ES2535816T3 - Enzima recombinante con sensibilidad alterada a la retroalimentación - Google Patents
Enzima recombinante con sensibilidad alterada a la retroalimentación Download PDFInfo
- Publication number
- ES2535816T3 ES2535816T3 ES05742717.1T ES05742717T ES2535816T3 ES 2535816 T3 ES2535816 T3 ES 2535816T3 ES 05742717 T ES05742717 T ES 05742717T ES 2535816 T3 ES2535816 T3 ES 2535816T3
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- ES
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- Prior art keywords
- homoserine
- amino acid
- transuccinylase
- methionine
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
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- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| WOPCT/IB2004/001901 | 2004-05-12 | ||
| PCT/IB2004/001901 WO2005111202A1 (en) | 2004-05-12 | 2004-05-12 | Recombinant enzyme with altered feedback sensitivity |
| PCT/EP2005/052180 WO2005108561A2 (en) | 2004-05-12 | 2005-05-12 | Recombinant enzyme with altered feedback sensitivity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2535816T3 true ES2535816T3 (es) | 2015-05-18 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| ES05742717.1T Expired - Lifetime ES2535816T3 (es) | 2004-05-12 | 2005-05-12 | Enzima recombinante con sensibilidad alterada a la retroalimentación |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8795990B2 (pl) |
| EP (1) | EP1747269B1 (pl) |
| JP (1) | JP5164566B2 (pl) |
| CN (1) | CN1954067B (pl) |
| ES (1) | ES2535816T3 (pl) |
| MX (1) | MXPA06013125A (pl) |
| PL (1) | PL1747269T3 (pl) |
| WO (2) | WO2005111202A1 (pl) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4110641B2 (ja) | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるl−メチオニンの製造法 |
| EP1846564A2 (en) * | 2005-02-07 | 2007-10-24 | Metabolic Explorer | Method for the enzymatic production of alpha-ketobutyrate |
| JP5172697B2 (ja) * | 2006-01-04 | 2013-03-27 | メタボリック エクスプローラー | 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法 |
| KR100905381B1 (ko) * | 2006-07-28 | 2009-06-30 | 씨제이제일제당 (주) | L-메치오닌 전구체 생산 균주 및 상기 l-메치오닌전구체로부터의 l-메치오닌 및 유기산의 생산방법 |
| CN101134948B (zh) * | 2006-08-31 | 2011-12-07 | 百瑞全球有限公司 | S-腺苷甲硫氨酸合成酶突变体、编码该突变体的dna以及突变体的应用 |
| CN103710319B (zh) * | 2007-04-11 | 2015-10-07 | Cj第一制糖株式会社 | 组合物及甲硫氨酸的生产方法 |
| ES2575082T3 (es) | 2007-04-11 | 2016-06-24 | Cj Cheiljedang Corporation | Composiciones y métodos de producción de metionina |
| CN102703398B (zh) * | 2007-04-11 | 2014-06-04 | Cj第一制糖株式会社 | 组合物及甲硫氨酸的生产方法 |
| EP2167654A2 (en) * | 2007-06-25 | 2010-03-31 | Plant Bioscience Limited | Enzymes involved in triterpene synthesis |
| WO2009043372A1 (en) | 2007-10-02 | 2009-04-09 | Metabolic Explorer | Increasing methionine yield |
| US7851180B2 (en) | 2008-04-04 | 2010-12-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| US9005952B2 (en) * | 2008-04-04 | 2015-04-14 | Cj Cheiljedang Corporation | Microorganism producing L-methionine precursor and the method of producing L-methionine precursor using the microorganism |
| WO2010022763A1 (en) * | 2008-08-25 | 2010-03-04 | Metabolic Explorer | Method for the preparation of 2-hydroxy-isobutyrate |
| CN102341502B (zh) | 2008-12-31 | 2015-07-01 | 代谢探索者公司 | 用于制备二醇的方法 |
| US8283152B2 (en) * | 2009-08-28 | 2012-10-09 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| US8609396B2 (en) * | 2009-08-28 | 2013-12-17 | Cj Cheiljedang Corporation | Microorganism producing O-acetyl-homoserine and the method of producing O-acetyl-homoserine using the microorganism |
| FR2951195B1 (fr) | 2009-10-14 | 2014-01-31 | Roquette Freres | Composition riche en methionine destinee a l'alimentation animale |
| BR112012012915B1 (pt) | 2009-11-30 | 2020-12-01 | Ajinomoto Co., Inc. | método para produção de l-cisteína, l-cistina, um derivado das mesmas, ou uma mistura das mesmas |
| WO2011073738A1 (en) | 2009-12-14 | 2011-06-23 | Metabolic Explorer | Use of inducible promoters in the production of methionine |
| MY172018A (en) | 2009-12-30 | 2019-11-12 | Metabolic Explorer Sa | Strains and method for the production of methionine |
| JP5819316B2 (ja) | 2009-12-30 | 2015-11-24 | メタボリック エクスプローラー | コハク酸デヒドロゲナーゼを過剰発現させることによるメチオニンの増産 |
| US8911978B2 (en) | 2010-07-02 | 2014-12-16 | Metabolic Explorer | Method for the preparation of hydroxy acids |
| TWI500768B (zh) | 2010-07-05 | 2015-09-21 | Metabolic Explorer Sa | 由蔗糖製備1,3-丙二醇之方法 |
| WO2012014228A1 (en) | 2010-07-28 | 2012-02-02 | Abhishek Narain Singh | A method to by-pass allosteric domain activity of an enzyme so as to alter its feedback or feed-forward inhibition or activation |
| JP5803927B2 (ja) | 2010-09-14 | 2015-11-04 | 味の素株式会社 | 含硫アミノ酸生産菌及び含硫アミノ酸の製造法 |
| AR083468A1 (es) * | 2010-10-25 | 2013-02-27 | Metabolic Explorer Sa | Aumento de la disponibilidad de nadph para la produccion de metionina |
| DK2657250T3 (en) | 2010-12-21 | 2017-12-11 | Cj Cheiljedang Corp | Polypeptide variant having homoserine acetyl transferase activity and microorganism expressing this |
| ES2528495T3 (es) * | 2010-12-30 | 2015-02-10 | Metabolic Explorer | Producción fermentativa de análogo hidroxi de metionina (MHA) |
| WO2012090021A1 (en) | 2010-12-30 | 2012-07-05 | Metabolic Explorer | Recombinant microorganism for the fermentative production of methionine |
| JP2014087259A (ja) | 2011-02-22 | 2014-05-15 | Ajinomoto Co Inc | L−システイン生産菌及びl−システインの製造法 |
| US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
| EP2695940B1 (en) | 2011-04-01 | 2016-11-30 | Ajinomoto Co., Inc. | Method for producing l-cysteine |
| EP2540834A1 (en) | 2011-06-29 | 2013-01-02 | Metabolic Explorer | Method for the preparation of 1,3-propanediol |
| EP2766492B1 (en) | 2011-10-11 | 2018-06-06 | Metabolic Explorer | Fermentative production of prenol |
| FR2983870B1 (fr) | 2011-12-08 | 2015-07-17 | Roquette Freres | Composition en methionine destinee a l'alimentation animale |
| EP2647718A3 (en) | 2012-04-06 | 2014-12-24 | Metabolic Explorer | Process for producing 5-aminopentanoate empolying a recombinant microorganism |
| JP2012196222A (ja) * | 2012-06-11 | 2012-10-18 | Metabolic Explorer | 硫酸透過酵素の発現が増強された微生物を用いてメチオニンおよびその前駆体ホモセリンまたはスクシニルホモセリンを製造するための方法 |
| MY168199A (en) | 2012-06-18 | 2018-10-15 | Evonik Degussa Gmbh | Recombinant microorganism for the fermentative production of methionine |
| SI2898086T1 (sl) * | 2012-09-19 | 2019-03-29 | F. Hoffmann-La Roche Ag | Načini in sestavki za preprečevanje napačnega vključevanja norlevcina v beljakovine |
| WO2014049382A2 (en) | 2012-09-26 | 2014-04-03 | Metabolic Explorer | Ethylenediamine fermentative production by a recombinant microorganism |
| BR112015007916B1 (pt) | 2013-05-13 | 2023-04-04 | Ajinomoto Co., Inc | Método para produzir l-aminoácido |
| KR102270626B1 (ko) | 2013-08-30 | 2021-06-30 | 에보니크 오퍼레이션즈 게엠베하 | 메티오닌 신타제 활성 및 메티오닌 유출이 개선된 메티오닌 생산용 미생물 |
| ES2694011T3 (es) | 2013-10-21 | 2018-12-17 | Ajinomoto Co., Inc. | Método para producir L-aminoácido |
| BR112016008830B1 (pt) | 2013-10-23 | 2023-02-23 | Ajinomoto Co., Inc | Método para produzir uma substância alvo |
| WO2016034536A1 (en) | 2014-09-01 | 2016-03-10 | Metabolic Explorer | Method and microorganism for methionine production by fermentation with improved methionine efflux |
| CN105505894A (zh) * | 2014-09-24 | 2016-04-20 | 中国科学院天津工业生物技术研究所 | 天冬氨酸激酶/高丝氨酸脱氢酶突变体及其应用 |
| SG11201708741YA (en) * | 2015-05-06 | 2017-11-29 | Trelys Inc | Compositions and methods for biological production of methionine |
| EP3095868A1 (en) | 2015-05-19 | 2016-11-23 | Evonik Degussa GmbH | Methionine production |
| CN107787368A (zh) | 2015-07-10 | 2018-03-09 | 赢创德固赛有限公司 | 氨基酸生产 |
| CN108026516A (zh) | 2015-08-07 | 2018-05-11 | 赢创德固赛有限公司 | 通过发酵的蛋白硫代羧化物依赖性l-甲硫氨酸生产 |
| MX2018006434A (es) | 2015-11-27 | 2018-09-28 | Evonik Degussa Gmbh | Metodo para producir l-metionina. |
| US20180355390A1 (en) | 2016-01-08 | 2018-12-13 | Evonik Degussa Gmbh | Method to produce L-methionine by a fermentative production |
| CN105838740B (zh) * | 2016-05-03 | 2020-11-06 | 湖北大学 | 一种茶树内生草螺菌制备纳米红色元素硒的方法 |
| CN109415418B (zh) | 2016-07-08 | 2024-02-09 | 代谢探索者公司 | 通过包含编码糖磷酸转移酶系统(pts)的基因的微生物发酵产生感兴趣的分子的方法 |
| EP3296404A1 (en) | 2016-09-15 | 2018-03-21 | Evonik Degussa GmbH | Modified microorganism for production of methionine |
| JP7066977B2 (ja) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | L-アミノ酸の製造法 |
| EP3856918A1 (en) | 2018-09-28 | 2021-08-04 | Ajinomoto Co., Inc. | Method for producing l-methionine using a bacterium |
| WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
| CN112725251B (zh) * | 2019-10-14 | 2022-07-22 | 江南大学 | 一种生产亚精胺的工程菌 |
| CN114107243B (zh) * | 2021-12-09 | 2023-04-07 | 江南大学 | 一种甲硫氨酸腺苷转移酶突变体 |
| CN116042561B (zh) * | 2022-11-11 | 2023-10-24 | 山东理工大学 | 一种s-腺苷蛋氨酸合成酶突变体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4110641B2 (ja) * | 1998-11-17 | 2008-07-02 | 味の素株式会社 | 発酵法によるl−メチオニンの製造法 |
| JP4622111B2 (ja) * | 2001-02-09 | 2011-02-02 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
| DE10247437A1 (de) * | 2002-10-11 | 2004-04-29 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen |
| DE10249642A1 (de) * | 2002-10-24 | 2004-05-13 | Consortium für elektrochemische Industrie GmbH | Feedback-resistente Homoserin-Transsuccinylasen mit modifiziertem C-Terminus |
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2004
- 2004-05-12 WO PCT/IB2004/001901 patent/WO2005111202A1/en not_active Ceased
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2005
- 2005-05-12 JP JP2007512216A patent/JP5164566B2/ja not_active Expired - Fee Related
- 2005-05-12 PL PL05742717T patent/PL1747269T3/pl unknown
- 2005-05-12 US US11/579,907 patent/US8795990B2/en active Active
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- 2005-05-12 CN CN2005800153152A patent/CN1954067B/zh not_active Expired - Fee Related
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- 2005-05-12 EP EP05742717.1A patent/EP1747269B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1954067B (zh) | 2011-08-03 |
| WO2005111202A1 (en) | 2005-11-24 |
| WO2005108561A3 (en) | 2006-07-20 |
| PL1747269T3 (pl) | 2015-08-31 |
| JP2007536921A (ja) | 2007-12-20 |
| US8795990B2 (en) | 2014-08-05 |
| EP1747269B1 (en) | 2015-03-25 |
| CN1954067A (zh) | 2007-04-25 |
| MXPA06013125A (es) | 2007-02-14 |
| JP5164566B2 (ja) | 2013-03-21 |
| EP1747269A2 (en) | 2007-01-31 |
| US20090029424A1 (en) | 2009-01-29 |
| WO2005108561A2 (en) | 2005-11-17 |
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