1-C6)-G-R6, en el que G es O, S, NH ó N(alquil C1-C6) y R6 es hidrógeno, cicloalquil C3-C7 ó alquil C1-C6; y W, X, Y y Z son independientemente N ó C-R7, en el que R7 es hidrógeno, cicloalquil C3-C7 ó alquil C1-C6.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8880898P | 1998-06-09 | 1998-06-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196820T3 true ES2196820T3 (es) | 2003-12-16 |
Family
ID=22213614
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99928519T Expired - Lifetime ES2196820T3 (es) | 1998-06-09 | 1999-06-08 | Derivados de pirido(2,3-b)indolizina y aza-analogos de la misma; ligandos especificos de crf 1. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6194574B1 (es) |
| EP (1) | EP1086103B1 (es) |
| JP (1) | JP2002517501A (es) |
| AT (1) | ATE239019T1 (es) |
| AU (1) | AU4556999A (es) |
| CA (1) | CA2334671A1 (es) |
| DE (1) | DE69907448T2 (es) |
| ES (1) | ES2196820T3 (es) |
| WO (1) | WO1999064422A1 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK742003A3 (en) | 2000-07-21 | 2003-06-03 | Schering Corp | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |
| AU2002226674B2 (en) | 2000-12-28 | 2007-03-22 | Ono Pharmaceutical Co., Ltd. | Tricyclic and heterocyclic derivative compounds and drugs containing these compounds as the active ingredient |
| AU2004249629B2 (en) | 2003-06-25 | 2009-07-30 | Ono Pharmaceutical Co., Ltd. | Methanesulfonic acid salt of pyrazolopyrimidine compound, crystal thereof, and process for producing the same |
| EP3510029B1 (en) | 2016-09-07 | 2025-11-05 | The Regents of The University of California | Allosteric corticotropin-releasing factor receptor 1 (crfr1) antagonists that decrease p-tau and improve cognition |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932431A (en) | 1970-06-24 | 1976-01-13 | Schering Corporation | Certain 2-[α(2-pyridyl)-benzyl] imidazolines and derivatives thereof |
| US3988338A (en) | 1974-04-24 | 1976-10-26 | Wisconsin Alumni Research Foundation | 4-Substituted amino-2-substituted thio-pyrrolo-[2,3-d]pyrimidine derivatives |
| US4605642A (en) | 1984-02-23 | 1986-08-12 | The Salk Institute For Biological Studies | CRF antagonists |
| EP0239191A3 (en) | 1986-01-30 | 1988-07-20 | Beecham Group Plc | Pyrazolo[4,3-b]pyridine derivatives, process for their preparation and pharmaceutical compositions containing them |
| KR0155955B1 (ko) | 1989-10-11 | 1998-11-16 | 이따가끼 히로시 | 2 환성 피리미딘 유도체, 그의 제조방법 및 그를 유효성분으로 하는 의약제제 |
| US5063245A (en) | 1990-03-28 | 1991-11-05 | Nova Pharmaceutical Corporation | Corticotropin-releasing factor antagonism compounds |
| US5244896A (en) | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
| BR9307646A (pt) | 1992-12-17 | 1999-05-25 | Pfizer | Pirrolopirimidinas como antagonistas de crf |
| JP3398152B2 (ja) | 1993-10-12 | 2003-04-21 | ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー | １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体 |
| JPH10506126A (ja) | 1995-05-12 | 1998-06-16 | ニューロゲン コーポレイション | 新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス |
| US5644057A (en) | 1995-05-12 | 1997-07-01 | Neurogen Corporation | Deazapurine derivatives; a new class of CRF1 specific ligands |
| US5804685A (en) | 1995-06-07 | 1998-09-08 | Neurogen Corporation | Deazapurine derivatives: a new class of CRF1 specific ligands |
| JPH10114744A (ja) * | 1996-08-22 | 1998-05-06 | Takeda Chem Ind Ltd | アミノグアニジンヒドラゾン誘導体、その製法及び剤 |
| PL332040A1 (en) * | 1996-08-28 | 1999-08-16 | Pfizer | Substitution 6,5-heterobicyclic derivatives |
-
1999
- 1999-06-08 AU AU45569/99A patent/AU4556999A/en not_active Abandoned
- 1999-06-08 DE DE69907448T patent/DE69907448T2/de not_active Expired - Fee Related
- 1999-06-08 WO PCT/US1999/012990 patent/WO1999064422A1/en not_active Ceased
- 1999-06-08 ES ES99928519T patent/ES2196820T3/es not_active Expired - Lifetime
- 1999-06-08 US US09/328,179 patent/US6194574B1/en not_active Expired - Fee Related
- 1999-06-08 CA CA002334671A patent/CA2334671A1/en not_active Abandoned
- 1999-06-08 JP JP2000553431A patent/JP2002517501A/ja active Pending
- 1999-06-08 AT AT99928519T patent/ATE239019T1/de not_active IP Right Cessation
- 1999-06-08 EP EP99928519A patent/EP1086103B1/en not_active Expired - Lifetime
-
2001
- 2001-02-23 US US09/791,370 patent/US6495686B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE239019T1 (de) | 2003-05-15 |
| AU4556999A (en) | 1999-12-30 |
| US6194574B1 (en) | 2001-02-27 |
| JP2002517501A (ja) | 2002-06-18 |
| EP1086103A1 (en) | 2001-03-28 |
| US20020019525A1 (en) | 2002-02-14 |
| CA2334671A1 (en) | 1999-12-16 |
| EP1086103B1 (en) | 2003-05-02 |
| US6495686B2 (en) | 2002-12-17 |
| DE69907448T2 (de) | 2004-03-18 |
| DE69907448D1 (de) | 2003-06-05 |
| WO1999064422A1 (en) | 1999-12-16 |
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