ES2311803T3 - Composiciones embolicas de silicie pirogena. - Google Patents

Composiciones embolicas de silicie pirogena. Download PDF

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Publication number
ES2311803T3
ES2311803T3 ES04715148T ES04715148T ES2311803T3 ES 2311803 T3 ES2311803 T3 ES 2311803T3 ES 04715148 T ES04715148 T ES 04715148T ES 04715148 T ES04715148 T ES 04715148T ES 2311803 T3 ES2311803 T3 ES 2311803T3
Authority
ES
Spain
Prior art keywords
pirogena
silicon
embolic compositions
sterilization
embolic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04715148T
Other languages
English (en)
Inventor
William Robert Patterson
Earl Slee
Ii Thomas J Whalen
Richard J Greff
Meyer R Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micro Therapeutics Inc
Original Assignee
Micro Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Micro Therapeutics Inc filed Critical Micro Therapeutics Inc
Application granted granted Critical
Publication of ES2311803T3 publication Critical patent/ES2311803T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0089—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing inorganic fillers not covered by groups A61L24/0078 or A61L24/0084
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/12—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L31/125—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L31/128—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Composite Materials (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Treatment And Processing Of Natural Fur Or Leather (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Una composición que comprende: (1) un polímero biocompatible insoluble en sangre u otro fluido corporal, (2) un disolvente biocompatible que es capaz de solubilizar el polímero biocompatible y es miscible en sangre u otro fluido corporal, (3) un agente de contraste biocompatible, y (4) una cantidad suficiente de sílice pirógena para actuar como modificador reológico en la composición y conferir un índice de reducción de cizalla a la composición, medido a velocidad de cizalla de 1 s- 1 y 10 s- 1 a 37ºC de al menos 4.
ES04715148T 2003-02-26 2004-02-26 Composiciones embolicas de silicie pirogena. Expired - Lifetime ES2311803T3 (es)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US45028903P 2003-02-26 2003-02-26
US45062603P 2003-02-26 2003-02-26
US45028803P 2003-02-26 2003-02-26
US45122803P 2003-02-27 2003-02-27
US45131003P 2003-02-27 2003-02-27
US46128303P 2003-04-07 2003-04-07
US46128803P 2003-04-07 2003-04-07
US46128903P 2003-04-07 2003-04-07
US46129003P 2003-04-07 2003-04-07
US46117703P 2003-04-07 2003-04-07
PCT/US2004/005994 WO2004075989A1 (en) 2003-02-26 2004-02-26 Fumed silica embolic compositions

Publications (1)

Publication Number Publication Date
ES2311803T3 true ES2311803T3 (es) 2009-02-16

Family

ID=32931806

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04715148T Expired - Lifetime ES2311803T3 (es) 2003-02-26 2004-02-26 Composiciones embolicas de silicie pirogena.

Country Status (6)

Country Link
US (1) US20040224864A1 (es)
EP (1) EP1599258B1 (es)
AT (1) ATE403469T1 (es)
DE (1) DE602004015574D1 (es)
ES (1) ES2311803T3 (es)
WO (1) WO2004075989A1 (es)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
AU2003301405A1 (en) * 2002-10-15 2004-05-04 Microtherapeutics, Inc. Prepolymeric materials for site specific delivery to the body
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
WO2004080503A1 (en) * 2003-03-07 2004-09-23 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels comprising high levels of contrast agent
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8021744B2 (en) 2004-06-18 2011-09-20 Borgwarner Inc. Fully fibrous structure friction material
US8603614B2 (en) 2004-07-26 2013-12-10 Borgwarner Inc. Porous friction material with nanoparticles of friction modifying material
US7429418B2 (en) * 2004-07-26 2008-09-30 Borgwarner, Inc. Porous friction material comprising nanoparticles of friction modifying material
US20060142631A1 (en) * 2004-12-29 2006-06-29 Attila Meretei Systems and methods for occluding a blood vessel
KR101201958B1 (ko) 2005-04-26 2012-11-16 보르그워너 인코퍼레이티드 마찰재
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
JP5043024B2 (ja) 2005-11-02 2012-10-10 ボーグワーナー インコーポレーテッド カーボン摩擦材料
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
EP2027729A2 (en) 2006-06-15 2009-02-25 MicroVention, Inc. Embolization device constructed from expansible polymer
RU2315634C1 (ru) * 2006-08-01 2008-01-27 Андрей Александрович Страхов Способ эмболизации артериовенозных мальформаций головного мозга в условиях общей анестезии и управляемой гипотонии
WO2009086208A2 (en) 2007-12-21 2009-07-09 Microvention, Inc. Hydrogel filaments for biomedical uses
DE102008013907B4 (de) 2008-03-12 2016-03-10 Borgwarner Inc. Reibschlüssig arbeitende Vorrichtung mit mindestens einer Reiblamelle
DE102009030506A1 (de) 2008-06-30 2009-12-31 Borgwarner Inc., Auburn Hills Reibungsmaterialien
US8757077B2 (en) 2009-04-30 2014-06-24 Technip France Spar mooring line sharing method and system
EP2493367B1 (en) 2009-10-26 2019-03-13 Microvention, Inc. Embolization device constructed from expansile polymer
IT1400620B1 (it) 2010-05-13 2013-06-14 Torino Politecnico Cementi ossei compositi iniettabili, osteoinduttivi ed a rilascio di farmaci
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
EP3984556B8 (en) 2012-06-14 2025-07-09 Microvention, Inc. Polymeric treatment compositions
AU2013331439B2 (en) 2012-10-15 2016-05-12 Microvention, Inc. Polymeric treatment compositions
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
CN110433326A (zh) 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation
WO2017069822A2 (en) * 2015-07-20 2017-04-27 The Brigham And Women's Hospital, Inc. Shear-thinning compositions as an intravascular embolic agent
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
WO2019074965A1 (en) 2017-10-09 2019-04-18 Microvention, Inc. EMBOLIC RADIOACTIVE LIQUID

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US5273728A (en) * 1990-09-04 1993-12-28 The Dow Chemical Company Mixed metal layered hydroxide/fumed silica adducts
DK0683809T3 (da) * 1993-02-12 1997-12-15 Cabot Corp Overflademodificeret silica
JP3351595B2 (ja) * 1993-12-22 2002-11-25 株式会社日立製作所 半導体メモリ装置
US5618522A (en) * 1995-01-20 1997-04-08 The Procter & Gamble Company Emulsion compositions
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US5580568A (en) * 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
US5695480A (en) * 1996-07-29 1997-12-09 Micro Therapeutics, Inc. Embolizing compositions
US6645167B1 (en) * 1999-05-21 2003-11-11 Micro Therapeutics, Inc. Methods for embolizing vascular sites with an embolizing composition
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US20050025707A1 (en) * 2003-02-27 2005-02-03 Patterson William R. Fumed silica embolic compositions

Also Published As

Publication number Publication date
ATE403469T1 (de) 2008-08-15
US20040224864A1 (en) 2004-11-11
EP1599258A1 (en) 2005-11-30
EP1599258B1 (en) 2008-08-06
DE602004015574D1 (de) 2008-09-18
WO2004075989A1 (en) 2004-09-10

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