ATE236134T1 - Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren - Google Patents
Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptorenInfo
- Publication number
- ATE236134T1 ATE236134T1 AT97952558T AT97952558T ATE236134T1 AT E236134 T1 ATE236134 T1 AT E236134T1 AT 97952558 T AT97952558 T AT 97952558T AT 97952558 T AT97952558 T AT 97952558T AT E236134 T1 ATE236134 T1 AT E236134T1
- Authority
- AT
- Austria
- Prior art keywords
- phtalazinamine
- isoquinolinamine
- react
- derivatives
- crf receptors
- Prior art date
Links
- 108010056643 Corticotropin-Releasing Hormone Receptors Proteins 0.000 title 1
- OSILBMSORKFRTB-UHFFFAOYSA-N isoquinolin-1-amine Chemical compound C1=CC=C2C(N)=NC=CC2=C1 OSILBMSORKFRTB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000028173 post-traumatic stress disease Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 108091005471 CRHR1 Proteins 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 239000004031 partial agonist Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Paper (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76898796A | 1996-12-18 | 1996-12-18 | |
| PCT/US1997/023555 WO1998027066A1 (en) | 1996-12-18 | 1997-12-15 | Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE236134T1 true ATE236134T1 (de) | 2003-04-15 |
Family
ID=25084071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97952558T ATE236134T1 (de) | 1996-12-18 | 1997-12-15 | Isoquinolinamin und phtalazinamin derivate, die reagieren mit crf rezeptoren |
Country Status (8)
| Country | Link |
|---|---|
| US (4) | US6235752B1 (de) |
| EP (1) | EP0946520B1 (de) |
| JP (1) | JP2001506653A (de) |
| AT (1) | ATE236134T1 (de) |
| AU (1) | AU5614198A (de) |
| CA (1) | CA2275686C (de) |
| DE (1) | DE69720515T2 (de) |
| WO (1) | WO1998027066A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2275686C (en) * | 1996-12-18 | 2006-10-17 | Neurogen Corporation | Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors |
| ITMI981671A1 (it) | 1998-07-21 | 2000-01-21 | Zambon Spa | Derivati ftalazinici inibitori della fosfodisterasi 4 |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| DE19963607B4 (de) * | 1999-12-23 | 2005-12-15 | Schering Ag | Verfahren zur Herstellung von 4-(Heteroaryl-methyl) halogen-1(2H)-phthalazinonen |
| AU2005243149A1 (en) * | 2004-05-08 | 2005-11-24 | Novartis International Pharmaceutical Ltd. | 1-Aryl-4-substituted isoquinolines |
| WO2006004589A2 (en) * | 2004-05-08 | 2006-01-12 | Neurogen Corporation | 3-aryl-5,6-disubstituted pyridazines |
| CA2593005A1 (en) * | 2005-01-03 | 2006-07-13 | Myriad Genetics Inc. | Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof |
| US7759337B2 (en) | 2005-03-03 | 2010-07-20 | Amgen Inc. | Phthalazine compounds and methods of use |
| WO2010042649A2 (en) | 2008-10-10 | 2010-04-15 | Amgen Inc. | PHTHALAZINE COMPOUNDS AS p38 MAP KINASE MODULATORS AND METHODS OF USE THEREOF |
| US8772481B2 (en) | 2008-10-10 | 2014-07-08 | Amgen Inc. | Aza- and diaza-phthalazine compounds as P38 map kinase modulators and methods of use thereof |
| KR102571296B1 (ko) | 2016-09-07 | 2023-08-28 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | P-tau를 감소시키고 인지를 개선하는 알로스테릭 코르티코트로핀-방출 인자 수용체 1 (crfr1) 길항제 |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3274185A (en) | 1963-10-08 | 1966-09-20 | S E Massengill Company | Phthalazine derivatives |
| GB1293565A (en) | 1969-05-03 | 1972-10-18 | Aspro Nicholas Ltd | Aminophthalazines and pharmaceutical compositions thereof |
| GB1303061A (de) * | 1969-05-03 | 1973-01-17 | ||
| GB2063249A (en) | 1979-10-09 | 1981-06-03 | Mitsubishi Yuka Pharma | 4-Phenylphthalazine derivatives |
| US4956371A (en) | 1989-09-19 | 1990-09-11 | Euroceltique, S.A. | Substituted isoquinolines and methods of using same |
| JPH03284669A (ja) | 1990-03-30 | 1991-12-16 | Mitsubishi Kasei Corp | ４―フェニルフタラジン誘導体 |
| JP3284669B2 (ja) | 1993-07-02 | 2002-05-20 | 大同特殊鋼株式会社 | 連続鋳造法における鋳造開始方法 |
| CA2275686C (en) * | 1996-12-18 | 2006-10-17 | Neurogen Corporation | Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors |
-
1997
- 1997-12-15 CA CA002275686A patent/CA2275686C/en not_active Expired - Fee Related
- 1997-12-15 WO PCT/US1997/023555 patent/WO1998027066A1/en not_active Ceased
- 1997-12-15 EP EP97952558A patent/EP0946520B1/de not_active Expired - Lifetime
- 1997-12-15 AU AU56141/98A patent/AU5614198A/en not_active Abandoned
- 1997-12-15 DE DE69720515T patent/DE69720515T2/de not_active Expired - Fee Related
- 1997-12-15 AT AT97952558T patent/ATE236134T1/de not_active IP Right Cessation
- 1997-12-15 US US09/331,380 patent/US6235752B1/en not_active Expired - Fee Related
- 1997-12-15 JP JP52799998A patent/JP2001506653A/ja not_active Ceased
-
1998
- 1998-06-22 US US09/102,310 patent/US6114530A/en not_active Expired - Fee Related
-
2000
- 2000-08-25 US US09/648,200 patent/US6353103B1/en not_active Expired - Fee Related
-
2001
- 2001-05-10 US US09/852,991 patent/US6440969B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69720515D1 (de) | 2003-05-08 |
| EP0946520B1 (de) | 2003-04-02 |
| US6440969B2 (en) | 2002-08-27 |
| EP0946520A1 (de) | 1999-10-06 |
| US6235752B1 (en) | 2001-05-22 |
| WO1998027066A1 (en) | 1998-06-25 |
| DE69720515T2 (de) | 2004-02-19 |
| AU5614198A (en) | 1998-07-15 |
| US20010036945A1 (en) | 2001-11-01 |
| US6114530A (en) | 2000-09-05 |
| JP2001506653A (ja) | 2001-05-22 |
| US6353103B1 (en) | 2002-03-05 |
| CA2275686C (en) | 2006-10-17 |
| CA2275686A1 (en) | 1998-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |