ES475587A1 - Procedimiento para preparar derivados de isoquinolina - Google Patents
Procedimiento para preparar derivados de isoquinolinaInfo
- Publication number
- ES475587A1 ES475587A1 ES475587A ES475587A ES475587A1 ES 475587 A1 ES475587 A1 ES 475587A1 ES 475587 A ES475587 A ES 475587A ES 475587 A ES475587 A ES 475587A ES 475587 A1 ES475587 A1 ES 475587A1
- Authority
- ES
- Spain
- Prior art keywords
- carbon atoms
- formula
- alkyl
- group
- r3iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 13
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- -1 di-substituted phenyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Procedimiento para preparar derivados de isoquinolina, de fórmula I **fórmula** en donde R1 es hidrógeno, halógeno con número atómico de 9 a 35 o un grupo alquilo o alcoxi conteniendo de 1 a 4 átomos de carbono, R2 es hidrógeno, alquilo conteniendo de 1 a 4 átomos de carbono, un grupo fenilo o un grupo fenilo mono-sustituido o di-sustituido por halógeno con número, atómico de 9 a 35, alquilo conteniendo de 1 a 4 átomos de carbno o alcoxi conteniendo de 1 a 4 átomos de carbono, y R3III es alquilo conteniendo de 1 a 4 átomos de carbono, un grupo alquenilo o alquinilo conteniendo de 3 a 6 átomos de carbono, cuyo enlace múltiple no se encuentra adyacente al átomo de nitrógeno de la estructura de anillo tri-cíclica, un grupo cicloalquilalquilo conteniendo de 4 a 10 átomos de carbono, un grupo cicloalquilo conteniendo de 3 a 7 átomos de carbono, un grupo fenilalquilo de 7 a 10 átomos de carbono que puede ser mono-sustituido o di-sustituido en el anillo fenílico por halógeno con número atómico de9 a 35, alquilo de 1 a 4 átomos de carbono o alcoxi de 1 a 4 átomos de carbono, o un grupo alcanoilalquilo conteniendo de 3 a 5 átomos de carbono, cuyo átomo de oxígeno está separado del átomo de nitrógeno de la estructura de anillo tri-cíclica por a lo menos 2 átomos de carbono y sus sales de adición de ácido, caracterizado porque comprende introducir el grupo R3IIIen compuestos de fórmula**fórmula** en donde R1 y R2 tienen los significados previamente indicados, preferentemente por reacción de los compuestos de fórmula Ib con compuestos de fórmula R3III-x en donde R3III se define como anteriormente y X es el radical ácido de un éster reactivo, y si se desea, se convierten los compuestos de fórmula Id resultantes en sus sales de adición de ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH82077A CH630902A5 (en) | 1977-01-24 | 1977-01-24 | Process for preparing novel derivatives of 1,2,3,4,4a,10b-hexahydrobenzo(f)isoquinoline. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES475587A1 true ES475587A1 (es) | 1980-02-16 |
Family
ID=4195950
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466245A Expired ES466245A1 (es) | 1977-01-24 | 1978-01-23 | Procedimiento para preparar derivados de isoquinolina |
| ES475587A Expired ES475587A1 (es) | 1977-01-24 | 1978-11-30 | Procedimiento para preparar derivados de isoquinolina |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES466245A Expired ES466245A1 (es) | 1977-01-24 | 1978-01-23 | Procedimiento para preparar derivados de isoquinolina |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5392778A (es) |
| AT (1) | AT367405B (es) |
| BE (1) | BE863215A (es) |
| CA (1) | CA1105468A (es) |
| CH (3) | CH630902A5 (es) |
| DE (1) | DE2801576A1 (es) |
| DK (1) | DK19278A (es) |
| ES (2) | ES466245A1 (es) |
| FI (1) | FI780130A7 (es) |
| FR (1) | FR2378015A1 (es) |
| GB (1) | GB1596170A (es) |
| IE (1) | IE46381B1 (es) |
| IL (1) | IL53869A (es) |
| IT (1) | IT7847687A0 (es) |
| NL (1) | NL7800719A (es) |
| NZ (1) | NZ186279A (es) |
| PH (1) | PH14194A (es) |
| PT (1) | PT67562B (es) |
| SE (1) | SE7800452L (es) |
| SU (1) | SU852172A3 (es) |
| ZA (1) | ZA78430B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8302361D0 (sv) * | 1983-04-27 | 1983-04-27 | Astra Laekemedel Ab | New tricyclic amines |
| US5294618A (en) * | 1989-07-28 | 1994-03-15 | Merck Sharp & Dohme Limited | Octahydrobenzisoquinoline derivatives as antipsychotic agents |
| GB8917333D0 (en) * | 1989-07-28 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| EP0539209A1 (en) * | 1991-10-24 | 1993-04-28 | The Upjohn Company | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
| CA2118920A1 (en) * | 1991-10-24 | 1993-04-29 | Arthur G. Romero | Benzo-isoquinoline derivatives and analogs and their use in therapeutics |
| TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
| AT407636B (de) * | 1999-07-09 | 2001-05-25 | Martin Dr Kratzel | Diels-alder-produkte von tetrahydropyridin-dienen mit naphthochinonen und deren oxidationsprodukte, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln |
-
1977
- 1977-01-24 CH CH82077A patent/CH630902A5/de not_active IP Right Cessation
-
1978
- 1978-01-14 DE DE19782801576 patent/DE2801576A1/de not_active Withdrawn
- 1978-01-16 FI FI780130A patent/FI780130A7/fi not_active Application Discontinuation
- 1978-01-16 SE SE7800452A patent/SE7800452L/xx unknown
- 1978-01-16 DK DK19278A patent/DK19278A/da not_active Application Discontinuation
- 1978-01-18 IT IT7847687A patent/IT7847687A0/it unknown
- 1978-01-20 NZ NZ186279A patent/NZ186279A/xx unknown
- 1978-01-20 NL NL7800719A patent/NL7800719A/xx not_active Application Discontinuation
- 1978-01-23 ES ES466245A patent/ES466245A1/es not_active Expired
- 1978-01-23 BE BE184555A patent/BE863215A/xx not_active IP Right Cessation
- 1978-01-23 JP JP534678A patent/JPS5392778A/ja active Pending
- 1978-01-23 IL IL53869A patent/IL53869A/xx unknown
- 1978-01-23 PT PT67562A patent/PT67562B/pt unknown
- 1978-01-23 AT AT0045478A patent/AT367405B/de not_active IP Right Cessation
- 1978-01-23 CA CA295,458A patent/CA1105468A/en not_active Expired
- 1978-01-23 PH PH20696A patent/PH14194A/en unknown
- 1978-01-23 SU SU782571448A patent/SU852172A3/ru active
- 1978-01-23 IE IE151/78A patent/IE46381B1/en unknown
- 1978-01-23 GB GB2603/78A patent/GB1596170A/en not_active Expired
- 1978-01-24 FR FR7801860A patent/FR2378015A1/fr active Granted
- 1978-01-24 ZA ZA00780430A patent/ZA78430B/xx unknown
- 1978-11-30 ES ES475587A patent/ES475587A1/es not_active Expired
-
1981
- 1981-03-20 CH CH190881A patent/CH630903A5/de not_active IP Right Cessation
- 1981-03-20 CH CH190981A patent/CH630904A5/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GB1596170A (en) | 1981-08-19 |
| PT67562A (fr) | 1978-02-01 |
| AT367405B (de) | 1982-07-12 |
| CH630902A5 (en) | 1982-07-15 |
| NZ186279A (en) | 1980-05-27 |
| ATA45478A (de) | 1981-11-15 |
| CH630904A5 (en) | 1982-07-15 |
| ZA78430B (en) | 1979-09-26 |
| CH630903A5 (en) | 1982-07-15 |
| ES466245A1 (es) | 1980-12-16 |
| BE863215A (fr) | 1978-07-24 |
| PT67562B (fr) | 1980-11-03 |
| SU852172A3 (ru) | 1981-07-30 |
| CA1105468A (en) | 1981-07-21 |
| NL7800719A (nl) | 1978-07-26 |
| DK19278A (da) | 1978-07-25 |
| FI780130A7 (fi) | 1978-07-25 |
| IL53869A0 (en) | 1978-04-30 |
| SE7800452L (sv) | 1978-07-25 |
| IL53869A (en) | 1981-05-20 |
| PH14194A (en) | 1981-03-26 |
| FR2378015B1 (es) | 1980-08-22 |
| IE46381B1 (en) | 1983-05-18 |
| IE780151L (en) | 1978-07-24 |
| AU3265478A (en) | 1979-08-02 |
| FR2378015A1 (fr) | 1978-08-18 |
| IT7847687A0 (it) | 1978-01-18 |
| JPS5392778A (en) | 1978-08-15 |
| DE2801576A1 (de) | 1978-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES388135A2 (es) | Procedimiento para la obtencion de lactamas sustituidas en el nitrogeno. | |
| ES8300699A1 (es) | Procedimiento para la preparacion de derivados del indol. | |
| ES477364A1 (es) | Un proceso para producir un ester glicolipido hidroxialqui- loeterificado. | |
| ES8200122A1 (es) | Un metodo para la preparacion de 17,21-diesteres de 6alfa- 9alfa-didluoro-16-metil-prednisolona | |
| MD422C2 (ro) | Derivaţi ai azolului şi compuţi intermediari pentru producerea lor | |
| ES484219A1 (es) | Un procedimiento para la preparacion de triazinonas | |
| GB1510977A (en) | Tetrahydropyridine and piperidine derivatives and processes for the production thereof | |
| ES2059626T3 (es) | Nuevos esteres de estramustina. | |
| ES2004141A6 (es) | Un procedimiento de preparacion de nuevas 1,4-dihidropiridinas | |
| ES480671A1 (es) | Un procedimiento para la preparacion de nuevos derivados de quinazolina. | |
| ES476385A1 (es) | Un procedimiento para preparar derivados de transpirindina | |
| ES448629A1 (es) | Procedimiento para la preparacion de nuevos derivados de 1,4-bis-(carboxil-alcohil-benzoxazolil)-naftaleno. | |
| PL255529A1 (en) | Method of obtaining novel n-alyl/en/o-n/",o-disubstituted thiophosphoryl/-n',n'-disubstituted glicinamides | |
| ES479025A1 (es) | Procedimiento para preparar esteres organicos de acido fos- forico. | |
| ES438736A1 (es) | Procedimiento para preparar esteres del acido dihidro-16, 17 apovincaminico. | |
| ES2036600T3 (es) | Procedimiento para preparar 1-(3-(2-dialquilaminoetoxi)-2-tienil)-3-fenil-1-propanonas. | |
| ES453997A1 (es) | Procedimiento para la preparacion de acetatos de eteraminas secundarias. | |
| ES274908A1 (es) | Procedimiento para la preparaciën de nuevos derivados de iminodibencilo | |
| ES362369A1 (es) | Procedimiento para la preparacion de nuevos derivados de piperidina. | |
| ES364725A1 (es) | Procedimiento para la preparacion de nuevos derivados de p-aminoalquil-bencensulfonamida. | |
| ES356717A1 (es) | Procedimiento para la preparacion de nuevos esteres difeni-licos. | |
| ES434406A1 (es) | Procedimiento para preparar derivados de naftiridina. | |
| ES402471A1 (es) | Un procedimiento para la preparacion de derivados de 1-ari-loxi-3-amino-propanol. | |
| ES432501A1 (es) | Procedimiento para la obtencion de pleuromutilinas. | |
| ES334978A1 (es) | Procedimiento para la preparacion de dibenzo (b,f)-1,4-oxa-cepinas y dibenzo (b,f)-1,4-tiacepinas 11-aminoalquilizadas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |