ES2354976T3 - Fosfatasa alcalina placentaria para controlar la diabetes. - Google Patents

Fosfatasa alcalina placentaria para controlar la diabetes. Download PDF

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Publication number
ES2354976T3
ES2354976T3 ES03796758T ES03796758T ES2354976T3 ES 2354976 T3 ES2354976 T3 ES 2354976T3 ES 03796758 T ES03796758 T ES 03796758T ES 03796758 T ES03796758 T ES 03796758T ES 2354976 T3 ES2354976 T3 ES 2354976T3
Authority
ES
Spain
Prior art keywords
palp
glucose
human
active derivative
physiologically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03796758T
Other languages
English (en)
Spanish (es)
Inventor
Zoltan Kiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ZOLTAN LAB
ZOLTAN LABORATORIES
Original Assignee
ZOLTAN LAB
ZOLTAN LABORATORIES
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZOLTAN LAB, ZOLTAN LABORATORIES filed Critical ZOLTAN LAB
Application granted granted Critical
Publication of ES2354976T3 publication Critical patent/ES2354976T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
    • C12Y301/03001—Alkaline phosphatase (3.1.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES03796758T 2002-12-12 2003-12-05 Fosfatasa alcalina placentaria para controlar la diabetes. Expired - Lifetime ES2354976T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US441992 1989-11-28
US10/317,916 US7048914B2 (en) 2002-12-12 2002-12-12 Placental alkaline phosphatase to control diabetes
US317916 2002-12-12

Publications (1)

Publication Number Publication Date
ES2354976T3 true ES2354976T3 (es) 2011-03-21

Family

ID=32506246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03796758T Expired - Lifetime ES2354976T3 (es) 2002-12-12 2003-12-05 Fosfatasa alcalina placentaria para controlar la diabetes.

Country Status (6)

Country Link
US (4) US7048914B2 (de)
EP (1) EP1733734B1 (de)
AT (1) ATE480256T1 (de)
DE (1) DE60334147D1 (de)
DK (1) DK1572230T3 (de)
ES (1) ES2354976T3 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003298036A1 (en) * 2002-12-12 2004-07-09 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
US7048914B2 (en) * 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
EP1696859A4 (de) * 2003-12-09 2007-08-22 Essential Skincare Llc Verfahren zur verbesserung der insulinsensitivität durch verabreichung eines antitrypsin-hemmers
AU2005210581B2 (en) 2004-02-04 2010-06-24 Am-Pharma B.V. Use of alkaline phosphatase for the detoxification of LPS present at mucosal barriers
US20110142817A1 (en) * 2004-02-04 2011-06-16 Pharmaaware Sepsis B.V. Means and method for treating and/or preventing necrotizing enterocolitis
EP1753446A4 (de) * 2004-05-27 2009-10-28 Essential Skincare Llc Alpha-1-säure-glykoprotein zur behandlung von diabetes
EP1988917A4 (de) * 2005-12-28 2009-08-19 Zoltan Lab Llc Zusammensetzungen und verfahren zur verstärkung der lebensfähigkeit und funktion von inselzellen
US20070149440A1 (en) * 2005-12-28 2007-06-28 Essential Skincare, Llc Transferrin and transferrin-based compositions for diabetes treatment
EP1965830B1 (de) * 2005-12-28 2014-05-14 Zoltan Laboratories Llc Verwendung von alkalischer phosphatase zur erhaltung von gesunder gewebemasse bei säugetieren
EP1952823A1 (de) * 2007-01-30 2008-08-06 AM-Pharma B.V. Verwendung von alkalischer Phosphatase bei der Behandlung eingeschränkter Nierenfunktion
US20090317372A1 (en) * 2008-06-20 2009-12-24 Zoltan Kiss Small molecules for the reduction of high blood glucose level
JP2010031006A (ja) * 2008-07-17 2010-02-12 Novartis Ag 有機化合物の使用
US20100215635A1 (en) * 2009-02-23 2010-08-26 Zoltan Kiss Small molecules to induce weight loss or to reduce weight gain
US20130251701A1 (en) * 2010-10-22 2013-09-26 Zoltan Kiss Consulting Alkaline phosphatase to correct insulin resistance, hyperinsulinemia, and dyslipidemia
WO2012177497A1 (en) * 2011-06-20 2012-12-27 Wisconsin Alumni Research Foundation Method to inhibit neuropathic pain by intrathecal injection of protein phosphatases
WO2015112017A1 (en) 2014-01-24 2015-07-30 Am-Pharma B.V. Chimeric alkaline phosphatase-like proteins
DK3461891T3 (da) 2014-01-24 2020-08-10 Am-Pharma Bv Nedstrømsbehandling af en alkalisk phosphatase
US10709773B2 (en) 2015-03-06 2020-07-14 Synthetic Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
WO2018175413A1 (en) 2017-03-21 2018-09-27 Synthetic Biologics, Inc. Alkaline phosphatase formulations
AU2019207600B2 (en) 2018-01-09 2025-01-09 Theriva Biologics, Inc. Alkaline phosphatase agents for treatment of neurodevelopmental disorders
EP3768302B1 (de) 2018-03-20 2025-05-07 Theriva Biologics, Inc. Intestinale alkalische phosphataseformulierungen
EP4275761A3 (de) 2018-03-20 2024-02-28 Theriva Biologics, Inc. Alkalische phosphatasemittel zur behandlung von bestrahlungsstörungen
WO2020227263A1 (en) 2019-05-06 2020-11-12 Synthetic Biologics, Inc. Alkaline phosphate-based oncology treatments
EP3975999A4 (de) 2019-06-03 2023-07-19 Theriva Biologics, Inc. Alkalische phosphataseformulierungen und ihre verwendungen
ES3024384T3 (en) 2019-07-18 2025-06-04 Theriva Biologics Inc Intestinal alkaline phosphatase-based treatments of metabolic disorders
WO2022150034A1 (en) * 2021-01-06 2022-07-14 Zoltan Laboratories, Llc Placental alkaline phosphatase for starting early treatment of cancer patients exhibiting no detectable loss of body and muscle weight as yet to prevent or reduce the loss of muscle proteins
US20240165209A1 (en) * 2021-02-16 2024-05-23 Zoltan Laboratories, Llc Placental alkaline phosphatase for reducing the loss of red blood cells, white blood cells, and platelets in chemotherapy treated cancer patients

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4030995A (en) 1976-07-13 1977-06-21 Sigma Chemical Company Alkaline phosphatase isoenzyme determination
GB1594389A (en) 1977-06-03 1981-07-30 Max Planck Gesellschaft Dressing material for wounds
IT1108964B (it) 1978-01-20 1985-12-16 Sclavo Inst Sieroterapeut Composizione adatta all'analisi della fosfatasi alcalina e metodo utilizzante la stessa
US4265233A (en) 1978-04-12 1981-05-05 Unitika Ltd. Material for wound healing
DE3007226A1 (de) 1980-02-27 1981-09-10 Erich 2400 Lübeck Hofacker Arzneikapsel
SU1138410A1 (ru) 1982-09-10 1985-02-07 Астраханский государственный медицинский институт им.А.В.Луначарского Способ выделени термостабильной плацентарной щелочной фосфатазы
US4818540A (en) 1985-02-25 1989-04-04 Rutgers, The State University Of New Jersey Transdermal fertility control system and process
JPS61277626A (ja) 1985-05-31 1986-12-08 Sugiura Shinyaku Kaihatsu Kenkyusho:Kk ス−パ−オキシドジスムタ−ゼを高濃度に含有する胎盤エキスおよびその製法
DE3836971C1 (de) 1988-10-31 1990-05-17 Weck, Wolfgang, Dr.Med., 6990 Bad Mergentheim, De
JPH05506673A (ja) 1991-02-22 1993-09-30 アムジエン・インコーポレーテツド 迅速な創傷の治癒を促進するためのgm―csf及びg―csfの使用
JPH08501203A (ja) 1992-06-03 1996-02-13 ケイス・ウエスタン・リザーブ・ユニバーシティー 生理活性物質を連続的に適用するための包帯
AU4835693A (en) * 1993-08-13 1995-03-14 Rijksuniversiteit Te Groningen Pharmaceutical composition comprising phosphatase or a derivative thereof
US5707624A (en) 1994-06-03 1998-01-13 The Regents Of The University Of Michigan Treatment of Kaposi's sarcoma by inhibition of scatter factor
US5932779A (en) 1996-06-10 1999-08-03 Millennium Pharmaceuticals, Inc. Screening methods for compounds useful in the regulation of body weight
US6005000A (en) 1996-08-22 1999-12-21 Oxis International, Inc. 5,5-Disubstituted-3, 4-dihydroxy-2(5H)-furanones and methods of use therefor
US6414036B1 (en) 1999-09-01 2002-07-02 Van Beek Global/Ninkov Llc Composition for treatment of infections of humans and animals
US6627425B1 (en) 2000-06-02 2003-09-30 Millennium Pharmaceuticals, Inc. Human glucose-6-phosphatase molecules and uses thereof
US7011965B2 (en) 2001-03-09 2006-03-14 Regents Of The University Of Minnesota Compositions and methods for stimulating wound healing and fibroblast proliferation
AU2003298036A1 (en) 2002-12-12 2004-07-09 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
US7048914B2 (en) 2002-12-12 2006-05-23 Zoltan Laboratories Placental alkaline phosphatase to control diabetes
US7374754B2 (en) 2003-09-02 2008-05-20 Essential Skincare, Llc Use of placental alkaline phosphatase to promote skin cell proliferation
EP1965830B1 (de) 2005-12-28 2014-05-14 Zoltan Laboratories Llc Verwendung von alkalischer phosphatase zur erhaltung von gesunder gewebemasse bei säugetieren

Also Published As

Publication number Publication date
US20110123513A1 (en) 2011-05-26
US20040115185A1 (en) 2004-06-17
DK1572230T3 (da) 2011-01-03
EP1733734A3 (de) 2011-09-28
US7858085B2 (en) 2010-12-28
US7014852B2 (en) 2006-03-21
US20040120940A1 (en) 2004-06-24
DE60334147D1 (de) 2010-10-21
US20090130080A1 (en) 2009-05-21
EP1733734A2 (de) 2006-12-20
EP1733734B1 (de) 2020-01-22
US7048914B2 (en) 2006-05-23
ATE480256T1 (de) 2010-09-15
US8603464B2 (en) 2013-12-10

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