ES307302A1 - Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES307302A1
ES307302A1 ES0307302A ES307302A ES307302A1 ES 307302 A1 ES307302 A1 ES 307302A1 ES 0307302 A ES0307302 A ES 0307302A ES 307302 A ES307302 A ES 307302A ES 307302 A1 ES307302 A1 ES 307302A1
Authority
ES
Spain
Prior art keywords
lower alkyl
radical
general formula
formula
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0307302A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES307302A1 publication Critical patent/ES307302A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22Bridged ring systems
    • C07D221/26Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Discharge Lamp (AREA)

Abstract

Procedure for preparing new substituted 6,7-benzomorpans, of the general formula I ** (See formula) ** in which R1 means hydrogen, the hydroxyl group or an alkoxy or lower alkanoyloxy radical, R2 means hydrogen, a lower alkyl or beta-methoxyethyl radical or a phenyl radical, sometimes substituted by a halogen atom, a hydroxyl group or an alkoxy, alkanoyloxy or lower alkyl group, R3 signifies hydrogen or a lower alkyl radical and R4 signifies a lower alkyl radical or a phenyl radical, which is characterized by reacting a compound of the general formula II ** (See formula) ** in which R5_ means hydrogen or a lower alkyl radical, and R1, R2, and R3 have the meaning set forth in formula I, with a carboxylic acid derivative of the general formula III ** (See formula) ** in which Hal means a halogen atom and R4 has the meaning stated in formula I, and, if desired, by alkylating or alkylating, in a manner known per se, a compound of the general formula I in which R 1 signifies the hydroxyl group, or else hydrolyzing it, in a manner known per se, in the case that R 1 means an alkoxy or alkanoyloxy group and, if desired, by converting a compound of the general formula I into an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES0307302A 1963-12-20 1964-12-19 Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding) Expired ES307302A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33229663A 1963-12-20 1963-12-20

Publications (1)

Publication Number Publication Date
ES307302A1 true ES307302A1 (en) 1965-05-16

Family

ID=23297612

Family Applications (4)

Application Number Title Priority Date Filing Date
ES0307299A Expired ES307299A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307302A Expired ES307302A1 (en) 1963-12-20 1964-12-19 Procedure for preparing new substituteed 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307300A Expired ES307300A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307301A Expired ES307301A1 (en) 1963-12-20 1964-12-19 Benzomorphans and process for their preparation

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES0307299A Expired ES307299A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES0307300A Expired ES307300A1 (en) 1963-12-20 1964-12-19 Procedure for the preparation of new substitute 6,7-benzomorphanes. (Machine-translation by Google Translate, not legally binding)
ES0307301A Expired ES307301A1 (en) 1963-12-20 1964-12-19 Benzomorphans and process for their preparation

Country Status (12)

Country Link
AT (4) AT249276B (en)
BE (2) BE657406A (en)
CH (7) CH446371A (en)
DE (2) DE1445854A1 (en)
DK (4) DK108495C (en)
ES (4) ES307299A1 (en)
FR (2) FR4345M (en)
GB (2) GB1092394A (en)
IL (2) IL22643A (en)
NL (3) NL6414820A (en)
NO (2) NO119274B (en)
SE (2) SE322779B (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2987788A1 (en) 2002-05-17 2016-02-24 Taiwanj Pharmaceuticals Co., Ltd. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
CA2678577A1 (en) 2007-02-26 2008-09-04 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
EP2183228B1 (en) 2007-07-26 2014-08-20 Vitae Pharmaceuticals, Inc. CYCLIC INHIBITORS OF 11ß -HYDROXYSTERIOD DEHYDROGENASE 1
AR069207A1 (en) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc CYCLIC UREAS AS INHIBITORS OF THE 11 BETA - HIDROXI-ESTEROIDE DESHIDROGENASA 1
CL2008003407A1 (en) 2007-11-16 2010-01-11 Boehringer Ingelheim Int Substituted heterobicyclo aryl- and heteroarylcarbonyl derivative compounds; pharmaceutical composition; preparation procedure; and its use in the treatment and / or prevention of metabolic disorders, mediated by the inhibition of the enzyme hsd-1.
CA2708303A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5734666B2 (en) 2008-02-11 2015-06-17 ヴァイティー ファーマシューティカルズ,インコーポレイテッド 1,3-oxaazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase 1
CA2711757C (en) * 2008-02-12 2016-07-26 Boehringer Ingelheim International Gmbh Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AR071236A1 (en) 2008-05-01 2010-06-02 Vitae Pharmaceuticals Inc CYCLE INHIBITORS OF 11BETA-HYDROXIESTEROID DEHYDROGENASE 1
CA2723032A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CL2009001059A1 (en) 2008-05-01 2010-11-12 Boehringer Ingelheim Int Compounds derived from substituted 1,3-oxazin-2-one-3.6, inhibitors of the activity of 11-beta-hydroxysteroid dehydrogenase i; pharmaceutical composition that includes them; Useful in the treatment of diseases such as diabetes mellitus, among others.
WO2009134387A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8765780B2 (en) 2008-05-13 2014-07-01 Boehringer Ingelheim International Gmbh Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010011314A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
AR073920A1 (en) 2008-10-23 2010-12-09 Boehringer Ingelheim Int UREA DERIVATIVES OF SUBSTITUTED NORTROPANS, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE IN THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF THE 11BETA-HYDROXIESTEROID DISHYDROGENASE DISEASE AND PROCESS FOR PREPARATION.
CA2744946A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
UA109255C2 (en) 2009-04-30 2015-08-10 Берінгер Інгельхайм Інтернешнл Гмбх Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
WO2010139673A1 (en) 2009-06-02 2010-12-09 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
AR078887A1 (en) 2009-11-06 2011-12-07 Boehringer Ingelheim Int ARILO AND HETEROARILCARBONILO DERIVATIVES OF HEXAHYDROINDENOPIRIDINE AND OCTAHYDROBENZOQUINOLINE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
JP5813106B2 (en) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Azaspirohexanone as an inhibitor of 11-β-HSD1 for the treatment of metabolic disorders
PH12013500808A1 (en) 2010-11-02 2015-10-07 Boehringer Ingelheim Int Pharmaceutical combinations for the treatment of metabolic disorders
TWI537258B (en) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
JP2014524438A (en) 2011-08-17 2014-09-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Indenopyridine derivatives

Also Published As

Publication number Publication date
CH449639A (en) 1968-01-15
SE305657B (en) 1968-11-04
CH448118A (en) 1967-12-15
ES307299A1 (en) 1965-05-16
DE1445853A1 (en) 1968-12-05
AT249276B (en) 1966-09-12
CH446371A (en) 1967-11-15
NL6414820A (en) 1965-06-21
FR4345M (en) 1966-08-16
GB1092394A (en) 1967-11-22
SE322779B (en) 1970-04-20
DK108496C (en) 1967-12-27
IL22643A (en) 1968-07-25
NL127995C (en)
BE657406A (en) 1965-06-21
ES307300A1 (en) 1965-05-01
ES307301A1 (en) 1965-05-16
CH449641A (en) 1968-01-15
FR4346M (en) 1966-08-16
AT253687B (en) 1967-04-25
IL22642A (en) 1968-07-25
DK108497C (en) 1967-12-27
CH449640A (en) 1968-01-15
NL6414821A (en) 1965-06-21
AT249277B (en) 1966-09-12
DK108495C (en) 1967-12-27
BE657405A (en) 1965-06-21
GB1077711A (en) 1967-08-02
DK106552C (en) 1967-02-20
AT261126B (en) 1968-04-10
DE1445854A1 (en) 1968-12-05
NO119273B (en) 1970-04-27
NO119274B (en) 1970-04-27
CH449642A (en) 1968-01-15
CH449643A (en) 1968-01-15

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