ES2276419T3 - Aparato de siembra de hielo para sistema de criopreservacion. - Google Patents

Aparato de siembra de hielo para sistema de criopreservacion. Download PDF

Info

Publication number: ES2276419T3
Authority: ES; Spain
Prior art keywords: ice; liquefied; containers; gas; package
Prior art date: 1996-01-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES97904153T

Other languages

English (en)

Spanish (es)

Inventor

Maury D. Cosman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organogenesis Inc

Original Assignee

Organogenesis Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-30

Filing date

1997-01-30

Publication date

2007-06-16

1997-01-30 Application filed by Organogenesis Inc filed Critical Organogenesis Inc

2007-06-16 Application granted granted Critical

2007-06-16 Publication of ES2276419T3 publication Critical patent/ES2276419T3/es

2017-01-30 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

238000010899 nucleation Methods 0.000 title description 17
238000004321 preservation Methods 0.000 title description 2
239000007921 spray Substances 0.000 claims abstract description 54
238000005138 cryopreservation Methods 0.000 claims abstract description 31
238000009331 sowing Methods 0.000 claims abstract description 17
239000012472 biological sample Substances 0.000 claims abstract description 12
239000007789 gas Substances 0.000 claims description 63
238000000034 method Methods 0.000 claims description 34
238000001816 cooling Methods 0.000 claims description 24
239000002577 cryoprotective agent Substances 0.000 claims description 23
230000015572 biosynthetic process Effects 0.000 claims description 21
QWTDNUCVQCZILF-UHFFFAOYSA-N isopentane Chemical compound CCC(C)C QWTDNUCVQCZILF-UHFFFAOYSA-N 0.000 claims description 14
239000007788 liquid Substances 0.000 claims description 14
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 11
239000007787 solid Substances 0.000 claims description 7
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 6
150000001875 compounds Chemical class 0.000 claims description 6
AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 claims description 6
229910052757 nitrogen Inorganic materials 0.000 claims description 5
239000000523 sample Substances 0.000 claims description 5
ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims description 4
239000007791 liquid phase Substances 0.000 claims description 2
230000010412 perfusion Effects 0.000 claims description 2
239000001294 propane Substances 0.000 claims description 2
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
229910052799 carbon Inorganic materials 0.000 claims 1
239000001301 oxygen Substances 0.000 claims 1
229910052760 oxygen Inorganic materials 0.000 claims 1
238000010583 slow cooling Methods 0.000 claims 1
239000007790 solid phase Substances 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 107
210000004027 cell Anatomy 0.000 description 53
210000001519 tissue Anatomy 0.000 description 47
238000007710 freezing Methods 0.000 description 29
230000008014 freezing Effects 0.000 description 29
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
239000000243 solution Substances 0.000 description 20
239000002609 medium Substances 0.000 description 14
239000003795 chemical substances by application Substances 0.000 description 10
239000006144 Dulbecco’s modiﬁed Eagle's medium Substances 0.000 description 9
239000012071 phase Substances 0.000 description 9
230000003834 intracellular effect Effects 0.000 description 8
230000008569 process Effects 0.000 description 8
238000003860 storage Methods 0.000 description 8
230000002338 cryopreservative effect Effects 0.000 description 7
238000007496 glass forming Methods 0.000 description 7
230000035899 viability Effects 0.000 description 7
230000006378 damage Effects 0.000 description 6
230000006870 function Effects 0.000 description 6
238000010276 construction Methods 0.000 description 5
230000007246 mechanism Effects 0.000 description 5
230000004083 survival effect Effects 0.000 description 5
238000004017 vitrification Methods 0.000 description 5
239000013078 crystal Substances 0.000 description 4
239000012530 fluid Substances 0.000 description 4
230000014759 maintenance of location Effects 0.000 description 4
230000000149 penetrating effect Effects 0.000 description 4
230000035699 permeability Effects 0.000 description 4
238000010257 thawing Methods 0.000 description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
241000282412 Homo Species 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
238000013459 approach Methods 0.000 description 3
230000005779 cell damage Effects 0.000 description 3
208000037887 cell injury Diseases 0.000 description 3
230000001413 cellular effect Effects 0.000 description 3
238000002425 crystallisation Methods 0.000 description 3
230000008025 crystallization Effects 0.000 description 3
230000007423 decrease Effects 0.000 description 3
230000018044 dehydration Effects 0.000 description 3
238000006297 dehydration reaction Methods 0.000 description 3
PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000011521 glass Substances 0.000 description 3
230000002269 spontaneous effect Effects 0.000 description 3
231100000331 toxic Toxicity 0.000 description 3
230000002588 toxic effect Effects 0.000 description 3
VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 description 2
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
229920001612 Hydroxyethyl starch Polymers 0.000 description 2
-1 IDMEM Substances 0.000 description 2
CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
230000008901 benefit Effects 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
210000000170 cell membrane Anatomy 0.000 description 2
230000008859 change Effects 0.000 description 2
230000000959 cryoprotective effect Effects 0.000 description 2
239000008150 cryoprotective solution Substances 0.000 description 2
235000019404 dichlorodifluoromethane Nutrition 0.000 description 2
230000008020 evaporation Effects 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
238000001727 in vivo Methods 0.000 description 2
239000000463 material Substances 0.000 description 2
230000006911 nucleation Effects 0.000 description 2
230000036961 partial effect Effects 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
238000004781 supercooling Methods 0.000 description 2
230000007704 transition Effects 0.000 description 2
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
229920001287 Chondroitin sulfate Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000012980 RPMI-1640 medium Substances 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
230000009471 action Effects 0.000 description 1
230000004913 activation Effects 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000002411 adverse Effects 0.000 description 1
238000005280 amorphization Methods 0.000 description 1
239000012620 biological material Substances 0.000 description 1
235000014633 carbohydrates Nutrition 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
CURLTUGMZLYLDI-UHFFFAOYSA-N carbon dioxide Natural products O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
239000006143 cell culture medium Substances 0.000 description 1
230000003833 cell viability Effects 0.000 description 1
239000000460 chlorine Substances 0.000 description 1
229910052801 chlorine Inorganic materials 0.000 description 1
229940059329 chondroitin sulfate Drugs 0.000 description 1
230000001010 compromised effect Effects 0.000 description 1
238000005336 cracking Methods 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 1
229940099364 dichlorofluoromethane Drugs 0.000 description 1
238000007865 diluting Methods 0.000 description 1
229910001873 dinitrogen Inorganic materials 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
238000007599 discharging Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
230000007613 environmental effect Effects 0.000 description 1
238000004880 explosion Methods 0.000 description 1
210000003722 extracellular fluid Anatomy 0.000 description 1
125000001153 fluoro group Chemical group F* 0.000 description 1
239000012595 freezing medium Substances 0.000 description 1
230000004927 fusion Effects 0.000 description 1
230000008821 health effect Effects 0.000 description 1
230000002440 hepatic effect Effects 0.000 description 1
229940027278 hetastarch Drugs 0.000 description 1
229940050526 hydroxyethylstarch Drugs 0.000 description 1
238000002513 implantation Methods 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000010874 in vitro model Methods 0.000 description 1
238000001802 infusion Methods 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
239000002245 particle Substances 0.000 description 1
238000010587 phase diagram Methods 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 description 1
239000003380 propellant Substances 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
230000008707 rearrangement Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
239000004065 semiconductor Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
238000009423 ventilation Methods 0.000 description 1
239000002912 waste gas Substances 0.000 description 1
239000002699 waste material Substances 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/42—Low-temperature sample treatment, e.g. cryofixation
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
- A01N1/145—Stationary or portable vessels generating cryogenic temperatures, e.g. liquid nitrogen baths
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D29/00—Arrangement or mounting of control or safety devices
- F25D29/001—Arrangement or mounting of control or safety devices for cryogenic fluid systems
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
- F25D3/102—Stationary cabinets

Landscapes

Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Physics & Mathematics (AREA)
Chemical & Material Sciences (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Thermal Sciences (AREA)
Health & Medical Sciences (AREA)
Mechanical Engineering (AREA)
Combustion & Propulsion (AREA)
Zoology (AREA)
Environmental Sciences (AREA)
Wood Science & Technology (AREA)
Dentistry (AREA)
Immunology (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)
Hydroponics (AREA)
Devices That Are Associated With Refrigeration Equipment (AREA)
Liquid Crystal (AREA)

ES97904153T 1996-01-30 1997-01-30 Aparato de siembra de hielo para sistema de criopreservacion. Expired - Lifetime ES2276419T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/593,587 US5689961A (en)	1996-01-30	1996-01-30	Ice seeding apparatus for cryopreservation systems
US593587		1996-01-30

Publications (1)

Publication Number	Publication Date
ES2276419T3 true ES2276419T3 (es)	2007-06-16

Family

ID=24375320

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES97904153T Expired - Lifetime ES2276419T3 (es)	1996-01-30	1997-01-30	Aparato de siembra de hielo para sistema de criopreservacion.

Country Status (8)

Country	Link
US (3)	US5689961A (2)
EP (2)	EP1763997A3 (2)
JP (2)	JP4080534B2 (2)
AT (1)	ATE348289T1 (2)
AU (1)	AU1852097A (2)
DE (1)	DE69737109T2 (2)
ES (1)	ES2276419T3 (2)
WO (1)	WO1997028402A1 (2)

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US5891617A (en) *	1993-09-15	1999-04-06	Organogenesis Inc.	Cryopreservation of harvested skin and cultured skin or cornea equivalents by slow freezing
TW333451B (en) *	1996-05-21	1998-06-11	Kulpa Kk	Method and apparatus for embalming a dead body
US6337205B1 (en)	1998-01-06	2002-01-08	Integrated Biosystems, Inc	Cryopreservation vial apparatus and methods
EP2295540A1 (en)	1998-11-19	2011-03-16	Organogenesis, Inc.	Bioengineered tissue constructs and methods for producing and using them
US20010036665A1 (en) *	1999-03-18	2001-11-01	Susan M. Young	Method of preparing cryogenically preserved adherent cell containing plate for tissue culture applications
US7144729B2 (en)	2000-09-01	2006-12-05	Dfb Pharmaceuticals, Inc.	Methods and compositions for tissue regeneration
US6684646B2 (en) *	2001-05-22	2004-02-03	Integrated Biosystems, Inc.	Systems and methods for freezing, storing and thawing biopharmaceutical material
US6945056B2 (en) *	2001-11-01	2005-09-20	Integrated Biosystems, Inc.	Systems and methods for freezing, mixing and thawing biopharmaceutical material
US6698213B2 (en) *	2001-05-22	2004-03-02	Integrated Biosystems, Inc.	Systems and methods for freezing and storing biopharmaceutical material
WO2003006989A1 (fr) *	2001-07-12	2003-01-23	Kyowa Medex Co., Ltd.	Procede de quantification de lipoproteines denaturees, reactifs pour la quantification de lipoproteines denaturees, procede de detection de maladies du systeme circulatoire et reactifs pour la detection de maladies du systeme circulatoire
US7104074B2 (en)	2001-11-01	2006-09-12	Integrated Biosystems, Inc.	Systems and methods for freezing, storing, transporting and thawing biopharmaceutical material
UA46673C2 (en) *	2002-01-14	2005-04-15	Halyna Stepanivna Lobintseva	Method of cryopreservation of human hemopoietic cells
WO2004010780A2 (en) *	2002-07-30	2004-02-05	General Biotechnology, Llc	Innocuous intracellular ice
WO2004055456A1 (en) *	2002-12-13	2004-07-01	Integrated Biosystems, Inc.	Scaled down freezing and thawing system for bioparmaceuticals and biologics
WO2004069156A2 (en) *	2003-01-30	2004-08-19	The Regents Of The University Of California	Inactivated probiotic bacteria and methods of use thereof
US7278278B2 (en) *	2003-06-12	2007-10-09	21St Century Medicine, Inc.	Cryogenic storage system
US20050241333A1 (en) *	2003-12-03	2005-11-03	Hamilton Robert W	Rate-controlled freezer and cooling methods thereof
EP1634496A1 (en) *	2004-09-14	2006-03-15	The Automation Partnership (Cambridge) Limited	Ultra-low temperature storage system
EP1639892B1 (en) *	2004-09-14	2013-01-23	The Automation Partnership (Cambridge) Limited	Ultra-low temperature storage system
CA2584203A1 (en) *	2004-10-14	2006-04-20	James Hardie International Finance B.V.	Cavity wall system
DE102005009065A1 (de) *	2005-02-22	2006-08-24	Eberhard-Karls-Universität Tübingen	Kryokonservierung von definierten Zellverbänden
WO2007103917A2 (en)	2006-03-06	2007-09-13	Integrated Biosystems, Inc.	Systems and methods for freezing, storing and thawing biopharmaceutical materials
US7540168B2 (en) *	2006-10-20	2009-06-02	Custom Biogenic Systems	Cryogenic storage container system
AU2010242985B2 (en)	2009-04-29	2015-06-18	Biolife Solutions, Inc.	Apparatuses and compositions for cryopreservation of cellular monolayers
US20140328766A1 (en) *	2010-08-24	2014-11-06	Ge Healthcare Limited	Composition and method for generating a metabolic profile using 13c-mr detection
JP5867893B2 (ja) *	2010-09-14	2016-02-24	株式会社ミツヤコーポレーション	凍結方法
WO2012138944A1 (en) *	2011-04-06	2012-10-11	Celltronix	Method and scalable devices for hyper-fast cooling
US9534992B2 (en) *	2011-05-18	2017-01-03	Biocision, Llc	Ventilation assisted passive cell freezing device
DE102011108251A1 (de) *	2011-07-22	2013-01-24	Gottfried Wilhelm Leibniz Universität Hannover, Körperschaft des öffentlichen Rechts	Verfahren zum Induzieren der Nukleation in einer Probe und System hierfür
WO2014160000A1 (en) *	2013-03-13	2014-10-02	Stratatech Corporation	Cryopreservation of viable human skin substitutes
US10544387B2 (en) *	2013-03-27	2020-01-28	Biostage, Inc.	Bioreactors and uses thereof
JP6573363B2 (ja) *	2015-03-27	2019-09-11	国立大学法人東北大学	凍結装置、凍結方法
RU2650888C1 (ru) *	2017-04-23	2018-04-18	Федеральное государственное автономное образовательное учреждение высшего образования "Северо-Восточный федеральный университет имени М.К.Аммосова"	Способ криогенной обработки семян растений
GB201716729D0 (en)	2017-10-12	2017-11-29	Asymptote Ltd	Cryopreservation method and apparatus
US11352262B2 (en)	2017-12-18	2022-06-07	Praxair Technology, Inc.	Methods for automatic filling, charging and dispensing carbon dioxide snow block
EP3846634B1 (en) *	2018-09-06	2023-12-20	The Coca-Cola Company	Supercooled beverage nucleation and ice crystal formation using a high-pressure gas
CN110596227B (zh) *	2019-08-08	2021-11-23	河北省食品检验研究院（国家果类及农副加工产品质量监督检验中心、河北省食品安全实验室）	飞行时间质谱即用型斯坦利沙门氏菌定性标准样品的制备方法
WO2021083648A1 (en)	2019-10-30	2021-05-06	Liconic Ag	High-efficiency low-temperature storage device
FI129124B (en) *	2020-01-23	2021-07-30	Acoustic Extra Freezing Oy	Device and method for controllable growth of crystals in a process of freezing
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1996
- 1996-01-30 US US08/593,587 patent/US5689961A/en not_active Expired - Lifetime
1997
- 1997-01-30 JP JP52786597A patent/JP4080534B2/ja not_active Expired - Fee Related
- 1997-01-30 ES ES97904153T patent/ES2276419T3/es not_active Expired - Lifetime
- 1997-01-30 DE DE69737109T patent/DE69737109T2/de not_active Expired - Lifetime
- 1997-01-30 EP EP06025552A patent/EP1763997A3/en not_active Withdrawn
- 1997-01-30 AU AU18520/97A patent/AU1852097A/en not_active Abandoned
- 1997-01-30 WO PCT/US1997/001619 patent/WO1997028402A1/en not_active Ceased
- 1997-01-30 US US09/117,412 patent/US6167710B1/en not_active Expired - Fee Related
- 1997-01-30 AT AT97904153T patent/ATE348289T1/de not_active IP Right Cessation
- 1997-01-30 EP EP97904153A patent/EP1012499B1/en not_active Expired - Lifetime
2001
- 2001-01-02 US US09/753,168 patent/US6347525B2/en not_active Expired - Fee Related
2007
- 2007-12-05 JP JP2007314892A patent/JP4693834B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1012499A4 (en)	2000-07-05
EP1763997A2 (en)	2007-03-21
JP4080534B2 (ja)	2008-04-23
US6347525B2 (en)	2002-02-19
JP2000505872A (ja)	2000-05-16
US20010000848A1 (en)	2001-05-10
ATE348289T1 (de)	2007-01-15
AU1852097A (en)	1997-08-22
JP2008067719A (ja)	2008-03-27
DE69737109T2 (de)	2007-07-12
US5689961A (en)	1997-11-25
EP1012499A1 (en)	2000-06-28
EP1012499B1 (en)	2006-12-13
EP1763997A3 (en)	2007-04-04
WO1997028402A1 (en)	1997-08-07
DE69737109D1 (de)	2007-01-25
JP4693834B2 (ja)	2011-06-01
US6167710B1 (en)	2001-01-02

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