ES455026A1 - Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico. - Google Patents
Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico.Info
- Publication number
- ES455026A1 ES455026A1 ES455026A ES455026A ES455026A1 ES 455026 A1 ES455026 A1 ES 455026A1 ES 455026 A ES455026 A ES 455026A ES 455026 A ES455026 A ES 455026A ES 455026 A1 ES455026 A1 ES 455026A1
- Authority
- ES
- Spain
- Prior art keywords
- acid chloride
- semi
- manufacture
- penicillin antibiotics
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 229940049954 penicillin Drugs 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000006884 silylation reaction Methods 0.000 abstract 2
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
- C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/10—Modification of an amino radical directly attached in position 6
- C07D499/12—Acylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT47643/76A IT1053313B (it) | 1976-01-15 | 1976-01-15 | Procedimento per produrre antibiotici semisintetici |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES455026A1 true ES455026A1 (es) | 1977-12-16 |
Family
ID=11261624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES455026A Expired ES455026A1 (es) | 1976-01-15 | 1977-01-14 | Un procedimiento para la fabricacion de un producto antibio-tico de acido 6-acilaminopenicilanico. |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5287191A (da) |
| AU (1) | AU512150B2 (da) |
| BE (1) | BE850382A (da) |
| CH (1) | CH627182A5 (da) |
| DE (1) | DE2701406A1 (da) |
| DK (1) | DK13977A (da) |
| ES (1) | ES455026A1 (da) |
| FR (1) | FR2338279A1 (da) |
| GB (1) | GB1569427A (da) |
| IT (1) | IT1053313B (da) |
| NL (1) | NL7700396A (da) |
| SE (1) | SE437989B (da) |
| YU (1) | YU9277A (da) |
| ZA (1) | ZA77195B (da) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB958478A (en) * | 1962-03-13 | 1964-05-21 | Beecham Res Lab | Production of penicillins |
| FR68F (da) * | 1962-10-17 | |||
| US3351597A (en) * | 1966-11-23 | 1967-11-07 | Lilly Co Eli | Process for acylating 7-amino cephalosporanic acid |
| ZA695612B (en) * | 1968-08-23 | 1971-03-31 | Lilly Co Eli | Preparation of cephalosporin compounds |
| US3595855A (en) * | 1968-12-05 | 1971-07-27 | American Home Prod | Process for producing aminopenicillins |
| IT1043957B (it) * | 1970-12-31 | 1980-02-29 | Lorenzini Sas Inst Biochim | Processo per la preparazione della forma anidra dell acido 6, d, meno alfa aminofenilacetamido penicillanico |
| GB1494902A (en) * | 1974-05-09 | 1977-12-14 | Glaxo Lab Ltd | Penicillins |
| IT1039495B (it) * | 1975-06-26 | 1979-12-10 | Dobfar Spa | Procedimento per la preparazione di sostanze antibiotiche |
-
1976
- 1976-01-15 IT IT47643/76A patent/IT1053313B/it active
-
1977
- 1977-01-13 CH CH43377A patent/CH627182A5/de not_active IP Right Cessation
- 1977-01-14 BE BE174079A patent/BE850382A/xx not_active IP Right Cessation
- 1977-01-14 ES ES455026A patent/ES455026A1/es not_active Expired
- 1977-01-14 ZA ZA770195A patent/ZA77195B/xx unknown
- 1977-01-14 FR FR7701123A patent/FR2338279A1/fr active Granted
- 1977-01-14 NL NL7700396A patent/NL7700396A/xx not_active Application Discontinuation
- 1977-01-14 DE DE19772701406 patent/DE2701406A1/de not_active Withdrawn
- 1977-01-14 YU YU00092/77A patent/YU9277A/xx unknown
- 1977-01-14 SE SE7700393A patent/SE437989B/xx unknown
- 1977-01-14 AU AU21340/77A patent/AU512150B2/en not_active Expired
- 1977-01-14 JP JP252077A patent/JPS5287191A/ja active Pending
- 1977-01-14 GB GB1542/77A patent/GB1569427A/en not_active Expired
- 1977-01-14 DK DK13977A patent/DK13977A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK13977A (da) | 1977-07-16 |
| JPS5287191A (en) | 1977-07-20 |
| NL7700396A (nl) | 1977-07-19 |
| ZA77195B (en) | 1977-11-30 |
| AU512150B2 (en) | 1980-09-25 |
| SE7700393L (sv) | 1977-07-16 |
| CH627182A5 (en) | 1981-12-31 |
| SE437989B (sv) | 1985-03-25 |
| IT1053313B (it) | 1981-08-31 |
| FR2338279B1 (da) | 1980-09-05 |
| YU9277A (en) | 1982-06-30 |
| FR2338279A1 (fr) | 1977-08-12 |
| GB1569427A (en) | 1980-06-18 |
| AU2134077A (en) | 1978-07-20 |
| BE850382A (fr) | 1977-07-14 |
| DE2701406A1 (de) | 1977-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |