ES2509883T3 - Antagonistas de glucagón - Google Patents

Antagonistas de glucagón Download PDF

Info

Publication number: ES2509883T3
Authority: ES; Spain
Prior art keywords: glucagon; kda peg; seq; pla6; antagonism
Prior art date: 2007-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES08845852.6T

Other languages

English (en)

Spanish (es)

Inventor

Richard D. Dimarchi

Bin Yang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Indiana University Research and Technology Corp

Original Assignee

Indiana University Research and Technology Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-30

Filing date

2008-10-23

Publication date

2014-10-20

2008-10-23 Application filed by Indiana University Research and Technology Corp filed Critical Indiana University Research and Technology Corp

2014-10-20 Application granted granted Critical

2014-10-20 Publication of ES2509883T3 publication Critical patent/ES2509883T3/es

Status Active legal-status Critical Current

2028-10-23 Anticipated expiration legal-status Critical

Links

MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract description 50
108060003199 Glucagon Proteins 0.000 title abstract description 30
102000051325 Glucagon Human genes 0.000 title abstract description 29
229960004666 glucagon Drugs 0.000 title abstract description 29
239000005557 antagonist Substances 0.000 title abstract description 5
150000001413 amino acids Chemical group 0.000 abstract description 3
NWCHELUCVWSRRS-SECBINFHSA-N (2r)-2-hydroxy-2-phenylpropanoic acid Chemical group OC(=O)[C@@](O)(C)C1=CC=CC=C1 NWCHELUCVWSRRS-SECBINFHSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1
230000008485 antagonism Effects 0.000 description 10
108090000765 processed proteins & peptides Proteins 0.000 description 9
230000008878 coupling Effects 0.000 description 4
238000010168 coupling process Methods 0.000 description 4
238000005859 coupling reaction Methods 0.000 description 4
125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 3
230000008484 agonism Effects 0.000 description 3
102000004196 processed proteins & peptides Human genes 0.000 description 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
125000002252 acyl group Chemical group 0.000 description 2
230000006320 pegylation Effects 0.000 description 2
239000011347 resin Substances 0.000 description 2
229920005989 resin Polymers 0.000 description 2
-1 spacer amino acid Chemical class 0.000 description 2
JXGYPHBCPYMHSR-OYKVQYDMSA-N (2s)-2,6-diamino-7-(9h-fluoren-9-ylmethoxy)-7-oxoheptanoic acid Chemical group C1=CC=C2C(COC(=O)C(N)CCC[C@H](N)C(O)=O)C3=CC=CC=C3C2=C1 JXGYPHBCPYMHSR-OYKVQYDMSA-N 0.000 description 1
JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 1
125000000539 amino acid group Chemical group 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
AJDPNPAGZMZOMN-UHFFFAOYSA-N diethyl (4-oxo-1,2,3-benzotriazin-3-yl) phosphate Chemical compound C1=CC=C2C(=O)N(OP(=O)(OCC)OCC)N=NC2=C1 AJDPNPAGZMZOMN-UHFFFAOYSA-N 0.000 description 1
239000000539 dimer Substances 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
238000011065 in-situ storage Methods 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
125000006239 protecting group Chemical group 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
239000007787 solid Substances 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Obesity (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Toxicology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

ES08845852.6T 2007-10-30 2008-10-23 Antagonistas de glucagón Active ES2509883T3 (es)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US98378307P	2007-10-30	2007-10-30
US983783P		2007-10-30
PCT/US2008/080973 WO2009058662A2 (en)	2007-10-30	2008-10-23	Glucagon antagonists

Publications (1)

Publication Number	Publication Date
ES2509883T3 true ES2509883T3 (es)	2014-10-20

Family

ID=40591715

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES08845852.6T Active ES2509883T3 (es)	2007-10-30	2008-10-23	Antagonistas de glucagón

Country Status (12)

Country	Link
US (1)	US8981047B2 (2)
EP (1)	EP2217701B9 (2)
JP (1)	JP5669582B2 (2)
AR (1)	AR069110A1 (2)
AU (1)	AU2008318986B2 (2)
CA (1)	CA2707861A1 (2)
CL (1)	CL2008003222A1 (2)
ES (1)	ES2509883T3 (2)
MX (1)	MX2010004297A (2)
PE (1)	PE20091393A1 (2)
TW (1)	TW200920404A (2)
WO (1)	WO2009058662A2 (2)

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TW201625669A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625670A (zh)	2014-04-07	2016-07-16	賽諾菲公司	衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
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2008
- 2008-10-23 WO PCT/US2008/080973 patent/WO2009058662A2/en not_active Ceased
- 2008-10-23 JP JP2010532154A patent/JP5669582B2/ja not_active Expired - Fee Related
- 2008-10-23 ES ES08845852.6T patent/ES2509883T3/es active Active
- 2008-10-23 US US12/739,342 patent/US8981047B2/en not_active Expired - Fee Related
- 2008-10-23 MX MX2010004297A patent/MX2010004297A/es active IP Right Grant
- 2008-10-23 EP EP08845852.6A patent/EP2217701B9/en not_active Not-in-force
- 2008-10-23 AU AU2008318986A patent/AU2008318986B2/en not_active Ceased
- 2008-10-23 CA CA2707861A patent/CA2707861A1/en not_active Abandoned
- 2008-10-29 AR ARP080104739A patent/AR069110A1/es unknown
- 2008-10-29 CL CL2008003222A patent/CL2008003222A1/es unknown
- 2008-10-30 TW TW097141806A patent/TW200920404A/zh unknown
- 2008-10-30 PE PE2008001856A patent/PE20091393A1/es not_active Application Discontinuation

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Publication number	Publication date
AU2008318986B2 (en)	2014-12-04
EP2217701A4 (en)	2011-06-15
US8981047B2 (en)	2015-03-17
US20120122783A1 (en)	2012-05-17
AR069110A1 (es)	2009-12-30
PE20091393A1 (es)	2009-09-11
CL2008003222A1 (es)	2009-02-27
EP2217701B1 (en)	2014-07-02
EP2217701B9 (en)	2015-02-18
AU2008318986A1 (en)	2009-05-07
JP2011502155A (ja)	2011-01-20
HK1143994A1 (en)	2011-01-21
WO2009058662A2 (en)	2009-05-07
JP5669582B2 (ja)	2015-02-12
MX2010004297A (es)	2010-05-03
EP2217701A2 (en)	2010-08-18
WO2009058662A3 (en)	2010-01-07
CA2707861A1 (en)	2009-05-07
TW200920404A (en)	2009-05-16

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