ES2229355T3 - Procedimiento para la fabricacion de complejos medicamentosos. - Google Patents

Procedimiento para la fabricacion de complejos medicamentosos.

Info

Publication number: ES2229355T3
Authority: ES; Spain
Prior art keywords: compound; gly; polyalcohol; solution; spacer
Prior art date: 1996-06-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES97924326T

Other languages

English (en)

Spanish (es)

Inventor

Kazuhiro Daiichi Pharmaceutical Co. Ltd. INOUE

Hiroshi Daiichi Pharmaceutical Co. Ltd. SUSAKI

Masahiro Daiichi Pharmaceutical Co. Ltd. IKEDA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Daiichi Pharmaceutical Co Ltd

Original Assignee

Daiichi Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-06

Filing date

1997-06-05

Publication date

2005-04-16

1997-06-05 Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd

2005-04-16 Application granted granted Critical

2005-04-16 Publication of ES2229355T3 publication Critical patent/ES2229355T3/es

2017-06-05 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000000034 method Methods 0.000 title claims abstract description 78
238000004519 manufacturing process Methods 0.000 title claims description 11
150000001875 compounds Chemical class 0.000 claims abstract description 243
239000003814 drug Substances 0.000 claims abstract description 188
229940079593 drug Drugs 0.000 claims abstract description 179
125000006850 spacer group Chemical group 0.000 claims abstract description 91
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 75
229920001282 polysaccharide Polymers 0.000 claims abstract description 67
239000005017 polysaccharide Substances 0.000 claims abstract description 67
238000006243 chemical reaction Methods 0.000 claims abstract description 40
-1 amine salt Chemical class 0.000 claims abstract description 39
150000001413 amino acids Chemical class 0.000 claims abstract description 27
150000004676 glycans Chemical class 0.000 claims abstract 11
150000005846 sugar alcohols Polymers 0.000 claims description 152
229920002307 Dextran Polymers 0.000 claims description 59
150000003839 salts Chemical class 0.000 claims description 55
239000002246 antineoplastic agent Substances 0.000 claims description 21
239000003795 chemical substances by application Substances 0.000 claims description 21
230000008569 process Effects 0.000 claims description 21
150000002596 lactones Chemical group 0.000 claims description 20
229940034982 antineoplastic agent Drugs 0.000 claims description 13
150000001412 amines Chemical class 0.000 claims description 5
229910052783 alkali metal Inorganic materials 0.000 claims description 4
230000003110 anti-inflammatory effect Effects 0.000 claims description 3
230000002829 reductive effect Effects 0.000 abstract description 19
125000000686 lactone group Chemical group 0.000 abstract 1
238000007086 side reaction Methods 0.000 abstract 1
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 180
239000000243 solution Substances 0.000 description 173
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 159
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 116
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 87
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239000002244 precipitate Substances 0.000 description 42
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238000000108 ultra-filtration Methods 0.000 description 37
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206010028980 Neoplasm Diseases 0.000 description 31
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 30
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 27
230000000259 anti-tumor effect Effects 0.000 description 26
QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 24
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JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 16
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HXUVTXPOZRFMOY-NSHDSACASA-N 2-[[(2s)-2-[[2-[(2-aminoacetyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid Chemical compound NCC(=O)NCC(=O)N[C@H](C(=O)NCC(O)=O)CC1=CC=CC=C1 HXUVTXPOZRFMOY-NSHDSACASA-N 0.000 description 14
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125000003277 amino group Chemical group 0.000 description 14
FOCAUTSVDIKZOP-UHFFFAOYSA-N chloroacetic acid Chemical compound OC(=O)CCl FOCAUTSVDIKZOP-UHFFFAOYSA-N 0.000 description 14
239000003480 eluent Substances 0.000 description 14
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 12
230000001613 neoplastic effect Effects 0.000 description 12
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 11
238000004458 analytical method Methods 0.000 description 11
229910052708 sodium Inorganic materials 0.000 description 11
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NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 10
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108010016626 Dipeptides Proteins 0.000 description 8
230000000118 anti-neoplastic effect Effects 0.000 description 8
239000000706 filtrate Substances 0.000 description 8
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 8
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 7
230000036961 partial effect Effects 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 6
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230000002757 inflammatory effect Effects 0.000 description 5
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231100000419 toxicity Toxicity 0.000 description 5
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LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
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VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
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238000002347 injection Methods 0.000 description 4
239000007924 injection Substances 0.000 description 4
KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 4
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 4
108091005804 Peptidases Proteins 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

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Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

ES97924326T 1996-06-06 1997-06-05 Procedimiento para la fabricacion de complejos medicamentosos. Expired - Lifetime ES2229355T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP14452296		1996-06-06
JP14452296		1996-06-06

Publications (1)

Publication Number	Publication Date
ES2229355T3 true ES2229355T3 (es)	2005-04-16

Family

ID=15364300

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES97924326T Expired - Lifetime ES2229355T3 (es)	1996-06-06	1997-06-05	Procedimiento para la fabricacion de complejos medicamentosos.

Country Status (16)

Country	Link
US (1)	US6291671B1 (de)
EP (1)	EP0955064B1 (de)
JP (1)	JP4137184B2 (de)
CN (1)	CN1227034C (de)
AT (1)	ATE273716T1 (de)
AU (1)	AU723442B2 (de)
CA (1)	CA2257233A1 (de)
DE (1)	DE69730352T2 (de)
DK (1)	DK0955064T3 (de)
EA (1)	EA001897B1 (de)
ES (1)	ES2229355T3 (de)
ID (1)	ID17243A (de)
NO (1)	NO323626B1 (de)
PT (1)	PT955064E (de)
TW (1)	TW409058B (de)
WO (1)	WO1997046261A1 (de)

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EP3386956B1 (de)	2015-12-10	2021-07-14	Syndevrx, Inc.	Fumagillolderivate und polymorphe davon
AU2017206718B2 (en)	2016-01-11	2021-09-30	Syndevrx, Inc.	Treatment for tumors driven by metabolic dysfunction
TWI862473B (zh)	2016-12-12	2024-11-21	日商第一三共股份有限公司	抗體-藥物結合物與免疫檢查點抑制劑之組合、以及醫藥組成物之用途
TWI780104B (zh)	2017-01-17	2022-10-11	日商第一三共股份有限公司	抗ｇｐｒ２０抗體及抗ｇｐｒ２０抗體-藥物結合物、以及其製造方法及用途
TWI855528B (zh)	2017-05-15	2024-09-11	日商第一三共股份有限公司	抗體-藥物結合物之製造方法
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1997
- 1997-05-31 TW TW086107456A patent/TW409058B/zh not_active IP Right Cessation
- 1997-06-05 JP JP50042298A patent/JP4137184B2/ja not_active Expired - Fee Related
- 1997-06-05 EP EP97924326A patent/EP0955064B1/de not_active Expired - Lifetime
- 1997-06-05 CN CNB971971153A patent/CN1227034C/zh not_active Expired - Fee Related
- 1997-06-05 ES ES97924326T patent/ES2229355T3/es not_active Expired - Lifetime
- 1997-06-05 ID IDP971929A patent/ID17243A/id unknown
- 1997-06-05 AU AU29788/97A patent/AU723442B2/en not_active Ceased
- 1997-06-05 EA EA199900002A patent/EA001897B1/ru not_active IP Right Cessation
- 1997-06-05 DK DK97924326T patent/DK0955064T3/da active
- 1997-06-05 AT AT97924326T patent/ATE273716T1/de not_active IP Right Cessation
- 1997-06-05 WO PCT/JP1997/001915 patent/WO1997046261A1/ja not_active Ceased
- 1997-06-05 CA CA002257233A patent/CA2257233A1/en not_active Abandoned
- 1997-06-05 DE DE69730352T patent/DE69730352T2/de not_active Expired - Lifetime
- 1997-06-05 PT PT97924326T patent/PT955064E/pt unknown
- 1997-06-05 US US09/147,341 patent/US6291671B1/en not_active Expired - Fee Related
1998
- 1998-12-04 NO NO19985667A patent/NO323626B1/no unknown

Also Published As

Publication number	Publication date
DE69730352D1 (de)	2004-09-23
WO1997046261A1 (fr)	1997-12-11
EP0955064A4 (de)	2000-12-06
EA001897B1 (ru)	2001-10-22
NO323626B1 (no)	2007-06-18
AU723442B2 (en)	2000-08-24
AU2978897A (en)	1998-01-05
NO985667D0 (no)	1998-12-04
EP0955064A1 (de)	1999-11-10
US6291671B1 (en)	2001-09-18
NO985667L (no)	1999-02-04
CA2257233A1 (en)	1997-12-11
ATE273716T1 (de)	2004-09-15
CN1227034C (zh)	2005-11-16
DK0955064T3 (da)	2004-12-06
JP4137184B2 (ja)	2008-08-20
ID17243A (id)	1997-12-11
EP0955064B1 (de)	2004-08-18
EA199900002A1 (ru)	1999-08-26
TW409058B (en)	2000-10-21
PT955064E (pt)	2004-10-29
DE69730352T2 (de)	2005-09-08
CN1227500A (zh)	1999-09-01

Publication	Publication Date	Title
ES2229355T3 (es)	2005-04-16	Procedimiento para la fabricacion de complejos medicamentosos.
ES2229354T3 (es)	2005-04-16	Complejos medicamentosos polialcohol-alquildextrano.
JP4560210B2 (ja)	2010-10-13	薬物複合体
JPWO1997046260A1 (ja)	1999-07-21	薬物複合体
JPWO1997046261A1 (ja)	1999-07-21	薬物複合体の製造方法
KR100387191B1 (ko)	2003-10-04	캄프토테신유도체
JPWO1999061061A1 (ja)	2002-11-12	薬物複合体
EP0640622B1 (de)	2000-08-09	Polysaccharidderivat und wirkstoffträger
JP4420472B2 (ja)	2010-02-24	薬物複合体
ES2371865T3 (es)	2012-01-10	Conjugados de hidroxialquilalmidón-principio activo.
US6811996B1 (en)	2004-11-02	DDS compounds and method for assaying the same
AU4094300A (en)	2000-11-17	Amplification of folate-mediated targeting to tumor cells using polymers
JPWO1997038727A1 (ja)	1999-05-25	薬物複合体
JPH1192405A (ja)	1999-04-06	薬物複合体
KR100481434B1 (ko)	2006-10-24	약물복합체의제조방법
JP5189243B2 (ja)	2013-04-24	薬物複合体および薬物送達用担体
JP2002030002A (ja)	2002-01-29	薬物複合体