ES466605A1 - Procedimiento para la preparacion de heterociclos aminoal- cohilicos. - Google Patents

Procedimiento para la preparacion de heterociclos aminoal- cohilicos.

Info

Publication number: ES466605A1
Authority: ES; Spain
Prior art keywords: carbon atoms; hydrogen; alkyl; trifluoromethyl; halogen
Prior art date: 1976-03-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

ES466605A

Other languages

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CH Boehringer Sohn AG and Co KG

Original Assignee

CH Boehringer Sohn AG and Co KG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-03-09

Filing date

1978-02-03

Publication date

1978-10-01

1978-02-03 Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG

1978-10-01 Publication of ES466605A1 publication Critical patent/ES466605A1/es

Status Expired legal-status Critical Current

Links

150000005130 benzoxazines Chemical class 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 10
229910052739 hydrogen Inorganic materials 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 8
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
125000000217 alkyl group Chemical group 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical group 0.000 abstract 4
-1 methylenedioxy Chemical group 0.000 abstract 4
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000001589 carboacyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229940124549 vasodilator Drugs 0.000 abstract 1
239000003071 vasodilator agent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Thiazole And Isothizaole Compounds (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Quinoline Compounds (AREA)
Laminated Bodies (AREA)
Nonwoven Fabrics (AREA)

ES466605A 1976-03-09 1978-02-03 Procedimiento para la preparacion de heterociclos aminoal- cohilicos. Expired ES466605A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19762609645 DE2609645A1 (de)	1976-03-09	1976-03-09	Aminoalkylheterocyclen

Publications (1)

Publication Number	Publication Date
ES466605A1 true ES466605A1 (es)	1978-10-01

Family

ID=5971857

Family Applications (10)

Application Number	Title	Priority Date	Filing Date
ES456622A Expired ES456622A1 (es)	1976-03-09	1977-03-08	Procedimiento para la preparacion de heterociclos aminoalco-hilicos.
ES466604A Expired ES466604A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466598A Expired ES466598A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466602A Expired ES466602A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466601A Expired ES466601A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoalco-hilicos.
ES466605A Expired ES466605A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466600A Expired ES466600A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466603A Expired ES466603A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoalco-hilicos.
ES466599A Expired ES466599A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466606A Expired ES466606A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.

Family Applications Before (5)

Application Number	Title	Priority Date	Filing Date
ES456622A Expired ES456622A1 (es)	1976-03-09	1977-03-08	Procedimiento para la preparacion de heterociclos aminoalco-hilicos.
ES466604A Expired ES466604A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466598A Expired ES466598A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466602A Expired ES466602A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466601A Expired ES466601A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoalco-hilicos.

Family Applications After (4)

Application Number	Title	Priority Date	Filing Date
ES466600A Expired ES466600A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466603A Expired ES466603A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoalco-hilicos.
ES466599A Expired ES466599A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES466606A Expired ES466606A1 (es)	1976-03-09	1978-02-03	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.

Country Status (36)

Country	Link
US (4)	US4154829A (es)
JP (2)	JPS52108970A (es)
AT (1)	AT360542B (es)
AU (1)	AU515953B2 (es)
BE (1)	BE852223A (es)
BG (4)	BG28052A4 (es)
CA (1)	CA1086317A (es)
CH (8)	CH630358A5 (es)
CS (2)	CS209435B2 (es)
DD (1)	DD130037A5 (es)
DE (1)	DE2609645A1 (es)
DK (1)	DK102177A (es)
ES (10)	ES456622A1 (es)
FI (1)	FI69070C (es)
FR (2)	FR2343731A1 (es)
GB (1)	GB1571231A (es)
GR (1)	GR64553B (es)
HK (1)	HK12884A (es)
HU (1)	HU177953B (es)
IE (1)	IE45300B1 (es)
IL (1)	IL51627A (es)
LU (1)	LU76898A1 (es)
MX (1)	MX4878E (es)
MY (1)	MY8500079A (es)
NL (1)	NL7702403A (es)
NO (1)	NO147950C (es)
NZ (1)	NZ183536A (es)
PH (3)	PH16110A (es)
PL (2)	PL111240B1 (es)
PT (1)	PT66282B (es)
RO (3)	RO76589A (es)
SE (1)	SE435059B (es)
SG (1)	SG55583G (es)
SU (4)	SU698530A3 (es)
YU (1)	YU62377A (es)
ZA (1)	ZA771412B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2609645A1 (de) *	1976-03-09	1977-09-15	Boehringer Sohn Ingelheim	Aminoalkylheterocyclen
DE2644833A1 (de) *	1976-10-05	1978-04-20	Boehringer Sohn Ingelheim	Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung
DE2833140A1 (de) *	1978-07-28	1980-02-07	Boehringer Sohn Ingelheim	Neue n-substituierte heterocyclen
SE8003277L (sv)	1979-05-04	1980-11-05	Continental Pharma	Bensimidazolderivat, deras framstellning och anvendning samt kompositioner innehallande dessa derivat
DE3026534A1 (de) *	1980-07-12	1982-03-18	C.H. Boehringer Sohn, 6507 Ingelheim	3,1-benzoxazin-2-one, ihre herstellung und verwendung
US4460581A (en) *	1982-10-12	1984-07-17	Boehringer Ingelheim Kg	(1-Hydroxy-2-amino-alkyl)-substituted benzoxazinones and benzoxazolinones
DE3325875A1 (de) *	1983-07-18	1985-01-31	Boehringer Ingelheim KG, 6507 Ingelheim	Neue 1-phenylimidazolidin-2-on-derivate, ihre herstellung und verwendung
US4743613A (en) *	1986-04-08	1988-05-10	Smithkline Beckman Corporation	Ester prodrugs of dopamine-β-hydroxylase, inhibitors, composition containing them, and method of using them to inhibit dopamine-β-hydroxylase activity
GB8609331D0 (en) *	1986-04-16	1986-05-21	Pfizer Ltd	Anti-arrythmia agents
TW203049B (es) *	1990-04-13	1993-04-01	Yamanouchi Pharma Co Ltd
US6075040A (en) *	1996-09-05	2000-06-13	Eli Lilly And Company	Selective β3 adrenergic agonists
ZA967892B (en) *	1995-09-21	1998-03-18	Lilly Co Eli	Selective β3 adrenergic agonists.
ES2171839T3 (es)	1996-09-05	2002-09-16	Lilly Co Eli	Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
CO5011072A1 (es) *	1997-12-05	2001-02-28	Lilly Co Eli	Etanolaminas pirazinil substituidas como agfonistas de los receptores
EP1385518B1 (en) *	2001-04-18	2008-08-06	Euro-Celtique S.A.	Benzimidazolone compounds
IL158484A0 (en)	2001-04-18	2004-05-12	Euro Celtique Sa	Nociceptin analogs
JP4489354B2 (ja)	2001-04-18	2010-06-23	ユーロ−セルティークエス．エイ．	スピロインデンおよびスピロインダン化合物類
RU2265018C2 (ru) *	2001-04-18	2005-11-27	Эро-Селтик, С.А.	Производные бензимидазола и фармацевтические композиции на их основе
RU2268883C2 (ru)	2001-04-18	2006-01-27	Эро-Селтик, С.А.	Аналоги ноницептина и фармацевтическая композиция на их основе
KR100628292B1 (ko)	2001-04-18	2006-09-27	유로-셀티크 소시에떼 아노뉨	스파이로파이라졸 화합물
US7056916B2 (en) *	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
AU2003297562A1 (en) *	2002-11-27	2004-06-23	Artesian Therapeutics, Inc.	COMPOUNDS WITH MIXED PDE-INHIBITORY AND Beta-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE
US20070117978A1 (en) *	2002-12-23	2007-05-24	Artesian Therapecutics, Inc	Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
DE102004001413A1 (de) *	2004-01-09	2005-08-18	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Hydroxymethyl-4-Hydroxy-Phenyl-Derivate zur Behandlung von chronisch obstruktiver Lungenerkrankung
DE102004003428A1 (de) *	2004-01-23	2005-08-11	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue langwirksame Beta-2-Agonisten, und deren Verwendung als Arzneimittel
US20050272726A1 (en) *	2004-04-22	2005-12-08	Boehringer Ingelheim International Gmbh	Novel medicaments for the treatment of respiratory diseases
DE102004021779A1 (de) *	2004-04-30	2005-11-24	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US20050255050A1 (en) *	2004-05-14	2005-11-17	Boehringer Ingelheim International Gmbh	Powder formulations for inhalation, comprising enantiomerically pure beta agonists
US20050256115A1 (en) *	2004-05-14	2005-11-17	Boehringer Ingelheim International Gmbh	Aerosol formulation for the inhalation of beta-agonists
US7220742B2 (en) *	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004045648A1 (de) *	2004-09-21	2006-03-23	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Betamimetika zur Behandlung von Atemwegserkrankungen
EP1833480A2 (en) *	2004-11-30	2007-09-19	Artesian Therapeutics, Inc.	Cardiotonic compounds with inhibitory activity against beta-adrenergic receptors and phosphodiesterase
US20080090827A1 (en) *	2004-11-30	2008-04-17	Artesian Therapeutics, Inc.	Compounds With Mixed Pde-Inhibitory and Beta-Adrenergic Antagonist or Partial Agonist Activity For Treatment of Heart Failure
DE102005007654A1 (de) *	2005-02-19	2006-08-24	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen
DE102005030733A1 (de) *	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
BRPI0614410A2 (pt) *	2005-08-15	2011-03-29	Boehringer Ingelheim Int	processo para preparação de betamiméticos
DE102005052102A1 (de) *	2005-10-28	2007-05-03	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102005052127A1 (de) *	2005-10-28	2007-05-03	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue indol-haltige Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
DE102005052101A1 (de) *	2005-10-28	2007-05-03	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Beta-Agonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP1986644A1 (de) *	2006-02-16	2008-11-05	Boehringer Ingelheim International GmbH	Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
PE20080142A1 (es)	2006-03-15	2008-04-14	Boehringer Ingelheim Int	Beta-agonistas enantiomericamente puros y sus procedimientos de preparacion
CA2660186A1 (en)	2006-08-07	2008-02-14	Boehringer Ingelheim International Gmbh	Pharmaceutical combinations for the treatment of respiratory diseases
US8809381B2 (en) *	2007-08-16	2014-08-19	The University Of Mississippi	Highly selective sigma receptor ligands
US8686008B2 (en) *	2007-08-16	2014-04-01	The University Of Mississippi	Highly selective sigma receptor ligands
US9604926B2 (en)	2007-08-16	2017-03-28	The University Of Mississippi	Highly selective sigma receptor radioligands

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA631296A (en) *		1961-11-21	Merck And Co.	Substituted benzimidazolones
CH149009A (de) *	1929-08-10	1931-08-15	Chem Ind Basel	Verfahren zur Darstellung einer N-substituierten Verbindung der Pyridonreihe.
US2857394A (en) *	1957-05-10	1958-10-21	Ciba Pharm Prod Inc	Heterocyclic compounds
NL284529A (es) *	1961-10-24
FR1516714A (fr) *	1962-11-07	1968-02-05	Bayer Ag	Procédé de préparation de dérivés de l'imidazolidine
FR1384708A (fr) *	1963-11-21	1965-01-08	Thomson Houston Comp Francaise	Perfectionnements aux dispositifs de mise en place d'objets
BE659364A (es) *	1964-02-05
US3355457A (en) *	1965-05-21	1967-11-28	American Cyanamid Co	Substituted 2-imidazolinones
FR1573739A (es) *	1968-07-26	1969-07-04
US3984405A (en) *	1971-06-28	1976-10-05	E. R. Squibb & Sons, Inc.	Anti-inflammatory agents
BE787103A (fr) *	1971-08-04	1973-02-02	Pfizer	Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
FR2168140A1 (en) *	1972-01-17	1973-08-31	Bellon Labor Sa Roger	Dihydro-benzoxazine derivs - antidepressants
US3925383A (en) *	1972-12-08	1975-12-09	Janssen Pharmaceutica Nv	Bicyclic imidazoles and pyrimidines
US3994901A (en) *	1974-06-13	1976-11-30	Otsuka Pharmaceutical Company Limited	5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4081447A (en) *	1975-04-09	1978-03-28	Abbott Laboratories	5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
DE2609645A1 (de) *	1976-03-09	1977-09-15	Boehringer Sohn Ingelheim	Aminoalkylheterocyclen

1976
- 1976-03-09 DE DE19762609645 patent/DE2609645A1/de not_active Withdrawn
1977
- 1977-02-22 SU SU772453505A patent/SU698530A3/ru active
- 1977-02-23 FI FI770586A patent/FI69070C/fi not_active IP Right Cessation
- 1977-02-24 AT AT122377A patent/AT360542B/de not_active IP Right Cessation
- 1977-03-01 RO RO7796539A patent/RO76589A/ro unknown
- 1977-03-01 RO RO7789565A patent/RO70569A/ro unknown
- 1977-03-01 RO RO77101591A patent/RO79706A/ro unknown
- 1977-03-02 US US05/773,394 patent/US4154829A/en not_active Expired - Lifetime
- 1977-03-03 MX MX775497U patent/MX4878E/es unknown
- 1977-03-04 CS CS771476A patent/CS209435B2/cs unknown
- 1977-03-04 CS CS775352A patent/CS220320B2/cs unknown
- 1977-03-07 CH CH281977A patent/CH630358A5/de not_active IP Right Cessation
- 1977-03-07 BG BG036629A patent/BG28052A4/xx unknown
- 1977-03-07 NL NL7702403A patent/NL7702403A/xx not_active Application Discontinuation
- 1977-03-07 BG BG035601A patent/BG27743A3/xx unknown
- 1977-03-07 DD DD7700197718A patent/DD130037A5/xx unknown
- 1977-03-07 LU LU76898A patent/LU76898A1/xx unknown
- 1977-03-07 BG BG036628A patent/BG28051A4/xx unknown
- 1977-03-08 PT PT66282A patent/PT66282B/pt unknown
- 1977-03-08 CA CA273,388A patent/CA1086317A/en not_active Expired
- 1977-03-08 GR GR52928A patent/GR64553B/el unknown
- 1977-03-08 PL PL1977196505A patent/PL111240B1/pl unknown
- 1977-03-08 ES ES456622A patent/ES456622A1/es not_active Expired
- 1977-03-08 PL PL1977215210A patent/PL112937B1/pl unknown
- 1977-03-08 IE IE507/77A patent/IE45300B1/en unknown
- 1977-03-08 NZ NZ183536A patent/NZ183536A/xx unknown
- 1977-03-08 AU AU23009/77A patent/AU515953B2/en not_active Expired
- 1977-03-08 JP JP2532377A patent/JPS52108970A/ja active Pending
- 1977-03-08 HU HU77BO1653A patent/HU177953B/hu unknown
- 1977-03-08 ZA ZA00771412A patent/ZA771412B/xx unknown
- 1977-03-08 IL IL51627A patent/IL51627A/xx unknown
- 1977-03-08 BE BE175593A patent/BE852223A/xx not_active IP Right Cessation
- 1977-03-08 DK DK102177A patent/DK102177A/da not_active Application Discontinuation
- 1977-03-08 YU YU00623/77A patent/YU62377A/xx unknown
- 1977-03-08 SE SE7702609A patent/SE435059B/xx not_active IP Right Cessation
- 1977-03-08 NO NO770804A patent/NO147950C/no unknown
- 1977-03-09 FR FR7707018A patent/FR2343731A1/fr active Granted
- 1977-03-09 PH PH19550A patent/PH16110A/en unknown
- 1977-03-09 GB GB9952/77A patent/GB1571231A/en not_active Expired
- 1977-11-16 SU SU772542149A patent/SU685149A3/ru active
- 1977-11-16 SU SU772543651A patent/SU683616A3/ru active
- 1977-11-16 SU SU772541704A patent/SU676163A3/ru active
1978
- 1978-02-01 FR FR7802775A patent/FR2372810A1/fr active Granted
- 1978-02-03 ES ES466604A patent/ES466604A1/es not_active Expired
- 1978-02-03 ES ES466598A patent/ES466598A1/es not_active Expired
- 1978-02-03 ES ES466602A patent/ES466602A1/es not_active Expired
- 1978-02-03 ES ES466601A patent/ES466601A1/es not_active Expired
- 1978-02-03 ES ES466605A patent/ES466605A1/es not_active Expired
- 1978-02-03 ES ES466600A patent/ES466600A1/es not_active Expired
- 1978-02-03 ES ES466603A patent/ES466603A1/es not_active Expired
- 1978-02-03 ES ES466599A patent/ES466599A1/es not_active Expired
- 1978-02-03 ES ES466606A patent/ES466606A1/es not_active Expired
- 1978-06-14 BG BG036630A patent/BG28053A4/xx unknown
1979
- 1979-04-03 US US06/026,608 patent/US4215119A/en not_active Expired - Lifetime
- 1979-12-13 US US06/102,904 patent/US4271158A/en not_active Expired - Lifetime
1980
- 1980-07-11 PH PH24278A patent/PH16149A/en unknown
- 1980-12-22 US US06/218,786 patent/US4363814A/en not_active Expired - Fee Related
1981
- 1981-01-23 PH PH25130A patent/PH17635A/en unknown
- 1981-04-30 CH CH285181A patent/CH630364A5/de not_active IP Right Cessation
- 1981-04-30 CH CH285081A patent/CH630363A5/de not_active IP Right Cessation
- 1981-04-30 CH CH284781A patent/CH630360A5/de not_active IP Right Cessation
- 1981-04-30 CH CH284681A patent/CH630359A5/de not_active IP Right Cessation
- 1981-04-30 CH CH285281A patent/CH630365A5/de not_active IP Right Cessation
- 1981-04-30 CH CH284981A patent/CH630362A5/de not_active IP Right Cessation
- 1981-04-30 CH CH284881A patent/CH630361A5/de not_active IP Right Cessation
1983
- 1983-09-01 SG SG555/83A patent/SG55583G/en unknown
1984
- 1984-02-16 HK HK128/84A patent/HK12884A/xx unknown
1985
- 1985-06-12 JP JP60126401A patent/JPS6172A/ja active Pending
- 1985-12-30 MY MY79/85A patent/MY8500079A/xx unknown

Also Published As

Publication number	Publication date
SU698530A3 (ru)	1979-11-15
NL7702403A (nl)	1977-09-13
YU62377A (en)	1982-10-31
NO147950B (no)	1983-04-05
CA1086317A (en)	1980-09-23
US4363814A (en)	1982-12-14
AU2300977A (en)	1978-09-14
GB1571231A (en)	1980-07-09
PL196505A1 (pl)	1979-06-18
IL51627A (en)	1980-10-26
DE2609645A1 (de)	1977-09-15
BE852223A (fr)	1977-09-08
PH16110A (en)	1983-06-30
SU685149A3 (ru)	1979-09-05
ES466604A1 (es)	1978-10-01
BG28052A4 (bg)	1980-02-25
LU76898A1 (es)	1978-06-01
NO770804L (no)	1977-09-12
AT360542B (de)	1981-01-12
ZA771412B (en)	1978-11-29
SU683616A3 (ru)	1979-08-30
CH630359A5 (de)	1982-06-15
PL111240B1 (en)	1980-08-30
CH630364A5 (de)	1982-06-15
PH16149A (en)	1983-07-12
CS220320B2 (en)	1983-03-25
MY8500079A (en)	1985-12-31
RO76589A (ro)	1981-04-30
BG28051A4 (bg)	1980-02-25
BG27743A3 (bg)	1979-12-12
NO147950C (no)	1983-07-13
DK102177A (da)	1977-09-10
ES456622A1 (es)	1978-03-16
CS209435B2 (en)	1981-12-31
CH630360A5 (de)	1982-06-15
ES466600A1 (es)	1978-10-01
CH630362A5 (de)	1982-06-15
HU177953B (en)	1982-02-28
BG28053A4 (bg)	1980-02-25
SG55583G (en)	1984-07-27
CH630363A5 (de)	1982-06-15
US4154829A (en)	1979-05-15
SE435059B (sv)	1984-09-03
FI69070B (fi)	1985-08-30
JPS52108970A (en)	1977-09-12
PH17635A (en)	1984-10-18
FR2343731B1 (es)	1982-02-26
RO79706A (ro)	1982-08-17
FI770586A7 (es)	1977-09-10
ES466598A1 (es)	1978-10-01
HK12884A (en)	1984-02-24
FR2372810A1 (fr)	1978-06-30
US4215119A (en)	1980-07-29
PL112937B1 (en)	1980-11-29
ES466603A1 (es)	1978-10-01
IE45300L (en)	1977-09-09
FI69070C (fi)	1985-12-10
ES466602A1 (es)	1978-10-01
JPS6172A (ja)	1986-01-06
IE45300B1 (en)	1982-07-28
RO70569A (ro)	1981-11-24
GR64553B (en)	1980-04-14
FR2372810B1 (es)	1982-11-26
US4271158A (en)	1981-06-02
DD130037A5 (de)	1978-03-01
NZ183536A (en)	1981-11-19
ES466599A1 (es)	1978-10-01
PT66282B (pt)	1979-01-17
FR2343731A1 (fr)	1977-10-07
PT66282A (pt)	1977-04-01
ES466606A1 (es)	1978-10-01
AU515953B2 (en)	1981-05-14
MX4878E (es)	1982-11-26
SU676163A3 (ru)	1979-07-25
CH630361A5 (de)	1982-06-15
ES466601A1 (es)	1978-10-01
ATA122377A (de)	1980-06-15
CH630358A5 (de)	1982-06-15
SE7702609L (sv)	1977-10-11
IL51627A0 (en)	1977-05-31
CH630365A5 (de)	1982-06-15

Legal Events

Date	Code	Title	Description
2000-02-01	FD1A	Patent lapsed	Effective date: 20000103

Publication	Publication Date	Title
ES466598A1 (es)	1978-10-01	Procedimiento para la preparacion de heterociclos aminoal- cohilicos.
ES464162A1 (es)	1978-09-01	Procedimiento para la preparacion de derivados de quinazolo-na.
ES475677A1 (es)	1979-04-16	Procedimiento para la preparacion de nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamido-1,1-dioxidos.
ES453376A1 (es)	1979-06-01	Un procedimiento para la preparacion de una composicion her-bicida a partir de derivados de pirazol.
ES452921A1 (es)	1977-11-01	Procedimiento para la preparacion de nuevas amidas de acidosamino-benzoicos.
ES467565A1 (es)	1978-10-16	Procedimiento para la preparacion de nuevas 4-acilamino-fe- nil-etanol-aminas.
ES414159A1 (es)	1976-02-01	Procedimiento para la preparacion de nuevos derivados de 2-fenilamino-imidazolina-(2).
ES465225A1 (es)	1978-09-16	Procedimiento para la preparacion de n-cicloalcohilmetil-2- fenilamino-imidazolinas-(2).
ES450166A1 (es)	1977-11-16	Procedimiento de preparacion de nuevos derivados de amino- benzociclohepteno.
ATE52249T1 (de)	1990-05-15	Aminoalkyl-substituierte harnstoffderivate, deren saeureadditionssalze und enantiomere.
GB2117762B (en)	1985-09-25	4-phenyl-4 5 6 7-tetrahydro-thieno (2 3-clpyridines)
SE8300432L (sv)	1983-01-28	Reaktiva kanelsyraderivat for framstellning av biologiskt aktiva amider
SE7908940L (sv)	1980-05-01	Nya acyl-1h-1,2,4-triazolderivat
SE7606497L (sv)	1976-12-11	Substituerade 4-fenylimidazoliner, deras syraadditinossalter och forfarande for framstellning derav
ES490675A0 (es)	1981-05-16	Un procedimiento para la preparacion de nuevos derivados de oxazolina y tiazolina
ES8502115A1 (es)	1984-12-16	Procedimiento para preparar nuevos 4-hidroxi-2h-1, 2-benzotiazin-3-carboxamido-1, 1-dioxidos
ES8502442A1 (es)	1985-01-01	Procedimiento para preparar nuevos compuestos heterociclicos
ES488702A1 (es)	1980-09-16	Procedimiento para la preparacion de amidinas heterociclicasde condensacion espiro
ES445339A1 (es)	1977-06-01	Un procedimiento para la preparacion de derivados pirrolidi-nicos.
GB2006762A (en)	1979-05-10	Chroman Derivatives
ES8502427A1 (es)	1985-01-01	Procedimiento para preparar nuevas semicarbazidas