ES2354756T3 - Piperidinilamino-piridazinas y su utilización como antagonistas de disociación rápida del receptor 2 de la dopamina. - Google Patents

Piperidinilamino-piridazinas y su utilización como antagonistas de disociación rápida del receptor 2 de la dopamina. Download PDF

Info

Publication number: ES2354756T3
Authority: ES; Spain
Prior art keywords: disorder; piperidin; benzyl; formula; pyridazine
Prior art date: 2006-12-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES07847833T

Other languages

English (en)

Spanish (es)

Inventor

Gregor James Macdonald

José Ignacio Andrés-Gil

Frans Alfons Maria Van Den Keybus

José Manuel Bartolomé-Nebreda

Michiel Luc Maria Van Gool

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Janssen Pharmaceutica NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-08

Filing date

2007-12-05

Publication date

2011-03-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37964744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2354756(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-12-05 Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV

2011-03-17 Application granted granted Critical

2011-03-17 Publication of ES2354756T3 publication Critical patent/ES2354756T3/es

Status Active legal-status Critical Current

2027-12-05 Anticipated expiration legal-status Critical

Links

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NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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238000002483 medication Methods 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000003020 moisturizing effect Effects 0.000 description 1
YAQYQDHHCXSWOO-UHFFFAOYSA-N n-(1-benzylpiperidin-4-yl)-6-phenylpyridazin-3-amine Chemical compound C=1C=CC=CC=1CN(CC1)CCC1NC(N=N1)=CC=C1C1=CC=CC=C1 YAQYQDHHCXSWOO-UHFFFAOYSA-N 0.000 description 1
DUWWHGPELOTTOE-UHFFFAOYSA-N n-(5-chloro-2,4-dimethoxyphenyl)-3-oxobutanamide Chemical compound COC1=CC(OC)=C(NC(=O)CC(C)=O)C=C1Cl DUWWHGPELOTTOE-UHFFFAOYSA-N 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
239000002858 neurotransmitter agent Substances 0.000 description 1
239000002547 new drug Substances 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
125000005246 nonafluorobutyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 description 1
230000009871 nonspecific binding Effects 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
239000002674 ointment Substances 0.000 description 1
229960005017 olanzapine Drugs 0.000 description 1
KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
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WLJNZVDCPSBLRP-UHFFFAOYSA-N pamoic acid Chemical compound C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 WLJNZVDCPSBLRP-UHFFFAOYSA-N 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000003961 penetration enhancing agent Substances 0.000 description 1
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230000000144 pharmacologic effect Effects 0.000 description 1
BCIIMDOZSUCSEN-UHFFFAOYSA-N piperidin-4-amine Chemical compound NC1CCNCC1 BCIIMDOZSUCSEN-UHFFFAOYSA-N 0.000 description 1
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
KBOGICFUPOMDKS-UHFFFAOYSA-N piperidin-4-ylcarbamic acid Chemical compound OC(=O)NC1CCNCC1 KBOGICFUPOMDKS-UHFFFAOYSA-N 0.000 description 1
150000003053 piperidines Chemical class 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
235000019260 propionic acid Nutrition 0.000 description 1
238000000159 protein binding assay Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
208000020016 psychiatric disease Diseases 0.000 description 1
230000000506 psychotropic effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
LETVJWLLIMJADE-UHFFFAOYSA-N pyridazin-3-amine Chemical class NC1=CC=CN=N1 LETVJWLLIMJADE-UHFFFAOYSA-N 0.000 description 1
PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 description 1
125000000714 pyrimidinyl group Chemical group 0.000 description 1
229940107700 pyruvic acid Drugs 0.000 description 1
229960004431 quetiapine Drugs 0.000 description 1
URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 description 1
230000005855 radiation Effects 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
229960001534 risperidone Drugs 0.000 description 1
RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
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239000003549 soybean oil Substances 0.000 description 1
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230000009870 specific binding Effects 0.000 description 1
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230000000707 stereoselective effect Effects 0.000 description 1
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239000008223 sterile water Substances 0.000 description 1
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235000000346 sugar Nutrition 0.000 description 1
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239000000829 suppository Substances 0.000 description 1
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238000007910 systemic administration Methods 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ES07847833T 2006-12-08 2007-12-05 Piperidinilamino-piridazinas y su utilización como antagonistas de disociación rápida del receptor 2 de la dopamina. Active ES2354756T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06125685		2006-12-08
EP06125685		2006-12-08

Publications (1)

Publication Number	Publication Date
ES2354756T3 true ES2354756T3 (es)	2011-03-17

Family

ID=37964744

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES07847833T Active ES2354756T3 (es)	2006-12-08	2007-12-05	Piperidinilamino-piridazinas y su utilización como antagonistas de disociación rápida del receptor 2 de la dopamina.

Country Status (28)

Country	Link
US (1)	US8466153B2 (pt)
EP (1)	EP2091938B1 (pt)
JP (1)	JP5255568B2 (pt)
KR (1)	KR101468384B1 (pt)
CN (1)	CN101547915B (pt)
AR (1)	AR064198A1 (pt)
AT (1)	ATE486070T1 (pt)
AU (1)	AU2007328897B2 (pt)
BR (1)	BRPI0720247A2 (pt)
CA (1)	CA2665924C (pt)
CL (1)	CL2007003556A1 (pt)
CY (1)	CY1112227T1 (pt)
DE (1)	DE602007010179D1 (pt)
DK (1)	DK2091938T3 (pt)
EA (1)	EA016654B1 (pt)
ES (1)	ES2354756T3 (pt)
IL (1)	IL199076A (pt)
JO (1)	JO2642B1 (pt)
MX (1)	MX2009005983A (pt)
MY (1)	MY148772A (pt)
NO (1)	NO20092574L (pt)
NZ (1)	NZ576484A (pt)
PL (1)	PL2091938T3 (pt)
PT (1)	PT2091938E (pt)
SI (1)	SI2091938T1 (pt)
TW (1)	TWI433676B (pt)
UA (1)	UA98940C2 (pt)
WO (1)	WO2008068277A1 (pt)

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2007
- 2007-11-19 JO JO2007479A patent/JO2642B1/en active
- 2007-12-05 CN CN2007800446538A patent/CN101547915B/zh active Active
- 2007-12-05 EP EP07847833A patent/EP2091938B1/en active Active
- 2007-12-05 DE DE602007010179T patent/DE602007010179D1/de active Active
- 2007-12-05 PT PT07847833T patent/PT2091938E/pt unknown
- 2007-12-05 AU AU2007328897A patent/AU2007328897B2/en not_active Ceased
- 2007-12-05 SI SI200730472T patent/SI2091938T1/sl unknown
- 2007-12-05 BR BRPI0720247-4A patent/BRPI0720247A2/pt active Search and Examination
- 2007-12-05 MX MX2009005983A patent/MX2009005983A/es active IP Right Grant
- 2007-12-05 CA CA2665924A patent/CA2665924C/en active Active
- 2007-12-05 UA UAA200903503A patent/UA98940C2/ru unknown
- 2007-12-05 WO PCT/EP2007/063338 patent/WO2008068277A1/en not_active Ceased
- 2007-12-05 NZ NZ576484A patent/NZ576484A/en not_active IP Right Cessation
- 2007-12-05 AT AT07847833T patent/ATE486070T1/de active
- 2007-12-05 US US12/516,645 patent/US8466153B2/en active Active
- 2007-12-05 EA EA200970553A patent/EA016654B1/ru not_active IP Right Cessation
- 2007-12-05 ES ES07847833T patent/ES2354756T3/es active Active
- 2007-12-05 MY MYPI20092235A patent/MY148772A/en unknown
- 2007-12-05 PL PL07847833T patent/PL2091938T3/pl unknown
- 2007-12-05 DK DK07847833.6T patent/DK2091938T3/da active
- 2007-12-05 KR KR1020097010872A patent/KR101468384B1/ko not_active Expired - Fee Related
- 2007-12-05 JP JP2009539743A patent/JP5255568B2/ja active Active
- 2007-12-07 TW TW096146645A patent/TWI433676B/zh not_active IP Right Cessation
- 2007-12-07 CL CL200703556A patent/CL2007003556A1/es unknown
- 2007-12-07 AR ARP070105498A patent/AR064198A1/es unknown
2009
- 2009-06-02 IL IL199076A patent/IL199076A/en active IP Right Grant
- 2009-07-07 NO NO20092574A patent/NO20092574L/no not_active Application Discontinuation
2011
- 2011-01-27 CY CY20111100088T patent/CY1112227T1/el unknown

Also Published As

Publication number	Publication date
EA016654B1 (ru)	2012-06-29
DE602007010179D1 (de)	2010-12-09
AR064198A1 (es)	2009-03-18
PT2091938E (pt)	2011-01-20
IL199076A (en)	2012-12-31
WO2008068277A1 (en)	2008-06-12
SI2091938T1 (sl)	2011-02-28
US20100076187A1 (en)	2010-03-25
DK2091938T3 (da)	2011-02-07
CN101547915B (zh)	2013-08-21
BRPI0720247A2 (pt)	2013-12-31
CY1112227T1 (el)	2015-12-09
EA200970553A1 (ru)	2009-10-30
CL2007003556A1 (es)	2008-06-13
CA2665924C (en)	2014-08-12
TW200831098A (en)	2008-08-01
NZ576484A (en)	2010-10-29
CA2665924A1 (en)	2008-06-12
JP2010511673A (ja)	2010-04-15
HK1137434A1 (en)	2010-07-30
JO2642B1 (en)	2012-06-17
AU2007328897B2 (en)	2013-01-10
ATE486070T1 (de)	2010-11-15
US8466153B2 (en)	2013-06-18
MY148772A (en)	2013-05-31
KR101468384B1 (ko)	2014-12-03
CN101547915A (zh)	2009-09-30
UA98940C2 (ru)	2012-07-10
EP2091938B1 (en)	2010-10-27
AU2007328897A1 (en)	2008-06-12
JP5255568B2 (ja)	2013-08-07
EP2091938A1 (en)	2009-08-26
TWI433676B (zh)	2014-04-11
PL2091938T3 (pl)	2011-04-29
NO20092574L (no)	2009-09-08
MX2009005983A (es)	2009-06-16
KR20090089858A (ko)	2009-08-24

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AU2008240727B2 (en)	2013-03-21	Pyridine derivatives as fast dissociating dopamine 2 receptor antagonists
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