ES2375350T3 - Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo. - Google Patents
Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo. Download PDFInfo
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- ES2375350T3 ES2375350T3 ES02002043T ES02002043T ES2375350T3 ES 2375350 T3 ES2375350 T3 ES 2375350T3 ES 02002043 T ES02002043 T ES 02002043T ES 02002043 T ES02002043 T ES 02002043T ES 2375350 T3 ES2375350 T3 ES 2375350T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/58—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2003—Alcohols; Phenols
- C11D3/2041—Dihydric alcohols
- C11D3/2044—Dihydric alcohols linear
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- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
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- C—CHEMISTRY; METALLURGY
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- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/20—Organic compounds containing oxygen
- C11D3/2075—Carboxylic acids-salts thereof
- C11D3/2082—Polycarboxylic acids-salts thereof
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/24—Organic compounds containing halogen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/34—Organic compounds containing sulfur
- C11D3/3418—Toluene -, xylene -, cumene -, benzene - or naphthalene sulfonates or sulfates
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/261—Alcohols; Phenols
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/26—Organic compounds containing oxygen
- C11D7/265—Carboxylic acids or salts thereof
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/28—Organic compounds containing halogen
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D7/00—Compositions of detergents based essentially on non-surface-active compounds
- C11D7/22—Organic compounds
- C11D7/34—Organic compounds containing sulfur
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
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- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/144—Alcohols; Metal alcoholates
- D06M13/148—Polyalcohols, e.g. glycerol or glucose
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- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/152—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen having a hydroxy group bound to a carbon atom of a six-membered aromatic ring
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- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/165—Ethers
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- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
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- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
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- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/10—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing oxygen
- D06M13/184—Carboxylic acids; Anhydrides, halides or salts thereof
- D06M13/203—Unsaturated carboxylic acids; Anhydrides, halides or salts thereof
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Abstract
Una formulación líquida concentrada (b) que comprende (b1) 10 a 25% en peso de un ingrediente microbicidamente activo de fórmula en donde Y es cloro o bromo, Z es SO2H, NO2 o alquilo C1-C4, r es 0 a 3, o es 0 a 3, p es 0 o 1, m es 0 o 1 y n es 0 o 1, (b2) 10 a 70% en peso de cumenosulfonato, (b3) 10 a 50% en peso de ácido láctico, (b4) 5 a 75% en peso de 1,2-propanodiol y agua hasta completar el 100%.
Description
Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo
La presente invención se refiere a formulaciones líquidas que comprenden ingredientes microbicidamente activos, al uso de estas formulaciones como ingrediente farmacológicamente activo en productos cosméticos, artículos de uso 5 doméstico o desinfectantes para las manos, y al uso como conservantes en artículos de uso doméstico y productos cosméticos.
La US-A-5.403.864 describe una composición antimicrobiana que comprende de 0,5 a 3,0% en peso aproximadamente de triclosan, de 0,5 a 2,0% en peso aproximadamente de cloroxifenol y de 40 a 70% en peso aproximadamente de un alcohol.
10 La EP-A-0.259.249 describe preparados y usos de los mismos para la desinfección de piel y manos. La referencia describe que los hidroxibifeniléteres halogenados con considerados como no solubles en cantidades proporcionalmente pequeñas de etanol, propanol, isopropanol o propilenglicol.
La WO 93/07250 describe una composición de limpieza antiséptica que comprende un alcanol y un concentrado acuoso de un surfactante. La composición puede también comprender un biocida. El surfactante es un componente
15 esencial en esta composición.
La WO 96/06152 describe formulaciones de jabón surfactantes que comprenden (a) 0,01 a 0,2% en peso de una sustancia activa microbicida, (b) 0,1 a 7,5% en peso de uno o más de un agente hidrotrópico, (c) 0 a 2% en peso de uno o más de una sustancia surfactante sintética o de un jabón o de una combinación de dichas sustancias y/o una sal de un ácido graso C8-C22 saturado y/o insaturado; (d) 0 a 10% en peso de un alcohol dihídrico; (e) 0 a 70% en
20 peso de un alcohol monohídrico; y (f) agua de la red o agua desionizada para completar el 100%.
La CH 604523 describe una formulación antimicrobiana sinérgica que comprende o-hidroxidifeniléter, un surfactante solubilizante y opcionalmente un disolvente tal como agua.
La presente invención se refiere a formulaciones líquidas concentradas (b) que comprenden
(b1) 10 a 25% en peso de un ingrediente microbicidamente activo de fórmula (1)
en donde
Y es cloro o bromo,
Z es SO2H, NO2 o alquilo C1-C4,
r es 0 a 3, 30 o es 0 a 3,
p es 0 o 1,
m es 0 o 1 y
n es 0 o 1,
(b2) 10 a 70% en peso de cumenosulfonato, 35 (b3) 10 a 50% en peso de ácido láctico,
(b4) 5 a 75% en peso de 1,2-propanodiol y
agua hasta completar el 100%.
Compuestos especialmente interesantes de fórmula (1) son aquellos en donde
Y es cloro o bromo,
5 m es 0,
n es 0 o 1,
o es 1 o 2,
r es 1 o 2 y
p es 0.
10 Compuestos muy especialmente interesantes de fórmula (1) son aquellos en donde Y es cloro, m es 0, n es 0,
o es 1,
15 r es 2 y p es 0. Muy especialmente preferido es el compuesto de fórmula
El ácido láctico, que se emplea de acuerdo con la invención, puede también emplearse preferentemente en forma de 20 sus sales de metales alcalinos o sales amónicas solubles en agua.
Las formulaciones líquidas de acuerdo con la invención se emplean como ingrediente activo en productos cosméticos, por ejemplo desodorantes, limpiadores, lociones/cremas, en artículos de uso doméstico, por ejemplo como un aditivo en líquidos de lavado, detergentes líquidos de uso doméstico; como un aditivo en productos para la higiene dental, por ejemplo en colutorios o pastas de dientes, o como un ingrediente antimicrobialmente activo para
25 superficies duras y blandas, por ejemplo polímeros, papel, textiles y, en particular, la piel humana.
Las formulaciones líquidas de acuerdo con la invención son además también adecuadas como conservantes para productos cosméticos y artículos de uso doméstico.
Igualmente, también son útiles como desinfectantes para materiales de fibras textiles.
Las formulaciones líquidas de acuerdo con la invención se preparan disolviendo el componente (b1) en el
30 componente (b4), añadiendo los componentes (b2) y (b3) a la solución resultante, con agitación, completando la solución resultante con agua desionizada hasta 90-95% del volumen final, si es adecuado ajustando el pH con una base cosméticamente aceptable, por ejemplo mono- o dietanolamina, y completando la mezcla con agua desionizada hasta un volumen final de 100%.
El ingrediente microbicidamente activo disuelto puede ser incorporado en productos cosméticos y artículos de uso doméstico sin inconveniente alguno. El ingrediente activo, que de por sí es pulverulento, se ofrece al usuario en forma disuelta. De este modo deja de ser ya necesario una predisolución consumidora de tiempo en disolventes adecuados mientras se aporta calor.
Además, las formulaciones líquidas de acuerdo con la invención se distinguen por una acción antimicrobiana 5 sinérgica (véase ejemplo 4) y por una buena estabilidad en almacenamiento.
Los ejemplos, que siguen, ilustran la preparación de las formulaciones líquidas de acuerdo con la invención. Las partes son partes en peso.
Ejemplos de preparación de las formulaciones líquidas concentradas
Ejemplo 1:
10 10 partes del compuesto de fórmula (101) y 5 partes de 1,2-propanodiol se pesan en un recipiente y se agita a temperatura ambiente. 40 partes de ácido láctico se añaden. El pH se lleva a un valor de 3 a 4 por adición de etanolamina. 30 partes de cumenosulfonato sódico y 10 partes de agua desionizada se añaden en la secuencia anterior y se continúa la agitación hasta que se
15 disuelven todos los constituyentes. La mezcla se completa a 100 partes con agua desionizada.
Microorganismos Staphylococcus aureus ATCC 9144
de ensayo:
Enterococcus faecium ATCC 10541
Escherichia coli ATCC 10536 Pseudomonas aeruginosa CIP A-22 Candida albicans ATCC 10231
Medios Caldo de caseína peptona de harina de soja para el crecimiento del inóculo nutrientes: Agar de caseína peptona de harina de soja con 3% de monooleato de polioxietileno
(20) sorbitán; 0,3% de lecitina; 0,1% de L-histidina
Medio de Caldo de tripticasa peptona de harina de soja con 10% de monooleato de polioxietileno dilución: (20) sorbitán; 3% de lecitina; 0,1% de L-histidina y 0,5% de tiosulfato sódico.
a. Uso de la formulación del ejemplo 1 como desinfectante Estos ensayos demuestran que las formulaciones líquidas de acuerdo con la invención presentan una actividad
20 microbicida muy potente, incluso a bajas concentraciones. Estas propiedades son importantes para desinfectantes en general, pero en particular para la desinfección de textiles. Procedimiento: Se diluyen 0,1 ml de la formulación del ejemplo 1 con 8,9 ml de agua y la dilución se trata posteriormente con 1 ml
de una dilución 1:10 de un cultivo de la bacteria de ensayo que se incuba durante 16 a 24 horas a 37º C. 25 La concentración de los organismos de ensayo en el lote es de 108 microorganismos /ml.
El lote se mezcla a fondo y posteriormente se incuba durante 5 minutos a temperatura ambiente con agitación suave. Después de 5 minutos, se separa 1 ml del lote y se determina el recuento de bacterias vivas. Para este fin, se llevan
a cabo diluciones en el medio de dilución y se efectúan deposiciones de 0,1 ml de cada uno de estas diluciones
sobre los medios de agar.
El recuento de bacterias vivas se determina una vez que las placas han sido incubadas durante 24 a 48 horas a 37º
C contando las colonias teniendo en cuenta el factor de dilución.
Los resultados del ensayo se muestran en la tabla 1.
- Tabla 1
- Lote
- Reducción en el recuento bacterial después de 5 minutos (log)
- S. aureus ATCC 9144
- Ent. faecium ATCC 10541 E. coli ATCC 10536 P. aeruginosa CIP A-22
- Agua
- 0 0 0 0
- 1% formulación 6
- > 105 > 105 > 105 > 105
La formulación ensayada del ejemplo 41 muestra una reducción de todos los microorganismos del ensayo de al menos 5 potencias de 10 después de un tiempo tan pequeño como 5 minutos en el ensayo de suspensión.
7% de laurilsulfato sódico
10 7% de miret sulfato sódico 4% de laurilglucósido 1% de cocamidopropilbetaína 1% de la formulación del ejemplo 4 1% de cloruro sódico
15 0,02% de dibromodicianobutano 0,08% de fenoxietanol 78,9% de agua Preparación: Se mezcla laurilsulfato sódico con miret sulfato sódico y laurilglucósido y se disuelve en 30 partes de agua. Se
20 añade la formulación del ejemplo 1 y se homogeniza. Se añaden cocamidopropilbetaína, cloruro sódico, dibromodicianobutano y fenoxietanol. El pH se ajusta a 6,0 con ácido cítrico. Se añade agua para completar 100 partes.
50% de las formulaciones del ejemplo 1
25 10% de poliglicoléter de alcohol laurílico hasta 100% de agua El pH se lleva a 5 con monoetanolamina.
Claims (2)
- REIVINDICACIONES1. Una formulación líquida concentrada (b) que comprende (b1) 10 a 25% en peso de un ingrediente microbicidamente activo de fórmula5 en donde Y es cloro o bromo, Z es SO2H, NO2 o alquilo C1-C4, r es 0 a 3,o es 0 a 3,10 p es 0 o 1, m es 0 o 1 y n es 0 o 1, (b2) 10 a 70% en peso de cumenosulfonato, (b3) 10 a 50% en peso de ácido láctico,15 (b4) 5 a 75% en peso de 1,2-propanodiol y agua hasta completar el 100%.
- 2. Una formulación líquida según la reivindicación 1, en donde el componente (b1) tiene la fórmula
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH140396 | 1996-06-04 | ||
| CH140396 | 1996-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2375350T3 true ES2375350T3 (es) | 2012-02-29 |
Family
ID=4209620
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97923969T Expired - Lifetime ES2182077T3 (es) | 1996-06-04 | 1997-05-22 | Formulaciones liquidas concentradas que comprenden un ingrediente microbicidamente activo. |
| ES02002043T Expired - Lifetime ES2375350T3 (es) | 1996-06-04 | 1997-05-22 | Formulaciones líquidas concentradas que comprenden un ingrediente microbicidamente activo. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97923969T Expired - Lifetime ES2182077T3 (es) | 1996-06-04 | 1997-05-22 | Formulaciones liquidas concentradas que comprenden un ingrediente microbicidamente activo. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6358906B1 (es) |
| EP (2) | EP0914085B1 (es) |
| JP (1) | JP4106091B2 (es) |
| CN (1) | CN1133418C (es) |
| AR (2) | AR008760A1 (es) |
| AU (1) | AU2959497A (es) |
| BR (1) | BR9709422A (es) |
| CO (1) | CO4850630A1 (es) |
| DE (1) | DE69715421T2 (es) |
| ES (2) | ES2182077T3 (es) |
| ID (1) | ID17019A (es) |
| MY (1) | MY126299A (es) |
| TW (1) | TW464491B (es) |
| WO (1) | WO1997046218A2 (es) |
| ZA (1) | ZA974871B (es) |
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| US6358906B1 (en) | 1996-06-04 | 2002-03-19 | Ciba Specialty Chemicals Corporation | Concentrated liquid accumulations comprising a microbicidally active ingredient |
-
1997
- 1997-05-22 US US09/194,801 patent/US6358906B1/en not_active Expired - Fee Related
- 1997-05-22 ES ES97923969T patent/ES2182077T3/es not_active Expired - Lifetime
- 1997-05-22 CN CNB971950997A patent/CN1133418C/zh not_active Expired - Fee Related
- 1997-05-22 ES ES02002043T patent/ES2375350T3/es not_active Expired - Lifetime
- 1997-05-22 JP JP50015098A patent/JP4106091B2/ja not_active Expired - Lifetime
- 1997-05-22 WO PCT/EP1997/002605 patent/WO1997046218A2/en not_active Ceased
- 1997-05-22 EP EP97923969A patent/EP0914085B1/en not_active Expired - Lifetime
- 1997-05-22 AU AU29594/97A patent/AU2959497A/en not_active Abandoned
- 1997-05-22 BR BR9709422A patent/BR9709422A/pt not_active Application Discontinuation
- 1997-05-22 EP EP02002043A patent/EP1201229B1/en not_active Expired - Lifetime
- 1997-05-22 DE DE69715421T patent/DE69715421T2/de not_active Expired - Lifetime
- 1997-05-27 CO CO97029078A patent/CO4850630A1/es unknown
- 1997-05-30 MY MYPI97002398A patent/MY126299A/en unknown
- 1997-05-30 ID IDP971830A patent/ID17019A/id unknown
- 1997-06-02 TW TW086107514A patent/TW464491B/zh not_active IP Right Cessation
- 1997-06-02 AR ARP970102384A patent/AR008760A1/es active IP Right Grant
- 1997-06-03 ZA ZA9704871A patent/ZA974871B/xx unknown
-
2010
- 2010-06-10 AR ARP100102051A patent/AR077053A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ID17019A (id) | 1997-12-04 |
| BR9709422A (pt) | 1999-08-10 |
| DE69715421T2 (de) | 2003-08-07 |
| US6358906B1 (en) | 2002-03-19 |
| WO1997046218A3 (en) | 1998-03-12 |
| JP2000512276A (ja) | 2000-09-19 |
| EP0914085A2 (en) | 1999-05-12 |
| JP4106091B2 (ja) | 2008-06-25 |
| CO4850630A1 (es) | 1999-10-26 |
| TW464491B (en) | 2001-11-21 |
| AR077053A2 (es) | 2011-07-27 |
| WO1997046218A2 (en) | 1997-12-11 |
| EP0914085B1 (en) | 2002-09-11 |
| EP1201229A1 (en) | 2002-05-02 |
| MY126299A (en) | 2006-09-29 |
| EP1201229B1 (en) | 2011-11-09 |
| CN1133418C (zh) | 2004-01-07 |
| CN1220597A (zh) | 1999-06-23 |
| ZA974871B (en) | 1998-05-20 |
| DE69715421D1 (de) | 2002-10-17 |
| AU2959497A (en) | 1998-01-05 |
| ES2182077T3 (es) | 2003-03-01 |
| AR008760A1 (es) | 2000-02-23 |
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