ES2526544T3 - Derivado de ácido aminocarboxílico y uso médico del mismo - Google Patents

Derivado de ácido aminocarboxílico y uso médico del mismo Download PDF

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Publication number
ES2526544T3
ES2526544T3 ES13154050.2T ES13154050T ES2526544T3 ES 2526544 T3 ES2526544 T3 ES 2526544T3 ES 13154050 T ES13154050 T ES 13154050T ES 2526544 T3 ES2526544 T3 ES 2526544T3
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Prior art keywords
edg
acid derivative
medical use
aminocarboxylic acid
formula
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ES13154050.2T
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English (en)
Inventor
Hiromu Habashita
Haruto Kurata
Shinji Nakade
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Ono Pharmaceutical Co Ltd
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Ono Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
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    • A61K31/12—Ketones
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

Un compuesto seleccionado del grupo que consiste en: 1-({6-[3-(4-fluorofenil)propoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxilato de metilo, 1-({6-[3-(4-clorofenil)propoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxilato de metilo, 1-({6-[2-(4-isopropilfenil)propoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxilato de metilo, 1-[(6-{[(2R)-3-(4-fluorofenil)-2-metilpropil]oxi}1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidinacarboxilato de metilo, 1-[(6-{[(2S)-3-(4-fluorofenil)-2-metilpropil]oxi}1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidinacarboxilato de metilo, 1-({1-cloro-6-[3-(4-fluorofenil)propoxi]-3,4-dihidro-2-naftalenil}metil)-3-azetidinacarboxilato de metilo, 1-[(6-{[1-(4-fluorobencil)ciclopropil]metoxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3-azetidinacarboxilato de metilo, 1-[(6-{[(2S)-3-(2,4-difluorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidinacarboxilato de metilo, 1-[(6-{[(2S)-3-(4-cloro-2-fluorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidinacarboxilato de metilo, 1-[(6-{[(2S)-3-(4-clorofenil)-2-metilpropil]oxi}--3-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidinacarboxilato de metilo, Clorhidrato de ácido 1-({6-[2-(4-isopropilfenil)propoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxílico Ácido 1-[(6-{[(2R)-3-(4-fluorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidincarboxílico, Ácido 1-[(6-{[(2S)-3-(4-fluorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidincarboxílico, Ácido 1-({1-cloro-6-[3-(4-fluorofenil)propoxi]-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxílico, Ácido 1-[(6-{[1-(4-fluorobencil)ciclopropil]metoxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3-azetidincarboxílico, Ácido 1-[(6-{[(2S)-3-(2,4-difluorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidincarboxílico, Ácido 1-[((6-{[(2S)-3-(4-cloro-2-fluorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidincarboxílico Ácido 1-[(6-{[(2S)-3-(4-clorofenil)-2-metilpropil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3- azetidincarboxílico, Ácido 1-({6-cloro-6-[3-(4-clorofenil)propoxi]-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxílico, Ácido 1-({6-[4-(4-clorofenil)butoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxílico, Clorhidrato de ácido 1-({6-[3-(4-clorofenil)-2,2-dimetilpropoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxílico Clorhidrato de ácido 1-[(6-{[1-(4-clorobencil)ciclopropil]metoxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3-azetidincarboxílico, Clorhidrato de ácido 1-[((6-{[(2E)-3-(4-clorofenil)-2-propenil]oxi}-1-metil-3,4-dihidro-2-naftalenil)metil]-3-azetidincarboxílico, Clorhidrato de ácido 1-({6-[4-(4-fluorofenil)butoxi]-1-metil-3,4-dihidro-2-naftalenil}metil)-3-azetidincarboxílico, 1-[(6-{[(2E)-3-(4-fluorofenil)-2-metilpropan-2-enil]oxi}-1-metil-3,4-dihidronaftalenil-2-il)metil]azetidinacarboxilato de metilo, 1-[(6-{[(2E)-2-(4-fluorobencil)butil]oxi}-1-metil-3,4-dihidronaftalenil-2-il)metil]azetidinacarboxilato de metilo, 1-[(6-{[(2R)-2-(4-fluorobencil)-3-metilbutil]oxi]-1-metil-3,4-dihidronaftalen-2-il)metil]azetidinacarboxilato de metilo, 1-[(6-{[(2S)-3-(4-fluorofenil)-2-metilpropil]oxi}-4,4-dimetil-3,4-dihidronaftalenil-2-il)metil]azetidina-3-carboxilato de metilo, 1-{[1-cloro-6-(3-ciclohexilpropoxi)-3,4-dihidronaftalen-2-il]metil}azetidina-3-carboxilato de metilo, 1-({1-cloro-6-[3-(4-clorofenil)propoxi]-3,4-dihidronatalenil}metil)-3-azetidinacarboxilato de metilo, 1-[(1-cloro-6-{[(2S)-3-(4-clorofenil)-2-metilpropil]oxi}-3,4-dihidronaftalen-2-il)metil]azetidina-3- carboxilato de metilo, 1-({6-[2-(4-fluorofenoxi)etoxi]-1-metil-3,4-dihidronaftalen-2-il}metil)azetidina-3-carboxilato de metilo, 1-({6-[2-(4-fluorofenoxi)propoxi]-1-metil-3,4-dihidronaftalen-2-il}metil)azetidina-3-carboxilato de metilo, 1-({6-[(4-isobutil-1,3-oxazol-2-il)metoxi]-1-metil-3,4-dihidronaftalen-2-il}metil)azetidina-3- carboxilato de metilo, 1-({6-[3-(4-metoxifenil)propoxi]-1-metil-3,4-dihidronaftalen-2-il}metil)azetidina-3-carboxilato de metilo, 1-({6-[3-(4-fluorofenoxi)propoxi]-1-metil-3,4-dihidronaftalen-2-il}metil)azetidina-3-carboxilato de metilo, 1-({6-[3-{[terc-butil(dimetil)silil]oxi}-2-(4-fluorobencil)propoxi]-1-metil-3,4-dihidronaftalen-2-il}metil)azetidina-3-carb oxilato de metilo

Description

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Claims (1)

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