ES465742A1 - Un procedimiento para la preparacion de nuevas pirazincar- boxamidas. - Google Patents

Un procedimiento para la preparacion de nuevas pirazincar- boxamidas.

Info

Publication number
ES465742A1
ES465742A1 ES465742A ES465742A ES465742A1 ES 465742 A1 ES465742 A1 ES 465742A1 ES 465742 A ES465742 A ES 465742A ES 465742 A ES465742 A ES 465742A ES 465742 A1 ES465742 A1 ES 465742A1
Authority
ES
Spain
Prior art keywords
pyrazinecarboxamides
processes
preparing same
formula
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES465742A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES465742A1 publication Critical patent/ES465742A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Un procedimiento para la preparación de nuevas pirazincarboxamidas de fórmula:*** (ver fórmula I)dondeR1 es hidrógeno;
ES465742A 1975-12-15 1978-01-03 Un procedimiento para la preparacion de nuevas pirazincar- boxamidas. Expired ES465742A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US64080375A 1975-12-15 1975-12-15

Publications (1)

Publication Number Publication Date
ES465742A1 true ES465742A1 (es) 1978-10-01

Family

ID=24569755

Family Applications (2)

Application Number Title Priority Date Filing Date
ES454160A Expired ES454160A1 (es) 1975-12-15 1976-12-10 Un procedimiento para la preparacion de nuevas pirazincarbo-xamidas.
ES465742A Expired ES465742A1 (es) 1975-12-15 1978-01-03 Un procedimiento para la preparacion de nuevas pirazincar- boxamidas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES454160A Expired ES454160A1 (es) 1975-12-15 1976-12-10 Un procedimiento para la preparacion de nuevas pirazincarbo-xamidas.

Country Status (14)

Country Link
US (1) US4085211A (es)
JP (1) JPS52106877A (es)
AU (1) AU511429B2 (es)
BE (1) BE849379A (es)
CH (1) CH630369A5 (es)
DE (1) DE2656374A1 (es)
DK (1) DK531476A (es)
ES (2) ES454160A1 (es)
FR (1) FR2335226A1 (es)
GB (1) GB1527297A (es)
HU (1) HU175504B (es)
NL (1) NL7613276A (es)
SE (1) SE431452B (es)
ZA (1) ZA767431B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208413A (en) * 1977-03-04 1980-06-17 Merck & Co., Inc. N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same
US4163781A (en) * 1978-04-17 1979-08-07 Merck & Co., Inc. 3-Amino-N-[(phosphonoamino)iminomethyl]-6-halopyrazinecarboxamide compounds, compositions and methods of use
EP0009054A1 (en) * 1978-09-19 1980-04-02 Merck & Co. Inc. N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same
US4272537A (en) * 1980-07-02 1981-06-09 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(4,4-disubstituted-6-substituted-1,3,5-triazin-2-yl)-2-pyrazinecarboxamides
US4277602A (en) * 1980-07-02 1981-07-07 Merck & Co., Inc. 3-Amino-5-substituted-6-halo-N-(3,4-dihydro-6-substituted-1,3,5-truazin-2-yl)2-pyrazinecarboxamides
IE52345B1 (en) * 1981-02-02 1987-09-16 Ici Plc Alkanolamine derivatives
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
JPS62291361A (ja) * 1986-06-09 1987-12-18 株式会社ブリヂストン 床支持装置
JPS6342741U (es) * 1986-09-04 1988-03-22
GB8810934D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Amides
GB8810933D0 (en) * 1987-05-26 1988-06-15 Ici America Inc Heterocyclic compounds
GB8812343D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Amino compounds
GB8812342D0 (en) * 1988-05-25 1988-06-29 Ici America Inc Bicyclic compounds
JPH02101937U (es) * 1989-01-31 1990-08-14
AUPP646498A0 (en) * 1998-10-12 1998-11-05 Australian National University, The A method of modulating ion channel functional activity
US6858615B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
US20090253714A1 (en) * 2003-08-20 2009-10-08 Johnson Michael R Methods of reducing risk of infection from pathogens
WO2006023617A2 (en) * 2004-08-18 2006-03-02 Johnson Michael R Cyclic amide & ester pyrazinoylguanidine sodium channel blockers
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
GB0526244D0 (en) * 2005-12-22 2006-02-01 Novartis Ag Organic compounds
CL2008003651A1 (es) * 2007-12-10 2009-06-19 Novartis Ag Compuestos derivados de 3,5-diamino-6-cloropirazinamida sustituida; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de una condición inflamatoria o alergica, en particular una enfermedad inflamatoria u obstructiva de las vias respiratorias.
DE102008053024B4 (de) 2008-10-24 2015-04-30 RUHR-UNIVERSITäT BOCHUM Verwendung von Amilorid-Derivaten zur Bekämpfung von Insekten und Milben
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
RU2018138195A (ru) 2012-12-17 2018-12-18 Пэрион Сайенсиз, Инк. Соединения 3,5-диамино-6-хлор-n-(n-(4- фенилбутил)карбамимидоил)пиразин-2-карбоксамида
SG10201708931XA (en) 2012-12-17 2017-12-28 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
KR102367765B1 (ko) * 2014-09-18 2022-02-24 닛산 가가쿠 가부시키가이샤 액정 배향제, 액정 배향막, 및 액정 표시 소자

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639393A (es) * 1962-10-30
BE639386A (es) * 1962-10-30

Also Published As

Publication number Publication date
AU2018176A (en) 1978-06-08
JPS6238350B2 (es) 1987-08-17
DK531476A (da) 1977-06-16
DE2656374A1 (de) 1977-06-16
BE849379A (fr) 1977-06-14
SE7613289L (sv) 1977-06-16
NL7613276A (nl) 1977-06-17
US4085211A (en) 1978-04-18
ES454160A1 (es) 1978-03-01
FR2335226A1 (fr) 1977-07-15
SE431452B (sv) 1984-02-06
FR2335226B1 (es) 1979-03-09
GB1527297A (en) 1978-10-04
AU511429B2 (en) 1980-08-21
DE2656374C2 (es) 1989-08-10
ZA767431B (en) 1978-07-26
HU175504B (hu) 1980-08-28
JPS52106877A (en) 1977-09-07
CH630369A5 (de) 1982-06-15

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