ES361975A2 - Procedimiento de preparacion de nuevos derivados del spiro (4,5) decano - Google Patents

Procedimiento de preparacion de nuevos derivados del spiro (4,5) decano

Info

Publication number: ES361975A2
Authority: ES; Spain
Prior art keywords: radical; spiro; general formula; formula; translation
Prior art date: 1964-04-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES361975A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Science Union et Cie

Original Assignee

Science Union et Cie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1964-04-22

Filing date

1968-12-28

Publication date

1971-01-16

1968-12-28 Application filed by Science Union et Cie filed Critical Science Union et Cie

1971-01-16 Publication of ES361975A2 publication Critical patent/ES361975A2/es

Status Expired legal-status Critical Current

Links

238000000034 method Methods 0.000 title abstract 2
125000003003 spiro group Chemical group 0.000 title 1
-1 chlorobenzamido Chemical group 0.000 abstract 4
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
CTDQAGUNKPRERK-UHFFFAOYSA-N spirodecane Chemical compound C1CCCC21CCCCC2 CTDQAGUNKPRERK-UHFFFAOYSA-N 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
150000007522 mineralic acids Chemical class 0.000 abstract 1
150000007524 organic acids Chemical class 0.000 abstract 1
235000005985 organic acids Nutrition 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000003198 secondary alcohol group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)

ES361975A 1964-04-22 1968-12-28 Procedimiento de preparacion de nuevos derivados del spiro (4,5) decano Expired ES361975A2 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB16696/64A GB1100281A (en)	1964-04-22	1964-04-22	New spiro-decane derivatives and process for the preparation thereof
ES0312091A ES312091A1 (es)	1964-04-22	1965-04-21	Procedimiento de preparacion de nuevos derivados del spiro (4, 5) decano

Publications (1)

Publication Number	Publication Date
ES361975A2 true ES361975A2 (es)	1971-01-16

Family

ID=10081982

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
ES0312091A Expired ES312091A1 (es)	1964-04-22	1965-04-21	Procedimiento de preparacion de nuevos derivados del spiro (4, 5) decano
ES361975A Expired ES361975A2 (es)	1964-04-22	1968-12-28	Procedimiento de preparacion de nuevos derivados del spiro (4,5) decano

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
ES0312091A Expired ES312091A1 (es)	1964-04-22	1965-04-21	Procedimiento de preparacion de nuevos derivados del spiro (4, 5) decano

Country Status (9)

Country	Link
US (1)	US3399192A (es)
BE (1)	BE662817A (es)
CH (1)	CH454160A (es)
DE (1)	DE1620262C3 (es)
ES (2)	ES312091A1 (es)
FR (2)	FR1441575A (es)
GB (1)	GB1100281A (es)
NL (2)	NL6504602A (es)
SE (1)	SE307793B (es)

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NL129025C (es) *	1965-04-29
US3542729A (en) *	1968-03-19	1970-11-24	Sankyo Co	Stabilization of synthetic polymers
BE790675A (fr) *	1971-10-29	1973-04-27	Science Union & Cie	Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
US4244961A (en) *	1978-10-26	1981-01-13	Syntex (U.S.A.) Inc.	1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
US4255432A (en) *	1979-09-06	1981-03-10	Syntex (U.S.A.) Inc.	8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
ES8401072A1 (es) *	1982-11-23	1983-12-16	Faes	Procedimiento de preparacion de un nuevo espirodecano.
HU204054B (en) *	1989-08-10	1991-11-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions comprising same
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
FR2666583B1 (fr) *	1990-09-06	1994-09-09	Adir	Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant.
FR2734265B1 (fr) *	1995-05-17	1997-06-13	Adir	Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant
US6982251B2 (en) *	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
PT1363668E (pt) *	2001-01-26	2007-11-07	Schering Corp	Combinaçoes de sequestrante(s) de ácidos biliares e inibidor(es) de absorção de esterol e tratamento de indicações vasculares
IL156445A0 (en) *	2001-01-26	2004-01-04	Schering Corp	Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
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US7071181B2 (en) *	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
NZ542090A (en) *	2001-01-26	2006-09-29	Schering Corp	Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions
KR20070120617A (ko) *	2001-01-26	2007-12-24	쉐링 코포레이션	치환된 아제티딘온 화합물을 포함하는 약제학적 조성물
TW200840563A (en) *	2001-01-26	2008-10-16	Schering Corp	Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(S) and treatments for vascular indications
WO2002096415A2 (en) *	2001-05-25	2002-12-05	Schering Corporation	Use of azetidinone substituted derivatives in the treatment of alzheimer's disease
DE10130020A1 (de) *	2001-06-25	2003-12-04	Gruenenthal Gmbh	Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
DE10146275A1 (de)	2001-09-18	2003-04-24	Gruenenthal Gmbh	Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
EP1429756B1 (en) *	2001-09-21	2006-11-22	Schering Corporation	Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
DE60229406D1 (de) *	2001-09-21	2008-11-27	Schering Corp	Verfahren zur behandlung oder verhinderung von vaskulärer entzündung mit sterol-absorbierungs- inhibitor(en)
US20030119808A1 (en) *	2001-09-21	2003-06-26	Schering Corporation	Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7053080B2 (en) *	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7056906B2 (en) *	2001-09-21	2006-06-06	Schering Corporation	Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
EA200500234A1 (ru)	2002-08-19	2005-08-25	Пфайзер Продактс Инк.	Комбинированная терапия гиперпролиферативных болезней
CA2504916A1 (en) *	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
WO2004081004A1 (en) *	2003-03-07	2004-09-23	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en)	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2004081002A1 (en)	2003-03-07	2004-09-23	Schering Corporation	Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
DE602004018617D1 (de)	2003-03-07	2009-02-05	Schering Corp	Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
WO2005046797A2 (en) *	2003-11-05	2005-05-26	Schering Corporation	Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
EP1716156A2 (en) *	2004-02-10	2006-11-02	F.Hoffmann-La Roche Ag	Chemokine ccr5 receptor modulators
US20060063803A1 (en) *	2004-09-23	2006-03-23	Pfizer Inc	4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
GT200600381A (es)	2005-08-25	2007-03-28		Compuestos organicos
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7919506B2 (en)	2006-03-10	2011-04-05	Pfizer Inc.	Dibenzyl amine compounds and derivatives
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
BRPI0809646A2 (pt) *	2007-03-29	2014-09-23	Hoffmann La Roche	Compostod antivirais heterocíclicos
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2008151257A2 (en)	2007-06-04	2008-12-11	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2627848T3 (es)	2008-06-04	2017-07-31	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
ES2624828T3 (es)	2008-07-16	2017-07-17	Synergy Pharmaceuticals Inc.	Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CN102766147B (zh) *	2012-08-03	2015-07-15	无锡药兴医药科技有限公司	一种芬司匹利及其氢卤酸盐的制备方法
US9708367B2 (en)	2013-03-15	2017-07-18	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase and their uses
EP2968439A2 (en)	2013-03-15	2016-01-20	Synergy Pharmaceuticals Inc.	Compositions useful for the treatment of gastrointestinal disorders
CN105143203A (zh)	2013-04-17	2015-12-09	辉瑞大药厂	用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物
PL3004138T3 (pl)	2013-06-05	2024-07-29	Bausch Health Ireland Limited	Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
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US2437388A (en) *		1948-03-09		Z-oxazolidone compounds and proc
US3193559A (en) *		1965-07-06		New derivatives of z-oxazolidinones
US2500714A (en) *	1944-10-30	1950-03-14	Abbott Lab	4-phenyl-1-alkyl isonipecotic acid lactones
US3054794A (en) *	1958-01-17	1962-09-18	Us Vitamin Pharm Corp	Process for preparing 3-(aminoalkyl)-oxazolidine-2, 4-diones
GB974134A (en) *	1963-03-28	1964-11-04	Science Union Et Compagnie Soc	Oxazolidinone derivatives

0
- NL NL127065D patent/NL127065C/xx active
1964
- 1964-04-22 GB GB16696/64A patent/GB1100281A/en not_active Expired
1965
- 1965-03-27 SE SE4001/65A patent/SE307793B/xx unknown
- 1965-04-09 DE DE1620262A patent/DE1620262C3/de not_active Expired
- 1965-04-12 NL NL6504602A patent/NL6504602A/xx unknown
- 1965-04-14 US US447952A patent/US3399192A/en not_active Expired - Lifetime
- 1965-04-16 FR FR13521A patent/FR1441575A/fr not_active Expired
- 1965-04-21 BE BE662817A patent/BE662817A/xx unknown
- 1965-04-21 ES ES0312091A patent/ES312091A1/es not_active Expired
- 1965-04-22 CH CH558965A patent/CH454160A/fr unknown
- 1965-06-25 FR FR22211A patent/FR4463M/fr not_active Expired
1968
- 1968-12-28 ES ES361975A patent/ES361975A2/es not_active Expired

Also Published As

Publication number	Publication date
SE307793B (es)	1969-01-20
NL6504602A (es)	1965-10-25
DE1620262A1 (de)	1972-03-23
CH454160A (fr)	1968-04-15
FR1441575A (fr)	1966-06-10
DE1620262C3 (de)	1980-07-03
US3399192A (en)	1968-08-27
ES312091A1 (es)	1965-10-01
FR4463M (es)	1966-09-26
NL127065C (es)
BE662817A (es)	1965-10-21
GB1100281A (en)	1968-01-24
DE1620262B2 (de)	1979-10-11

Publication	Publication Date	Title
ES302622A1 (es)	1965-03-16	Procedimiento para la preparacion de derivados heterociclicos.
ES334560A1 (es)	1967-11-01	Un procedimiento para la preparacion de un compuesto tetrahidro-halo-sulfamil-quinazolinonas.
ES306817A1 (es)	1965-05-16	Procedimiento para preparar un nuevo derivado de isoxazol.
ES425900A1 (es)	1976-06-16	Procedimiento para la preparacion de nuevos compuestos de isoflavona.
ES331339A1 (es)	1967-07-01	Procedimiento para la preparacion de alquilenpiperidinas sustituidas.
GB1031367A (en)	1966-06-02	Photographic light-sensitive materials
ES440029A1 (es)	1977-02-16	Un procedimiento para preparar nuevos derivados de 2-ami- noindano.
ES295832A1 (es)	1964-06-16	Procedimiento para la preparación de antiparasitarios
ES395701A1 (es)	1973-12-01	Procedimiento para la produccion de un compuesto de fenil- hidrazonas.
GB1042480A (en)	1966-09-14	Substituted pyridyl coumarins
ES302819A1 (es)	1965-03-16	Un procedimiento para la preparacion de nuevos sulfanilamidoisoxazoles.
ES327846A1 (es)	1967-08-01	Procedimiento para la preparacion de derivados de la isoindolobenzodiacepin-6-ona.
ES332645A1 (es)	1967-07-16	Procedimiento para la preparacion de nuevos n-heterociclos.
ES328752A1 (es)	1967-09-01	Procedimiento para la produccion de derivados de la benzodiacepin-8-ona.
ES298316A1 (es)	1964-06-01	Procedimiento para la preparación de derivados de benzoxazepina
ES295069A1 (es)	1963-11-01	Procedimiento para la preparación de agentes para combatir los parásitos del algodón
ES317572A1 (es)	1966-07-01	Procedimiento para la preparaciën de compuestos de actividad antibiëtica
ES422351A1 (es)	1976-07-16	Un procedimiento para la preparacion de un nuevo compuesto aralquilo.
ES293872A1 (es)	1964-03-01	Un procedimiento para la preparaciën de una composiciën antihelmintica
ES322107A1 (es)	1966-11-16	Procedimiento para la obtenciën de derivados de 6-epi-6-desoxitetraciclinas
ES368566A1 (es)	1971-05-01	Procedimiento para la preparacion de derivados de alfa-ni- cotinoil - beta - (fenilsustituido) etileno.
ES259951A1 (es)	1960-11-16	Procedimiento de preparaciën de nuevos compuestos diazoaminos
ES399271A1 (es)	1975-01-01	Procedimiento de preparacion de nuevos bromometilatos de n-amino-terciariometil) - 4 - metil - 2 - (trimetoxi-4,6,7- benzofuran-5'-il)-2-dioxolano-1,3.
ES302526A3 (es)	1965-02-16	Un procedimiento para la preparaciën de composiciones herbicidas
ES329886A2 (es)	1967-11-01	Procedimiento de obtencion de una dispersion de particulas.