NO323626B1 - Fremgangsmate for fremstilling av et medikamentkompleks - Google Patents

Fremgangsmate for fremstilling av et medikamentkompleks Download PDF

Info

Publication number
NO323626B1
NO323626B1 NO19985667A NO985667A NO323626B1 NO 323626 B1 NO323626 B1 NO 323626B1 NO 19985667 A NO19985667 A NO 19985667A NO 985667 A NO985667 A NO 985667A NO 323626 B1 NO323626 B1 NO 323626B1
Authority
NO
Norway
Prior art keywords
drug
gly
drug compound
compound
spacer
Prior art date
Application number
NO19985667A
Other languages
English (en)
Norwegian (no)
Other versions
NO985667D0 (no
NO985667L (no
Inventor
Masahiro Ikeda
Hiroshi Susaki
Kazuhiro Inoue
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of NO985667D0 publication Critical patent/NO985667D0/no
Publication of NO985667L publication Critical patent/NO985667L/no
Publication of NO323626B1 publication Critical patent/NO323626B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
NO19985667A 1996-06-06 1998-12-04 Fremgangsmate for fremstilling av et medikamentkompleks NO323626B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14452296 1996-06-06
PCT/JP1997/001915 WO1997046261A1 (fr) 1996-06-06 1997-06-05 Procede de fabrication de complexes medicamenteux

Publications (3)

Publication Number Publication Date
NO985667D0 NO985667D0 (no) 1998-12-04
NO985667L NO985667L (no) 1999-02-04
NO323626B1 true NO323626B1 (no) 2007-06-18

Family

ID=15364300

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19985667A NO323626B1 (no) 1996-06-06 1998-12-04 Fremgangsmate for fremstilling av et medikamentkompleks

Country Status (16)

Country Link
US (1) US6291671B1 (de)
EP (1) EP0955064B1 (de)
JP (1) JP4137184B2 (de)
CN (1) CN1227034C (de)
AT (1) ATE273716T1 (de)
AU (1) AU723442B2 (de)
CA (1) CA2257233A1 (de)
DE (1) DE69730352T2 (de)
DK (1) DK0955064T3 (de)
EA (1) EA001897B1 (de)
ES (1) ES2229355T3 (de)
ID (1) ID17243A (de)
NO (1) NO323626B1 (de)
PT (1) PT955064E (de)
TW (1) TW409058B (de)
WO (1) WO1997046261A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
EA003398B1 (ru) * 1998-05-22 2003-04-24 Дайити Фармасьютикал Ко., Лтд. Лекарственный комплекс c полимерным носителем
US20030166513A1 (en) * 2000-06-29 2003-09-04 Akihiro Imura Dds compound and process for the preparation thereof
EP1401875A4 (de) * 2001-05-04 2005-01-26 Univ Utah Res Found Hyaluronsäure enthaltende biokonjugate: gezielte abgabe von antikrebsmitteln an krebszellen
US20030049253A1 (en) * 2001-08-08 2003-03-13 Li Frank Q. Polymeric conjugates for delivery of MHC-recognized epitopes via peptide vaccines
US20050169883A1 (en) * 2002-05-06 2005-08-04 Prestwich Glenn D. Preblocking with non-ha gags increases effectiveness of ha conjugated anticancer agents
US7691830B2 (en) * 2005-02-17 2010-04-06 Clive Elson Method and composition for treatment of a mucosal tissue disorder
MX2007013725A (es) 2005-05-05 2008-04-09 Sensient Flavors Inc Produccion de beta-glucanos y mananos.
WO2007004675A1 (ja) * 2005-07-06 2007-01-11 Seikagaku Corporation 薬剤導入光架橋ヒアルロン酸誘導体ゲル
ITPD20050242A1 (it) 2005-08-03 2007-02-04 Fidia Farmaceutici Bioconiugati antitumorali dell'acido ialuronico o dei suoi derivati, ottenibili per coniugazione chimica diretta o indiretta, e loro impiego in campo farmaceutico
CN1973902B (zh) * 2006-12-12 2010-11-10 东北师范大学 以人参多糖为载体的抗肿瘤药物阿霉素复合物及制备方法
US9895449B2 (en) 2010-05-25 2018-02-20 Syndevrx, Inc. Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof
WO2011150022A2 (en) 2010-05-25 2011-12-01 Syndevrx, Inc. Polymer-conjugated metap2 inhibitors, and therapeutic methods of use thereof
ES2773710T3 (es) 2012-10-11 2020-07-14 Daiichi Sankyo Co Ltd Enlazadores para conjugados de anticuerpo - fármaco
WO2014061277A1 (ja) 2012-10-19 2014-04-24 第一三共株式会社 親水性構造を含むリンカーで結合させた抗体-薬物コンジュゲート
CA2908993C (en) 2013-04-10 2023-05-23 Syndevrx, Inc. Metap2 inhibitors and methods of treating obesity
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
AU2014371934B2 (en) 2013-12-25 2020-01-23 Daiichi Sankyo Company, Limited Anti-TROP2 antibody-drug conjugate
IL310627B2 (en) 2014-01-31 2026-04-01 Daiichi Sankyo Co Ltd Anti-HER2 antibody-drug conjugates, compositions containing them and uses thereof
EP3130608B1 (de) 2014-04-10 2019-09-04 Daiichi Sankyo Co., Ltd. (anti-her2-antikörper)-arzneimittelkonjugat
KR102445502B1 (ko) 2014-04-10 2022-09-21 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
CN116059395A (zh) 2015-06-29 2023-05-05 第一三共株式会社 用于选择性制造抗体-药物缀合物的方法
ES2893749T3 (es) 2015-12-10 2022-02-10 Syndevrx Inc Derivados de fumagilol y polimorfos de los mismos
CA3239447A1 (en) 2016-01-11 2017-07-20 Syndevrx, Inc. Treatment for tumors driven by metabolic dysfunction
US11273155B2 (en) 2016-12-12 2022-03-15 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and immune checkpoint inhibitor
JP6679762B2 (ja) 2017-01-17 2020-04-15 第一三共株式会社 抗gpr20抗体及び抗gpr20抗体−薬物コンジュゲート
TW202532104A (zh) 2017-05-15 2025-08-16 日商第一三共股份有限公司 抗體-藥物結合物及其用途
IL324591A (en) 2017-08-31 2026-01-01 Daiichi Sankyo Co Ltd Improved antibody-drug conjugate production methods
CA3074208C (en) 2017-08-31 2023-10-03 Daiichi Sankyo Company, Limited Novel method for producing antibody-drug conjugate
SG11202010496WA (en) 2018-05-18 2020-12-30 Daiichi Sankyo Co Ltd Anti-muc1 antibody-drug conjugate
WO2020022475A1 (ja) 2018-07-27 2020-01-30 第一三共株式会社 抗体-薬物コンジュゲートの薬物部位を認識する蛋白質
CA3108044A1 (en) 2018-07-31 2020-02-06 Daiichi Sankyo Company, Limited Treatment of metastatic brain tumor by administration of antibody-drug conjugate
JP2022512826A (ja) 2018-10-26 2022-02-07 シンデブルックス,インコーポレイティド MetAP2阻害剤のバイオマーカーとその応用
US11555019B2 (en) 2019-07-10 2023-01-17 Cybrexa 3, Inc. Peptide conjugates of microtubule-targeting agents as therapeutics
MX2022000449A (es) 2019-07-10 2022-04-25 Cybrexa 2 Inc Conjugados peptídicos de citotoxinas como terapéuticos.
TW202320858A (zh) 2021-07-19 2023-06-01 美商薩諾管理公司 免疫接合物及方法
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746920A (en) * 1980-09-03 1982-03-17 Kyosei Seiyaku Kk Drug for digestive tract
DE3152319C2 (de) 1980-09-03 1986-05-07 Kyosei Pharmaceutical Co., Ltd., Hokkaido Verwendung einer Lösung eines Salzes der Alginsäure zur Behandlung von Strahlenschäden und Ulcera
JPS59220197A (ja) 1983-05-30 1984-12-11 Snow Brand Milk Prod Co Ltd 新規な含窒素多糖体およびその製造方法
JP2604930B2 (ja) 1990-12-14 1997-04-30 株式会社ディ・ディ・エス研究所 ヒアルロン酸およびコンドロイチン誘導体
CA2059693C (en) * 1991-01-28 2003-08-19 Peter J. Kniskern Polysaccharide antigens from streptococcus pneumoniae
JPH0784481B2 (ja) 1991-02-21 1995-09-13 株式会社デイ・デイ・エス研究所 カルボキシメチルマンノグルカン及びその誘導体
JP3359955B2 (ja) 1992-07-16 2002-12-24 第一製薬株式会社 抗腫瘍剤
ES2149867T3 (es) 1993-02-26 2000-11-16 Drug Delivery System Inst Ltd Derivados de polisacaridos y soportes para farmacos.
JPH0784481A (ja) 1993-06-26 1995-03-31 Ricoh Co Ltd 画像形成装置
SG50747A1 (en) 1995-08-02 1998-07-20 Tanabe Seiyaku Co Comptothecin derivatives
TW527183B (en) 1996-06-06 2003-04-11 Daiichi Seiyaku Co Drug complex
US6299881B1 (en) * 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts

Also Published As

Publication number Publication date
AU2978897A (en) 1998-01-05
ID17243A (id) 1997-12-11
ES2229355T3 (es) 2005-04-16
ATE273716T1 (de) 2004-09-15
EA199900002A1 (ru) 1999-08-26
WO1997046261A1 (fr) 1997-12-11
NO985667D0 (no) 1998-12-04
NO985667L (no) 1999-02-04
EP0955064A4 (de) 2000-12-06
US6291671B1 (en) 2001-09-18
AU723442B2 (en) 2000-08-24
DE69730352D1 (de) 2004-09-23
CN1227500A (zh) 1999-09-01
CA2257233A1 (en) 1997-12-11
EA001897B1 (ru) 2001-10-22
EP0955064B1 (de) 2004-08-18
TW409058B (en) 2000-10-21
JP4137184B2 (ja) 2008-08-20
DE69730352T2 (de) 2005-09-08
DK0955064T3 (da) 2004-12-06
EP0955064A1 (de) 1999-11-10
PT955064E (pt) 2004-10-29
CN1227034C (zh) 2005-11-16

Similar Documents

Publication Publication Date Title
NO323626B1 (no) Fremgangsmate for fremstilling av et medikamentkompleks
EP0916348B1 (de) Alkyldextran-polyalcohol Arzneimittel-Komplexe
JPWO1997046260A1 (ja) 薬物複合体
JP4560210B2 (ja) 薬物複合体
JPWO1997046261A1 (ja) 薬物複合体の製造方法
EP0640622B1 (de) Polysaccharidderivat und wirkstoffträger
JPWO1999061061A1 (ja) 薬物複合体
US20040192644A1 (en) DDS compound and method for measurement thereof
AU6790494A (en) Vitamin B-12 mediated oral delivery systems for GCSF and EPO
EP1206252A1 (de) Verstärkung der folate-vermittelten zielgerichtetheit auf tumorzellen unter verwendung von polymeren
JPH1192405A (ja) 薬物複合体
CA3076289A1 (en) Psma-targeting amanitin conjugates
WO2006017180A2 (en) Glycopeptide dimers and uses thereof
CN120435309A (zh) 含有glp-2衍生物或其长效缀合物的用于预防或治疗移植物抗宿主病的药物组合物
KR100481434B1 (ko) 약물복합체의제조방법
CN119424668A (zh) β-葡聚糖抗体药物偶联物、制备方法及免疫抗肿瘤应用
NZ762962B2 (en) Long-acting conjugates of glp-2 derivatives
AU2004201277A1 (en) Amplification of folate-mediated targeting to tumor cells using polymers
JPWO2000025825A1 (ja) Dds化合物及びその測定方法