ES2353133T3 - Derivados de esteroides tetracíclicos útiles como moduladores del receptor de progesterona. - Google Patents

Derivados de esteroides tetracíclicos útiles como moduladores del receptor de progesterona. Download PDF

Info

Publication number: ES2353133T3
Authority: ES; Spain
Prior art keywords: group; alkyl; phenyl; compound; pharmaceutically acceptable
Prior art date: 2006-02-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES07757092T

Other languages

English (en)

Spanish (es)

Inventor

Zhihua Sui

Nareshkumar F. Jain

Ningyi Chen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-17

Filing date

2007-02-16

Publication date

2011-02-25

2007-02-16 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2011-02-25 Application granted granted Critical

2011-02-25 Publication of ES2353133T3 publication Critical patent/ES2353133T3/es

Status Active legal-status Critical Current

2027-02-16 Anticipated expiration legal-status Critical

Links

RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims abstract description 35
239000000186 progesterone Substances 0.000 title claims abstract description 18
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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 24
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
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150000001875 compounds Chemical class 0.000 claims description 292
-1 -C1-4alkyl-OH Chemical group 0.000 claims description 82
238000000034 method Methods 0.000 claims description 56
239000000203 mixture Substances 0.000 claims description 51
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 43
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125000001424 substituent group Chemical group 0.000 claims description 30
150000003839 salts Chemical class 0.000 claims description 25
238000002360 preparation method Methods 0.000 claims description 23
230000000694 effects Effects 0.000 claims description 22
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WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 15
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229910052736 halogen Inorganic materials 0.000 claims description 12
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125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 4
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 4
125000004199 4-trifluoromethylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C(F)(F)F 0.000 claims description 4
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims description 4
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238000005160 1H NMR spectroscopy Methods 0.000 description 11
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Gynecology & Obstetrics (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)

ES07757092T 2006-02-17 2007-02-16 Derivados de esteroides tetracíclicos útiles como moduladores del receptor de progesterona. Active ES2353133T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77434806P	2006-02-17	2006-02-17
US774348P		2006-02-17

Publications (1)

Publication Number	Publication Date
ES2353133T3 true ES2353133T3 (es)	2011-02-25

Family

ID=38290140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES07757092T Active ES2353133T3 (es)	2006-02-17	2007-02-16	Derivados de esteroides tetracíclicos útiles como moduladores del receptor de progesterona.

Country Status (15)

Country	Link
US (1)	US7390831B2 (de)
EP (1)	EP1996571B1 (de)
JP (1)	JP5230451B2 (de)
CN (1)	CN101421261B (de)
AT (1)	ATE485286T1 (de)
AU (1)	AU2007217097B2 (de)
CA (1)	CA2642763A1 (de)
CY (1)	CY1111110T1 (de)
DE (1)	DE602007009945D1 (de)
DK (1)	DK1996571T3 (de)
ES (1)	ES2353133T3 (de)
PL (1)	PL1996571T3 (de)
PT (1)	PT1996571E (de)
SI (1)	SI1996571T1 (de)
WO (1)	WO2007098384A2 (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2077752B1 (de) *	1970-02-11	1973-03-16	Roussel Uclaf

2007
- 2007-02-16 EP EP07757092A patent/EP1996571B1/de not_active Not-in-force
- 2007-02-16 AT AT07757092T patent/ATE485286T1/de active
- 2007-02-16 CN CN2007800135609A patent/CN101421261B/zh not_active Expired - Fee Related
- 2007-02-16 PT PT07757092T patent/PT1996571E/pt unknown
- 2007-02-16 JP JP2008555507A patent/JP5230451B2/ja not_active Expired - Fee Related
- 2007-02-16 AU AU2007217097A patent/AU2007217097B2/en not_active Expired - Fee Related
- 2007-02-16 DK DK07757092.7T patent/DK1996571T3/da active
- 2007-02-16 CA CA002642763A patent/CA2642763A1/en not_active Abandoned
- 2007-02-16 DE DE602007009945T patent/DE602007009945D1/de active Active
- 2007-02-16 SI SI200730467T patent/SI1996571T1/sl unknown
- 2007-02-16 ES ES07757092T patent/ES2353133T3/es active Active
- 2007-02-16 PL PL07757092T patent/PL1996571T3/pl unknown
- 2007-02-16 WO PCT/US2007/062280 patent/WO2007098384A2/en not_active Ceased
- 2007-02-16 US US11/675,665 patent/US7390831B2/en not_active Expired - Fee Related
2011
- 2011-01-14 CY CY20111100046T patent/CY1111110T1/el unknown

Also Published As

Publication number	Publication date
SI1996571T1 (sl)	2011-02-28
AU2007217097B2 (en)	2012-12-06
CN101421261A (zh)	2009-04-29
DE602007009945D1 (de)	2010-12-02
CY1111110T1 (el)	2015-06-11
US20070197634A1 (en)	2007-08-23
DK1996571T3 (da)	2011-02-07
US7390831B2 (en)	2008-06-24
PL1996571T3 (pl)	2011-04-29
JP2009527492A (ja)	2009-07-30
JP5230451B2 (ja)	2013-07-10
EP1996571A2 (de)	2008-12-03
WO2007098384A2 (en)	2007-08-30
HK1126475A1 (en)	2009-09-04
ATE485286T1 (de)	2010-11-15
WO2007098384A3 (en)	2007-10-04
PT1996571E (pt)	2010-12-07
AU2007217097A1 (en)	2007-08-30
CN101421261B (zh)	2013-01-23
CA2642763A1 (en)	2007-08-30
EP1996571B1 (de)	2010-10-20

Publication	Publication Date	Title
ES2337521T3 (es)	2010-04-26	Derivados esteroides 17-fosforados utilizados como moduladores del receptor de la progesterona.
ES2388752T3 (es)	2012-10-18	Derivados esteroideos 11-fosforosos útiles como moduladores del receptor de progesterona
US7981927B2 (en)	2011-07-19	Steroids derivatives as selective progesterone receptor modulators
EP1996571B1 (de)	2010-10-20	Tetracyclische steroidderivate als progesteron-rezeptormodulatoren
ES2389113T3 (es)	2012-10-23	Derivados de oxa-esteroides como moduladores selectivos del receptor de progesterona
HK1126475B (en)	2011-07-15	Tetracyclic steroid derivatives useful as progesterone receptor modulators
HK1131974A (en)	2010-02-12	Tetracyclic steroid derivatives useful as progesterone receptor modulators
HK1131787B (en)	2012-10-19	Oxa-steroids derivatives as selective progesterone receptor modulators