ES2530428T3 - Métodos y composiciones para el tratamiento de neuropatías mediadas por anticuerpos - Google Patents

Métodos y composiciones para el tratamiento de neuropatías mediadas por anticuerpos Download PDF

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Publication number
ES2530428T3
ES2530428T3 ES07837788T ES07837788T ES2530428T3 ES 2530428 T3 ES2530428 T3 ES 2530428T3 ES 07837788 T ES07837788 T ES 07837788T ES 07837788 T ES07837788 T ES 07837788T ES 2530428 T3 ES2530428 T3 ES 2530428T3
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Prior art keywords
antibody
treatment
compositions
methods
mediated neuropathies
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ES07837788T
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English (en)
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Susan Halstead
Hugh Willison
Russell Rother
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Alexion Pharmaceuticals Inc
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Alexion Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un anticuerpo para uso en el tratamiento de síndrome de Guillain-Barré en un mamífero, en el que dicho anticuerpo se une a: (i) el componente del complemento C5 e inhibe la escisión de C5 en fragmentos C5a y C5b; o (ii) C5b, en el que dicho anticuerpo inhibe la formación del complejo de ataque a membrana.
ES07837788T 2006-09-05 2007-09-05 Métodos y composiciones para el tratamiento de neuropatías mediadas por anticuerpos Active ES2530428T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84229606P 2006-09-05 2006-09-05
PCT/US2007/019416 WO2008030505A2 (en) 2006-09-05 2007-09-05 Methods and compositions for the treatment of antibody mediated neuropathies

Publications (1)

Publication Number Publication Date
ES2530428T3 true ES2530428T3 (es) 2015-03-02

Family

ID=39157834

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11005615.7T Active ES2616204T3 (es) 2006-09-05 2007-09-05 Métodos y composiciones para el tratamiento de neuropatías mediadas por anticuerpos
ES07837788T Active ES2530428T3 (es) 2006-09-05 2007-09-05 Métodos y composiciones para el tratamiento de neuropatías mediadas por anticuerpos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES11005615.7T Active ES2616204T3 (es) 2006-09-05 2007-09-05 Métodos y composiciones para el tratamiento de neuropatías mediadas por anticuerpos

Country Status (16)

Country Link
US (1) US9388235B2 (es)
EP (4) EP3199549A1 (es)
JP (2) JP5695317B2 (es)
KR (1) KR101503540B1 (es)
AU (1) AU2007293013B2 (es)
BR (1) BRPI0715869A2 (es)
CA (1) CA2662480C (es)
DK (1) DK2061810T3 (es)
ES (2) ES2616204T3 (es)
IL (1) IL197148A (es)
MX (1) MX2009002426A (es)
NZ (1) NZ575018A (es)
PL (1) PL2061810T3 (es)
PT (1) PT2061810E (es)
SI (1) SI2061810T1 (es)
WO (1) WO2008030505A2 (es)

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WO2010048212A2 (en) * 2008-10-21 2010-04-29 Donndelinger Thomas M Methods and compositions for preventing artifacts in tissue samples
WO2013126006A1 (en) 2012-02-20 2013-08-29 Swedish Orphan Biovitrum Ab (Publ) Polypeptides binding to human complement c5
CN104870475B (zh) 2012-10-25 2019-11-08 美国比奥维拉迪维股份有限公司 抗补体C1s抗体和其用途
DK2914291T3 (da) 2012-11-02 2022-05-16 Bioverativ Usa Inc Anti-komplement-c1s-antistoffer og anvendelser deraf
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WO2015006507A1 (en) 2013-07-09 2015-01-15 Annexon, Inc. Methods of treatment for alzheimer's disease and huntington's disease
SI3116887T1 (sl) 2014-03-13 2021-06-30 Universitaet Basel Ogljikohidratni ligandi, ki se vežejo na protitelesa img proti glikoproteinu, ki je povezan z mielinom
HUE070383T2 (hu) 2014-11-05 2025-06-28 Annexon Inc Humanizált C1Q anti-komplement faktor antitestek és alkalmazásaik
CN113563468A (zh) * 2014-12-19 2021-10-29 雷根尼桑斯公司 结合人c6的抗体及其用途
WO2016164358A1 (en) 2015-04-06 2016-10-13 True North Therapeutics, Inc. Humanized anti-c1s antibodies and methods of use thereof
US11091591B2 (en) 2015-09-16 2021-08-17 Universität Basel Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
WO2017091719A1 (en) 2015-11-24 2017-06-01 Annexon, Inc. Anti-complement factor c1q fab fragments and uses thereof
ES2984352T3 (es) 2016-06-14 2024-10-29 Regeneron Pharma Anticuerpos anti-C5 y usos de los mismos
HUE073475T2 (hu) 2016-10-12 2026-01-28 Bioverativ Usa Inc C1s elleni antitestek és alkalmazási eljárásaik
MA51147A (fr) 2017-12-13 2021-03-24 Regeneron Pharma Associations d'anticorps anti-c5 et utilisations associées
US20190247560A1 (en) 2018-02-13 2019-08-15 Gambro Lundia Ab Extracorporeal devices and methods of treating complement factor related diseases
KR20210080390A (ko) * 2018-10-22 2021-06-30 라 파마슈티컬스 인코포레이티드 질루코플란을 이용한 신경 질환 치료
GB2584105B (en) * 2019-05-21 2023-08-02 Argenx Bvba Methods of treating neuropathy
CN113966224A (zh) 2019-06-04 2022-01-21 Ra制药公司 采用补体抑制剂的炎性疾病治疗
WO2023114763A1 (en) 2021-12-13 2023-06-22 Annexon, Inc. Anti-complement factor c1q antibodies with single binding arms and uses thereof
TW202404632A (zh) * 2022-04-04 2024-02-01 瑞士商赫孚孟拉羅股份公司 用於藉由使用抗ｃ５抗體克羅伐單抗治療或預防格林－巴利症候群之劑量及投予方案

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Also Published As

Publication number Publication date
EP3199549A1 (en) 2017-08-02
EP2913342A1 (en) 2015-09-02
AU2007293013B2 (en) 2013-06-27
KR20090051063A (ko) 2009-05-20
EP2061810A2 (en) 2009-05-27
KR101503540B1 (ko) 2015-03-17
ES2616204T3 (es) 2017-06-09
SI2061810T1 (sl) 2015-04-30
MX2009002426A (es) 2009-03-20
BRPI0715869A2 (pt) 2013-07-30
WO2008030505A3 (en) 2008-06-19
CA2662480C (en) 2016-11-08
WO2008030505A2 (en) 2008-03-13
IL197148A (en) 2016-06-30
US9388235B2 (en) 2016-07-12
JP2014240438A (ja) 2014-12-25
HK1126793A1 (en) 2009-09-11
CA2662480A1 (en) 2008-03-13
NZ575018A (en) 2012-04-27
US20100143343A1 (en) 2010-06-10
WO2008030505A8 (en) 2009-03-05
IL197148A0 (en) 2011-08-01
PT2061810E (pt) 2015-02-05
EP2380907B1 (en) 2016-11-30
JP5695317B2 (ja) 2015-04-01
EP2380907A1 (en) 2011-10-26
DK2061810T3 (en) 2015-02-16
AU2007293013A1 (en) 2008-03-13
PL2061810T3 (pl) 2015-05-29
JP2010502708A (ja) 2010-01-28
EP2061810B1 (en) 2014-11-12

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