ATE236134T1 - Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren - Google Patents

Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren

Info

Publication number: ATE236134T1
Authority: AT; Austria
Prior art keywords: phtalazinamine; isoquinolinamine; react; derivatives; crf receptors
Prior art date: 1996-12-18

Application number

AT97952558T

Other languages

English (en)

Inventor

Jun Yuan

Taeyoung Yoon

Original Assignee

Neurogen Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-18

Filing date

1997-12-15

Publication date

2003-04-15

1997-12-15 Application filed by Neurogen Corp filed Critical Neurogen Corp

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236134T1 publication Critical patent/ATE236134T1/de

Links

108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
OSILBMSORKFRTB-UHFFFAOYSA-N isoquinolin-1-amine Chemical compound C1=CC=C2C(N)=NC=CC2=C1 OSILBMSORKFRTB-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
208000019901 Anxiety disease Diseases 0.000 abstract 1
108091005471 CRHR1 Proteins 0.000 abstract 1
206010019233 Headaches Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
231100000869 headache Toxicity 0.000 abstract 1
239000004031 partial agonist Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Cosmetics (AREA)
Paper (AREA)

AT97952558T 1996-12-18 1997-12-15 Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren ATE236134T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US76898796A	1996-12-18	1996-12-18
PCT/US1997/023555 WO1998027066A1 (en)	1996-12-18	1997-12-15	Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors

Publications (1)

Publication Number	Publication Date
ATE236134T1 true ATE236134T1 (de)	2003-04-15

Family

ID=25084071

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97952558T ATE236134T1 (de)	1996-12-18	1997-12-15	Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren

Country Status (8)

Country	Link
US (4)	US6235752B1 (de)
EP (1)	EP0946520B1 (de)
JP (1)	JP2001506653A (de)
AT (1)	ATE236134T1 (de)
AU (1)	AU5614198A (de)
CA (1)	CA2275686C (de)
DE (1)	DE69720515T2 (de)
WO (1)	WO1998027066A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE236134T1 (de) *	1996-12-18	2003-04-15	Neurogen Corp	Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren
ITMI981671A1 (it) *	1998-07-21	2000-01-21	Zambon Spa	Derivati ftalazinici inibitori della fosfodisterasi 4
US6432989B1 (en)	1999-08-27	2002-08-13	Pfizer Inc	Use of CRF antagonists to treat circadian rhythm disorders
DE19963607B4 (de) *	1999-12-23	2005-12-15	Schering Ag	Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen
ATE554768T1 (de) *	2004-05-08	2012-05-15	Novartis Int Pharm Ltd	1-aryl-4-substituierte isochinoline
US8338591B2 (en)	2004-05-08	2012-12-25	Novartis International Pharmaceutical Ltd.	3-aryl-5,6-disubstituted pyridazines
CA2593005A1 (en) *	2005-01-03	2006-07-13	Myriad Genetics Inc.	Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof
US7759337B2 (en)	2005-03-03	2010-07-20	Amgen Inc.	Phthalazine compounds and methods of use
WO2010042646A1 (en)	2008-10-10	2010-04-15	Amgen Inc.	Aza- and diaza-phthalazine compounds as p38 map kinase modulators and methods of use thereof
US8497269B2 (en)	2008-10-10	2013-07-30	Amgen Inc.	Phthalazine compounds as p38 map kinase modulators and methods of use thereof
AU2017324942B2 (en)	2016-09-07	2022-01-27	The Regents Of The University Of California	Allosteric corticotropin-releasing factor receptor 1 (CRFR1) antagonists that decrease p-Tau and improve cognition
US11618751B1 (en)	2022-03-25	2023-04-04	Ventus Therapeutics U.S., Inc.	Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives
US11319319B1 (en)	2021-04-07	2022-05-03	Ventus Therapeutics U.S., Inc.	Compounds for inhibiting NLRP3 and uses thereof
US12331048B2 (en)	2022-10-31	2025-06-17	Ventus Therapeutics U.S., Inc.	Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3274185A (en) *	1963-10-08	1966-09-20	S E Massengill Company	Phthalazine derivatives
GB1303061A (de) *	1969-05-03	1973-01-17
GB1293565A (en)	1969-05-03	1972-10-18	Aspro Nicholas Ltd	Aminophthalazines and pharmaceutical compositions thereof
GB2063249A (en)	1979-10-09	1981-06-03	Mitsubishi Yuka Pharma	4-Phenylphthalazine derivatives
US4956371A (en)	1989-09-19	1990-09-11	Euroceltique, S.A.	Substituted isoquinolines and methods of using same
JPH03284669A (ja)	1990-03-30	1991-12-16	Mitsubishi Kasei Corp	４―フェニルフタラジン誘導体
JP3284669B2 (ja)	1993-07-02	2002-05-20	大同特殊鋼株式会社	連続鋳造法における鋳造開始方法
ATE236134T1 (de) *	1996-12-18	2003-04-15	Neurogen Corp	Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren

1997
- 1997-12-15 AT AT97952558T patent/ATE236134T1/de not_active IP Right Cessation
- 1997-12-15 CA CA002275686A patent/CA2275686C/en not_active Expired - Fee Related
- 1997-12-15 JP JP52799998A patent/JP2001506653A/ja not_active Ceased
- 1997-12-15 DE DE69720515T patent/DE69720515T2/de not_active Expired - Fee Related
- 1997-12-15 EP EP97952558A patent/EP0946520B1/de not_active Expired - Lifetime
- 1997-12-15 US US09/331,380 patent/US6235752B1/en not_active Expired - Fee Related
- 1997-12-15 WO PCT/US1997/023555 patent/WO1998027066A1/en not_active Ceased
- 1997-12-15 AU AU56141/98A patent/AU5614198A/en not_active Abandoned
1998
- 1998-06-22 US US09/102,310 patent/US6114530A/en not_active Expired - Fee Related
2000
- 2000-08-25 US US09/648,200 patent/US6353103B1/en not_active Expired - Fee Related
2001
- 2001-05-10 US US09/852,991 patent/US6440969B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU5614198A (en)	1998-07-15
DE69720515D1 (de)	2003-05-08
EP0946520B1 (de)	2003-04-02
EP0946520A1 (de)	1999-10-06
US6440969B2 (en)	2002-08-27
JP2001506653A (ja)	2001-05-22
US6235752B1 (en)	2001-05-22
WO1998027066A1 (en)	1998-06-25
CA2275686C (en)	2006-10-17
US6114530A (en)	2000-09-05
US20010036945A1 (en)	2001-11-01
DE69720515T2 (de)	2004-02-19
CA2275686A1 (en)	1998-06-25
US6353103B1 (en)	2002-03-05

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Legal Events

Date	Code	Title	Description
2003-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties