ES2636464T5 - Multivalent recombinant avian herpes viruses and vaccines for immunizing avian species - Google Patents

Multivalent recombinant avian herpes viruses and vaccines for immunizing avian species Download PDF

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Publication number
ES2636464T5
ES2636464T5 ES13713195T ES13713195T ES2636464T5 ES 2636464 T5 ES2636464 T5 ES 2636464T5 ES 13713195 T ES13713195 T ES 13713195T ES 13713195 T ES13713195 T ES 13713195T ES 2636464 T5 ES2636464 T5 ES 2636464T5
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Prior art keywords
recombinant
promoter
protein
nucleotide sequence
avian
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ES13713195T
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Spanish (es)
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ES2636464T3 (es
Inventor
Ayumi Fujisawa
Mayumi Kubomura
Sakiko Saeki
Shuji Saito
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Ceva Sante Animale SA
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Ceva Sante Animale SA
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/17—Newcastle disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16311—Mardivirus, e.g. Gallid herpesvirus 2, Marek-like viruses, turkey HV
    • C12N2710/16341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/10011—Birnaviridae
    • C12N2720/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
    • C12N2760/18134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ES13713195T 2012-03-30 2013-03-29 Multivalent recombinant avian herpes viruses and vaccines for immunizing avian species Active ES2636464T5 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20120305390 EP2644702A1 (fr) 2012-03-30 2012-03-30 Virus herpès aviaire recombinant multivalents et vaccin pour immuniser les espèces aviaires
EP12305390 2012-03-30
PCT/EP2013/056839 WO2013144355A1 (fr) 2012-03-30 2013-03-29 Virus herpès aviaire recombinant multivalents et vaccins pour immuniser les espèces aviaires

Publications (2)

Publication Number Publication Date
ES2636464T3 ES2636464T3 (es) 2017-10-05
ES2636464T5 true ES2636464T5 (en) 2025-04-03

Family

ID=48040245

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13713195T Active ES2636464T5 (en) 2012-03-30 2013-03-29 Multivalent recombinant avian herpes viruses and vaccines for immunizing avian species
ES17168632T Active ES2807952T3 (es) 2012-03-30 2013-03-29 Herpesvirus aviares recombinantes multivalentes y vacunas para inmunizar especies aviares

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES17168632T Active ES2807952T3 (es) 2012-03-30 2013-03-29 Herpesvirus aviares recombinantes multivalentes y vacunas para inmunizar especies aviares

Country Status (22)

Country Link
US (6) US10251951B2 (fr)
EP (4) EP2644702A1 (fr)
JP (2) JP6505593B2 (fr)
KR (1) KR102070217B1 (fr)
CN (2) CN104364381B (fr)
BR (1) BR112014024094A2 (fr)
CA (1) CA2868132C (fr)
CO (1) CO7160021A2 (fr)
ES (2) ES2636464T5 (fr)
HU (2) HUE050602T2 (fr)
MA (1) MA37446B1 (fr)
MX (1) MX357365B (fr)
MY (1) MY173016A (fr)
PE (2) PE20150334A1 (fr)
PH (2) PH12014502162A1 (fr)
PL (2) PL2831246T5 (fr)
PT (2) PT2831246T (fr)
RU (2) RU2766003C2 (fr)
TN (1) TN2014000392A1 (fr)
UA (1) UA118335C2 (fr)
WO (1) WO2013144355A1 (fr)
ZA (1) ZA201406979B (fr)

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Publication number Priority date Publication date Assignee Title
EP2644702A1 (fr) * 2012-03-30 2013-10-02 Ceva Sante Animale Virus herpès aviaire recombinant multivalents et vaccin pour immuniser les espèces aviaires
EP2845904A1 (fr) 2013-09-06 2015-03-11 Ceva Sante Animale Virus de l'herpes de la volaille recombinants et leurs utilisations
CN104120110B (zh) * 2014-07-11 2017-01-18 中国农业科学院哈尔滨兽医研究所 表达增强型绿色荧光蛋白基因的鸭瘟病毒重组疫苗株及其构建方法和应用
CN107043774B (zh) * 2014-09-25 2021-05-04 中国人民解放军第二军医大学东方肝胆外科医院 一种嵌合强启动子及其用途
AR103245A1 (es) * 2014-12-24 2017-04-26 Intervet Int Bv Vacuna vectorial basada en hvt (herpes virus de los pavos) frente a nd (enfermedad de newcastle) - ibd (enfermedad de gumboro) mejorada
HK1257191A1 (zh) * 2015-08-10 2019-10-18 The Texas A&M University System 重组火鸡疱疹病毒疫苗及其用途
US11596687B2 (en) 2016-06-17 2023-03-07 Intervet Inc. Recombinant non-pathogenic Marek's disease virus constructs encoding infectious laryngotracheitis virus and infectious bursal disease virus antigens
CN106350475A (zh) * 2016-08-26 2017-01-25 江苏省农业科学院 一种新型火鸡疱疹病毒的细菌人工染色体、构建方法与应用
KR102780119B1 (ko) 2016-12-14 2025-03-12 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 조류 병원체의 다중 항원을 발현하는 재조합 hvt 벡터 및 그를 포함하는 백신
CN106929483B (zh) * 2017-01-19 2020-09-25 北京邦卓生物科技有限公司 表达鸡新城疫病毒f基因的重组火鸡疱疹病毒的构建及其应用
EP3694987A1 (fr) 2017-10-12 2020-08-19 Intervet International B.V. Constructions de virus de la maladie de marek non pathogènes recombinantes codant de multiples antigènes hétérologues
CN107815469A (zh) * 2017-10-16 2018-03-20 北京市农林科学院 一种重组火鸡疱疹病毒及其制备方法
CN108060141B (zh) * 2017-12-14 2021-05-28 天津瑞普生物技术股份有限公司 Vp2基因和np基因重组腺病毒及其应用
CN109402071B (zh) * 2018-11-08 2021-04-27 中国农业大学 一种表达h9n2亚型禽流感病毒h9蛋白的重组火鸡疱疹病毒
CN113226363B (zh) 2018-12-21 2024-08-23 法国诗华大药厂 含有多个外来基因的重组禽疱疹病毒
BR112021012434A2 (pt) 2018-12-27 2021-09-28 Ceva Sante Animale Vírus recombinantes e usos dos mesmos
CN114616325A (zh) 2019-09-11 2022-06-10 硕腾服务有限责任公司 表达禽病原体抗原的重组火鸡疱疹病毒载体和其用途
CN110684744A (zh) * 2019-10-22 2020-01-14 青岛易邦生物工程有限公司 一种表达鸡传染性法氏囊病病毒vp2基因的重组火鸡疱疹病毒株
CN114828882A (zh) 2019-12-20 2022-07-29 英特维特国际股份有限公司 多价hvt载体疫苗
KR20230040328A (ko) 2020-06-17 2023-03-22 베링거잉겔하임베트메디카게엠베하 인플루엔자 헤마글루티닌을 발현하는 재조합 hvt 벡터 및 면역원성 조성물, 및 이의 제조 및 용도
EP4228683A2 (fr) * 2020-10-15 2023-08-23 Ceva Santé Animale Herpès virus recombinant de la dinde (hvt) et ses utilisations
CN114369580A (zh) * 2020-10-15 2022-04-19 浙江诗华诺倍威生物技术有限公司 重组hvt及其用途
CN116648259A (zh) * 2020-12-24 2023-08-25 英特维特国际股份有限公司 多价hvt载体疫苗
US20250352642A1 (en) 2022-05-05 2025-11-20 Intervet Inc. New multivalent hvt vector vaccine
WO2024105245A1 (fr) 2022-11-18 2024-05-23 Ceva Sante Animale Virus recombinant de la maladie de marek et ses utilisations
US20250064917A1 (en) 2023-08-25 2025-02-27 Boehringer Ingelheim Vetmedica Gmbh Hvt aiv vectors and uses thereof
CN120555370A (zh) * 2024-02-29 2025-08-29 诗华动保科技(杭州)有限公司 重组hvt及其应用

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US10500270B2 (en) 2019-12-10
PE20150334A1 (es) 2015-03-25
ZA201406979B (en) 2016-01-27
PH12014502162B1 (en) 2014-12-10
BR112014024094A2 (pt) 2017-07-18
UA118335C2 (uk) 2019-01-10
MY173016A (en) 2019-12-19
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US20150118250A1 (en) 2015-04-30
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EP2831246A1 (fr) 2015-02-04
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US20180256707A1 (en) 2018-09-13
EP2831246B1 (fr) 2017-05-03
US20180256706A1 (en) 2018-09-13
MA20150281A2 (fr) 2015-08-31
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US11123425B2 (en) 2021-09-21
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CN104364381A (zh) 2015-02-18
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