ES2573710T3 - Circulación de componentes durante la homogeneización y de microfluidización de emulsiones - Google Patents

Circulación de componentes durante la homogeneización y de microfluidización de emulsiones Download PDF

Info

Publication number
ES2573710T3
ES2573710T3 ES10812803.4T ES10812803T ES2573710T3 ES 2573710 T3 ES2573710 T3 ES 2573710T3 ES 10812803 T ES10812803 T ES 10812803T ES 2573710 T3 ES2573710 T3 ES 2573710T3
Authority
ES
Spain
Prior art keywords
emulsion
container
circulation
components
homogenizer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES10812803.4T
Other languages
English (en)
Inventor
Harald Rueckl
Hanno Scheffczik
Barbara Santry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43923723&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2573710(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2573710T3 publication Critical patent/ES2573710T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/44—Mixers in which the components are pressed through slits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/80—Mixing plants; Combinations of mixers
    • B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
    • B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Edible Oils And Fats (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Liquid Carbonaceous Fuels (AREA)

Abstract

Un método para la fabricación de un adyuvante de vacuna de emulsión de aceite en agua que comprende a escualeno, a polisorbato 80 y a trioleato de sorbitano, donde el método comprende del paso de: (i) La formación de una primera emulsión que tiene un primer tamaño promedio de gotas de aceite usando un homogeneizador, donde la primera emulsión es formada mediante una circulación que comprende: (a) una circulación tipo I de transferencia de los componentes de la primera emulsión entre un primer contenedor y un homogeneizador seguida por (b) una circulación de tipo II de transferencia de los componentes de la primera emulsión desde el primer contenedor a un 2º contenedor a través de un homogeneizador, y luego regresandolos desde el 2º contenedor al primer contenedor a través del mismo homogeneizador, donde sustancialmente todos los componentes de la emulsión desde el primer contenedor son pasados a través del homogeneizador al 2º contenedor, y entonces sustancialmente a todos los componentes de la emulsión desde el 2º contenedor son pasados a través del homogeneizador de vuelta al primer contenedor; (ii) la micro-fluidización de la primera emulsión para formar a una 2ª emulsión que tiene un 2º tamaño promedio de gotas de aceite que es menor que el primer tamaño promedio de gotas de aceite, al circular a los componentes de la 2ª emulsión a través de un dispositivo de micro-fluidización varias veces, donde la circulación comprende la transferencia de los componentes de la 2ª emulsión desde el de la emulsión, y entonces a través del mismo dispositivo de micro-fluidización.

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
imagen8
imagen9
imagen10
imagen11
imagen12
imagen13
imagen14
imagen15
imagen16
imagen17
imagen18
imagen19
imagen20

Claims (1)

  1. imagen1
    imagen2
ES10812803.4T 2009-12-03 2010-12-03 Circulación de componentes durante la homogeneización y de microfluidización de emulsiones Active ES2573710T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28351809P 2009-12-03 2009-12-03
US283518P 2009-12-03
PCT/IB2010/003394 WO2011067673A2 (en) 2009-12-03 2010-12-03 Circulation of components during homogenization of emulsions

Publications (1)

Publication Number Publication Date
ES2573710T3 true ES2573710T3 (es) 2016-06-09

Family

ID=43923723

Family Applications (3)

Application Number Title Priority Date Filing Date
ES10252043T Active ES2402569T3 (es) 2009-12-03 2010-12-03 Circulación de los componentes durante la homogeneización de las emulsiones
ES13155782T Active ES2975170T3 (es) 2009-12-03 2010-12-03 Circulación de los componentes durante la homogeneización de las emulsiones
ES10812803.4T Active ES2573710T3 (es) 2009-12-03 2010-12-03 Circulación de componentes durante la homogeneización y de microfluidización de emulsiones

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES10252043T Active ES2402569T3 (es) 2009-12-03 2010-12-03 Circulación de los componentes durante la homogeneización de las emulsiones
ES13155782T Active ES2975170T3 (es) 2009-12-03 2010-12-03 Circulación de los componentes durante la homogeneización de las emulsiones

Country Status (24)

Country Link
US (6) USRE46441E1 (es)
EP (4) EP2506834B1 (es)
JP (2) JP5820390B2 (es)
KR (1) KR101523215B1 (es)
CN (2) CN102753149B (es)
AU (1) AU2010325752B2 (es)
BR (1) BR112012013427B8 (es)
CA (1) CA2782511C (es)
DK (2) DK2356983T3 (es)
EA (1) EA024770B1 (es)
ES (3) ES2402569T3 (es)
FI (1) FI2638895T3 (es)
HR (1) HRP20130398T1 (es)
HU (1) HUE066873T2 (es)
IL (1) IL219984B (es)
MX (3) MX2012006216A (es)
NZ (1) NZ600323A (es)
PL (1) PL2356983T3 (es)
PT (1) PT2356983E (es)
RS (1) RS52748B (es)
SG (2) SG10201501611QA (es)
SI (2) SI2506834T1 (es)
SM (1) SMT201300044B (es)
WO (1) WO2011067673A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11707520B2 (en) 2005-11-03 2023-07-25 Seqirus UK Limited Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
CA2628152C (en) * 2005-11-04 2016-02-02 Novartis Vaccines And Diagnostics S.R.L. Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture
EP3173097A3 (en) 2009-02-10 2017-07-12 Seqirus UK Limited Influenza vaccines with reduced amounts of squalene
DE102009056883B4 (de) 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) * 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CN104688687A (zh) 2009-12-03 2015-06-10 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
EP2506834B1 (en) 2009-12-03 2016-03-02 Novartis AG Circulation of components during homogenization and microfluidization of emulsions
NZ603918A (en) 2010-05-12 2015-04-24 Novartis Ag Improved methods for preparing squalene
MX372965B (es) 2012-03-08 2020-04-01 Glaxosmithkline Biologicals Sa Formulaciones adyuvadas de vacunas de difteria, tetanos y tos ferina (dtp) de refuerzo.
JP6324961B2 (ja) 2012-09-06 2018-05-16 ノバルティス アーゲー 血清群ｂ髄膜炎菌とｄ／ｔ／ｐとの組み合わせワクチン
EP2906239A1 (en) 2012-10-12 2015-08-19 GlaxoSmithKline Biologicals SA Non-cross-linked acellular pertussis antigens for use in combination vaccines
US20150320852A1 (en) 2012-12-18 2015-11-12 Glaxosmithkline Biologicals Sa Conjugates for protecting against diphtheria and/or tetanus
RU2550253C2 (ru) * 2013-06-25 2015-05-10 Татьяна Владимировна Шленская Устройство для получения гомогенного молочного продукта и способ гидратации полярных молекул аминокислот молочных белков в процессе приготовления гомогенного молочного продукта
US9127542B2 (en) 2014-01-28 2015-09-08 Lawrence O. Price Subterranean well treatment process
DK3197487T3 (da) 2014-09-26 2022-09-05 Seqirus Uk Ltd Vaccination af immunsvækkede individer
AU2015323334B2 (en) 2014-09-26 2021-02-25 Seqirus UK Limited Vaccination of immunocompromised subjects
US10238739B2 (en) 2014-12-02 2019-03-26 Novartis Ag Manufacture of surfactant-containing compositions with enhanced stability
EP3468530A4 (en) 2016-06-10 2020-03-11 Clarity Cosmetics Inc. NON-COMEDOGEN FORMULA FOR HAIR AND SCALP CARE AND METHOD FOR USE
IT201800007790A1 (it) * 2018-08-02 2020-02-02 Gea Mech Equipment Italia Spa Omogeneizzatore ad alta pressione
EP3714968A1 (en) * 2019-03-29 2020-09-30 Sulzer Mixpac AG Dynamic mixer, dispensing assembly and method of dispensing multi- component material from a cartridge
CN111999489B (zh) * 2020-09-21 2024-08-09 上海科华生物工程股份有限公司 用于连续生产胶乳免疫比浊法的过滤分散设备和方法
WO2022112191A1 (en) * 2020-11-25 2022-06-02 Univerza V Ljubljani Liquid decontamination system comprising a cavitation device and method of decontamination of a liquid
CN116549387A (zh) * 2022-01-29 2023-08-08 江苏瑞科生物技术股份有限公司 乳剂制备方法

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1876979U (de) 1963-06-14 1963-08-01 Rehau Plastiks Sickerleitungsrohr.
CA951238A (en) 1970-06-10 1974-07-16 Ralph R. Calaceto Abrasion resistant venturi scrubbers
US4060082A (en) 1976-08-16 1977-11-29 Mpl, Inc. Dual-ingredient medication dispenser
US4340482A (en) 1978-02-21 1982-07-20 Millipore Corporation Process for grafting amino acid molecules onto preformed polymer surfaces and products prepared thereby
US4673504A (en) 1980-10-27 1987-06-16 Cuno Inc. Charge modified microporous membrane
US4473474A (en) 1980-10-27 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane and process for filtration of fluid
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US4473475A (en) 1981-05-29 1984-09-25 Amf Inc. Charge modified microporous membrane, process for charge modifying said membrane, and process for filtration of fluids
US4432875A (en) 1981-05-29 1984-02-21 Brunswick Corporation Semi-permeable membranes and processes for making the same
US4413074A (en) 1982-01-25 1983-11-01 Brunswick Corporation Hydrophilic surfaces and process for making the same
NZ209308A (en) 1983-08-30 1991-08-27 Genentech Inc Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein
US4705753A (en) 1984-06-08 1987-11-10 Gregor Harry P Biologically active acrylonitrile-based copolymeric membrane
US4618533A (en) 1984-11-30 1986-10-21 Millipore Corporation Porous membrane having hydrophilic surface and process
US4794002A (en) 1985-11-01 1988-12-27 Monsanto Company Modified polymeric surfaces and process for preparing same
US4964990A (en) 1987-05-20 1990-10-23 Gelman Sciences, Inc. Filtration membranes and method of making the same
US4943374A (en) 1988-04-21 1990-07-24 Gessner & Co., Gmbh Use of a microporous membrane constructed of polyether sulfon and hydrophilization agent for the filtration of beer
EP0520979B1 (en) 1988-10-17 1999-01-13 Hemasure, Inc. Process for the covalent surface modification of hydrophobic polymers and articles made therefrom
CA2017507C (en) 1989-05-25 1996-11-12 Gary Van Nest Adjuvant formulation comprising a submicron oil droplet emulsion
CA2086831C (en) * 1991-05-08 1999-03-16 Reinhard Gluck Immunostimulating and immunopotentiating reconstituted influenza virosomes and vaccines containing them
JPH0614756Y2 (ja) 1991-06-26 1994-04-20 株式会社アルテ 組み立て式の２室式容器兼用注射器
US5178765A (en) 1991-09-18 1993-01-12 Gelman Sciences Inc. Hydrophilic membranes prepared from polyethersulfone/poly-2-oxazoline/polyvinylpyrrolidone blend
EP0656779B1 (en) 1992-08-28 2000-04-12 Pharmos Corporation Submicron emulsions as ocular drug delivery vehicles
US5531893A (en) 1993-02-12 1996-07-02 Gelman Sciences Inc. Inter-penetrating network charge modified microporous membrane
US5277812A (en) 1993-02-12 1994-01-11 Gelman Sciences Inc. Inter-penetrating network charge modified microporous membrane
US6645463B1 (en) 1994-05-16 2003-11-11 The Board Of Regents Of The University Of Michigan Blood-pool selective carrier for lipophilic imaging agents
US5843334A (en) 1994-06-20 1998-12-01 Nippon Shinyaku Co., Ltd. Method of producing emulsions and an emulsification apparatus
US5487965A (en) 1994-09-06 1996-01-30 Xerox Corporation Processes for the preparation of developer compositions
US5496284A (en) 1994-09-27 1996-03-05 Waldenburg; Ottfried Dual-chamber syringe & method
US5510118A (en) * 1995-02-14 1996-04-23 Nanosystems Llc Process for preparing therapeutic compositions containing nanoparticles
DE19542499A1 (de) 1995-11-15 1997-05-22 Bayer Ag Verfahren und Vorrichtung zur Herstellung einer parenteralen Arzneistoffzubereitung
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
AU3186297A (en) 1996-07-05 1998-02-02 Debiotech S.A. Dual-chamber syringe for mixing two substances prior to injection
US6168718B1 (en) 1996-11-08 2001-01-02 Pall Corporation Method for purifying blood plasma and apparatus suitable therefor
JP4451931B2 (ja) 1996-11-12 2010-04-14 ホアットマン，インコーポレーテッド 親水性のポリマー状の相転換メンブレン
WO1999017820A1 (en) 1997-10-03 1999-04-15 Texas Pharmaceuticals, Inc. Improved dual chamber syringe apparatus
US5971953A (en) 1998-01-09 1999-10-26 Bachynsky; Nicholas Dual chamber syringe apparatus
US6039872A (en) 1997-10-27 2000-03-21 Pall Corporation Hydrophilic membrane
WO1999050189A1 (en) 1998-03-30 1999-10-07 Ebara Corporation Method and device for treating manganese-containing water
GB9808689D0 (en) 1998-04-23 1998-06-24 Kalsep Ltd Improved membrane
JP3995830B2 (ja) 1999-01-13 2007-10-24 富士フイルム株式会社 熱現像画像記録材料
US6193077B1 (en) 1999-02-08 2001-02-27 Osmonics, Inc. Non-cracking hydrophilic polyethersulfone membranes
EP1156781B1 (en) * 1999-02-26 2005-06-08 Chiron Corporation Microemulsions with adsorbed macromolecules and microparticles
KR100310234B1 (ko) 1999-08-20 2001-11-14 안복현 반도체 소자 ｃｍｐ용 금속산화물 슬러리의 제조방법
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
DE10059430A1 (de) 2000-11-30 2002-06-06 Cognis Deutschland Gmbh Feinteilige Emulsionen
MY134424A (en) 2001-05-30 2007-12-31 Saechsisches Serumwerk Stable influenza virus preparations with low or no amount of thiomersal
US20060148776A1 (en) 2003-03-13 2006-07-06 Conforma Therapeutics Corporation Drug formulations having long and medium chain triglycerides
US20040185068A1 (en) 2003-03-18 2004-09-23 Zhi-Jian Yu Self-emulsifying compositions, methods of use and preparation
AU2004226591B2 (en) * 2003-04-04 2009-06-04 Zoetis Services Llc Microfluidized oil-in-water emulsions and vaccine compositions
US20050208083A1 (en) 2003-06-04 2005-09-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof
AU2004273779B2 (en) 2003-06-04 2009-10-22 Nanobio Corporation Compositions for inactivating pathogenic microorganisms, methods of making the compositions, and methods of use thereof
KR101179393B1 (ko) * 2004-03-23 2012-09-07 노파르티스 아게 제약 조성물
GB0406515D0 (en) * 2004-03-23 2004-04-28 Novartis Ag Organic compounds
KR101153898B1 (ko) 2004-03-23 2012-06-18 니프로 가부시키가이샤 프리필드 시린지
KR20110132416A (ko) 2004-04-05 2011-12-07 화이자 프로덕츠 인코포레이티드 미세유체화된 수중유 유화액 및 백신 조성물
GB0411411D0 (en) * 2004-05-21 2004-06-23 Glaxosmithkline Biolog Sa Vaccines
DE102004031550A1 (de) 2004-06-29 2006-02-02 Cognis Ip Management Gmbh Hochkonzentrierte, selbstemulgierende Emulsionsgrundlagen zur Herstellung von Öl in Wasser Emulsionen
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
US7537718B2 (en) 2004-10-13 2009-05-26 3M Innovative Properties Company Hydrophilic polyethersulfone membrane and method for preparing same
TW200611880A (en) 2004-10-14 2006-04-16 Bi-Chang Li The microprocessor unit of bio-sludge-hydrolyzing equipment
AU2005304035B2 (en) 2004-11-09 2010-07-22 Santen Sas Ophthalmic oil-in-water type emulsion with stable positive zeta potential
GB0427568D0 (en) 2004-12-16 2005-01-19 Resolution Chemicals Ltd Particle-size reduction apparatus, and the use thereof
AR054020A1 (es) 2005-03-23 2007-05-30 Glaxosmithkline Biolog Sa Nuevo uso
US8703095B2 (en) 2005-07-07 2014-04-22 Sanofi Pasteur S.A. Immuno-adjuvant emulsion
EP1951200A2 (en) * 2005-08-09 2008-08-06 Nanobio Corporation Nanoemulsion compositions having anti-inflammatory activity
WO2008048271A2 (en) 2005-10-24 2008-04-24 Magsense Life Sciences, Inc. Polymer coated microparticles
NZ594482A (en) 2005-11-04 2012-11-30 Novartis Vaccines & Diagnostic Influenza vaccines with reduced amount of oil-in-water emulsion as adjuvant
JP5005700B2 (ja) * 2005-11-04 2012-08-22 ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル アルミニウムアジュバントに即座に吸着されるインフルエンザワクチン
FR2896162B1 (fr) 2006-01-13 2008-02-15 Sanofi Pasteur Sa Emulsion huile dans eau thermoreversible
EP1988918A4 (en) * 2006-02-22 2010-04-28 Novavax Inc ADJUVANZ AND VACCINE COMPOSITIONS
EP1849452A1 (de) * 2006-04-27 2007-10-31 Cognis IP Management GmbH Dispersionen, enthaltend Acylglutamate
PT2422810E (pt) 2006-07-17 2014-12-03 Glaxosmithkline Biolog Sa Vacina da gripe
GB0622282D0 (en) 2006-11-08 2006-12-20 Novartis Ag Quality control methods
PT2121011E (pt) * 2006-12-06 2014-07-31 Novartis Ag Vacinas compreendendo um antigénio a partir de quatro estirpes do vírus da gripe
US8506966B2 (en) 2008-02-22 2013-08-13 Novartis Ag Adjuvanted influenza vaccines for pediatric use
BRPI0821895A2 (pt) 2008-04-04 2014-10-07 Robert Shorr Composiçao farmacêutica, método de tratamento ou prevenção de uma doença, uma condição e sintomas das mesmas em animais de sangue quente, incluindo seres humanos, método de preparação da composição farmacêutica e método para diagnosticar uma doença, condição, síndrome.
US8187554B2 (en) 2008-04-23 2012-05-29 Microfluidics International Corporation Apparatus and methods for nanoparticle generation and process intensification of transport and reaction systems
US8771746B2 (en) * 2008-06-19 2014-07-08 Otonomy, Inc. Colloidal suspensions comprising a therapeutic agent and squalene
CN104688687A (zh) 2009-12-03 2015-06-10 诺华股份有限公司 疫苗佐剂制备中的亲水过滤
EP2506834B1 (en) * 2009-12-03 2016-03-02 Novartis AG Circulation of components during homogenization and microfluidization of emulsions
DE102009056871A1 (de) 2009-12-03 2011-06-22 Novartis AG, 4056 Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
CL2012001399A1 (es) * 2009-12-03 2013-03-08 Novartis Ag Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
RS52565B (sr) 2009-12-03 2013-04-30 Novartis Ag Metod interakcije i komore sa povratnim pritiskom za mikrofluidizaciju
DE102009056883B4 (de) * 2009-12-03 2012-08-16 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
DE102009056884B4 (de) 2009-12-03 2021-03-18 Novartis Ag Impfstoff-Adjuvantien und verbesserte Verfahren zur Herstellung derselben
WO2011106565A1 (en) 2010-02-24 2011-09-01 Travers William A Methods and devices for controlling particle size and particle size distribution
GB201009671D0 (en) 2010-06-10 2010-07-21 Glaxosmithkline Biolog Sa Novel process

Also Published As

Publication number Publication date
MX360299B (es) 2018-10-29
SG10201501611QA (en) 2015-04-29
HK1160396A1 (en) 2012-08-17
MX2012006216A (es) 2012-07-12
US20130142833A1 (en) 2013-06-06
US10463615B2 (en) 2019-11-05
US20160113870A1 (en) 2016-04-28
EP2638895B1 (en) 2024-03-20
WO2011067673A2 (en) 2011-06-09
AU2010325752A1 (en) 2012-06-21
ES2402569T3 (es) 2013-05-06
MX344381B (es) 2016-12-14
JP2013512892A (ja) 2013-04-18
HK1175404A1 (zh) 2013-07-05
IL219984B (en) 2018-06-28
BR112012013427A2 (pt) 2016-04-05
JP2015193656A (ja) 2015-11-05
EA201290426A1 (ru) 2012-11-30
CN102753149B (zh) 2015-10-14
EA024770B1 (ru) 2016-10-31
EP4410306A3 (en) 2024-11-13
RS52748B (sr) 2013-08-30
KR20120099750A (ko) 2012-09-11
EP4410306A2 (en) 2024-08-07
PT2356983E (pt) 2013-04-23
US11141376B2 (en) 2021-10-12
BR112012013427B1 (pt) 2021-03-30
EP2356983A1 (en) 2011-08-17
DK2356983T3 (da) 2013-03-11
EP2506834B1 (en) 2016-03-02
PL2356983T3 (pl) 2013-08-30
JP5820390B2 (ja) 2015-11-24
IL219984A0 (en) 2012-07-31
EP2638895A2 (en) 2013-09-18
EP2638895A3 (en) 2014-02-19
KR101523215B1 (ko) 2015-05-27
CN102753149A (zh) 2012-10-24
HRP20130398T1 (en) 2013-06-30
US20200268661A1 (en) 2020-08-27
USRE46441E1 (en) 2017-06-20
US8895629B2 (en) 2014-11-25
CA2782511C (en) 2013-11-12
SI2506834T1 (sl) 2016-04-29
US9750690B2 (en) 2017-09-05
HUE066873T2 (hu) 2024-09-28
CN105055311A (zh) 2015-11-18
EP2356983B1 (en) 2013-02-20
EP2506834A2 (en) 2012-10-10
US20180055769A1 (en) 2018-03-01
CA2782511A1 (en) 2011-06-09
AU2010325752B2 (en) 2013-12-19
DK2638895T3 (da) 2024-06-17
NZ600323A (en) 2013-12-20
ES2975170T3 (es) 2024-07-03
WO2011067673A3 (en) 2012-05-10
SMT201300044B (it) 2013-07-09
SI2356983T1 (sl) 2013-05-31
US20160128937A1 (en) 2016-05-12
BR112012013427B8 (pt) 2021-05-25
SG181096A1 (en) 2012-07-30
FI2638895T3 (fi) 2024-06-20

Similar Documents

Publication Publication Date Title
ES2573710T3 (es) Circulación de componentes durante la homogeneización y de microfluidización de emulsiones
ES2629780T3 (es) Máquina transportadora para paquetes y método correspondiente
CY1121563T1 (el) Συστημα απελευθερωσης φαρμακου για χρηση στην αντισυλληψη που περιλαμβανει πυρηνα και μια θηκη
MX366971B (es) Metodo de generacion de datos, metodo de reproduccion de datos, dispositivo de generacion de datos y dispositivo de reproduccion de datos.
ES2579703T3 (es) Eólica sobre soporte flotante estabilizada por un sistema de anclaje sobreelevado
ES2546992T3 (es) Método para desintonizar los álabes de un motor de turbina de gas
ES2644438T3 (es) Aparato para generar energía mediante gasificación
ECSP099524A (es) Mousse
AR083395A1 (es) Derivado peptidico nmu (neuromedina u) con elevado efecto anorectico
BR112013005517A2 (pt) emulsão comestível, bebida compreendendo a mesma e método para produzir uma emulsão
CL2016001386A1 (es) Sistemas y métodos para estimar la eficiencia alimenticia y la huella de carbono para animal productor de leche.
ECSP17059323A (es) Formulacion de combinacion de tesofensina y betabloqueante
SV2016005273A (es) Relajaciã“n del tiempo de respuesta para wlan de alto rendimiento
ES2488868B1 (es) Procedimiento para la obtención de nanoestructuras de plata y nanoestructuras obtenidas mediante dicho procedimiento
ES2628097T3 (es) Método y dispositivo para empaquetar alimentos cocinados en al menos una bandeja
ES2605440T3 (es) Emulsiones estabilizadas con micelas de proteínas de suero de leche
ES2611776T3 (es) Uso de sales de tungsteno (VI) para el tratamiento de la esterilidad femenina en mamíferos no diabéticos
BR112019009151A2 (pt) habilitação e desabilitação de monitoramento de página
MX367808B (es) Método de búsqueda y aparato de búsqueda.
AR071104A1 (es) Metodo para determinar una proteina de haemophilus parasuis que comprende un determinante antigenico de reaccion cruzada
CL2012001399A1 (es) Metodo para fabricar adyuvante para vacuna (emulsion aceite/agua con escualeno, polisorbato 80 y trioleato de sorbitan), que comprende (i) formar primera emulsion en homogenizador desde un contendor a otro para formar segunda emulsion, (ii) y microfluidizar primera emulsion para formar segunda emulsion.
ES2602152T3 (es) Procedimiento de tratamiento de carne en línea
ECSP18079073A (es) Antígenos y anticuerpos de chagas y composiciones, métodos y usos de los mismos
ES2496673T3 (es) Método y aparato para empaquetar un producto en un empaque con bandeja y cubierta
UY36549A (es) Procedimiento para la preparación de diosmina