ES277406A1 - A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES277406A1 ES277406A1 ES277406A ES277406A ES277406A1 ES 277406 A1 ES277406 A1 ES 277406A1 ES 277406 A ES277406 A ES 277406A ES 277406 A ES277406 A ES 277406A ES 277406 A1 ES277406 A1 ES 277406A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- substituted
- aralcohlylating
- tetracycline
- aralkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000004098 Tetracycline Substances 0.000 title abstract 5
- 229960002180 tetracycline Drugs 0.000 title abstract 5
- 229930101283 tetracycline Natural products 0.000 title abstract 5
- 235000019364 tetracycline Nutrition 0.000 title abstract 5
- 150000003522 tetracyclines Chemical class 0.000 title abstract 5
- 238000000034 method Methods 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000003277 amino group Chemical group 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 230000002152 alkylating effect Effects 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical group O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 150000001721 carbon Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for preparing tetracycline derivatives containing a 7- and/or 9-amino group, in which at least one of said amino groups is substituted by one or two radicals of the formula ** (See formula) ** wherein R3 and R4 are the same or different and are hydrogen atoms or lower alkyl, aryl, substituted aryl, aralkyl or substituted aralkyl groups, characterized in that (a) a tetracycline having a 7-amino group and/or 9-amino, in which the amino group can be formed in situ with one or two moles by amino groups of an alkylating, aralcohlylating or substituted aralcohlylating reagent capable of forming a carbon bond with the nitrogen atom of the amine, (b) and, if necessary, separately or simultaneously with operation (a), react the product of operation (a) with hydrogen to reduce any unsaturated carbon to nitrogen bond, or to replace any other radical with hydrogen of hydrogen in the alkyl portion of the substituted alkyl, aralkyl or aralkyl group; with the proviso that when there is a carbonyl oxygen atom in the carbon bonded to the nitrogen of the amine, the product of operation (a) which is reacted with hydrogen, is then only a 7-formylamino tetracycline and/or -formylamino tetracycline, (c) and if two moles of the alkylating, aralcohlylating and/or substituted aralcohlylating reagent are used, the second mole can be introduced separately or simultaneously with the formation of the carbon-to-nitrogen bond and/or reaction with hydrogen. (Machine-translation by Google Translate, not legally binding)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES338710A ES338710A2 (en) | 1961-10-24 | 1967-03-31 | A procedure for preparing tetracycline derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES379444A ES379444A2 (en) | 1961-10-24 | 1970-05-08 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14713761A | 1961-10-24 | 1961-10-24 | |
| US161412A US3148212A (en) | 1961-12-22 | 1961-12-22 | Reductive alkylation process |
| US17159962A | 1962-02-07 | 1962-02-07 | |
| US53928266A | 1966-04-01 | 1966-04-01 | |
| US54436866A | 1966-04-22 | 1966-04-22 | |
| US58920666A | 1966-10-25 | 1966-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES277406A1 true ES277406A1 (en) | 1962-12-01 |
Family
ID=56089740
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES277406A Expired ES277406A1 (en) | 1961-10-24 | 1962-05-17 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
| ES338710A Expired ES338710A2 (en) | 1961-10-24 | 1967-03-31 | A procedure for preparing tetracycline derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES379444A Expired ES379444A2 (en) | 1961-10-24 | 1970-05-08 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES338710A Expired ES338710A2 (en) | 1961-10-24 | 1967-03-31 | A procedure for preparing tetracycline derivatives. (Machine-translation by Google Translate, not legally binding) |
| ES379444A Expired ES379444A2 (en) | 1961-10-24 | 1970-05-08 | A procedure for preparing tetracycline derivatives (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE618065A (en) |
| CH (2) | CH444848A (en) |
| DK (1) | DK126586B (en) |
| ES (3) | ES277406A1 (en) |
| GB (1) | GB1003474A (en) |
| LU (1) | LU41768A1 (en) |
| MC (1) | MC370A1 (en) |
| SE (1) | SE309416B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2316468A1 (en) | 2002-02-22 | 2011-05-04 | Shire LLC | Delivery system and methods for protecting and administering dextroamphetamine |
-
1962
- 1962-05-16 MC MC389A patent/MC370A1/en unknown
- 1962-05-17 ES ES277406A patent/ES277406A1/en not_active Expired
- 1962-05-17 GB GB19034/62A patent/GB1003474A/en not_active Expired
- 1962-05-22 CH CH618162A patent/CH444848A/en unknown
- 1962-05-22 CH CH1577466A patent/CH448070A/en unknown
- 1962-05-24 BE BE618065A patent/BE618065A/en unknown
- 1962-05-24 LU LU41768D patent/LU41768A1/xx unknown
- 1962-05-24 DK DK235062AA patent/DK126586B/en unknown
-
1963
- 1963-11-22 SE SE12945/63A patent/SE309416B/xx unknown
-
1967
- 1967-03-31 ES ES338710A patent/ES338710A2/en not_active Expired
-
1970
- 1970-05-08 ES ES379444A patent/ES379444A2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1003474A (en) | 1965-09-02 |
| MC370A1 (en) | 1963-03-28 |
| ES379444A2 (en) | 1972-11-01 |
| SE309416B (en) | 1969-03-24 |
| BE618065A (en) | 1962-11-26 |
| DK126586B (en) | 1973-07-30 |
| CH444848A (en) | 1967-10-15 |
| LU41768A1 (en) | 1962-07-24 |
| CH448070A (en) | 1967-12-15 |
| ES338710A2 (en) | 1968-04-01 |
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