ES339432A1 - Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos. - Google Patents

Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.

Info

Publication number: ES339432A1
Authority: ES; Spain
Prior art keywords: formula; hydrogen atom; atom; chlorine; tetrahydroquinazoline
Prior art date: 1966-04-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES339432A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Boehringer Ingelheim Pharma GmbH and Co KG

Original Assignee

Dr Karl Thomae GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1966-04-20

Filing date

1967-04-18

Publication date

1968-07-16

1967-04-18 Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH

1968-07-16 Publication of ES339432A1 publication Critical patent/ES339432A1/es

Status Expired legal-status Critical Current

Links

PKORYTIUMAOPED-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinazoline Chemical class C1=CC=C2NCNCC2=C1 PKORYTIUMAOPED-UHFFFAOYSA-N 0.000 title abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 7
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 3
239000002253 acid Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 3
238000006243 chemical reaction Methods 0.000 abstract 3
239000000460 chlorine Substances 0.000 abstract 3
229910052801 chlorine Inorganic materials 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
GVOYKJPMUUJXBS-UHFFFAOYSA-N 2-(aminomethyl)aniline Chemical class NCC1=CC=CC=C1N GVOYKJPMUUJXBS-UHFFFAOYSA-N 0.000 abstract 2
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 2
229910052987 metal hydride Inorganic materials 0.000 abstract 2
150000004681 metal hydrides Chemical class 0.000 abstract 2
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 1
CTOUNZIAEBIWAW-UHFFFAOYSA-N 3,4-dihydro-1h-quinazolin-2-one Chemical class C1=CC=C2NC(=O)NCC2=C1 CTOUNZIAEBIWAW-UHFFFAOYSA-N 0.000 abstract 1
YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
230000000954 anitussive effect Effects 0.000 abstract 1
230000001754 anti-pyretic effect Effects 0.000 abstract 1
239000002221 antipyretic Substances 0.000 abstract 1
229940124584 antitussives Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000031709 bromination Effects 0.000 abstract 1
238000005893 bromination reaction Methods 0.000 abstract 1
238000005660 chlorination reaction Methods 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000005350 hydroxycycloalkyl group Chemical group 0.000 abstract 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ES339432A 1966-04-20 1967-04-18 Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos. Expired ES339432A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DET0030948		1966-04-20

Publications (1)

Publication Number	Publication Date
ES339432A1 true ES339432A1 (es)	1968-07-16

Family

ID=36887743

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
ES339371A Expired ES339371A1 (es)	1966-04-20	1967-04-15	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.
ES339394A Expired ES339394A1 (es)	1966-04-20	1967-04-17	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.
ES339432A Expired ES339432A1 (es)	1966-04-20	1967-04-18	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.
ES339483A Expired ES339483A1 (es)	1966-04-20	1967-04-19	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
ES339371A Expired ES339371A1 (es)	1966-04-20	1967-04-15	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.
ES339394A Expired ES339394A1 (es)	1966-04-20	1967-04-17	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
ES339483A Expired ES339483A1 (es)	1966-04-20	1967-04-19	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.

Country Status (15)

Country	Link
US (1)	US3454574A (es)
BE (1)	BE697188A (es)
CH (5)	CH493531A (es)
CS (1)	CS162434B1 (es)
DE (1)	DE1620541C3 (es)
DK (1)	DK120345B (es)
ES (4)	ES339371A1 (es)
FI (1)	FI48929C (es)
FR (2)	FR1524445A (es)
GB (1)	GB1131164A (es)
GR (1)	GR33644B (es)
IL (1)	IL27764A (es)
NL (2)	NL6705206A (es)
SE (1)	SE323685B (es)
YU (4)	YU32364B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5924990B2 (ja) *	1979-11-21	1984-06-13	協和醗酵工業株式会社	新規なピペリジン誘導体
US4753944A (en) *	1985-11-04	1988-06-28	American Cyanamid Company	Pharmaceutical methods of using 3-heteroarylalkyl-4-quinazolinones
US4710502A (en) *	1985-11-04	1987-12-01	American Cyanamid Company	3-heteroarylalkyl-4-quinazolinones
CS272018B1 (en) *	1988-11-01	1990-12-13	Fisnerova Ludmila	Ethereal derivatives of 4/3h/-quinazolinone
JP2007512227A (ja)	2003-08-06	2007-05-17	セノミックス、インコーポレイテッド	Ｔ１ｒヘテロオリゴマー味覚受容体、この受容体を発現する細胞株、および味覚化合物
EP3235811B1 (en)	2006-04-21	2018-07-25	Senomyx, Inc.	Process of preparing oxalamides
CN102898383A (zh) *	2012-11-16	2013-01-30	葛长乐	一种氨溴索反式杂质6,8-二溴-3-(反式-4-羟基环己基)-1,2,3,4-四氢喹唑啉的制备方法

0
- NL NL131479D patent/NL131479C/xx active
1966
- 1966-04-20 DE DE1620541A patent/DE1620541C3/de not_active Expired
1967
- 1967-03-30 DK DK173367AA patent/DK120345B/da unknown
- 1967-04-06 CH CH1648169A patent/CH493531A/de not_active IP Right Cessation
- 1967-04-06 CH CH895370A patent/CH508637A/de not_active IP Right Cessation
- 1967-04-06 CH CH1648269A patent/CH493532A/de not_active IP Right Cessation
- 1967-04-06 CH CH1648369A patent/CH493533A/de not_active IP Right Cessation
- 1967-04-06 CH CH483567A patent/CH483433A/de not_active IP Right Cessation
- 1967-04-10 IL IL27764A patent/IL27764A/en unknown
- 1967-04-10 US US629417A patent/US3454574A/en not_active Expired - Lifetime
- 1967-04-13 NL NL6705206A patent/NL6705206A/xx unknown
- 1967-04-13 GB GB17098/67A patent/GB1131164A/en not_active Expired
- 1967-04-15 YU YU0756/67A patent/YU32364B/xx unknown
- 1967-04-15 ES ES339371A patent/ES339371A1/es not_active Expired
- 1967-04-17 ES ES339394A patent/ES339394A1/es not_active Expired
- 1967-04-18 ES ES339432A patent/ES339432A1/es not_active Expired
- 1967-04-18 FR FR103183A patent/FR1524445A/fr not_active Expired
- 1967-04-18 FR FR103182A patent/FR6442M/fr not_active Expired
- 1967-04-18 BE BE697188D patent/BE697188A/xx unknown
- 1967-04-19 ES ES339483A patent/ES339483A1/es not_active Expired
- 1967-04-19 GR GR670133644A patent/GR33644B/el unknown
- 1967-04-20 FI FI671165A patent/FI48929C/fi active
- 1967-04-20 SE SE5557/67A patent/SE323685B/xx unknown
1968
- 1968-09-25 CS CS6704A patent/CS162434B1/cs unknown
1973
- 1973-03-19 YU YU742/73A patent/YU33957B/xx unknown
- 1973-03-19 YU YU740/73A patent/YU35360B/xx unknown
- 1973-03-19 YU YU74173A patent/YU35587B/xx unknown

Also Published As

Publication number	Publication date
DE1620541A1 (de)	1970-04-16
CS162434B1 (es)	1975-07-15
YU33957B (en)	1978-09-08
CH493532A (de)	1970-07-15
YU74273A (en)	1978-02-28
YU32364B (en)	1974-10-31
FI48929B (es)	1974-10-31
FR1524445A (fr)	1968-05-10
FI48929C (fi)	1975-02-10
CH493531A (de)	1970-07-15
DK120345B (da)	1971-05-17
YU75667A (en)	1974-04-30
ES339483A1 (es)	1968-07-16
CH508637A (de)	1971-06-15
BE697188A (es)	1967-10-18
ES339371A1 (es)	1968-07-16
YU74073A (en)	1980-06-30
ES339394A1 (es)	1968-07-16
NL6705206A (es)	1967-10-23
CH483433A (de)	1969-12-31
CH493533A (de)	1970-07-15
FR6442M (es)	1968-11-12
NL131479C (es)
GR33644B (el)	1968-01-03
GB1131164A (en)	1968-10-23
YU35587B (en)	1981-04-30
DE1620541C3 (de)	1975-09-25
US3454574A (en)	1969-07-08
YU74173A (en)	1980-09-25
SE323685B (es)	1970-05-11
YU35360B (en)	1980-12-31
IL27764A (en)	1971-02-25
DE1620541B2 (de)	1975-02-20

Publication	Publication Date	Title
GB1178191A (en)	1970-01-21	Amino-Dihalophenyl-Ethylamines
ES425084A2 (es)	1976-12-16	Procedimiento para la preparacion de aminoalcoholes.
ES379739A1 (es)	1973-02-01	Procedimiento para la preparacion de preparados farmaceuti-cos que contienen en calidad de sustancia activa nuevos 1-fenoxi-2-hidroxi-3-sec - alcohilaminopropanos racemicos u opticamente activos.
ES340221A1 (es)	1968-06-01	Procedimiento para la obtencion de nuevas hidroxi-ciclohe- xil-aminas.
ES339483A1 (es)	1968-07-16	Un procedimiento para la obtencion de nuevas tetrahidro- quinazolinas sustituidas por halogenos.
GB1481813A (en)	1977-08-03	Substituted thiazolinylidenyl ketones and their pharmaceutical compositions
GB1296544A (es)	1972-11-15
GB1274652A (en)	1972-05-17	Adamantanyl-alkylamine derivatives and their preparation
GB1169945A (en)	1969-11-05	Pharmaceutical Compositions containing Diphenylalkyl-amine Derivatives
DE3668888D1 (de)	1990-03-15	Ein imidazolidintrion-derivat oder ein seiner pharmazeutisch akzeptierbaren salze enthaltende pharmazeutische zusammenstellung.
GB1455624A (en)	1976-11-17	Imidazoline derivatives
GB1193917A (en)	1970-06-03	Improvements in or relating to Heterocyclic Compounds and the Manufacture Thereof
GB1152964A (en)	1969-05-21	Substituted Imidazoline Derivatives
GB1341698A (en)	1973-12-25	3-amino-indeno-1,2,3-a,e-phthalazines and pharmaceutical compositions thereof
GB1296802A (es)	1972-11-22
GB1195319A (en)	1970-06-17	Alkyl Sulfate Salts of 1-(p-Chlorobenzhydryl)-4-Methylhomopiperazines
GB1203430A (en)	1970-08-26	Heterocyclic spiro compounds
ES350955A1 (es)	1969-05-16	Un procedimiento para preparar derivados de acido barbitu- rico.
GB1159748A (en)	1969-07-30	Thiol-Type Thiamine Thionocarbonates
GB1249512A (en)	1971-10-13	0,2,3,4-tetrahydro-7-halo-6-sulfamyl-4-quinazolinones, process for preparing the same and pharmaceutical compositions comprising the same
ES374475A1 (es)	1972-04-01	Procedimiento para la obtencion de 1-amino-3-hidroxiguani- dina.
GB1173802A (en)	1969-12-10	Quinazolinones
GB1211387A (en)	1970-11-04	0-benzylpiperidine derivative and a process for the preparation thereof
ES350639A1 (es)	1969-11-01	Procedimiento para la preparacion de derivados del acido acetico.
GB1235409A (en)	1971-06-16	Improvements in or relating to anticestode hydrazinoquinolines