ES2299178T3 - Profarmacos de productos farmaceuticos con una biodisponibilidad mejorada. - Google Patents

Profarmacos de productos farmaceuticos con una biodisponibilidad mejorada. Download PDF

Info

Publication number: ES2299178T3
Authority: ES; Spain
Prior art keywords: compound; group; octadecyl; mixture; alkyl
Prior art date: 1995-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES96919361T

Other languages

English (en)

Spanish (es)

Inventor

Karl Y. Hostetler

Ganesh D. Kini

James R. Beadle

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-07

Publication date

2008-05-16

1996-06-07 Application filed by Individual filed Critical Individual

2008-05-16 Application granted granted Critical

2008-05-16 Publication of ES2299178T3 publication Critical patent/ES2299178T3/es

2016-06-07 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

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230000000717 retained effect Effects 0.000 description 1
230000001177 retroviral effect Effects 0.000 description 1
229910052711 selenium Inorganic materials 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
238000000527 sonication Methods 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
150000003408 sphingolipids Chemical class 0.000 description 1
239000010959 steel Substances 0.000 description 1
235000003702 sterols Nutrition 0.000 description 1
150000003432 sterols Chemical class 0.000 description 1
239000012258 stirred mixture Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical class CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical compound O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 1
229960002317 succinimide Drugs 0.000 description 1
238000003239 susceptibility assay Methods 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
CVYZCIFAHYJSCQ-UHFFFAOYSA-N trifluoro(diphenyl)-$l^{5}-phosphane Chemical compound C=1C=CC=CC=1P(F)(F)(F)C1=CC=CC=C1 CVYZCIFAHYJSCQ-UHFFFAOYSA-N 0.000 description 1
IIYTXTQVIDHSSL-UHFFFAOYSA-N trimethylsilylmethanethiol Chemical compound C[Si](C)(C)CS IIYTXTQVIDHSSL-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
DFHAXXVZCFXGOQ-UHFFFAOYSA-K trisodium phosphonoformate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)P([O-])([O-])=O DFHAXXVZCFXGOQ-UHFFFAOYSA-K 0.000 description 1
238000005866 tritylation reaction Methods 0.000 description 1
238000002211 ultraviolet spectrum Methods 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
201000001862 viral hepatitis Diseases 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/098—Esters of polyphosphoric acids or anhydrides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4062—Esters of acids containing the structure -C(=X)-P(=X)(XR)2 or NC-P(=X)(XR)2, (X = O, S, Se)
- C07F9/4065—Esters of acids containing the structure -C(=X)-P(=X)(XR)2, (X = O, S, Se)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Crystallography & Structural Chemistry (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dispersion Chemistry (AREA)
Biophysics (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ES96919361T 1995-06-07 1996-06-07 Profarmacos de productos farmaceuticos con una biodisponibilidad mejorada. Expired - Lifetime ES2299178T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US487081		1983-04-27
US08/487,081 US7517858B1 (en)	1995-06-07	1995-06-07	Prodrugs of pharmaceuticals with improved bioavailability

Publications (1)

Publication Number	Publication Date
ES2299178T3 true ES2299178T3 (es)	2008-05-16

Family

ID=23934330

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES96919361T Expired - Lifetime ES2299178T3 (es)	1995-06-07	1996-06-07	Profarmacos de productos farmaceuticos con una biodisponibilidad mejorada.

Country Status (9)

Country	Link
US (1)	US7517858B1 (2)
EP (1)	EP0837630B1 (2)
JP (1)	JP4301571B2 (2)
AT (1)	ATE382051T1 (2)
AU (1)	AU711774B2 (2)
CA (1)	CA2223989C (2)
DE (1)	DE69637381T2 (2)
ES (1)	ES2299178T3 (2)
WO (1)	WO1996039831A1 (2)

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WO2014132134A1 (en)	2013-02-28	2014-09-04	Pronova Biopharma Norge As	A composition comprising a lipid compound, a triglyceride, and a surfactant, and methods of using the same
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BR112017005111B1 (pt)	2014-09-15	2023-02-14	The Regents Of The University Of California	Compostos análogos de nucleotídeo acíclico, composição farmacêutica contendo tais compostos, e usos da composição no tratamento de uma infecção por papilomavírus
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1995
- 1995-06-07 US US08/487,081 patent/US7517858B1/en not_active Expired - Fee Related
1996
- 1996-06-07 AT AT96919361T patent/ATE382051T1/de not_active IP Right Cessation
- 1996-06-07 CA CA2223989A patent/CA2223989C/en not_active Expired - Lifetime
- 1996-06-07 JP JP50218097A patent/JP4301571B2/ja not_active Expired - Fee Related
- 1996-06-07 EP EP96919361A patent/EP0837630B1/en not_active Expired - Lifetime
- 1996-06-07 WO PCT/US1996/010054 patent/WO1996039831A1/en not_active Ceased
- 1996-06-07 AU AU61717/96A patent/AU711774B2/en not_active Expired
- 1996-06-07 ES ES96919361T patent/ES2299178T3/es not_active Expired - Lifetime
- 1996-06-07 DE DE69637381T patent/DE69637381T2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69637381D1 (de)	2008-02-07
DE69637381T2 (de)	2008-12-11
AU6171796A (en)	1996-12-30
JP4301571B2 (ja)	2009-07-22
AU711774B2 (en)	1999-10-21
ATE382051T1 (de)	2008-01-15
EP0837630A4 (en)	1998-11-25
CA2223989C (en)	2010-11-23
US7517858B1 (en)	2009-04-14
EP0837630A1 (en)	1998-04-29
JPH11512078A (ja)	1999-10-19
EP0837630B1 (en)	2007-12-26
CA2223989A1 (en)	1996-12-19
WO1996039831A1 (en)	1996-12-19

Publication	Publication Date	Title
ES2299178T3 (es)	2008-05-16	Profarmacos de productos farmaceuticos con una biodisponibilidad mejorada.
ES2217287T3 (es)	2004-11-01	Profarmaco antiviral mejorado.
ES2609095T3 (es)	2017-04-18	Métodos de reducción de la nefrotoxicidad en sujetos a quienes se administra nucleósido
US5484809A (en)	1996-01-16	Prodrugs for oral administration containing taxol or substituted taxol covalently bound to a phospholipid
EP0781138B1 (en)	2008-05-21	Lipid analogs for treating viral infections
JP4782365B2 (ja)	2011-09-28	ウイルス感染症と癌細胞を二重ターゲッティングする組成物及び方法
PT674646E (pt)	2002-03-28	Derivados lipidicos de fosfonoacidos destinados a ser incorporados nos lipossomas e processo de utilizacao
JPH04501255A (ja)	1992-03-05	抗ウィルス性ヌクレオシドの脂質誘導体、リポソームの取込みおよび使用方法
AU784146B2 (en)	2006-02-09	Compositions and methods for double-targeting virus infections and targeting cancer cells
CA2669450C (en)	2016-02-09	Novel nucleotide analogues as percursor molecules for antivirals
ES2230574T3 (es)	2005-05-01	Derivados fosfolipidos de acidos fosfonocarboxilicos, su preparacion, asi como su uso como medicamentos antiviricos.
US20140100186A1 (en)	2014-04-10	Method to improve antiviral activity of nucleotide analogue drugs
Cooperwood	1999	Synthesis of potential anti-HIV agents and prodrugs: Part I synthesis of L-3'-hydroxymethylnucleosides. Part II synthesis and pharmacokinetics of 3'-azido-2', 3'-dideoxyuridine (AZDU) as prodrugs
PT91101B (pt)	1995-01-31	Processo de preparacao de derivados lipidos de nucleosidos antivirais, de suspensoes de lipossomas e de composicoes farmaceuticas