ES2224686T3 - Solucion oftalmica con tetraciclina para el tratamiento topico del sindrome de ojo seco. - Google Patents

Solucion oftalmica con tetraciclina para el tratamiento topico del sindrome de ojo seco.

Info

Publication number: ES2224686T3
Authority: ES; Spain
Prior art keywords: concentration; approximately; solution; tetracycline; present
Prior art date: 1998-08-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES99937618T

Other languages

English (en)

Spanish (es)

Inventor

Jeffrey P. Gilbard

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Advanced Vision Research LLC

Original Assignee

Advanced Vision Research LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-06

Filing date

1999-07-29

Publication date

2005-03-01

1999-07-29 Application filed by Advanced Vision Research LLC filed Critical Advanced Vision Research LLC

2005-03-01 Application granted granted Critical

2005-03-01 Publication of ES2224686T3 publication Critical patent/ES2224686T3/es

2019-07-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000011282 treatment Methods 0.000 title claims description 28
230000000699 topical effect Effects 0.000 title claims description 17
208000003556 Dry Eye Syndromes Diseases 0.000 title abstract description 13
206010013774 Dry eye Diseases 0.000 title abstract description 13
239000004098 Tetracycline Substances 0.000 claims abstract description 97
235000019364 tetracycline Nutrition 0.000 claims abstract description 97
229960002180 tetracycline Drugs 0.000 claims abstract description 89
229930101283 tetracycline Natural products 0.000 claims abstract description 89
238000002360 preparation method Methods 0.000 claims abstract description 51
206010061218 Inflammation Diseases 0.000 claims abstract description 31
230000004054 inflammatory process Effects 0.000 claims abstract description 31
239000003792 electrolyte Substances 0.000 claims abstract description 23
-1 tetracycline compound Chemical class 0.000 claims abstract description 23
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims abstract description 12
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 12
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 12
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims abstract description 12
239000011591 potassium Substances 0.000 claims abstract description 12
229910052700 potassium Inorganic materials 0.000 claims abstract description 12
239000011734 sodium Substances 0.000 claims abstract description 12
229910052708 sodium Inorganic materials 0.000 claims abstract description 12
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 10
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 10
229910019142 PO4 Inorganic materials 0.000 claims abstract description 10
239000011575 calcium Substances 0.000 claims abstract description 10
229910052791 calcium Inorganic materials 0.000 claims abstract description 10
239000011777 magnesium Substances 0.000 claims abstract description 10
229910052749 magnesium Inorganic materials 0.000 claims abstract description 10
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 10
239000010452 phosphate Substances 0.000 claims abstract description 10
239000007864 aqueous solution Substances 0.000 claims abstract description 7
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XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical group [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 claims description 8
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FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 10
208000035475 disorder Diseases 0.000 description 10
210000001519 tissue Anatomy 0.000 description 10
ZTKMNYDOFAYRAK-UHFFFAOYSA-N isoacronycine Natural products CN1C2=CC=CC=C2C(=O)C2=C1C=C1OC(C)(C)C=CC1=C2OC ZTKMNYDOFAYRAK-UHFFFAOYSA-N 0.000 description 9
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206010010741 Conjunctivitis Diseases 0.000 description 4
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
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FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 description 3
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239000004100 Oxytetracycline Substances 0.000 description 3
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210000004087 cornea Anatomy 0.000 description 3
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210000003979 eosinophil Anatomy 0.000 description 3
210000003560 epithelium corneal Anatomy 0.000 description 3
230000035876 healing Effects 0.000 description 3
238000005461 lubrication Methods 0.000 description 3
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210000000440 neutrophil Anatomy 0.000 description 3
239000003921 oil Substances 0.000 description 3
229960000625 oxytetracycline Drugs 0.000 description 3
IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 description 3
235000019366 oxytetracycline Nutrition 0.000 description 3
230000008439 repair process Effects 0.000 description 3
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 3
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
241000282412 Homo Species 0.000 description 2
230000000844 anti-bacterial effect Effects 0.000 description 2
230000001580 bacterial effect Effects 0.000 description 2
239000001110 calcium chloride Substances 0.000 description 2
235000011148 calcium chloride Nutrition 0.000 description 2
229910001628 calcium chloride Inorganic materials 0.000 description 2
238000011161 development Methods 0.000 description 2
238000003745 diagnosis Methods 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
208000027866 inflammatory disease Diseases 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
229910001629 magnesium chloride Inorganic materials 0.000 description 2
230000001404 mediated effect Effects 0.000 description 2
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
238000007910 systemic administration Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
GHPYJLCQYMAXGG-WCCKRBBISA-N (2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride Chemical compound Cl.N[C@@H](CSCCB(O)O)C(O)=O GHPYJLCQYMAXGG-WCCKRBBISA-N 0.000 description 1
SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 description 1
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102000029816 Collagenase Human genes 0.000 description 1
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FMTDIUIBLCQGJB-UHFFFAOYSA-N Demethylchlortetracyclin Natural products C1C2C(O)C3=C(Cl)C=CC(O)=C3C(=O)C2=C(O)C2(O)C1C(N(C)C)C(O)=C(C(N)=O)C2=O FMTDIUIBLCQGJB-UHFFFAOYSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
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206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 description 1
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CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
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230000008859 change Effects 0.000 description 1
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CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
230000003366 colagenolytic effect Effects 0.000 description 1
229960002424 collagenase Drugs 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
210000003683 corneal stroma Anatomy 0.000 description 1
239000007857 degradation product Substances 0.000 description 1
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210000004207 dermis Anatomy 0.000 description 1
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238000002224 dissection Methods 0.000 description 1
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238000011156 evaluation Methods 0.000 description 1
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150000003840 hydrochlorides Chemical class 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
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230000011268 leukocyte chemotaxis Effects 0.000 description 1
235000019626 lipase activity Nutrition 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
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AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
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BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Inorganic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ES99937618T 1998-08-06 1999-07-29 Solucion oftalmica con tetraciclina para el tratamiento topico del sindrome de ojo seco. Expired - Lifetime ES2224686T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US130638		1980-03-17
US09/130,638 US6432934B1 (en)	1998-08-06	1998-08-06	Methods and compositions for topical treatment of eye surface inflammation and related dry eye disease

Publications (1)

Publication Number	Publication Date
ES2224686T3 true ES2224686T3 (es)	2005-03-01

Family

ID=22445630

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES99937618T Expired - Lifetime ES2224686T3 (es)	1998-08-06	1999-07-29	Solucion oftalmica con tetraciclina para el tratamiento topico del sindrome de ojo seco.

Country Status (9)

Country	Link
US (1)	US6432934B1 (fr)
EP (1)	EP1105139B1 (fr)
JP (1)	JP2003523925A (fr)
AT (1)	ATE265856T1 (fr)
AU (1)	AU777744B2 (fr)
CA (1)	CA2339792C (fr)
DE (1)	DE69917040T2 (fr)
ES (1)	ES2224686T3 (fr)
WO (1)	WO2000007601A1 (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK1676579T3 (da) *	1998-05-08	2009-03-16	Univ Miami	Anvendelse af sub-antimikrobielle tetracykliner til behandling af okulær rosacea
EP1212050B1 (fr) *	1999-09-14	2006-12-06	Mucosal Therapeutics LLC	Formulations permettant de traiter ou de prevenir l'inflammation d'une muqueuse
EP1829546A1 (fr) *	1999-09-14	2007-09-05	Mucosal Therapeutics LLC	Formulations pour traiter ou prévenir la mucosite
US6946118B1 (en)	1999-09-14	2005-09-20	Orapharma, Inc.	Formulations for treating or preventing mucositis
US7211267B2 (en)	2001-04-05	2007-05-01	Collagenex Pharmaceuticals, Inc.	Methods of treating acne
EP1716856A3 (fr) *	2001-04-05	2009-02-18	Collagenex Pharmaceuticals, Inc.	Le traitement de l'acné
US20030211043A1 (en) *	2001-09-28	2003-11-13	Korb Donald R.	Eye treatment
US8192749B2 (en)	2003-04-16	2012-06-05	Galderma Laboratories Inc.	Methods of simultaneously treating ocular rosacea and acne rosacea
WO2003088906A2 (fr)	2002-04-16	2003-10-30	Collagenex Pharmaceuticals, Inc.	Procedes pour traiter simultanement de la keratite rosacee et de l'acne rosacee
US7985405B2 (en) *	2002-09-17	2011-07-26	Jin Jun Zhang	Treatment solution and method for preventing posterior capsular opacification by selectively inducing detachment and/or death of lens epithelial cells
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- 1999-07-29 ES ES99937618T patent/ES2224686T3/es not_active Expired - Lifetime
- 1999-07-29 JP JP2000563286A patent/JP2003523925A/ja active Pending
- 1999-07-29 DE DE69917040T patent/DE69917040T2/de not_active Expired - Lifetime
- 1999-07-29 CA CA002339792A patent/CA2339792C/fr not_active Expired - Fee Related
- 1999-07-29 AU AU52412/99A patent/AU777744B2/en not_active Ceased
- 1999-07-29 AT AT99937618T patent/ATE265856T1/de active
- 1999-07-29 WO PCT/US1999/017185 patent/WO2000007601A1/fr not_active Ceased

Also Published As

Publication number	Publication date
CA2339792A1 (fr)	2000-02-17
AU777744B2 (en)	2004-10-28
AU5241299A (en)	2000-02-28
EP1105139B1 (fr)	2004-05-06
JP2003523925A (ja)	2003-08-12
US6432934B1 (en)	2002-08-13
DE69917040D1 (de)	2004-06-09
DE69917040T2 (de)	2005-04-28
ATE265856T1 (de)	2004-05-15
CA2339792C (fr)	2009-03-31
EP1105139A1 (fr)	2001-06-13
WO2000007601A1 (fr)	2000-02-17

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